Position

Associate Professor
College of Medicine and Public Health

Biography

I completed my undergraduate degree then worked in Plant Virology with the late Prof Bob Symons before completing my PhD with Prof John Wallace, University of Adelaide. I then worked as a post-doc with Professor Chris Burrell and Dr Peng Li at the IMVS/SA Pathology from 1996-2008, part-time from 1998-2011 due to family commitments, studying the basic mechanisms of replication of HIV and virus-host interactions. From 2008-2011 I was also involved in the diagnostic management of clinical HIV drug resistance. At the same time I developed my own research interests in dengue virus stemming from an initial collaboration with A/Professor Peter Wright (Monash University). In March 2011 I re-located to my current full-time position at Flinders University. My current research interests continue in Medical Virology, in particular dengue virus and the interaction with the host cell that is associated with pathogenesis.

Qualifications

  • BSc, University of Adelaide, 1990
  • BSc, First Class Hons, University of Adelaide, Department of Biochemistry, 1991
  • PhD, Department of Biochemistry, University of Adelaide, 1995

Honours, awards and grants

For a full publication list go to Google Scholar https://scholar.google.com.au/citations?user=HdsCukAAAAAJ&hl=en

Key responsibilities

Research Activities: Laboratory head
Teaching: Microbiology and Infectious Diseases in first year graduate entry Medicine, second and third year Bachelor of Medical Science

Teaching interests

Medical microbiology and virology, in particular Dengue virus.

For more information: studying virology at Flinders University.

BMedSci year 2 course co-ordinator

Topic Coordinator:

  • MMED2935  Human Immunology and Infectious Diseases
  • MMED3939  Virology, Immunology and Immunopathogenesis

Topic Lecturer:

  • MMED8120A Knowledge of Health and Illness 1A - IMD

Research expertise

  • Medical microbiology

Research interests

Overall theme of host responses to viral infections and determinants of pathogenesis. For more information about the lab, go to Virology Research.

  1. DENV interaction with the sphingosine kinase (SK)/sphingosine 1-phosophate (S1P) axis. In collaboration with Prof Stuart Pitson, Centre for Cancer Biology, SA Pathology.
  2. DENV effects on the endothelium. In collaboration with Dr Claudine Bonder, Centre for Cancer Biology, SA Pathology. An important cell target for the pathogeneic effects of DENV is the endothelium. We will investigate parameters effecting DENV infection of the endothelium, the cellular response to infection and the effect of this on endothelial function.
  3. The innate immune response and DENV. In collaboration with A/Prof Michael Beard, School of Molecular and Biomedical Science, University of Adelaide to investigate the action of the anti-viral factor, viperin. Addtionally, we are studying the interatction between DENV and factor H, a negative regulator of the alternative complement pathway in collaboration with Professor Dave Gordon, Head of MID at Flinders University.
  4. Viral inflammatory eye disease. In collaboration with Professor Justine Smith, Eye and Vision Health, Flinders University. Studies include investigation of the replication of viruses such as DENV and zika virus in different cells of the eye and the effect on occular, in particular retinal inflammatory responses.

Supervisory interests

  • Dengue virus
  • Virus, virology

RHD research supervision

Current

Principal supervisor : Analysis of the role of sphingosine kinase in dengue virus replication and pathogenesis (1) ; Microbiology and infectious diseases (1) ; Role of sphinhisane kinase and endotherlial cells in dengue virus pathogenesis. (1) ;

Completion

Principal supervisor : Altered responses of dengue virus infected cells to TNF-a (Univ of Adelaide) (1) ;

