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Stroke Research Programme - TQEH

stroke, prevention, diagnosis, treatment, translation...

Dental Pulp Stem Cells

JJ Li & AG Milton, 2011 Stroke Research Programme,
University of Adelaide

Research Summary

The Stroke Research Programme at CALHN, collaborating with the University of Adelaide, has been actively involved with national research for stroke prevention, diagnosis and treatment, since 1992. Our stroke-related research investigates genetic and proteomic factors that may change the risk for stroke, inflammatory pathways involved in stroke and primary health stroke prevention research.
We have international links in our stroke-related research on genetic investigations, via collaborations with the International Stroke Genetics Collaborative through the Australian Stroke Genetics Collaborative. Another major area of interest is the therapeutic application of adult stem cells to repair the brain following stroke. We also seek to elucidate the genetic control factors for the Npas4 gene that affect the process of neurogenesis. The SRP is an associate laboratory of the Centre for Neuroscience.
60,000 Australians suffer a stroke every year and one third are left with severe disability. We aim to improve stroke outcomes by administering stem cells. Previously we demonstrated in rats that dental pulp stem cells injected into the brain can improve neurological function after stroke. In 2016, we continued our work on genetic control factors for the Npas4 gene and on the non-invasive treatment of the stroke-affected brain with transcranial magnetic stimulation (TMS) in animal models.

The SRP is also part of a multi-institutional research project on neuroplasticity in stroke that has been awarded NHMRC project funding worth $735,660 over four years (2014-2017). Titled “Characterising post-stroke cortical plasticity in humans - identifying a critical window for rehabilitation".

 

 

Research Projects

> Australian Stroke Genetics Collaboration (ASGC).
> Biomarker Discovery in patients diagnosed with Transient Ischaemic Attack.
> Investigation into Dental Pulp Stem Cells.
> Investigation of Stem Cell Therapy for Stroke.
> Npas4, a brain-specific transcription factor and its role in Neurogenesis and Stroke.
> Transient Ischaemic Attack (TIA) Knowledge in General Practice.
> Transcranial Magnetic Stimulation (TMS) for chronic stroke.

For full details on the research projects undertaken by the SRP, please see their official website: www.adelaide.edu.au/srp/

Publications


Investigators

  • Simon A Koblar, BMBS FRACP PhD

    M Anne Hamilton-Bruce, BSc MSc MBA PhD AFCHSE CBiol MSB CSci FIBMS

    Jim Jannes, BMBS FRACP PhD

    Karlea Kremer, BBtech (Hons), PhD

    Fong Chan Choy, BSc (Hons), PhD

    Austin G Milton, BSc (Hons), DipCompSci

Students

  • Anjali Nagpal, MBBS MD FRCA (UK), PhD Candidate

    Dr Anupam Gupta, MBBS MD ClinDipPallMed(RACP) GradDipMuscMed FAFRM(RACP), PhD Candidate

    Chelsea Graham, BSc(Animal Sc)(Hons), PhD Candidate

    Joshua Winderlich, BSc(Health Sci)(Hons), PhD Candidiate

    Kendall Goldsmith, BA(Psychology), PhD Candidate

    Maria R Gancheva, BSc(Biomed.Sci)(Hons), PhD Candidate

    Michael Djukic, BHSc(Hons) GradCertBus(Acc) DPT(UniMelb), PhD Candidate

    Victor J Krawczyk, BSocSc(HumServ) BA(Hons) GDipArtHist, PhD Candidate

    Jenny Sutton, MPhil(Med) MN BComm BBus(Int) CPA, Masters Candidate

    Min Hui Tan, Summer Scholarship Student


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