Position

Academic Status & Web Supervisor
College of Medicine and Public Health

Qualifications

1970:   AB Magna cum Laude with Honours (Biology), Bryn College, PA, USA

Research expertise

  • Neurosciences

RHD research supervision

Current

Principal supervisor : Changes in uterine innervation during pregnancy, post-partum and in pre-eclampsia (1) ;

Publications

  • Verberne, A.J.M. and Llewellyn-Smith, I.J. (2013). Juxtacellular Neuronal Labelling, Physiological Characterization and Phenotypic Identification of Single Neurons In Vivo. In PM Pilowsky, MMJ Farnham & AY Fong, ed. Stimulation and Inhibition of Neurons. New York, USA: Humana Press, pp. 167-186.
    [10.1007/978-1-62703-233-9_10] [Scopus]
  • Llewellyn-Smith, I.J. (2011). Sympathetic Preganglionic Neurons. In I.J. Llewellyn-Smith and A.J.M. Verberne, ed. Central Regulation of Autonomic Functions. 2nd ed. New York: Oxford University Press, pp. 98-119.
    [Scopus] [Web Link]
  • Llewellyn-Smith, I.J. and Weaver, L. (2004). Interneuronal inputs to sympathetic preganglionic neurons: evidence from transected spinal cord. In Nae J. Dun, Benedito H. Machado and Paul M. Pilowsky, ed. NEURAL MECHANISMS OF CARDIOVASCULAR REGULATION. Boston, USA: Kluwer Academic Publishers, pp. 265-283.
  • Llewellyn-Smith, I.J. and Verberne, A.J.M. (Eds.). (2011). Central Reulation of Autonomic Functions. 2nd ed. New York: Oxford University Press.
  • Verberne, A.J.M., Korim, W., Sabetghadam, A. and Llewellyn-Smith, I.J. (2016). Adrenaline: insights into its metabolic roles in hypoglycaemia and diabetes. British Journal of Pharmacology, 173(9) pp. 1425-1437.
    [10.1111/bph.13458] [Scopus]
  • Thiebaud, N., Llewellyn-Smith, I.J., Gribble, F.M., Reimann, F., Trapp, S. and Fadool, D.A. (2016). The incretin hormone glucagon-like peptide 1 increases mitral cell excitability by decreasing conductance of a voltage-dependent potassium channel. Journal of Physiology-London, 594(10) pp. 2607-2628.
    [10.1113/JP272322] [Scopus]
  • Etlin, A., Braz, J.M., Kuhn, J.A., Wang, X., Hamel, K.A., Llewellyn-Smith, I.J., et al. (2016). Functional Synaptic Integration of Forebrain GABAergic Precursors into the Adult Spinal Cord. Journal of Neuroscience, 36(46) pp. 11634-11645.
    [10.1523/JNEUROSCI.2301-16.2016] [Scopus]
  • Korim, W., Llewellyn-Smith, I.J. and Verberne, A.J.M. (2016). Activation of Medulla-Projecting Perifornical Neurons Modulates the Adrenal Sympathetic Response to Hypoglycemia: Involvement of Orexin Type 2 (OX2-R) Receptors. Endocrinology, 157(2) pp. 810-819.
    [10.1210/en.2015-1712] [Scopus]
  • Solorzano, C., Villafuerte, D., Meda, K., Cevikbas, F., Braz, J., Sharif-Naeini, R., et al. (2015). Primary afferent and spinal cord expression of gastrin-releasing peptide: Message, protein and antibody concerns. Journal of Neuroscience, 35(2) pp. 648-657.
    [10.1523/JNEUROSCI.2955-14.2015] [Scopus]
  • Llewellyn-Smith, I.J., Marina, N., Manton, R.N., Reimann, F., Gribble, F.M. and Trapp, S. (2015). Spinally-projecting preproglucagon axons preferentially innervate sympathetic preganglionic neurons. Neuroscience, 284 pp. 872-878.
