Position

Academic Status
College of Medicine and Public Health

Biography

Professor Wong is Head, Pharmacogenomics Research Program, Mind and Brain Theme at the South Australian Health and Medical Research Institute, and Strategic Professor of Psychiatry, Flinders University,Adelaide, South Australia. Professor Wong was born in Hong Kong, grew up in Brazil, and lived for over 25 years in the United States, where she had clinical and research training in psychiatry at Albert Einstein College of Medicine, NIH, and Yale University. Professor Wong is recognised internationallyas a leader in research in the biology of depression and antidepressant drugs.She has conducted depression research for over 20 years at Yale, NIH, UCLA, University of Miami, and ANU. She is Associate Editor, Molecular Psychiatry (Impact Factor: 13.668, number 1 worldwide) and has co-edited two books: Pharmacogenomics: The Search for Individualized Therapeutics (2002) and Biology of Depression: From Novel Insights to Therapeutic Strategies (2005).

Qualifications

M.D., Faculdade de Medicina da Universidade de Sao Paulo, Sao Paulo, Brazil, 1982
FRANZCP, 2012

Honours, awards and grants

1980 Elected Medical Student Representative, MedicalEducation Board of USP, Brazil.
1989 MiltonRosenbaum Award for Psychiatric Research, Albert Einstein College of Medicine,New York, New York, USA.
1989 FogartyInternational Research Fellowship, U.S. Public Health Service, NationalInstitutes of Health (NIH), Bethesda, MD, USA.
1990 HonorableMention, Lilly Psychiatric Research Fellowship, awarded by the AmericanPsychiatric Association, Office of Research, Washington, DC, USA.
1990 SmithKline Beecham Award, Society of BiologicalPsychiatry, USA.
1991 YoungInvestigator Award, granted by the International Congress on SchizophreniaResearch and the Schizophrenia Branch, NIMH, USA.
1991 Bestsubmissions to Annual Meeting of the American College ofNeuropsychopharmacology, San Juan, Puerto Rico.
1993 APA/Dista Research Award, awarded by theAmerican Psychiatric Association, USA.
1993 Intramural Research Training Award, NIH, USA.
1996 Award Winner Poster, Science/American Federation for ClinicalResearch/American Society for Clinical Investigation/American Association ofPhysicians Biomedicine Meeting, Washington, DC, USA.
1996 NIHFARE Award, USA.
1997 NIH FARE Award, USA.
1998 Henry L. Moses Award, Montefiore MedicalCenter, Bronx, NY, USA.
2010 ANU Leadership Program, ANU,ACT, Australia.

Key responsibilities

Head, Pharmacogenomics Research Program, Mind and BrainTheme, South Australian Health and Medical Research Institute, SA, Australia.
Strategic Professor of Psychiatry, Flinders University, SA, Australia.

Teaching interests

  • Pharmacogenetics
  • Antidepressants
  • Major Depression
  • Neuroimmunomodulation

Research expertise

  • Genetics
  • Molecular biology
  • Neurosciences
  • Pharmacology and pharmaceutical sciences

Research interests

Prof Wong has over 25 years of experience in depression and neuroimmunology research. Her research is aimed at unravelling the fundamental biology of the central alterations of neuropeptides and cytokines in the brain that cause not only depressed mood, but also regulate the response to stress, body weight, endocrine rhythms, and immune function. She has pioneered studies that identified the expression of several cytokine genes in the brain (Nature Medicine 1996;2:581-4). She developed a line of research at the interface between major depression and obesity, focusing on neuroendocrine and neuroimmune interactions, metabolism and metabolic syndrome. She has developed integrated clinical and translational studies that have examined the neurobiology and regulation of a central cascade of inflammatory mediators and stress peptides. Additionally, she has also investigated the genetics of major depression and pharmacogenomics of antidepressants.