Publications

  • Quinn, E.J., Cheong, A.H.C., Calvert, J.K., Higgins, G., Hahesy, T., Gordon, D.L., et al. (2018). Clinical features and laboratory findings of travelers returning to South Australia with Dengue Virus infection. Tropical Medicine and Infectious Disease, 3(1)
    [10.3390/tropicalmed3010006]
  • Cabezas, S., Bracho Granado, G.R., Aloia, A.L., Adamson, P., Bonder, C.S., Smith, J.R., et al. (2018). Dengue virus induces increased activity of the complement alternative pathway in infected cells. Journal of Virology,
  • Al Shujairi, W.H., Clarke, J.N., Davies, L., Alsharifi, M., Pitson, S. and Carr, J.M. (2017). Intracranial injection of Dengue Virus induces interferon stimulated genes and CD8+ T cell infiltration by Sphingosine Kinase 1 independent pathways. PLoS One, 12(1) pp. Art: e0169814.
    [10.1371/journal.pone.0169814]
  • Aloia, A.L., Calvert, J.K., Clarke, J.N., Davies, L., Helbig, K., Pitson, S.M., et al. (2017). Investigation of sphingosine kinase 1 in interferon responses during dengue virus infection. Clinical & Translational Immunology, 6 pp. Art: e151.
    [10.1038/cti.2017.32]
  • Carr, J.M., Ashander, L.M., Calvert, J.K., Ma, Y., Aloia, A., Bracho, G.G., et al. (2017). Molecular responses of human retinal cells to infection with Dengue Virus. Mediators of Inflammation, 2017
    [10.1155/2017/3164375] [Scopus]
  • Van Der Hoek, K., Eyre, N.S., Shue, B., Khantisitthiporn, O., Glab-Ampi, K., Carr, J.M., et al. (2017). Viperin is an important host restriction factor in control of Zika virus infection. Nature, 7(1) pp. Art: 4475.
    [10.1038/s41598-017-04138-1]
  • Clarke, J.N., Davies, L.K., Calvert, J.K., Gliddon, B.L., Al Shujari, W.H., Aloia, A.L., et al. (2016). Reduction in sphingosine kinase 1 influences the susceptibility to dengue virus infection by altering antiviral responses. Journal of General Virology, 97(1) pp. 95-109.
    [10.1099/jgv.0.000334] [Scopus]
  • Ali, M.E., Rajapaksha, K.H., Carr, J.M. and Petrovsky, N. (2016). Norovirus drug candidates that inhibit viral capsid attachment to human histo-blood group antigens. ANTIVIRAL RESEARCH, 133 pp. 14-22.
    [10.1016/j.antiviral.2016.07.006] [Scopus]
  • Senaratne, T., Carr, J.M. and Noordeen, F. (2016). Elevation in liver enzymes is associated with increased IL-2 and predicts severe outcomes in clinically apparent dengue virus infection. Cytokine, 83 pp. 182-188.
    [10.1016/j.cyto.2016.04.010] [Scopus]
  • Senaratne, T., Wimalaratne, H., Alahakoon, D.G., Gunawardane, N., Carr, J.M. and Noordeen, F. (2016). Characterization of dengue virus infections in a sample of patients suggests unique clinical, immunological and virological profiles that impact on the diagnosis of dengue and dengue hemorrhagic fever. Journal of Medical Virology,
    [10.1002/jmv.24525] [Scopus]
  • Aloia, A.L., Abraham, A.M., Bonder, C., Pitson, S. and Carr, J.M. (2015). Dengue Virus-induced inflamamtion of the endothelium and the potential roles of Sphingosine Kinase-1 and MicroRNAs. Mediators of Inflammation, 2015(Art: 509306)
    [10.1155/2015/509306]
  • Calvert, J.K., Helbig, K., Dimasi, D.P., Cockshell, M.P., Beard, M.R., Pitson, S., et al. (2015). Dengue Virus infection of primary endothelial cells induces innate immune responses, changes in endothelial cells function and is restricted by Interferon-stimulated responses. Journal of Interferon and Cytokine Research, 35(8) pp. 654-665.
    [10.1089/jir.2014.0195] [Scopus]