    [10.1016/j.neuroscience.2014.10.043] [Scopus]
  • Mischel, N.A., Subramanian, M., Dombrowski, M.D., Llewellyn-Smith, I.J. and Mueller, P.J. (2015). h(In)activity-related neuroplasticity in brainstem control of sympathetic outflow: unraveling underlying molecular, cellular, and anatomical mechanisms. American Journal of Physiology-Heart and Circulatory Physiology, 309(2) pp. H235-H243.
    [10.1152/ajpheart.00929.2014]
  • Menuet, C., Sevigny, C., Connelly, A.A., Bassi, J.K., Jancovski, N., Williams, D., et al. (2014). Catecholaminergic C3 neurons are sympathoexcitatory and involved in glucose homeostasis. Journal of Neuroscience, 34 pp. 15110-15122.
    [10.1523/jneurosci.3179-14.2014] [Scopus]
  • Mischel, N.A., Llewellyn-Smith, I. and Mueller, P.J. (2014). Physical (in)activity-dependent structural plasticity in bulbospinal catecholaminergic neurons of rat rostral ventrolateral medulla. Journal of Comparative Neurology, 522(3) pp. 499-513.
    [10.1002/cne.23464] [Scopus]
  • Llewellyn-Smith, I.J., Gnanamanickam, G.J., Reimann, F., Gribble, F.M. and Trapp, S. (2013). Preproglucagon (PPG) neurons innervate neurochemically identified autonomic neurons in the mouse brainstem. Neuroscience, 229 pp. 130-143.
    [10.1016/j.neuroscience.2012.09.071] [Scopus]
  • Llewellyn-Smith, I.J. and Mueller, P.J. (2013). Immunoreactivity for the NMDA NR1 subunit in bulbospinal catecholamine and serotonin neurons of rat ventral medulla. Autonomic Neuroscience-Basic and Clinical, 177(2) pp. 114-122.
    [10.1016/j.autneu.2013.02.024] [Scopus]
  • Llewellyn-Smith, I.J., Kellett, D.O., Jordan, D., Browning, K.N. and Travagli, R.A. (2012). Oxytocin-immunoreactive innervation of identified neurons in the rat dorsal vagal complex. Neurogastroenterology and Motility, 24(3) pp. 136-146.
    [10.1111/j.1365-2982.2011.01851.x] [Scopus]
  • Llewellyn-Smith, I.J. and Gnanamanickam, G. (2011). Immunoperoxidase detection of neuronal antigens in full-thickness whole mount preparations of hollow organs and thick sections of central nervous tissue. Journal of Neuroscience Methods, 196(1) pp. 1-11.
    [10.1016/j.jneumeth.2010.12.004] [Scopus]
  • Gnanamanickam, G. and Llewellyn-Smith, I.J. (2011). Innervation of the rat uterus at estrus: A study in full-thickness, immunoperoxidase-stained whole-mount preparations. Journal of Comparative Neurology, 519(4) pp. 621-643.
    [10.1002/cne.22515] [Scopus]
  • Ruginsk, S.G., Uchoa, E.T., Elias, L.L.K., Antunes-Rodrigues, J. and Llewellyn-Smith, I.J. (2011). Hypothalamic cocaine- and amphetamine-regulated transcript and corticotrophin releasing factor neurons are stimulated by extracellular volume and osmotic changes. Neuroscience, 186 pp. 57-64.
    [10.1016/j.neuroscience.2011.04.047] [Scopus]
  • Llewellyn-Smith, I.J., Reimann, F., Gribble, F.M. and Trapp, S. (2011). Preproglucagon neurons project widely to autonomic control areas in the mouse brain. Neuroscience, 180 pp. 111-121.
    [10.1016/j.neuroscience.2011.02.023] [Scopus]