Supervisory interests

  • Genetics
  • Metabolism
  • Neuropharmacology
  • Neuroscience

RHD research supervision

Current

Associate supervisor : Translational Medicine (2) ;

RHD Student Achievements

  • P. Frost
    Travel Award - May 2003
  • Gillian W. Reierson
    Graduate Student Travel Award Winner - November 2009
  • Suhyun Lee
    Talk at the Feature Poster Session at the Endocrine Society's 95th Annual Meeting - June 2013
  • Ethan Dutcher
    RANZCP Student Scholarship Prize - February 2015

Publications

  • Wong, M.L., Lewis, M.D. and Licinio, J. (2015). Translational research in endocrinology and neuroimmunology applied to depression . In Vale, Nuno, ed. Biomedical Chemistry: Current Trends and Developments. Berlin, Germany: De Gruyter, pp. 119-131.
    [10.1515/9783110468755-004] [Scopus]
  • Paz-Filho, G., Wong, M.L. and Licinio, J. (2009). Circadian Rhythms of the HPA Axis and Stress. In Chrousos G., ed. Adrenal Physiology and Diseases. n/a: Endotext, pp. Chapter 27.
  • Blauner, S., Bond, C., Burguieres, P.J., Wong, M.L., Licinio, J. and Flores, D.L. (2005). The Experience of Depression. In Julio Licinio & Ma-Li Wong, ed. Biology of Depression: From Novel Insights to Therapeutic Strategies. Weinheim, Germany: Wiley-VCH Verlag, pp. 1023-1034.
  • Wong, M.L. (2005). History and Epidemiology of Depression. In Julio Licinio and Ma-Li Wong, ed. Biology of Depression: From Novel Insights to Therapeutic Strategies. Weinheim, Germany: Wiley-VCH Verlag, pp. 653-667.
  • Wong, M.L. (2005). Major Depression and Animal Models. In Julio Licinio and Ma-Li Wong, ed. Biology of Depression: From Novel Insights to Therapeutic Strategies. Weinheim, Germany: Wiley-VCH Verlag, pp. 669-688.
  • Wong, M.L. (2005). Pharmacogenetics and Pharmacogenomics of Antidepressant Drug Action. In Julio Licinio and Ma-Li Wong, ed. Biology of Depression: From Novel Insights to Therapeutic Strategies. Weinheim, Germany: Wiley-VCH Verlag, pp. 855-877.
  • Licinio, J. and Wong, M.L. (2003). Cytokine Pathways in the Brain. In Ziad Kronfol, ed. Neurobiological Foundation of Aberrant Behaviors Volume 7: Cytokines and Mental Health. New York, USA: Springer-Verlag, pp. 39-53.
    [10.1007/978-1-4615-0323-1_3]
  • Licinio, J. and Wong, M.L. (2003). Pharmacogenomic approaches to common and complex disorders: The paradigm of psychopharmacology. In McGraw-Hill 2003 Yearbook of Science & Technology. New York, USA: McGraw Hill.
  • Wong, M.L., Alvarado, I. and Licinio, J. (2002). Pharmacogenomics of Major Depression and Antidepressant Treatment. In Julio Licinio and Ma-Li Wong, ed. Pharmacogenomics: The Search for Individualized Therapies. Weiheim, Germany: Wiley-VCH Verlag, pp. 379-395.
  • Rinetti, G. and Wong, M.L. (2002). Major Depression and the Autonomic Nervous System. In C.L. Bolis, J. Licinio, S. Govoni, ed. Handbook of the Autonomic Nervous System in Health and Disease. n/a: CRC Press, pp. 642-655.
  • Yildiz, B., Ozata, M., Wong, M.L. and Licinio, J. (2002). Autonomic Nervous System-Leptin Interactions: Impact on metabolic rate and body weight regulation. In C.L. Bolis, J. Licinio, S. Govoni, ed. Handbook of the Autonomic Nervous System in Health and Disease. n/a: CRC Press, pp. 224-244.
  • Licinio, J. and Wong, M.L. (2001). Cytokines in the brain: From localization and function to clinical implications. In Itsvan Berczi and Reginald M. Gorczynski, ed. NeuroImmune Biology Volume 1: New Foundations of Biology. 1 ed. New York, USA: Elsevier Science, pp. 365-371.
    [10.1016/S1567-7443(01)80032-6] [Scopus]
  • Wong, M.L. and Prolo, P. (2001). A Role for Neuroimmunomodulators and Nitric Oxide in Aging. In Bolis CL, ed. Aging in Animals and Humans: from cell to organism. n/a: Academic Press.
