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Neurology Laboratory

neurological disease, biobanking, neuro-oncology, multiple sclerosis...

The late Robyn Flook with Flinders neurosurgeon
Dr Santosh Poonnoose, checking neurological
samples banked for research

 

Research Summary

The Neurology laboratory incorporates the activities of the:

  • South Australian Brain Bank
  • South Australian Neurology Tumour Bank
  • Multiple Sclerosis Laboratory.

Research Platforms

The SA Brain Bank, in collaboration with the Australian Brain Bank Network, collects, processes and distributes post-mortem human brain tissue and related samples for research into neurological and psychiatric conditions. Researchers are provided with clinically and neuropathologically well-characterised human brain tissue on which they can conduct analyses related to their fields of expertise.
To take a look at what's involved as a Donor, or for the answers to frequently asked questions, please see the Brain Bank information brochure.

The availability of banked tissue (and linked de-identified clinical information) to enable this research is vital. The Bank celebrated its 30th birthday in 2016. Dr Ormsby and Ms Malgorzata Krupa have provided cover for the brain bank since the manager position has been unfunded but this is no longer sustainable.
The SA Brain Bank managers position was unfilled for most of 2016 due to the ill-health and later passing of Ms Robyn Flook. Robyn had managed the bank for nearly 20 years. The position is still unfilled (as of October 2017) due to funding difficulties and the bank has essentially suspended operation pending further funding and appointment of a manager.
All enquiries during this time can be forwarded to
SABB@flinders.edu.au

SABB Executive Directors
Assoc Prof Mark Slee, Clinical Academic Neurologist, Department of Neurology, Discipline of Human Physiology, and Centre for Neuroscience
Prof Peter Blumbergs, Professor of Neuropathology, Centre for Neurological Diseases, University of Adelaide and SA Pathology.

Coordinator/Manager
This position is currently vacant.

Scientific Advisory Committee
Prof Peter Blumbergs
Dr Barbara Koszyca
Mr Jim Manavis
Mr Stephen Nygaard
Assoc Prof Mark Slee
Assoc Prof James Temlett
Dr Robert Wilcox

The tumour bank, established in 2013, is managed by Dr Ormsby. It is a collaboration between neurosurgery, oncology and neurology. Her position is funded via the Flinders Foundation and SA Police/Lightsview RideLikeCrazy.

SANTB Executive Directors
Assoc Prof Mark Slee, Clinical Academic Neurologist, Department of Neurology, Discipline of Human Physiology, and Centre for Neuroscience
Prof Peter Blumbergs, Professor of Neuropathology, Centre for Neurological Diseases, University of Adelaide and SA Pathology.

Coordinator/Manager
Dr Rebecca Ormsby, Coordinator SA Neurological Tumour Bank (rebecca.ormsby@flinders.edu.au)

Scientific Advisory Committee
Prof Peter Blumbergs
Dr Barbara Koszyca
Mr Jim Manavis
Mr Stephen Nygaard
Assoc Prof Mark Slee
Assoc Prof James Temlett
Dr Robert Wilcox

The MS Laboratory is led by Assoc Prof Slee and supported by Ms Krupa (SA Health funded). It has a DNA/RNA library which is accessed by groups nationally and internationally. It works closely with the SALHN MS clinical service.
Research projects include:
> Dr Brian Ng, Prof Derek Abbott, Dr Gretel Png, Dept Electrical and Electronic Engineering, Adelaide University: In vitro investigation of senile plaques using terahertz spectroscopy.
> Prof Glenda Halliday, Dept of Medical Sciences, Neuroscience Research Australia, Sydney NSW: Molecular genetics and neuropathology in dementia/ALS families.
> Dr Tim Chataway, Dept of Human Physiology, Flinders University: Analysis of neural inclusions in ageing and diseased brains.
> Dr Dean Pountney, Dept of Medical Science, Griffith University, Gold Coast, Qld: Role of Sumo-1 conjugates in alpha-synucleinopathies.
> Prof Rainer Haberberger, Dept Anatomy & Histology, Flinders University: Biolipids as modulators of synaptic transmission in the human dorsal root ganglia (DRG) and spinal cord.
> Assoc Prof Rob Casson, Ophthalmology Network, Royal Adelaide Hospital: The pathology of the optic nerve in human glaucoma: a case controlled study examining the pathology of the optic nerve in human glaucoma.

