Prof Marcello Costa

Marcello in Patagonia
Position/s:Professor of Neurophysiology
Human Physiology
Phone: +61 8 82044182
Email:
Location: Flinders Medical Centre (6E:128.1)
Postal address: GPO Box 2100, Adelaide 5001, South Australia

Biography

Marcello Costa was born in Torino (Turin, Italy) in 1940 where obtained in 1967 his Medical Degree (Laurea in Medicina e Chirurgia)
Migrated to Australia in 1970, was one of the founders of the new discipline of Neuroscience and the Australian Neuroscience Society (ANS), of which become President in the 90s. He holds a personal chair in Neurophysiology at Flinders University, the first in Australia. He has published over 230 scientific papers in international journals, 55 reviews and chapters and written two books in enteric neuroscience and gastrointestinal motor functions.
He was foundation co-chair of the the South Australian Neuroscience Institute (SANI) from 2003 to 2010.
He is active in the field of philosophy of science and education in neuroscience to university students and to the broader public (see publications and CV).
 He actively participates in the activities of the association Friends of Science in Medicine opposing pseudosciences (http://www.scienceinmedicine.org.au/).

Qualifications

He has a degree in Medicine (Laurea in Medicina e Chirurgia) from the University of Torino, Italy obtained in 1967.

Honours, awards and grants

He has been elected Fellow of the Australian Academy of Science 1988.
Received the honor of "Cavaliere della Repubblica Italiana" from the Italian Government in 1992.
Recipient of prize" Piedmontese of the Year" in 1994
Received a Centenary Medal, Australia 2003.
He received the Flinders 40Th anniversary medal for services to the University 2006
Was awarded, together with Ian Gibbins, the "Unsung Hero of South Australian Science Communication" Award for 2008 of the National Science Week, Australian Science Communicators (SA).
In 2012 he was made Matthew Flinders Distinguished Professor at Flinders University.

Key responsibilities

Marcello has a personal chair in Neurophysiology and is responsible for a number of topics in neuroscience and run his own experiments since he relinquished his role as directing a large research laboratory. He is leading a team of researchers in a project funded by the ARC (see research)

Teaching

Teaching interests

Marcello is a passionate teacher of neuroscience both at undergraduate level, postgraduate level and to the general public. He taught at the University of the third age (Flinders) a short topic on Brain and Cognition in 2009, and in 2010 a 6 parts topic on "The Physics of the Mind" at the U3A in Adelaide. He gave talks on Neuroscience at numerous primary and secondary schools. He gave a short course on "Illusions and the Brain" at the Australian School of Mathematics and Physics.
He has established most undergraduate topics in Neuroscience in the School of Medicine and now coordinates two of these.
Was a foundation member of the interfaculty Cognitive Science undergraduate course, now no longer available.
He has been involved in setting up and teaching in the postgraduate neuroscience course offered under the umbrella of SANI by Flinders University.
His commitment to education of scientific approach to human problems and neuroscience led him to be involved, under the umbrella of the South Australian Neuroscience Institute (SANI), in many public events including Science Outside of the Square (SOS) events organised by the South Australian Bragg Initiative and the RIAus. These included Brain and art, Brain and Dance, Brain and Soccer , Galileo celebration. He organised with Ian Gibbins a public event with the folksinger Ronnie Tahini and her group (Outhose Orchestra) on Brain and Music.

Topic Coordinator:

Topic Lecturer:

Research and supervision

Research interests

Marcello has been a pioneer in the study of the neural control of gastrointestinal functions with his first paper in this field published in 1965.
He has obtained research funds from National and International competitive peer reviewed granting bodies since his arrival to Flinders in 1975.
His laboratory was funded by the Pharmaceutical company Astra Zeneca for 11 years.
His research interest has been expanded to general issues of neuroscience and he is actively involved in exploring the conceptual foundations that brings neurosciences into fields as diverse as Philosophy, Social sciences, Psychology, History of Science, History of Art etc.
He has been funded by National and international granting bodies uninterruptedly since his arrival at Flinders University in 1975.
He is leading a team of researchers from 5 Institutions recipient of a significant  ARC discovery grant for 2012-2014 entitled "Unified framework of intestinal motility".