  • Wong, M.L. (1999). Cytokine gene expression in the brain: Impact on sickness behaviour. In C. Liana Bolis and Julio Licinio, ed. Genes, behaviour and health. Geneva, Switzerland: World Health Organization, pp. 61-74.
    [Web Link]
  • Wong, M.L. (1999). Cytokines in the brain - Molecular responses to systemic illness and impact on sickness behaviour. In The Advisory Committee on Health Research, ed. Genes, behaviour and health. Geneva, Switzerland: World Health Organization, pp. 61-73.
  • Wong, M.L. (1997). Recent Progress in Neuro-Immune Interactions. In Neuroscience, Neurology and Health. Geneva, Switzerland: World Health Organization, pp. 81-104.
    [Web Link]
  • Wong, M.L. and Gold, P.W. (1997). Molecular Neurobiology Approaches to Dysthymia. In J. Licinio, C.L. Bolis, P. Gold, ed. Dysthymia: from clinical neuroscience to treatment. Geneva, Switzerland: World Health Organization, pp. 45-53.
    [Web Link]
  • Wong, M.L. and Gold, P. (1997). New developments in molecular neurobiology: implications for dysthymia. In J. Licinio, C.L. Bolis, P. Gold, ed. Dysthymia: from clinical neuroscience to treatment. Geneva, Switzerland: World Health Organization, pp. 45-53.
    [Web Link]
  • Wong, M.L. and Gold, P.W. (1997). Molecular Mechanisms of the Stress Response and Their Role in the Pathogenesis of Dysthymia. In J. Licinio, L. Prilipko, C.L. Bolis, ed. Dysthymia in neurological disorders: Proceedings of the WHO Meeting. Geneva, Switzerland: World Health Organization, pp. 47-53.
    [Web Link]
  • Wong, M.L., Al-Shekhlee, A., Gold, P.W. and Licinio, J. (1996). Cytokines in the Brain. In Nancy J. Rothwell, ed. Cytokines in the Nervous System. Georgetown, Texas, USA: Landers Bioscience Publishers, pp. 3-20.
    [10.1007/978-1-4615-9695-0]
  • Licinio, J., Wong, M.L. and Gold, P.W. (1993). Interactions Between Thyroid Hormones and Other Endocrine Systems. In Russell T. Joffe and Anthony J. Levitt, ed. Thyroid Axis & Psychiatric Illness. Washington, USA: American Psychiatric Press, pp. 133-146.
  • Akiskal, H.S., Cazzullo, C., Gentil, V., Lecrubier, Y., Licinio, J., Linden, M., et al. (1996). Dysthymia in Neurological Disorders. Geneva, Switzerland: World Health Organization.
    [Web Link]
  • Wong, M.L. (2013). Pharmacogenomics of Antidepressants. In Presented at the Second National Symposium on Translational Psychiatry, SAHMRI and Flinders University. Adelaide, Australia. Aug 2013.
  • Mishra, A., Blackburn, A., Parish, C., Wong, M.L. and Licinio, J. (2013). Leptin increases the metastatic potential of breast cancer cells. In Poster presented at the 25th Lorne Cancer Conference. Lorne, Australia. Feb 2013.
  • Wong, M.L. (2013). Pharmacogenomics of Antidepressants. In Presented at the Discipline of Clinical Pharmacology, School of Medical Sciences, University of Adelaide. Adelaide, Australia. Jun 2013.
  • Wong, M.L. (2013). Pharmacogenomics of Antidepressants. In Presented at the Taishan Academic Forum on Mental Disorders. Yantai, China. Jun 2013.
  • Wong, M.L. (2012). Major Depression: A Common Complex Disorder. In Lecture, at the Academic Unit of Psychiatry & Addiction Medicine, ANU Medical School. Canberra, Australia. Mar 2012.
  • Wong, M.L. (2012). Overview of Translation and Introduction to Course. In The third Boots Course on Translational Medicine: The Pathway from Discovery to Healthcare, The John Curtin School of Medical Research. Canberra, Australia. Mar 2012.
  • Wong, M.L. (2012). Pharmacogenomics of depression: Pathways and mechanisms. In Lecture at the Queensland Institute of Medical Research. Brisbane, Australia. Jun 2012.
  • Wong, M.L. (2012). Pharmacogenomics. In Clinical Pharmacological Tutorial, Master of Translational Medicine Coursework Program, The John Curtin School of Medical Research. Canberra, Australia. Jan 2012.