  • Milic, N.L., Davis, S.B., Carr, J.M., Isberg, S., Beard, M.R. and Helbig, K. (2015). Sequence analysis and characterisation of virally induced viperin in the saltwater crocodile (Crocodylus porosus) Developmental and Comparative Immunology, 51 pp. 108-115.
    [Scopus]
  • Aloia, A., Eyre, N., Black, S., Bent, S., Gaeguta, A., Guo, Z., et al. (2014). Generation of a chimeric hepatitis C replicon encoding a genotype-6a NS3 protease and assessment of boceprevir (SCH503034) sensitivity and drug-associated mutations. Antiviral Therapy, Sept 15th
    [10.3851/IMP2850] [Scopus]
  • Boon, V.A.F., Carr, J. and Klebe, S. (2013). The role of viruses in carcinogenesis. Australian Medical Student Journal, 4(2) pp. 11-15.
    [Web Link]
  • Carr, J., Kua, T., Clarke, J., Calvert, J., Zebol, J., Beard, M., et al. (2013). Reduced sphingosine kinase 1 activity in dengue virus type-2 infected cells can be mediated by the 3' untranslated region of dengue virus type-2 RNA. Journal of General Virology, 94(PART 11) pp. 2437-2448.
    [10.1099/vir.0.055616-0] [Scopus]
  • Carr, J., Mahalingam, S., Bonder, C. and Pitson, S. (2013). Sphingosine kinase 1 in viral infections. Reviews in Medical Virology, 23(2) pp. 73-84.
    [10.1002/rmv.1718] [Scopus]
  • Helbig, K., Carr, J., Calvert, J., Wati, S., Clarke, J., Eyre, N.S., et al. (2013). Viperin is induced following Dengue Virus Type-2 (DENV-2) infection and has anti-viral actions requiring the C-terminal end of viperin. Plos Neglected Tropical Diseases, 7(4) pp. e2178.
    [10.1371/journal.pntd.0002178] [Scopus]
  • Wati, S., Rawlinson, S., Ivanov, R., Dorstyn, L., Beard, M., Jans, D., et al. (2011). Tumour necrosis factor alpha (TNF-alpha) stimulation of cells with established dengue virus type 2 infection induces cell death that is accompanied by reduced ability of TNF-alpha to activate nuclear factor kB and reduced sphingosine kinase1 activity. Journal of General Virology, 92(4) pp. 807-818.
    [10.1099/vir.0.028159-0] [Scopus]
  • Wati, S., Soo, M.L., Zilm, P., Li, P., Paton, A., Burrell, C., et al. (2009). Dengue Virus Infection Induces Upregulation of GRP78, Which Acts To Chaperone Viral Antigen Production. Journal of Virology, 83(24) pp. 12871-12880.
    [10.1128/JVI.01419-09] [Scopus]
  • Carr, J., Green, T., Shaw, D., Daly, L., Hart, W., Ratcliff, R., et al. (2009). Application of an allele specific PCR to clinical HIV genotyping samples detects additional K103N mutations in both therapy naïve and experienced patients. Journal of Medical Virology, 81(12) pp. 1983-1990.
    [10.1002/jmv.21628] [Scopus]
  • Carr, J., Coolen, C., Davis, A., Burrell, C. and Li, P. (2008). Human immunodeficiency virus 1 (HIV-1) virion infectivity factor (Vif) is part of reverse transcription complexes and acts as an accessory factor for reverse transcription. Virology, 372(1) pp. 147-156.
    [10.1016/j.virol.2007.10.041] [Scopus]
  • Davis, A., Carr, J., Bagley, C., Powell, J., Warrilow, D., Harrich, D., et al. (2008). Human immunodeficiency virus type-1 reverse transcriptase exists as post-translationally modified forms in virions and cells. Retrovirology, 5
    [10.1186/1742-4690-5-115] [Scopus]
  • Carr, J., Cheney, K., Coolen, C., Davis, A., Shaw, D., Ferguson, W., et al. (2007). Development of methods for co-ordinate measurement of total cell associated and integrated HIV-1 DNA forms in routine clinical samples: levels are not associated with clinical parameters but low levels of integrated HIV-1 DNA may be prognostic for co. Journal of Clinical Microbiology, 45(4) pp. 1288-1297.
    [10.1128/JCM.01926-06] [Scopus]