Publications

Book chapters
  • Costa, M. and Brookes, S.J. (2009). Neuropeptides: enteric nervous system. In Larry R. Squire, ed. Encyclopedia of Neuroscience. Oxford, UK: Academic Press, pp. 899-906.
  • Brookes, S.J. and Costa, M. (2006). Functional histoanatomy of the enteric nervous system. In editor-in-chief, Leonard R. Johnson ; associate editors, Kim Barrett et al., ed. Physiology of the Gastrointestinal Tract, Volume 1. 4th ed. Burlington, USA: Elsevier, pp. 577-602.
  • Costa, M. (2006). Advances in sensors; the lessons from neurosciences. In Jim Byrnes and Gerald Ostheimer, ed. Advances in Sensing with Security Applications. Dordrecht, The Netherlands: Springer, pp. 55-67. [doi:10.1007/1-4020-4295-7_03]
  • Brookes, S.J., Zagorodnyuk, V.P. and Costa, M. (2005). Mechanotransduction by vagal tension receptors in the upper gut. In Bradley J. Undem and Daniel Weinreich, ed. Advances in Vagal Afferent Neurobiology. Boca Raton, Florida, USA: CRC Press, pp. 147-166.
  • Brookes, S.J. and Costa, M. (2004). Functional neuroanatomy. In Robin Spiller, David Grundy, ed. PATHOPHYSIOLOGY OF THE ENTERIC NERVOUS SYSTEM. Malden, Mass.: Blackwell Publishing, pp. 3-12.
  • Brookes, S.J. and Costa, M. (2002). Cellular organisation of the mammalian enteric nervous system. In Simon Brookes and Marcello Costa, ed. Innervation of the gastrointestinal tract. London, UK: Taylor and Francis, pp. 393-467.
Refereed journal articles
  • Song, X., Chen, B.N., Zagorodnyuk, V.P., Lynn, P.A., Blackshaw, A., Grundy, D., et al. (2009). Identification of medium/high threshold extrinsic mechanosensitive afferent nerves to the gastrointestinal tract. Gastroenterology, 137(1) pp. 274-284. [doi:10.1053/j.gastro.2009.02.061]
  • Zagorodnyuk, V.P., Gregory, S.J., Costa, M., Brookes, S.J., Tramontana, M., Giuliani, S., et al. (2009). Spontaneous release of acetylcholine from autonomic nerves in the bladder. British Journal of Pharmacology, 157(4) pp. 607-619. [doi:10.1111/j.1476-5381.2009.00166.x]
  • Wattchow, D.A., DeFontgalland, D., Bampton, P.A., Leach, P.L., McLaughlin, K.J. and Costa, M. (2009). Clinical trial: the impact of cyclooxygenase inhibitors on gastrointestinal recovery after major surgery - a randomized double blind controlled trial of celecoxib or diclofenac vs. placebo. Alimentary Pharmacology and Therapeutics, 30(10) pp. 987-998. [doi:10.1111/j.1365-2036.2009.04126.x]
  • Wattchow, D.A., Brookes, S.J., Murphy, E., Carbone, S., DeFontgalland, D. and Costa, M. (2008). Regional variation in the neurochemical coding of the myenteric plexus of the human colon and changes in patients with slow transit constipation. Neurogastroenterology and Motility, 20(12) pp. 1298-1305. [doi:10.1111/j.1365-2982.2008.01165.x]