  • Wong, M.L. (2012). Pharmacogenomics. In Clinical Pharmacological Tutorial, Master of Translational Medicine Coursework Program, The John Curtin School of Medical Research. Canberra, Australia. Oct 2012.
  • Wong, M.L. (2012). The role of immunomediators in depression. In University of New South Wales Academic Forum. Sydney, Australia. Nov 2012.
  • Wong, M.L. (2012). The role of leptin in the pharmacogenomics of obesity. In Lecture in the symposium entitled “Pharmacogenomics and personalized medicine in psychiatry: Prospects for clinical implementation” at thr The International College of Neuropsychopharmacology (CINP) World Congress. Stockholm, Sweden. Jun 2012.
  • Wong, M.L. (2012). Unraveling the biology and medical complications of depression: From endocrine and metabolic effects to genomic science. In Research Meeting at Department of Psychological Medicine, National University of Singapore. Singapore. Jul 2012.
  • Mishra, A., Parish, C., Wong, M.L., Blackburn, A. and Licinio, J. (2012). Neuroendocrine and Inflammatory modulation of breast cancer. In 24th Lorne Cancer Conference. Lorne, Australia. Feb 2012.
  • Licinio, J. and Wong, M.L. (2012). Translational Research: Obesity, depression and their interface as case examples. In Department of Medicine Grand Rounds, National University of Singapore. Singapore. Jul 2012.
  • Licinio, J. and Wong, M.L. (2012). Stress, depression, obesity and their interface. In Plenary talk at the Cardinal Research: Obesity - Gut Hormone Conference. Gold Coast, Australia. Oct 2012.
  • Wong, M.L. (2012). Biological basis of schizophrenia. In Lecture in Block 6 - Year 2 Medical Students, ANU Medical School, CMBE. Canberra, Australia. Oct 2012.
  • Guo, S., Mastronardi, C., Paz-Filho, G., Licinio, J. and Wong, M.L. (2011). Social hierarchy influences weight gain in mice fed with high-fat diet. In Poster presentation at the Australian Society for Medical Research, New Investigator Forum. Canberra, Australia. Jun 2011.
  • Arachchige, R., Khan, A., Mastronardi, C., Wong, M.L., Licinio, J. and Paz-Filho, G. (2011). Effects of Adipose Tissue Transplantation on Weight, Locomotor Skills and Behaviour. In Poster presentation at the Australian Society for Medical Research, New Investigator Forum. Canberra, Australia. Jun 2011.
  • Inserra, A., Stojakovic, A., Paz-Filho, G., Wong, M.L. and Mastronardi, C. (2011). Caspase-1 Knockout mice appear to be resilient to depressive-like behavior. In Oral presentation at the Australian Society for Medical Research, New Investigator Forum. Canberra, Australia. Jun 2011.
  • Wong, M.L. (2011). Re-conceptualizing depression. In Invited Lecture, Brain & Mind Research Institute, University of Sydney. Sydney, Australia. Nov 2011.
  • Wong, M.L. (2011). Interactions between stress, antidepressants and diet. In Keynote speaker at the ACT Branch of the RANZCP Annual Branch Scientific Meeting. Corrigan's Cove, NSW, Australia. Mar 2011.
  • Wong, M.L. (2011). Biological basis of schizophrenia. In Lecture in Block 6 - Year 2 Medical Students, ANU Medical School, CMBE. Canberra, Australia. Oct 2011.
  • Mastronardi, C., Zanoni, M., Licinio, J. and Wong, M.L. (2011). The combination of stress, antidepressant use and high-fat diet is a risk factor for chronic obesity. In Poster presentation at the 93rd Endocrine Society Meeting. Boston, MA, USA.
  • Lee, S., Mastronardi, C., Paz-Filho, G., Licinio, J. and Wong, M.L. (2011). Understanding the long-term effect of weight gain induced by short-term exposure of antidepressants. In Poster presentation at the Australian Society for Medical Research, New Investigator Forum. Canberra, Australia. Jun 2011.
  • Khan, A., Arachchige, R., Mastronardi, C., Wong, M.L., Licinio, J. and Paz-Filho, G. (2011). Adipose tissue transplantation improves insulin sensitivity in leptin-deficient mice. In Poster presentation at the Australian Society for Medical Research, New Investigator Forum. Canberra, Australia. Jun 2011.
