The Neuronal Injury and Repair (NIR) laboratory began its research in 2014 on the effect of brain ischemia on producing the hallmarks of Alzheimer’s disease. The lab has been moved to a bigger space in 2016, closely collaborating with the Parkinson’s and Alzheimer’s laboratory. Working with three systems of animal (rat) model, human brain and cell culture, this lab is focused on understanding the immediate brain strategies to maintain the energy homeostasis, to protect the brain against death due to physiological changes in blood oxygen, or the situations which cause the sudden disruption in energy supply, such as stroke, cardiac arrest and traumatic brain injury. The lab also aims to reveal the underlying cellular mechanisms of response to low levels of oxygen in brain and their involvement in aging and the pathogenesis of neurodegenerative disorders.
Distribution of p-AMPK (a, green) within the neurons (NeuN; a, red)
brain samples of long-term recovery group (2 min ischaemia
followed by 4 weeks).
Accumulation of p-LKB1 is shown in long-term recovery group (b).
Immunofluorescent results, showing the presence of p-GSK-3β at Ser9 (e, red)
with some co-localization with tau (d, green) in the long-term group
Majd S, Power JH, Grantham HJ (2015) Neuronal response in Alzheimer's and Parkinson's disease: the effect of toxic proteins on intracellular pathways. BMC Neuroscience, 16:69
Majd S, Chegini F, Chataway TK, Zhou X and Gai W (2013) Reciprocal Induction Between a-synuclein and b-amyloid in Adult Rat Neurons. Neurotoxicity Research, 23(1):69-78
Dawson S, King L and Grantham H (2013) Review article: Improving the hospital clinical handover between paramedics and emergency department staff in the deteriorating patient. Emergency Medicine Australasia, 25(5):393-405
Grantham H and Narendranathan R (2012) Basic and advanced cardiac life support - what's new? Australian Family Physician, 41(6):386-390
Robinson K, Lockwood C and Grantham H (2012) First attempt success using intraosseous (IO) as an alternative to intravenous (IV) vascular access in Out of Hospital Cardiac Arrest (OHCA): a Systematic Review. JBI Library Systematic Review, 10(56)
Majd S, Smardencas A, Parish CL and Drago J (2011) Development of an In Vitro Model to Evaluate the Regenerative Capacity of Adult Brain-Derived Tyrosine Hydroxylase- Expressing Dopaminergic Neurons. Neurochemical Research, 36:967-977
Wang Y, Valadares D, Sun A, Majd S, Wang X, Zhong JH, Liu X, et al. (2010) Effects of proNGF on neuronal viability, neurite growth and amyloid-beta metabolism. Neurotoxicity Research, 17(3):257-267
Majd S, Zarifkar A, Rastegar K, Takhshid MA (2008) Different fibrillar Abeta 1-42 concentrations induce adult hippocampal neurons to reenter various phases of the cell cycle. Brain Research, 1218:224-9
Majd S, Rastegar K, Zarifkar A, Takhshid MA (2007) Fibrillar beta-amyloid (Abeta) (1-42) elevates extracellular Abeta in cultured hippocampal neurons of adult rats. Brain Research, 1185:321-7