Selected Publications

Lizak N, Lugaresi A, Alroughani R, Lechner-Scott J, Slee M, Havrdova E, Horakova D, Trojano M, Izquierdo G, Duquette P, Girard M, Prat A, Grammond P, Hupperts R, Grand'Maison F, Sola P, Pucci E, Bergamaschi R, Oreja-Guevara C, Van Pesch V, Ramo C, Spitaleri D, Iuliano G, Boz C, Granella F, Olascoaga J, Verheul F, Rozsa C, Cristiano E, Flechter S, Hodgkinson S, Amato MP, Deri N, Jokubaitis V, Spelman T, Butzkueven H, Kalincik T; MSBase Study Group (2017) Highly active immunomodulatory therapy ameliorates accumulation of disability in moderately advanced and advanced multiple sclerosis. Journal of Neurology, Neurosurgery & Psychiatry, 88:196-203

 

Kalincik T, Kuhle J, Pucci E, Rojas JI, Tsolaki M, Sirbu CA, Slee M, Butzkueven H; MSBase Scientific Leadership Group and MSBase Study Group (2017) Data quality evaluation for observational multiple sclerosis registries. Mult Scler, 23(5):647-655

 

Stewart T, Spelman T, Havrdova E, Horakova D, Trojano M, Izquierdo G, Duquette P, Girard M, Prat A, Lugaresi A, Grand'Maison F, Grammond P, Sola P, Shaygannejad V, Hupperts R, Alroughani R, Oreja-Guevara C, Pucci E, Boz C, Lechner-Scott J, Bergamaschi R, Van Pesch V, Iuliano G, Ramo C, Taylor B, Slee M, Spitaleri D, Granella F, Verheul F, McCombe P, Hodgkinson S, Amato MP, Vucic S, Gray O, Cristiano E, Barnett M, Sanchez Menoyo JL, van Munster E, Saladino ML, Olascoaga J, Prevost J, Deri N, Shaw C, Singhal B, Moore F, Rozsa C, Shuey N, Skibina O, Kister I, Petkovska-Boskova T, Ampapa R, Kermode A, Butzkueven H, Jokubaitis V, Kalincik T; MSBase Study Group (2017) Contribution of different relapse phenotypes to disability in multiple sclerosis. Mult Scler, 23(2):266-276

 

Mahurkar S, Moldovan M, Suppiah V, Sorosina M, Clarelli F, Liberatore G, Malhotra S, Montalban X, Antigüedad A, Krupa M, Jokubaitis VG, McKay FC, Gatt PN, Fabis-Pedrini MJ, Martinelli V, Comi G, Lechner-Scott J, Kermode AG, Slee M, Taylor BV, Vandenbroeck K, Comabella M, Boneschi FM; Australian and New Zealand Multiple Sclerosis Genetics Consortium (ANZgene), King C (2017) Response to interferon-beta treatment in multiple sclerosis patients: a genome-wide association study. The Pharmacogenomics Journal, 17:312–318

 

Pattichis AA, Slee M (2016) CSF hypotension: A review of its manifestations, investigation and management. J Clin Neurosci, 34:39-43. Review.

 

Lorscheider J, Buzzard K, Jokubaitis V, Spelman T, Havrdova E, Horakova D, Trojano M, Izquierdo G, Girard M, Duquette P, Prat A, Lugaresi A, Grand'Maison F, Grammond P, Hupperts R, Alroughani R, Sola P, Boz C, Pucci E, Lechner-Scott J, Bergamaschi R, Oreja- Guevara C, Iuliano G, Van Pesch V, Granella F, Ramo-Tello C, Spitaleri D, Petersen T, Slee M, Verheul F, Ampapa R, Amato MP, McCombe P, Vucic S, S.nchez Menoyo JL, Cristiano E, Barnett MH, Hodgkinson S, Olascoaga J, Saladino ML, Gray O, Shaw C, Moore F, Butzkueven H, Kalincik T; MSBase Study Group (2016) Defining secondary progressive multiple sclerosis. Brain, 139(Pt 9):2395-405

 