  • Mastronardi, C., Licinio, J. and Wong, M.L. (2010). Gene expression comparison between brain and heart during inflammatory stress. Genetics Society of AustralAsia 57th Annual Conference. Jul 2010.
  • Mastronardi, C., Zanoni, M., Licinio, J. and Wong, M.L. (2010). Spatial-temporal transcriptional responses during LPS-induced inflammatory stress. In American College of Neuropsychopharmacology 49h Annual Meeting. American College of Neuropsychopharmacology 49th Annual Meeting. Miami, USA. Dec 2010.
  • Paz-Filho, G., Andreev, V., Wong, M.L., Dwivedi, R.C., Krokhin, O.V., Wilkins, J.A., et al. (2010). Dynamics of Plasma Proteome of Genetically Leptin-deficient Patients during Leptin Replacement Therapy. 14th International Congress of Endocrinology. Kyoto, Japan. Mar 2010.
  • Paz-Filho, G., Andreev, V., Wong, M.L., Dwivedi, R.C., Krokhin, O.V., Wilkins, J.A., et al. (2010). Dynamics of Plasma Proteome of Genetically Leptin-deficient Patients during Leptin Replacement Therapy. 92nd Annual Endocrine Society's Meeting. San Diego, USA. Jun 2010.
  • Paz-Filho, G., Andreev, V., Wong, M.L., Dwivedi, R.C., Krokhin, O.V., Wilkins, J.A., et al. (2010). Dynamics of Plasma Proteome of Genetically Leptin-deficient Patients during Leptin Replacement Therapy. Annual Conference of the Genetics Society of Australasia 2010. Canberra, Australia. Jun 2010.
  • Wong, M.L. (2010). The role of cGMP in depression: Therapeutical implications. In International Symposium on Nitric Oxide-Cyclic GMP Signal Transduction in Brain. Valencia, Spain. Nov 2010.
  • Wong, M.L. (2010). Major Depression. In Invited lecture to the Smart Talk Seminar Series, Australian Institute of Sport, Australian Sports Commission. Canberra, Australia. Jul 2010.
  • Wong, M.L. (2010). Facilitating Cross-College Collaborations at ANU: Harnessing the ANU X-Disciplinary Potential. In ANU Leadership Program Academic Participants, Project Presentation. Canberra, Australia. Aug 2010.
  • Wong, M.L. (2010). Effects of leptin on energy metabolism and glucose homeostasis. In DGPPN Congress 2010 (German Association for Psychiatry and Psychotherapy) Berlin, Germany. Nov 2010.
  • Wong, M.L. (2010). Depression: a common complex disorder. In Invited lecture to ANU medical students at the Bruce Hall High Table Synopsis. Acton, ACT, Australia. May 2010.
  • Wong, M.L. (2010). Biological basis of schizophrenia. In Lecture in Block 6 - Year 2 Medical Students, ANU Medical School, CMBE. Canberra, Australia. Oct 2010.
  • Wong, M.L. (2010). Recent Advances in Major Depression Research. In 20th Annual TheMHS Conference. Sydney, Australia. Sep 2010.
  • Andreev, V., Dwivedi, R.C., Paz-Filho, G.J., Wong, M.L. and Licinio, J. (2009). Quantitative Study of Plasma Proteome Dynamics in Genetically Leptin Deficient Patients during Leptin Replacement Treatment. 57th ASMS Conference on Mass Spectrometry. Philadelphia, USA. May 2009.
  • Reierson, G.W., Mastronardi, C., Licinio, J. and Wong, M.L. (2009). Chronic imipramine downregulates cAMP signaling in rat hippocampus. 36th Eastern Atlantic Student Research Forum. Miami, USA. Feb 2009.
  • Mastronardi, C., Dong, C., Licinio, J. and Wong, M.L. (2009). Central and peripheral transcriptional responses during LPS-induced inflammatory stress. In Poster Presentation at the American College of Neuropsychopharmacology Annual Meeting. Hollywood, FL, USA. Hollywood, FL, USA. Dec 2009.
  • Paz-Filho, G.J., London, E.D., Lee, B., Chakrapani, S., Berman, S., Kohno, M., et al. (2009). Neuroplastic and functional effects of leptin replacement on the central nervous system. 91st Annual Endocrine Society's Meeting. Washington, DC, USA. Jun 2009.