Show all publications

Book chapters
  • Costa, M. (2009). Lombroso e le neuroscienze. In Montaldo S., Tappero P., ed. Cesare Lombroso cento anni dopo. Torino: Utet, pp. 361-394.
  • Costa, M. and Brookes, S.J. (2009). Neuropeptides: enteric nervous system. In Larry R. Squire, ed. Encyclopedia of Neuroscience. Oxford, UK: Academic Press, pp. 899-906.
  • Brookes, S.J. and Costa, M. (2006). Functional histoanatomy of the enteric nervous system. In editor-in-chief, Leonard R. Johnson ; associate editors, Kim Barrett et al., ed. Physiology of the Gastrointestinal Tract, Volume 1. 4th ed. Burlington, USA: Elsevier, pp. 577-602.
  • Costa, M. (2006). Advances in sensors; the lessons from neurosciences. In Jim Byrnes and Gerald Ostheimer, ed. Advances in Sensing with Security Applications. Dordrecht, The Netherlands: Springer, pp. 55-67. [doi:10.1007/1-4020-4295-7_03]
  • Brookes, S.J., Zagorodnyuk, V.P. and Costa, M. (2005). Mechanotransduction by vagal tension receptors in the upper gut. In Bradley J. Undem and Daniel Weinreich, ed. Advances in Vagal Afferent Neurobiology. Boca Raton, Florida, USA: CRC Press, pp. 147-166.
  • Brookes, S.J. and Costa, M. (2004). Functional neuroanatomy. In Robin Spiller, David Grundy, ed. PATHOPHYSIOLOGY OF THE ENTERIC NERVOUS SYSTEM. Malden, Mass.: Blackwell Publishing, pp. 3-12.
  • Brookes, S.J. and Costa, M. (2002). Cellular organisation of the mammalian enteric nervous system. In Simon Brookes and Marcello Costa, ed. Innervation of the gastrointestinal tract. London, UK: Taylor and Francis, pp. 393-467.
Refereed journal articles
  • Arkwright, J., Dickson, A., Maunder, S.A., Blenman, N.G., Lim, J., O'Grady, G., et al. (2013). The effect of luminal content and rate of occlusion on the interpretation of colonic manometry . Neurogastroenterology and Motility, 25(1) pp. e52-e59. [10.1111/nmo.12051]
  • Brookes, S., Spencer, N., Costa, M. and Zagorodnyuk, V. (2013). Extrinsic primary afferent signalling in the gut. Nature Reviews. Gastroenterology and Hepatology, 10(5) pp. 286-296. [10.1038/nrgastro.2013.29]
  • Carbone, S., Dinning, P.G., Costa, M., Spencer, N., Brookes, S. and Wattchow, D. (2013). Ascending excitatory neural pathways modulate slow phasic myogenic contractions in the isolated human colon. Neurogastroenterology and Motility, 25(8) pp. 670-676.
  • Costa, M., Wiklendt, L., Arkwright, J.W., Omari, T., Brookes, S.J.H. and Dinning, P.G. (2013). An experimental method to identify neurogenic and myogenic active mechanical states of intestinal motility. Frontiers in Systems Neuroscience, 7(7) pp. 1-18. [10.3389/fnsys.2013.00007]
  • Dinning, P.G., Costa, M., Brookes, S. and Spencer, N. (2012). Neurogenic and myogenic motor patterns of rabbit proximal, mid and distal colon. American Journal of Physiology-Gastrointestinal and Liver Physiology, 303(1) pp. G83-G92. [10.1152/ajpgi.00429.2011]
  • Arkwright, , Blenman, N., Underhill, I., Maunder, S., Spencer, N., Costa, M., et al. (2012). Measurement of muscular activity associated with peristalsis in the human gut using fibre Bragg grating arrays. IEEE Sensors Journal, 12(1) pp. 113-117. [10.1109/JSEN.2011.2123883]
  • Arkwright, , Blenman, N., Underhill, I., Maunder, S., Spencer, N., Costa, M., et al. (2011). A fibre optic catheter for simultaneous measurement of longitudinal and circumferential muscular activity in the gastrointestinal tract. Journal of Biophotonics, 4(4) pp. 244-251. [10.1002/jbio.201000056]
  • Dinning, P., Arkwright, , Costa, M., Wiklendt, L., Hennig, G., Brookes, S., et al. (2011). Temporal relationships between wall motion, intraluminal pressure, and flow in the isolated rabbit small intestine. American Journal of Physiology-Gastrointestinal and Liver Physiology, 300 pp. G577-G585. [10.1152/ajpgi.00532.2010]
  • Hennig, G., Gregory, S.J., Brookes, S.J. and Costa, M. (2010). Non-peristaltic patterns of motor activity in the guinea-pig proximal colon . Neurogastroenterology and Motility, 22(6) pp. e207-e217. [10.1111/j.1365-2982.2009.01453.x]
  • Wattchow, D.A., DeFontgalland, D., Bampton, P.A., Leach, P.L., McLaughlin, K.J. and Costa, M. (2009). Clinical trial: the impact of cyclooxygenase inhibitors on gastrointestinal recovery after major surgery - a randomized double blind controlled trial of celecoxib or diclofenac vs. placebo. Alimentary Pharmacology and Therapeutics, 30(10) pp. 987-998. [doi:10.1111/j.1365-2036.2009.04126.x]
  • Song, X., Chen, B.N., Zagorodnyuk, V.P., Lynn, P.A., Blackshaw, A., Grundy, D., et al. (2009). Identification of medium/high threshold extrinsic mechanosensitive afferent nerves to the gastrointestinal tract. Gastroenterology, 137(1) pp. 274-284. [doi:10.1053/j.gastro.2009.02.061]
  • Zagorodnyuk, V.P., Gregory, S.J., Costa, M., Brookes, S.J., Tramontana, M., Giuliani, S., et al. (2009). Spontaneous release of acetylcholine from autonomic nerves in the bladder. British Journal of Pharmacology, 157(4) pp. 607-619. [doi:10.1111/j.1476-5381.2009.00166.x]
  • Brookes, S.J., Zagorodnyuk, V.P., Lynn, P.A., Song, X., Chen, B.N., Olsson, C.A., et al. (2008). Structural basis of sensory nerve pathways from the gut. European Review for Medical & Pharmacological Sciences, 12(Suppl1) pp. 132-133.
  • Costa, M. and Brookes, S.J. (2008). Architecture of enteric neural circuits involved in intestinal motility. European Review for Medical & Pharmacological Sciences, 12(1(Suppl)) pp. 3-19.
  • DeFontgalland, D., Wattchow, D.A., Costa, M. and Brookes, S.J. (2008). Immunohistochemical characterization of the innervation of human colonic mesenteric and submucosal blood vessels. Neurogastroenterology and Motility, 20(11) pp. 1212-1226. [doi:10.1111/j.1365-2982.2008.01150.x]