  • Pajolla, G.P., Accorsi-Mendonça, D., Lunardi, C.N., Bendhack, L.M., Machado, B.H. and Llewellyn-Smith, I.J. (2009). Immunoreactivity for neuronal NOS and fluorescent indication of NO formation in the NTS of juvenile rats submitted to chronic intermittent hypoxia. Autonomic Neuroscience-Basic and Clinical, 148(1-2) pp. 55-62.
    [10.1016/j.autneu.2009.03.003] [Scopus]
  • Llewellyn-Smith, I.J. (2009). Anatomy of synaptic circuits controlling the activity of sympathetic preganglionic neurons. Journal of Chemical Neuroanatomy, 38(3) pp. 231-239.
    [10.1016/j.jchemneu.2009.06.001] [Scopus]
  • Hinrichs, J.M. and Llewellyn-Smith, I.J. (2009). Variability in the occurrence of nitric oxide synthase immunoreactivity in different populations of rat sympathetic preganglionic neurons. Journal of Comparative Neurology, 514(5) pp. 492-506.
    [10.1002/cne.22015] [Scopus]
  • Neumann, S., Braz, J.M., Skinner, K., Llewellyn-Smith, I.J. and Basbaum, A.I. (2008). Innocuous, not noxious, input activates PKCgamma interneurons of the spinal dorsal horn via myelinated afferent fibers. Journal of Neuroscience, 28(32) pp. 7936-7944.
    [10.1523/JNEUROSCI.1259-08.2008] [Scopus]
  • Peters, J.H., McDougall, S.J., Kellett, D.O., Jordan, D., Llewellyn-Smith, I.J. and Andresen, M.C. (2008). Oxytocin enhances cranial visceral afferent synaptic transmission to the solitary tract nucleus. Journal of Neuroscience, 28(45) pp. 11731-11740.
    [10.1523/JNEUROSCI.3419-08.2008] [Scopus]
  • Llewellyn-Smith, I.J., Martin, C.L., Fenwick, N.M., DiCarlo, S.E., Lujan, H.L. and Schreihofer, A.M. (2007). VGLUT1 and VGLUT2 innervation in autonomic regions of intact and transected rat spinal cord. Journal of Comparative Neurology, 503(6) pp. 741-767.
    [10.1002/cne.21414] [Scopus]
  • Llewellyn-Smith, I.J., Weaver, L.C. and Keast, J.R. (2006). Effects of spinal cord injury on synaptic inputs to sympathetic preganglionic neurons. Progress in Brain Research, 152 pp. 11-26.
    [10.1016/S0079-6123(05)52001-6] [Scopus]
  • Fenwick, N.M., Martin, C.L. and Llewellyn-Smith, I.J. (2006). Immunoreactivity for cocaine- and amphetamine-regulated transcript in rat sympathetic preganglionic neurons projecting to sympathetic ganglia and the adrenal medulla. Journal of Comparative Neurology, 495(4) pp. 422-433.
    [10.1002/cne.20870] [Scopus]
  • Llewellyn-Smith, I.J., DiCarlo, S., Collins, H. and Keast, J. (2005). Enkephalin-immunoreactive interneurons extensively innervate sympathetic preganglionic neurons regulating the pelvic viscera. Journal of Comparative Neurology, 488(3) pp. 278-289.
    [10.1002/cne.20552] [Scopus]
  • Burman, K.J., Verberne, A.J.M., Sartor, D.M. and Llewellyn-Smith, I.J. (2004). Cocaine- and amphetamine-regulated transcript in catecholamine and non-catecholamine presympathetic vasometer neurons of rat rostral ventrolateral medulla. Journal of Comparative Neurology, 476(1) pp. 19-31.
    [10.1002/cne.20198] [Scopus]
  • Burman, K.J., Ige, A.O., White, J.H., Marshall, F.H., Pangalos, M.N., Emson, P., et al. (2003). GABAB receptor subunits, R1 and R2, in brainstem catecholamine and serotonin neurons. Brain Research, 970(1-2) pp. 35-46.