  • Reierson, G., Mastronardi, C., Licinio, J. and Wong, M.L. (2009). Fluoxetine Treatment Increases Daytime Melatonin Synthesis in the Rodent. In American College of Neuropsychopharmacology Annual Meeting. Hollywood, FL, USA.
  • Reierson, G.W., Mastronardi, C., Licinio, J. and Wong, M.L. (2009). Chronic imipramine downregulates cAMP signaling in rat hippocampus. 162nd American Psychiatry Association Annual Meeting. San Francisco, USA. May 2009.
  • Andreev, V., Paz-Filho, G., Wong, M.L. and Licinio, J. (2009). Measuring and modeling of long and medium term effects. CSHL Meeting on Computational Cell Biology. Cold Spring Harbor, NY, USA. Mar 2009.
  • Reierson, G.W., Mastronardi, C., Licinio, J. and Wong, M.L. (2009). Repeated antidepressant thearpy increases cyclic GMP signaling in rat hippocampus. 39th Society for Neuroscience Annual Meeting. Chicago, USA. Oct 2009.
  • Reierson, G.W., Mastronardi, C., Licinio, J. and Wong, M.L. (2009). Repeated antidepressant therapy increases cyclic GMP signaling in rat hippocampus. Medical Scientist Training Program Annual MD/PhD Student Conference. Keystone, CO, USA. Jul 2009.
  • Wong, M.L. (2009). Research in the Dept of Psychiatry, University of Miami. In Lecture to the residents. Miami, FL, USA.
  • Wong, M.L. (2009). Role of Inflammation in Major Depressive Disorder: Clinical and Genetic Evidence. In Neurobiology of Stress and Emotion Regulation, ASPR Workshop, The John Curtin School of Medical Research. Canberra, Australia. Dec 2009.
  • Reierson, G., Mastronardi, C., Licinio, J. and Wong, M.L. (2008). Chronic antidepressants and cAMP signalling in rodent hippocampus. In Oral presentation at the University of Miami Neuroscience Retreat. Naples, FL, USA.
  • Wong, M.L., Dong, C., Maestre-Mesa, J. and Licinio, J. (2008). Association of variations in inflammation-related genes with susceptibility to Major Depression and Drug Response. In American College of Neuropsychopharmacology Annual Meeting. Scottsdale, AZ, USA.
  • Reierson, G., Mastronardi, C. and Wong, M.L. (2008). Effect of antidepressant treatment on cAMP signaling in the rat pineal gland. In Department of Psychiatry and Behavioral Sciences Poster Session. Miami, FL, USA. Apr 2008.
  • Paz-Filho, G.J., Esposito, K., Erol, H.K., Wong, M.L. and Licinio, J. (2008). Effects of Leptin Replacement Therapy on a Child with Congenital Leptin Deficiency. 90th Endocrine Society's Annual Meeting. San Francisco, USA. Jun 2008.
  • Paz-Filho, G., Erol, H.K., Ayala, A.R., Wong, M.L. and Licinio, J. (2008). Effects of leptin on hyperinsulinemia-mediated lipid metabolism. 13th International Congress of Endocrinology. Rio de Janeiro, Brazil. Aug 2008.
  • Mastronardi, C., Whelan, F., McCann, S., Licinio, J. and Wong, M.L. (2008). Integration of central and peripheral transcriptional responses during LPS-induced SIRS. In Department of Psychiatry and Behavioral Sciences Poster Session. Miami, FL, USA.
  • Mastronardi, C., Whelan, F., McCann, S., Licinio, J. and Wong, M.L. (2008). Integration of central and peripheral transcriptional responses during LPS-induced SIRS. In American College of Neuropsychopharmacology Annual Meeting. Scottsdale, AZ, USA.
  • Mastronardi, C., Whelan, F., McCann, S., Licinio, J. and Wong, M.L. (2008). Integration of central and peripheral transcriptional responses during LPS-induced SIRS. In 17th Annual Neurosciences Day. Miami, FL, USA. Mar 2008.
  • London, E., Chakrapani, S., Kohno, M., Kate, B., Sharma, A., Delibasi, T., et al. (2008). Short-term plasticity of grey matter change associated with leptin deficiency and replacement. In Oral presentation at the Society for Neuroscience Annual Conference. Washington, DC, USA.
  • Dong, C., Wong, M.L. and Licinio, J. (2008). Patterns of genetic differentiation between Mexican-Americans and three HapMap ethnic populations in candidate genes for depressive disorder and antidepressant response. In American Society for Human Genetics Annual Meeting. Philadelphia, PA, USA.