  • Lynn, P.A., Chen, B.N., Zagorodnyuk, V.P., Costa, M. and Brookes, S.J. (2008). TNBS-induced inflammation modulates the function of one class of low-threshold rectal mechanoreceptors in the guinea pig. American Journal of Physiology-Gastrointestinal and Liver Physiology, 295(4) pp. G862-G871. [doi:10.1152/ajpgi.00585.2007]
  • Wattchow, D.A., Brookes, S.J., Murphy, E., Carbone, S., DeFontgalland, D. and Costa, M. (2008). Regional variation in the neurochemical coding of the myenteric plexus of the human colon and changes in patients with slow transit constipation. Neurogastroenterology and Motility, 20(12) pp. 1298-1305. [doi:10.1111/j.1365-2982.2008.01165.x]
  • Murphy, E., DeFontgalland, D., Costa, M., Brookes, S.J. and Wattchow, D.A. (2007). Quantification of subclasses of human colonic myenteric neurons by immunoreactivity to Hu, choline acetyltransferase and nitric oxide synthase. Neurogastroenterology and Motility, 19(2) pp. 126-134. [doi:10.1111/j.1365-2982.2006.00843.x]
  • Zagorodnyuk, V.P., Gibbins, I.L., Costa, M., Brookes, S.J. and Gregory, S.J. (2007). Properties of the major classes of mechanoreceptors in the guinea pig bladder. Journal of Physiology-London, 585(1) pp. 147-163. [doi:10.1113/jphysiol.2007.140244]
  • Olsson, C.A., Chen, B.N., Jones, S., Chataway, T.K., Costa, M. and Brookes, S.J. (2006). Comparison of extrinsic efferent innervation of guinea pig distal colon and rectum. Journal of Comparative Neurology, 496(6) pp. 787-801. [doi:10.1002/cne.20965]
  • Zagorodnyuk, V.P., Costa, M. and Brookes, S.J. (2006). Major classes of sensory neurons to the urinary bladder. Autonomic Neuroscience-Basic and Clinical, 126-127 pp. 390-397. [doi:10.1016/j.autneu.2006.02.007]
  • Lynn, P.A., Zagorodnyuk, V.P., Hennig, G., Costa, M. and Brookes, S.J. (2005). Mechanical activation of rectal intraganglionic laminar endings in the guinea pig distal gut. Journal of Physiology-London, 564(2) pp. 589-601. [doi:10.1113/jphysiol.2004.080879]
  • Zagorodnyuk, V.P., Lynn, P.A., Costa, M. and Brookes, S.J. (2005). Mechanisms of mechanotransduction by specialised low-threshold mechanoreceptors in the guinea pig rectum. American Journal of Physiology-Gastrointestinal and Liver Physiology, 289(3) pp. G397-G406. [doi:10.1152/ajpgi.00557.2004]
  • Bornstein, J., Costa, M. and Grider, J.R. (2004). Enteric motor and interneuronal circuits controlling motility. Neurogastroenterology and Motility, 16(Supp1) pp. 34-38. [doi:10.1111/j.1743-3150.2004.00472.x]
  • Costa, M., Brookes, S.J. and Zagorodnyuk, V.P. (2004). How many kinds of visceral afferants? Gut, 52(suppl2) pp. ii1-ii4.
  • Olsson, C.A., Costa, M. and Brookes, S.J. (2004). Neurochemical characterization of extrinsic innervation of the guinea pig rectum. Journal of Comparative Neurology, 470(4) pp. 357-371. [doi:10.1002/cne.20000]
  • Zhang, L., Jones, S., Brody, K.M., Costa, M. and Brookes, S.J. (2004). Thermosensitive transient receptor potential channels in vagal afferent neurons of the mouse. American Journal of Physiology-Gastrointestinal and Liver Physiology, 286(6) pp. G983-G991. [doi:10.1152/ajpgi.00441.2003]
  • Lynn, P.A., Olsson, C.A., Zagorodnyuk, V.P., Costa, M. and Brookes, S.J. (2003). Rectal intraganglionic laminar endings are transduction sites of extrinsic mechanoreceptors in the guinea pig rectum. Gastroenterology, 125(3) pp. 786-794. [doi:10.1016/S0016-5085(03)01050-3]
  • Zagorodnyuk, V.P., Chen, B.N., Costa, M. and Brookes, S.J. (2003). Mechanotransduction by intraganglionic laminar endings of vagal tension receptors in the guinea-pig oesophagus. Journal of Physiology-London, 553(2) pp. 575-587. [doi:10.1113/jphysiol.2003.051862]
  • Berthoud, H.R., Hennig, G., Campbell, M.J., Volaufova, J. and Costa, M. (2002). Video-based spatio-temporal maps for analysis of gastric motility in vitro: effects of vagal stimulation in guinea-pigs. Neurogastroenterology and Motility, 14(6) pp. 677-688. [doi:10.1046/j.1365-2982.2002.00369.x]
  • Porter, A.J., Wattchow, D.A., Brookes, S.J. and Costa, M. (2002). Cholinergic and nitrergic interneurones in the myenteric plexus of the human colon. Gut, 51(1) pp. 70-75. [doi:10.1136/gut.51.1.70]
  • Zagorodnyuk, V.P., Chen, B.N., Costa, M. and Brookes, S.J. (2002). 4-aminopyridine- and dendrotoxin-sensitive potassium channels influence excitability of vagal mechano-sensitive endings in guinea-pig oesophagus. British Journal of Pharmacology, 137(8) pp. 1195-1206. [doi:10.1038/sj.bjp.0704964]
  • Zagorodnyuk, V.P., D'Antona, G., Brookes, S.J. and Costa, M. (2002). Functional GABA(B) receptors are present in guinea pig nodose ganglion cell bodies but not in peripheral mechanosensitive endings. Autonomic Neuroscience-Basic and Clinical, 102(1-2) pp. 20-29. [doi:10.1016/S1566-0702(02)00183-2]
  • Brookes, S.J., D'Antona, G., Zagorodnyuk, V.P., Humphreys, C.M. and Costa, M. (2001). Propagating contractions of the circular muscle evoked by slow stretch in flat sheets of guinea-pig ileum. Neurogastroenterology and Motility, 13(6) pp. 519-531.
  • D'Antona, G., Hennig, G., Costa, M., Humphreys, C.M. and Brookes, S.J. (2001). Analysis of motor patterns in the isolated guinea-pig large intestine by spatio-temporal maps. Neurogastroenterology and Motility, 13(5) pp. 483-492.
  • Yuan, S., Costa, M. and Brookes, S.J. (2001). Neuronal control of the pyloric sphincter of the guinea-pig. Neurogastroenterology and Motility, 13(3) pp. 187-198.
Refereed conference papers
  • Arkwright, J., Blenman, N.G., Underhill, I.D., Maunder, S.D., Spencer, N.J., Costa, M., et al. (2010). Measurement of the longitudinal and circumferential muscular activity associated with peristalsis using a single fibre grating array. In Proceedings of the SPIE 7653. USA: SPIE - International Society for Optical Engineering. 4th European Workshop on Optical Fibre Sensors. Porto, Portugal. Sep 2010, pp. 765330-765335. [10.1117/12.866307]
  • Yuan, S., Gregory, S.J., Brookes, S.J. and Costa, M. (2004). Enteric neuronal pathways across the gastro-duodenal junction in the guinea-pig. In Proc. Aust. Neurosci. Soc. ANS Conference, pp. 31.