  • Wati, S., Li, P., Burrell, C. and Carr, J. (2007). Dengue virus (DV) replication in monocyte-derived macrophages is not affected by tumor necrosis factor alpha (TNF-A) and DV infection induces altered responsiveness to TNF-A stimulation. Journal of Virology, 81(18) pp. 10161-10171.
    [10.1128/JVI.00313-07] [Scopus]
  • Carr, J., Davis, A., Coolen, C., Cheney, K., Burrell, C. and Li, P. (2006). Vif-deficient HIV reverse transcription complexes (RTCs) are subject to APOBEC3G-mediated structural changes and mutation of RTC associated reverse transcription products. Virology, 351(1) pp. 80-91.
    [10.1016/j.virol.2006.03.027] [Scopus]
  • Arriaga, M., Carr, J., Li, P., Wang, B. and Saksena, N. (2006). Interaction between HIV-1 and APOBEC3 sub-family of proteins. Current HIV research, 4(4) pp. 401-409.
    [10.2174/157016206778560063] [Scopus]
  • Carr, J., Davis, A., Feng, F., Burrell, C. and Li, P. (2006). Cellular interactions of virion infectivity factor (Vif) as potential therapeutic targets: APOBEC3G and more? Current Drug Targets, 7(12) pp. 1583-1593.
    [10.2174/138945006779025356] [Scopus]
  • Davis, A., Cheney, K., Carr, J., Karlis, J., Vandegraaff, N., Coolen, C., et al. (2006). Measurement of integrated HIV-1 DNA in patient samples and infected cells treated with candidate integration inhibitors. Current Topics in Virology, 5 pp. 9-19.
    [Web Link]
  • Feng, F., Davis, A., Lake, J.A., Carr, J., Xia, W., Burrell, C., et al. (2004). Ring finger protein ZIN interacts with Human Immunodeficiency Virus Type 1 Vif. Journal of Virology, 19 pp. 10574-10581.
    [10.1128/JVI.78.19.10574-10581.2004] [Scopus]
  • Carr, J., Hocking, H., Bunting, K., Wright, P., Davidson, A., Gamble, J., et al. (2003). Supernatants from dengue virus type-2 infected macrophages induce permeability changes in endothelial cell monolayers. Journal of Medical Virology, 69(4) pp. 521-528.
    [10.1002/jmv.10340] [Scopus]
  • Lake, J.A., Carr, J., Feng, F., Mundy, L., Burrell, C. and Li, P. (2003). The role of Vif during HIV-1 infection: interaction with novel host cellular factors. Journal of Clinical Virology, 26 pp. 143-152.
    [Scopus]
  • Carr, J., Calvert, J., Kumar, R., Burrell, C. and Li, P. (2001). Effect of deletion and the site of insertion in double copy anti-tat retroviral vectors : viral titres and production of anti-tat mRNA. Archives of Virology, 146(11) pp. 2191-2200.
    [10.1007/s007050170029] [Scopus]
  • Pryor, M., Carr, J., Hocking, H., Davidson, A., Li, P. and Wright, P. (2001). Replication of dengue virus type 2 in human monocyte-derived macrophages: comparison of isolates and recombinant viruses with substitutions at amino acid 390 in the envelope glycoprotein. American Journal of Tropical Medicine and Hygiene, 65(5) pp. 427-434.
    [Scopus] [Web Link]
  • Carr, J., Hocking, H., Li, P. and Burrell, C. (1999). Rapid and efficient cell-to-cell transmission of human immunodeficiency virus infection from monocyte-derived macrophages to peripheral blood lymphocytes. Virology, 265(2) pp. 319-329.
    [10.1006/viro.1999.0047] [Scopus]
  • Carr, J., Ramshaw, H., Li, P. and Burrell, C. (1998). CD34+ cells and their derivatives contain mRNA for CD4 and human immunodeficiency virus (HIV) co-receptors and are susceptible to infection with M- and T-tropic HIV. Journal of General Virology, 79(1) pp. 71-75.
    [Scopus] [Web Link]
  • Lucic, M., Forbes, B.E., Grosvenor, S., Carr, J., Wallace, J. and Forsberg, G. (1998). Secretion in Escherichia coli and phage-display of recombinant insulin-like growth factor binding protein-2. Journal of Biotechnology, 61 pp. 95-108.