    [10.1016/S0006-8993(02)04269-5] [Scopus]
  • Llewellyn-Smith, I.J., Martin, C.L., Marcus, J.N., Yanagisawa, M., Minson, J.B. and Scammel, T.E. (2003). Orexin-immunoreactive inputs to rat sympathetic preganglionic neurons. Neuroscience Letters, 351(2) pp. 115-119.
    [10.1016/S0304-3940(03)00770-5] [Scopus]
  • Minson, J.B., Arnolda, L.F. and Llewellyn-Smith, I.J. (2002). Neurochemistry of nerve fibers apposing sympathetic preganglionic neurons activated by sustained hypotension. Journal of Comparative Neurology, 449(4) pp. 307-318.
    [10.1002/cne.10282] [Scopus]
  • Jones, G.A., Llewellyn-Smith, I.J. and Jordan, D. (2002). Physiological, pharmacological, and immunohistochemical characterisation of juxtacellularly labelled neurones in rat nucleus tractus solitarius. Autonomic Neuroscience-Basic and Clinical, 98(1-2) pp. 12-16.
    [10.1016/S1566-0702(02)00022-X] [Scopus]
  • Llewellyn-Smith, I.J. (2002). GABA in the control of sympathetic preganglionic neurons. Clinical and Experimental Pharmacology and Physiology, 29(5-6) pp. 507-513.
    [10.1046/j.1440-1681.2002.03664.x] [Scopus]
  • Guyenet, P.G., Stornetta, R.L., Schreihofer, A.M., Pelaez, N.M., Hayar, A., Aicher, S., et al. (2002). Opioid signalling in the rat rostral ventrolateral medulla. Clinical and Experimental Pharmacology and Physiology, 29(3) pp. 238-242.
    [10.1046/j.1440-1681.2002.03636.x] [Scopus]
  • Llewellyn-Smith, I.J., Martin, C.L. and Minson, J.B. (2002). Glutamate and GABA content of calbindin-immunoreactive nerve terminals in the rat intermediolateral cell column. Autonomic Neuroscience-Basic and Clinical, 98(1-2) pp. 7-11.
    [10.1016/S1566-0702(02)00021-8] [Scopus]
  • Somogyi, J. and Llewellyn-Smith, I.J. (2001). Patterns of colocalization of GABA, glutamate and glycine immunoreactives in terminals that synapse on dendrites of noradernergic neurons in rat locus coeruleus. European Journal of Neuroscience, 14 pp. 219-228.
    [Scopus]
  • Minson, J.B., Llewellyn-Smith, I.J. and Arnolda, L.F. (2001). Neuropeptide Y mRNA expression in interneurons in rat spinal cord. Autonomic Neuroscience-Basic and Clinical, 93 pp. 14-20.
    [Scopus]
  • Llewellyn-Smith, I.J. and Weaver, L. (2001). Changes in synaptic inputs to sympathetic preganglionic neurons aftr spinal cord injury. Journal of Comparative Neurology, 435 pp. 226-240.
    [Scopus]
  • Burman, K.J., West, A.R., Llewellyn-Smith, I.J., Mckitrick, D.J., Arnolda, L.F. and Minson, J.B. (2001). Neurokinin-1 receptor immunoreactivity in hypotension sensitive sympathetic preganglionic neurons. Brain Research, 915 pp. 238-243.
    [Scopus]
  • Llewellyn-Smith, I.J., Schreihofer, A.M. and Guyenet, P.G. (2001). Distribution and amino acid content of enkephalin-immunoreactive inputs onto juxtacellularly labelled bulbospinal barosensitive neurons in rat rostral ventrolateral medulla. Neuroscience, 108(2) pp. 307-322.
    [Scopus]