  • Yuan, S., Gregory, S.J., Brookes, S.J. and Costa, M. (2003). Transition pattern of pacemaker activity in the guinea pig gastro-duodenal junction. In Neurogastroenterology & Motility. 19th International Symposium on Gastrointestinal Motility. Barcelona, Spain. Oct 2003, pp. 40-41.
  • Yuan, S., Brookes, S.J. and Costa, M. (2002). Pattern of pacemaker activity in the circular and longitudinal muscle layers of the guinea pig gastro-duodenal junction. In Proceedings of the Australian Heath & Medical Research Congress. NHMRC. 2002 Australian Heath & Medical Research Congress. Melbourne, VIC. Nov 2002, pp. 1125-1125.
Journal articles
  • Costa, M. (2006). Cortex values. Fast Thinking, Autumn 06 pp. 30-33.
  • Costa, M. (2006). Good to the bone: biological bases of morality. Fast Thinking, Spring 06 pp. 21-23.
  • Costa, M. (2006). It's all in the mind. Fast Thinking, Summer 06 pp. 24-25. [Link]
  • Costa, M. (2006). The Clock in Your Head: brain and time (Special Feature) Fast Thinking, Summer 06 pp. 55-58.
  • Brookes, S.J., Cook, I.J., Costa, M., De Giorgio, R., Dent, J., Grundy, D., et al. (2005). Education project for pathophysiology of gastrointestinal motility. Neurogastroenterology and Motility, 17(s3) pp. 2-3. [Link]
  • Shea-Donohue, T., Cook, I.J., De Giorgio, R., Tonini, M., Dent, J., Costa, M., et al. (2005). A teaching module on irritable bowel syndrome. Neurogastroenterology and Motility, 17(suppl3) pp. 20-40. [doi:10.1111/j.1365-2982.2005.00713.x]
Conference publications
  • Costa, M. (2007). Painting, Neuroscience and Mental Health. In Ian North, ed. Visual Animals: Crossovers, Evolution and New Aesthetics. Parkside, SA: Contemporary Art Centre of South Australia Inc. Visual Animals Symposium. Adelaide, SA. Apr 2007.
  • Chen, B.N., Song, X., Costa, M. and Brookes, S.J. (2006). Sensory innervation of intestinal blood vessels. In Program of the Annual Meeting of the Gastroenterological Association Institute and Digestive Disease Week. Annual Meeting of the Gastroenterological Association Institute and Digestive Disease Week. Los Angeles, USA. May 2006.
  • Zagorodnyuk, V.P., Costa, M. and Brookes, S.J. (2006). Two classes of stretch-sensitive pelvic mechanoreceptors in the bladder. In Paul Martin, ed. Proceedings of the Australian Neuroscience Society. Australian Neuroscience Society. 26th Annual Meeting of the Australian Neuroscience Society. Sydney, NSW. Jan 2006, pp. 33-33.
  • Lynn, P.A., Costa, M. and Brookes, S.J. (2006). Afferent innervation of the internal and external anal sphincter of the guinea pig. In Journal of Gastroenterology and Hepatology. Wiley. Australian Gastroenterology Week 2006. Adelaide, SA. Oct 2006, pp. A335-A335. [doi:10.1111/j.1440-1746.2006.04690.x]
  • Zagorodnyuk, V.P., Gregory, S.J., Costa, M. and Brookes, S.J. (2006). Different types of mechanoreceptors in the bladder. In Neuroulogy and Urodynamics. John Wiley and Sons. 36th Annual Meeting of the International Continence Society. Christchurch, New Zealand. Nov 2006, pp. 560-561. [doi:10.1002/nau.20358]
  • DeFontgalland, D., Wattchow, D.A., Costa, M. and Brookes, S.J. (2006). Neurochemical characterisation of the innervation of human colonic mesenteric blood vessels. In Paul Martin, ed. Proceedings of the Australian Neuroscience Society. Australian Neuroscience Society. 26th Annual Meeting of the Australian Neuroscience Society. Sydney, NSW. Jan 2006, pp. 96-96.
  • Song, X., Chen, B.N., Costa, M. and Brookes, S.J. (2006). Identification of Mechanically-Activated Pain Pathways from the Gut Wall. In Program of the Annual Meeting of the Gastroenterological Association Institute and Digestive Disease Week. Annual Meeting of the Gastroenterological Association Institute and Digestive Disease Week. Los Angeles, USA. May 2006.
  • Song, X., Chen, B.N., Costa, M. and Brookes, S.J. (2006). Afferent nerve innervation in the submucosa of guinea pig ileum. In Proceedings of the Australian Neuroscience Society. Australian Neuroscience Society. 26th Annual Meeting of the Australian Neuroscience Society. Sydney, NSW. Jan 2006, pp. 84-84.
  • Lynn, P.A., Costa, M. and Brookes, S.J. (2006). Responses to Mechanical Stimuli in Low-Threshold Slowly-Adapting Rectal Mechanoreceptors after TNBS-Induced Inflammation in the Guinea Pig. In Program of the Annual Meeting of the Gastroenterological Association Institute and Digestive Disease Week. Annual Meeting of the Gastroenterological Association Institute and Digestive Disease Week. Los Angeles, USA. May 2006.
  • Yuan, S., Brookes, S.J. and Costa, M. (2003). Communication between pacemaker and smooth muscle cells in the guinea-pig stomach. (Abstract) Proc. Aust. Neurosci. Soc: AUST NEUROSCIENCE SOCIETY INC, pp. 1.
  • Zhang, L., Brody, K.M., Costa, M. and Brookes, S.J. (2003). Temperature-sensitive ion channels in nodose ganglia and gut detected with RT-PCR. (Abstract) Adelaide: AUST NEUROSCIENCE SOCIETY INC, pp. 1.
  • Olsson, C.A., Costa, M. and Brookes, S.J. (2002). Characterisation of extrinsic innervation of the guinea pig rectum. In Journal of Gastroenterology and Hepatology. Wiley Blackwell. Australian Gastroenterology Week. Adelaide, SA. Oct 2002, pp. a168-a168. [doi:10.1046/j.1440-1746.17.s5.3.x]
  • Yuan, S., Brookes, S.J. and Costa, M. (2002). Functional identification of the pyloric sphincter in the guinea pig by localisation of the myogenic pacemaker transition zone. In Journal of Gastroenterology and Hepatology. Wiley Blackwell. Australian Gastroenterology Week. Adelaide, SA. Oct 2002, pp. a169-a169. [doi:10.1046/j.1440-1746.17.s5.3.x]
  • Murphy, E., Wattchow, D.A., Costa, M. and Brookes, S.J. (2002). Calcium binding proteins in human enteric neurons ANS Sydney. In ANS. ANS. Sydney, NSW. Jan 2002, pp. 108.