Kister I, Spelman T, Alroughani R, Lechner-Scott J, Duquette P, Grand'Maison F, Slee M, Lugaresi A, Barnett M, Grammond P, Iuliano G, Hupperts R, Pucci E, Trojano M, Butzkueven H; MSBase Study Group (2016) Discontinuing disease-modifying therapy in MS after a prolonged relapse-free period: a propensity score-matched study. J Neurol Neurosurg Psychiatry, 87(10):1133-7

 

Kalincik T, Cutter G, Spelman T, Jokubaitis V, Havrdova E, Horakova D, Trojano M, Izquierdo G, Girard M, Duquette P, Prat A, Lugaresi A, Grand' Maison F, Grammond P, Hupperts R, Oreja-Guevara C, Boz C, Pucci E, Bergamaschi R, Lechner-Scott J, Alroughani R, Van Pesch V, Iuliano G, Fernandez-Bolanos R, Ramo C, Terzi M, Slee M, Spitaleri D, Verheul F, Cristiano E, Sanchez-Menoyo JL, Fiol M, Gray O, Cabrera-Gomez JA, Barnett M, Butzkueven H (2016) Defining reliable disability outcomes in multiple sclerosis. Brain, 138(11):3287-98

 

*Yan XX, Ma C, Bao AM, Wang XM, Gai WP (2015) Brain banking as a cornerstone of neuroscience in China. The Lancet. Neurology, 14(2):136

 

*Chen T, Gai WP, Abbott CA (2014) Dipeptidyl peptidase 10 (DPP10(789)): a voltage gated potassium channel associated protein is abnormally expressed in Alzheimer's and other neurodegenerative diseases. Biomedical Research International, 2014:209398

 

*Corrigan F, Thornton E, Roisman LC, Leonard AV, Vink R, Blumbergs PC, van den Heuvel C, Cappai R (2014) The neuroprotective activity of the amyloid precursor protein against traumatic brain injury is mediated via the heparin binding site in residues 96-110. Journal of Neurochemistry, 128(1):196-204

 

*Greene ID, Mastaglia F, Meloni BP, West KA, Chieng J, Mitchell CJ, Gai WP, Boulos S (2014) Evidence that the LRRK2 ROC domain Parkinson's disease-associated mutants A1442P and R1441C exhibit increased intracellular degradation. Journal of Neuroscience Research, 92(4):506-16

 

*Leonard AV, Manavis J, Blumbergs PC, Vink R (2014) Changes in substance P and NK1 receptor immunohistochemistry following human spinal cord injury. Spinal Cord, 52(1):17-23

 

*Rcom-H cheo-Gauthier A, Goodwin J, Pountney DL (2014) Interactions between calcium and alpha-synuclein in neurodegeneration. Biomolecules, 4:795-811

 

*Yan XX, Ma C, Gai WP, Cai H, Luo XG (2014) Can BACE1 inhibition mitigate early axonal pathology in neurological diseases? Journal of Alzheimers Disease, 38(4):705-18

 

*Wong MB, Goodwin J, Norazit A, Meedeniya AC, Richter-Landsberg C, Gai WP, Pountney DL (2013) SUMO-1 is associated with a subset of lysosomes in glial protein aggregate diseases. Neurotoxicity Research, 23(1):1-21

 

*Kragh CL, Fillon G, Gysbers A, Hansen HD, Neumann M, Richter-Landsberg C, Haass C, Zalc B, Lubetzki C, Gai WP, Halliday GM, Kahle PJ, Jensen PH (2013) FAS-dependent cell death in α-synuclein transgenic oligodendrocyte models of multiple system atrophy. PLoS One, 8(1):e55243

 

*Guerreiro PS, Huang Y, Gysbers A, Cheng D, Gai WP, Outeiro TF, Halliday GM (2013) LRRK2 interactions with α-synuclein in Parkinson's disease brains and in cell models. Journal of Molecular Medicine (Berlin), 91(4):513-22

 

 

It is a requirement of obtaining tissues from the SA Brain Bank that it is acknowledged in all oral or written presentations or publications that arise from the use of brain bank material, even where the absence of agreed collaborations means that members of the SA Brain Bank are not authors on any publication. The publications noted with a *, have arisen as a result of the activities supported by the SA Brain Bank.

 

Investigator

  • Assoc Prof Mark Slee, BAppSc, BMBS, FRACP, PhD

Support Staff

  • Malgosia Krupa, Neurology Scientific Officer (SA Health)

Students

  • Jian (Harry) Teoh, MD Advanced Studies Student


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