  • Verberne, A.J.M. and Llewellyn-Smith, I.J. (2013). Juxtacellular Neuronal Labelling, Physiological Characterization and Phenotypic Identification of Single Neurons In Vivo. In PM Pilowsky, MMJ Farnham & AY Fong, ed. Stimulation and Inhibition of Neurons. New York, USA: Humana Press, pp. 167-186.
    [10.1007/978-1-62703-233-9_10] [Scopus]
  • Llewellyn-Smith, I.J. (2011). Sympathetic Preganglionic Neurons. In I.J. Llewellyn-Smith and A.J.M. Verberne, ed. Central Regulation of Autonomic Functions. 2nd ed. New York: Oxford University Press, pp. 98-119.
    [Scopus] [Web Link]
  • Llewellyn-Smith, I.J. and Weaver, L. (2004). Interneuronal inputs to sympathetic preganglionic neurons: evidence from transected spinal cord. In Nae J. Dun, Benedito H. Machado and Paul M. Pilowsky, ed. NEURAL MECHANISMS OF CARDIOVASCULAR REGULATION. Boston, USA: Kluwer Academic Publishers, pp. 265-283.
  • Korim, W., Llewellyn-Smith, I.J. and Verberne, A.J.M. (2016). Activation of Medulla-Projecting Perifornical Neurons Modulates the Adrenal Sympathetic Response to Hypoglycemia: Involvement of Orexin Type 2 (OX2-R) Receptors. Endocrinology, 157(2) pp. 810-819.
    [10.1210/en.2015-1712] [Scopus]
  • Thiebaud, N., Llewellyn-Smith, I.J., Gribble, F.M., Reimann, F., Trapp, S. and Fadool, D.A. (2016). The incretin hormone glucagon-like peptide 1 increases mitral cell excitability by decreasing conductance of a voltage-dependent potassium channel. Journal of Physiology-London, 594(10) pp. 2607-2628.
    [10.1113/JP272322] [Scopus]
  • Verberne, A.J.M., Korim, W., Sabetghadam, A. and Llewellyn-Smith, I.J. (2016). Adrenaline: insights into its metabolic roles in hypoglycaemia and diabetes. British Journal of Pharmacology, 173(9) pp. 1425-1437.
    [10.1111/bph.13458] [Scopus]
  • Etlin, A., Braz, J.M., Kuhn, J.A., Wang, X., Hamel, K.A., Llewellyn-Smith, I.J., et al. (2016). Functional Synaptic Integration of Forebrain GABAergic Precursors into the Adult Spinal Cord. Journal of Neuroscience, 36(46) pp. 11634-11645.
    [10.1523/JNEUROSCI.2301-16.2016] [Scopus]
  • Solorzano, C., Villafuerte, D., Meda, K., Cevikbas, F., Braz, J., Sharif-Naeini, R., et al. (2015). Primary afferent and spinal cord expression of gastrin-releasing peptide: Message, protein and antibody concerns. Journal of Neuroscience, 35(2) pp. 648-657.
    [10.1523/JNEUROSCI.2955-14.2015] [Scopus]
  • Mischel, N.A., Subramanian, M., Dombrowski, M.D., Llewellyn-Smith, I.J. and Mueller, P.J. (2015). h(In)activity-related neuroplasticity in brainstem control of sympathetic outflow: unraveling underlying molecular, cellular, and anatomical mechanisms. American Journal of Physiology-Heart and Circulatory Physiology, 309(2) pp. H235-H243.
    [10.1152/ajpheart.00929.2014]
  • Llewellyn-Smith, I.J. and Verberne, A.J.M. (Eds.). (2011). Central Reulation of Autonomic Functions. 2nd ed. New York: Oxford University Press.

Contact

Add to address book
Phone: +61 8 82044456
Email:
Location: Flinders Medical Centre (5D:313)
Postal address: GPO Box 2100, Adelaide 5001, South Australia

Further information

Adjunct Professor, Department of Physiology, Wayne State University, Detroit MI, USA

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