  • Murphy, E., Wattchow, D.A., Brookes, S.J., Costa, M. and Tottrup, A. (2002). Neurochemical coding of extrinsic mesenteric nerves in human colon and guinea-pig small intestine. In Royal Australasian College of Surgeons Annual Scientific Congress, Royal Australasian College of Surgeons Annual Scientific Congress, May 2002.
  • Lynn, P.A., Costa, M. and Brookes, S.J. (2002). Comparison of pelvic and colonic mechanoreceptors in the rectum and distal colon of the guinea pig. In Journal of Gastroenterology and Hepatology. Wiley Blackwell. Australian Gastroenterology Week. Adelaide, SA. Oct 2002, pp. a167-a167. [doi:10.1046/j.1440-1746.17.s5.3.x]
  • Costa, M., Davies, P.G., Brody, K.M., Brookes, S.J. and Bornstein, J. (2002). Identification of enteric primary afferent neurons in the guinea-pig small intestine. In DK Podolsky, ed. Gastroenterology. London: Gower Medical. Annual conference of the American Gastroenterological Association, San Francisco, USA. May 2002, pp. A91-A92.
  • Costa, M., Davies, P.G., Brody, K.M., Brookes, S.J. and Bornstein, J. (2002). Histochemical identification of enteric primary afferent neurons. In ANS. ANS. Sydney, NSW. Jan 2002, pp. 53.
  • Costa, M., Campbell, M.J., Yuan, S., Humphreys, C.M. and Brookes, S.J. (2002). Propagation of myogenic activity in the guinea-pig proximal colon. In DK Podolsky, ed. Gastroenterology. London: Gower Medical. Digestive Disease Week and American Gastroenterological Association, San Francisco, USA. May 2002, pp. A408-A409.
  • Chen, B.N., Brookes, S.J., Zagorodnyuk, V.P. and Costa, M. (2002). Morphological characterisation of extrinsic innervation of the guinea-pig distal colon. In ANS. ANS. Sydney, NSW. Jan 2002, pp. 97.
  • Campbell, M.J., Costa, M., Yuan, S. and Brookes, S.J. (2002). Slow propagation of myogenic activity in guinea-pig proximal colon. In ANS. ANS. Sydney, NSW. Jan 2002, pp. 143.
  • Brookes, S.J., Chen, B.N., Zagorodnyuk, V.P. and Costa, M. (2002). Chemical coding of extrinsic innnervation of the guinea pig colon. In DK Podolsky, ed. Gastroenterology. London: Gower Medical. Annual conference of the American Gastroenterological Association. San Francisco, USA. May 2002, pp. A160-A160.
  • Brody, K.M., Costa, M. and Brookes, S.J. (2002). Neu-N immunoreactivity marks primary afferent neurons in the guinea-pig submucous plexus. In ANS. ANS. Sydney, NSW. Jan 2002, pp. 105.
  • Brody, K.M., Costa, M. and Brookes, S.J. (2002). Chemical coding of putative enteric primary afferent neurons in the mouse myenteric plexus. In DK Podolsky, ed. Gastroenterology. London: Gower Medical. Annual conference of the American Gastroenterological Association. San Francisco, USA. May 2002, pp. A92-A92.
  • Yuan, S., Costa, M. and Brookes, S.J. (2002). Effect of exogenous prostaglandin on in situ pacemaker cells in isolated guinea-pig gastric antrum. In ANS. ANS. Sydney, NSW. Jan 2002, pp. 52.
  • Zagorodnyuk, V.P., Chen, B.N., Costa, M. and Brookes, S.J. (2002). Potassium channels influence excitability of vagal mechanosensitive endings in guinea-pig oesophagus. In D Grundy & M Camilleri, ed. Neurogastroenterology and Motility. Oxford: Blackwell Scientific Publications. 11th Symposium on Neurogastroenterology and Motility. Tubingen, Germany. Oct 2002, pp. 1.
  • Zagorodnyuk, V.P., Chen, B.N., Costa, M. and Brookes, S.J. (2002). Glutamate is not involved in mechanotransduction of vagal tension receptors in guinea-pig oesophagus. In Journal of Gastroenterology and Hepatology. Wiley Blackwell. Australian Gastroenterology Week. Adelaide, SA. Oct 2002, pp. a164-a164. [doi:10.1046/j.1440-1746.17.s5.3.x]
  • Zagorodnyuk, V.P., Chen, B.N., Costa, M. and Brookes, S.J. (2002). Calcium- and voltage-dependent potassium channels control excitability of vagal mechanoreceptors in guinea-pig oesophagus. In ANS. ANS. Sydney, NSW. Jan 2002, pp. 52.
  • Brody, K.M., Costa, M. and Brookes, S.J. (2001). Chemical coding of myenteric neurons in the ferret small intestine. In Proceedings of the Australian Neuroscience Society. Melbourne: Aust Neuroscience Soc. Inc. Twentyfirst Annual Meeting of the Australian Neuroscience Society. Brisbane, QLD. Jan 2001, pp. 120-120.
  • Zagorodnyuk, V.P., Chen, B.N., Costa, M. and Brookes, S.J. (2001). Transduction of mechanical stimuli by intraganglionic laminar endings of vagal mechanoreceptors in the guinea-pig stomach and oesophagus. In D Grundy and M Camilleri, ed. Neurogastroenterology and Motility. Oxford: Blackwell Publishing. XVIII International Symposium on Neurogastroenterology and Motility. Madison, USA. Nov 2001, pp. 446-446.
  • Chen, B.N., Brookes, S.J., Costa, M. and Zagorodnyuk, V.P. (2001). Morphological characterisation of vagal innervation of the guinea-pig upper stomach. In Proceedings of the Australian Neuroscience Society. Melbourne: Aust Neuroscience Soc. Inc. Twentyfirst Annual Meeting of the Australian Neuroscience Society. Brisbane, QLD. Jan 2001, pp. 118-118.
  • Costa, M., Brody, K.M. and Brookes, S.J. (2001). A new marker for enteric primary afferent neurons. In D Grundy and M Camilleri, ed. Neurogastroenterology and Motility. Oxford: Blackwell Publishing. XVIII International Symposium on Neurogastroenterology and Motility. Madison, USA. Nov 2001, pp. 383-383.
  • Costa, M., Currow, D.C., Humphreys, C.M. and Brookes, S.J. (2001). Neural and myogenic polarity in the movements of the guinea-pig small intestine. In Proceedings of the Australian Neuroscience Society. Melbourne: Aust Neuroscience Soc. Inc. Twentyfirst Annual Meeting of the Australian Neuroscience Society. Brisbane, QLD. Jan 2001, pp. 118-118.
  • Costa, M., Rainsford, T.J., Currow, D.C., Humphreys, C.M., Hennig, G. and Brookes, S.J. (2001). Effect of removal of endogenous inhibition on motor activity of the isolated guinea-pig small intestine. In D Grundy and M Camilleri, ed. Neurogastroenterology and Motility. Oxford: Blackwell Publishing. XVIII International Symposium on Neurogastroenterology and Motility. Madison, USA. Nov 2001, pp. 384-384.