    [Scopus]
  • Quinn, E.J., Cheong, A.H.C., Calvert, J.K., Higgins, G., Hahesy, T., Gordon, D.L., et al. (2018). Clinical features and laboratory findings of travelers returning to South Australia with Dengue Virus infection. Tropical Medicine and Infectious Disease, 3(1)
    [10.3390/tropicalmed3010006]
  • Cabezas, S., Bracho Granado, G.R., Aloia, A.L., Adamson, P., Bonder, C.S., Smith, J.R., et al. (2018). Dengue virus induces increased activity of the complement alternative pathway in infected cells. Journal of Virology,
  • Aloia, A.L., Calvert, J.K., Clarke, J.N., Davies, L., Helbig, K., Pitson, S.M., et al. (2017). Investigation of sphingosine kinase 1 in interferon responses during dengue virus infection. Clinical & Translational Immunology, 6 pp. Art: e151.
    [10.1038/cti.2017.32]
  • Al Shujairi, W.H., Clarke, J.N., Davies, L., Alsharifi, M., Pitson, S. and Carr, J.M. (2017). Intracranial injection of Dengue Virus induces interferon stimulated genes and CD8+ T cell infiltration by Sphingosine Kinase 1 independent pathways. PLoS One, 12(1) pp. Art: e0169814.
    [10.1371/journal.pone.0169814]
  • Carr, J.M., Ashander, L.M., Calvert, J.K., Ma, Y., Aloia, A., Bracho, G.G., et al. (2017). Molecular responses of human retinal cells to infection with Dengue Virus. Mediators of Inflammation, 2017
    [10.1155/2017/3164375] [Scopus]
  • Van Der Hoek, K., Eyre, N.S., Shue, B., Khantisitthiporn, O., Glab-Ampi, K., Carr, J.M., et al. (2017). Viperin is an important host restriction factor in control of Zika virus infection. Nature, 7(1) pp. Art: 4475.
    [10.1038/s41598-017-04138-1]
  • Ali, M.E., Rajapaksha, K.H., Carr, J.M. and Petrovsky, N. (2016). Norovirus drug candidates that inhibit viral capsid attachment to human histo-blood group antigens. ANTIVIRAL RESEARCH, 133 pp. 14-22.
    [10.1016/j.antiviral.2016.07.006] [Scopus]
  • Clarke, J.N., Davies, L.K., Calvert, J.K., Gliddon, B.L., Al Shujari, W.H., Aloia, A.L., et al. (2016). Reduction in sphingosine kinase 1 influences the susceptibility to dengue virus infection by altering antiviral responses. Journal of General Virology, 97(1) pp. 95-109.
    [10.1099/jgv.0.000334] [Scopus]
  • Senaratne, T., Carr, J.M. and Noordeen, F. (2016). Elevation in liver enzymes is associated with increased IL-2 and predicts severe outcomes in clinically apparent dengue virus infection. Cytokine, 83 pp. 182-188.
    [10.1016/j.cyto.2016.04.010] [Scopus]
  • Senaratne, T., Wimalaratne, H., Alahakoon, D.G., Gunawardane, N., Carr, J.M. and Noordeen, F. (2016). Characterization of dengue virus infections in a sample of patients suggests unique clinical, immunological and virological profiles that impact on the diagnosis of dengue and dengue hemorrhagic fever. Journal of Medical Virology,
    [10.1002/jmv.24525] [Scopus]

Professional and community engagement

Local Organising committee for the Asia Pacific Congress of Medical Virology 2012

Local Organising committee for the Australian Society for Microbiology Conference, Adelaide, 2013

Committee Member, Australasian Society for Virology (AVS) 2013-current

Reviewer, Flinders University Institutional Biosafety Committee (IBC), 2012-current

Contact

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Phone: +61 8 82046658
Email:
Location: Flinders Medical Centre (5D:316)
Postal address: GPO Box 2100, Adelaide 5001, South Australia
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