  • Costa, M., Yuan, S., Rainsford, T.J., Brookes, S.J. and Hennig, G. (2001). Correlation between electrical activity of smooth muscle and spatio-temporal motor events in the guinea-pig small intestine. In DK Podolsky, ed. Gastroenterology. Philadelphia: WB Saunders Company. The American Gastroenterological Association and Digestive Disease Week. Atlanta, USA. May 2001, pp. 225-225.
  • Costa, M., Yuan, S., Zhong, J.H., Brody, K.M., Brookes, S.J. and Zhou, X. (2001). The Vanilloid-like receptor VRL-1 in the rat and guinea-pig enteric nervous system. In DK Podolsky, ed. Gastroenterology. Philadelphia: WB Saunders Company. The American Gastroenterological Association and Digestive Disease Week. Atlanta, USA. May 2001, pp. 197-197.
  • Fraser, R., Frisby, C., Schirmer, M., Blackswhaw, A., Veoh, E.K., Costa, M., et al. (2001). Stimulation of clustered contractions increase in rat small intestine following abdominal irradiation. In DK Podolsky, ed. Gastroenterology. Philadelphia: WB Saunders Company. The American Gastroenterological Association and Digestive Disease Week. Atlanta, USA. May 2001, pp. 226-226.
  • Fraser, R.J., Frisby, C., Blackshaw, A., Costa, M., Campbell, M.J. and Hennig, G. (2001). Spontaneous clustered propagating motor activity in isolated arterially perfused rat intestine studied by concurrent video imaging and multipoint manometry. In DK Podolsky, ed. Gastroenterology. Philadelphia: WB Saunders Company. The American Gastroenterological Association and Digestive Disease Week. Atlanta, USA. May 2001, pp. A225-A225.
  • Gai, W., Wattchow, D.A., Power, J.H., Pountney, D. and Costa, M. (2001). Multiple system atrophy inclusion filaments contain ~10nm fibrillar core and mucltiple c-terminally truncated alpha-synucleins. In Proceedings of the Australian Neuroscience Society. Melbourne: Aust Neuroscience Soc. Inc. Twentyfirst Annual Meeting of the Australian Neuroscience Society. Brisbane, QLD. Jan 2001, pp. 138-138.
  • Murphy, E., Wattchow, D.A., Costa, M. and Brookes, S.J. (2001). Immunohistochemistry of extrinsic nerve fibres in human colon and guinea pig small intestine. In Proceedings of the Australian Neuroscience Society. Melbourne: Aust Neuroscience Soc. Inc. Twentyfirst Annual Meeting of the Australian Neuroscience Society. Brisbane, QLD. Jan 2001, pp. 121-121.
  • Murphy, E., Wattchow, D.A., Tottrup, A., Brookes, S.J. and Costa, M. (2001). Immunohistochemistry of the extrinsic nerve fibres in human colon and guinea-pig small intestine. In Proceedings of the Australian Neuroscience Society, pp. 121-121.
  • Rainsford, T.J., Costa, M. and Humphreys, C.M. (2001). Effect of removal on endogenous inhibition on intestinal peristalsis. In Proceedings of the Australian Neuroscience Society. Melbourne: Aust Neuroscience Soc. Inc. Twentyfirst Annual Meeting of the Australian Neuroscience Society. Brisbane, QLD. Jan 2001, pp. 119-119.
  • Rainsford, T.J., Costa, M., Hennig, G., Yuan, S. and Brookes, S.J. (2001). Electrical and mechanical activity in longitudinal and circular muscle in the isolated guinea-pig small intestine. In D Grundy and M Camilleri, ed. Neurogastroenterology and Motility. Oxford: Blackwell Publishing. XVIII International Symposium on Neurogastroenterology and Motility. Madison, USA. Nov 2001, pp. 423-423.
  • Yuan, S., Brookes, S.J. and Costa, M. (2001). Investigation of living pacemaker cells in isolated guinea-pig stomach and small intestine. In D Grundy and M Camilleri, ed. Neurogastroenterology and Motility. Oxford: Blackwell Publishing. XVIII International Symposium on Neurogastroenterology and Motility. Madison, USA. Nov 2001, pp. 445-446.
  • Yuan, S., Costa, M. and Brookes, S.J. (2001). Disinhibition of circular muscle slow waves by piroxicam in isolated guinea-pig gastric antrum and duodenum. In DK Podolsky, ed. Gastroenterology. Philadelphia: WB Saunders Company. The American Gastroenterological Association and Digestive Disease Week. Atlanta, USA. May 2001, pp. 534-534.
  • Zagorodnyuk, V.P., Chen, B.N., Costa, M. and Brookes, S.J. (2001). Intraganglionic laminar endings (IGLEs) are transduction sites of "in-series" vagal tension receptors in the stomach. In Gastroenterology. The American Gastroenterological Association and Digestive Disease Week. Atlanta, USA. May 2001, pp. 84-84.
  • Zagorodnyuk, V.P., Brookes, S.J., D'Antona, G. and Costa, M. (2001). Effects of GABA and Baclofen on guinea-pig vagal afferent neurones. In Proceedings of the Australian Neuroscience Society. Melbourne: Aust Neuroscience Soc. Inc. Twentyfirst Annual Meeting of the Australian Neuroscience Society. Brisbane, QLD. Jan 2001, pp. 119-119.
  • Yuan, S., Costa, M. and Brookes, S.J. (2001). Study of living pacemaker cells in isolated guinea-pig gut. In Proceedings of the Australian Neuroscience Society. Melbourne: Aust Neuroscience Soc. Inc. Twentyfirst Annual Meeting of the Australian Neuroscience Society. Brisbane, QLD. Jan 2001, pp. 117-117.
  • Campbell, M.J., Hennig, G., Costa, M. and Brookes, S.J. (2001). Analysis of motor activity of isolated rat small intestine using spatio-temporal maps. In Proceedings of the Australian Neuroscience Society. Melbourne: Aust Neuroscience Soc. Inc. Twentyfirst Annual Meeting of the Australian Neuroscience Society. Brisbane, QLD. Jan 2001, pp. 120-120.
Other public research outputs
  • Costa, M. (2010). The Neuropsychology of Mental Illness. Preface, pp. 9-10.
  • Zhang, L., Brody, K.M., Costa, M. and Brookes, S.J. (2003). Expression of temperature-sensitive ion channels in nodose ganglia and gut tissue, detected by RT-PCR and immunohistochemistry. Gastroenterology. 124(supple1) pp. a39-a39. [doi:10.1016/S0016-5085(03)80192-0]

Show selected publications

Professional and community engagement

Marcello is one of the five founding members and member of the executive of the association Friends of Science in Medicine. The Friends of Science in Medicine (FSM) was established in late 2011 by five founding members who represent a cross-section of concerned persons, each with a long but different history of involvement in educational activities fostering good science in Medicine. While the FSM was launched on the 20 December 2011, its association was registered with New South Wales (NSW), Department of Fair Trading on 13 February 2012. The FSM has now more than 550 members (see web page at http://www.scienceinmedicine.org.au/)

Marcello is involved in numerous activities to foster science education for the public. He participated to numerous activities under the umbrella of the RIAus, the Carnevale, the largest festival of the Italian community held yearly in Adelaide, the teaches courses for the University of the third age, gives talks to various community associations and will participate to the Adelaide Festival Centre program in conversation in July 2012.

Expertise for media contact

  • Neurogastroenterology enteric nervous system, visceral pain, intestinal motility, functional disorders of the digestive system
  • Neurosciences neurotransmitters, neural circuits, neuroanatomy, neurophysiology, neuropharmacology
  • philosophy of science brain, physics and the world

Subject/s

  • Autonomic nerves
  • Brain
  • Gastroenterology
  • Gastrointestinal physiology
  • Nervous system
  • Neuroscience
  • Philosophy

Further information

Marcello is actively involved in Neuroscience research (see publications) and is engaged in public education. 
He has written numerous articles on more general implication of Neuroscience in society (see Fast Thinking articles) and participated to public events on the relevance of Neuroscience in many human activities. He has given many talks on the philosophy of Neuroscience.

He has written articles for local and national magazines, introductions and chapters in edited books.
He is one of the five founder and actively involved in the association "Friends of Science in Medicine" that aims at removing pseudoscience teaching in health courses in tertiary institutions and opposing Goverment benefits to unproven therapies in the complementary and alternative medicine field.

A full list of these documents is appended as a document (Guide to Marcello Costa general science article publications).

Documents



inspiring achievement