  • Reierson, G., Mastronardi, C., Licinio, J. and Wong, M.L. (2008). Chronic imipramine downregulates cAMP signaling in rat hippocampus. In American College of Neuropsychopharmacology Annual Meeting. Scottsdale, AZ, USA.
  • Victor, P., Paz-Filho, G., Wong, M.L. and Licinio, J. (2008). Measuring and Modeling of Long and Medium Term Effects of Leptin Replacement Treatment in Genetically Leptin Deficient Patients. Computational Cell Biology. Cold Spring Harbor, NY, USA. Mar 2008.
  • Wong, M.L. (2008). Research in the Dept of Psychiatry, University of Miami. In Lecture to the residents. Miami, FL, USA.
  • Wong, M.L. (2008). Translational Research and Center on Pharmacogenomics. In Presentation to the Dean's Advisory Committee for Psychiatry, University of Miami Medical School. Miami, FL, USA. Oct 2008.
  • Reierson, G., Mastronardi, C. and Wong, M.L. (2008). Phosphodiesterase (PDE) gene expression in the rat central nervous system. In Citizen's Board Research and Creativity Forum. Coral Gables, FL, USA.
  • Wong, M.L. (2007). Phosphodiesterase Genes and Susceptibility to Depression. In University of Miami Psychiatry Grand Rounds. Miami, FL, USA. Mar 2007.
  • Mastronardi, C., Whelan, F., McCann, S., Licinio, J. and Wong, M.L. (2007). Integration of central and peripheral transcriptional responses during LPS-induced SIRS. In Society for Neuroscience Annual Meeting. San Diego, CA, USA.
  • Luo, H.R., Wu, G.S., Ribeiro, L., Licinio, J. and Wong, M.L. (2007). Association of PDE11A Global Haplotype with Major Depression and Outcome of Antidepressant Treatment. In American Society for Human Genetics Annual Meeting. San Diego, CA, USA.
  • Licinio, J. and Wong, M.L. (2007). The Relationship between Antidepressant use and Suicide: Negative, Positive or Coincidental? In Oral plenary presentation at the 2nd Congress of the South American Association for Suicidology (ASULAC) Belo Horizonete, Brazil. Jun 2007.
  • Licinio, J. and Wong, M.L. (2007). Are pharmacodynamic genes ready for psychiatric clinical practice or not? 2007 Society for Biological Psychiatry Annual Meeting. San Diego, USA. May 2007.
  • Licinio, J. and Wong, M.L. (2007). Closing the global performance gap in managing major depression disorder & co-morbid anxiety. Second International Congress of Biological Psychiatry. Santiago, Chile. Apr 2007.
  • Licinio, J. and Wong, M.L. (2007). Pharmacogenomics of neuroimmuno interactions in psychiatric disorders. Experimental Biology Annual Meeting. Washington, DC, USA. May 2007.
  • Wong, M.L. (2006). Immune Mediators, Depression and Heart Disease: a Mechanistic Link. In XXII Ibero- American Congress of Physiological Sciences. Buenos Aires, Argentina. Nov 2006.
  • Wong, M.L. (2006). Pharmacogenomics of Antidepressants. In University of Miami Neuroscience Program Faculty Candidate Seminar. Miami, FL, USA. Oct 2006.
  • Wong, M.L. (2006). Pharmacogenomics of Antidepressants. In XXII Ibero-American Congress of Physiological Sciences. Buenos Aires, Argentina. Nov 2006.
  • Wong, M.L. (2006). Updates on Pharmacogenomics of Antidepressants. In X National Congress of Psychiatry. Seville, Spain. Oct 2006.
  • Wong, M.L. (2005). The Academic Career. In The 12th Annual Course: The Essentials of Clinical Investigation: Developing a Research Proposal, UCLA General Clinical Research Center. Los Angeles, CA, USA. Jul 2005.
  • Cordero, J., O'Kirwan, F., Hannestad, J., Licinio, J. and Wong, M.L. (2005). LPS-induced Differential Gene Expression in Rat Hypothalamus and Hippocampus. In Society for Neuroscience Annual Meeting. Washington, DC, USA.
  • Licinio, J. and Wong, M.L. (2005). Pharmacogenetics: New horizons in the treatment of mood disorders. Bipolar Disorder Conference. Porto Alegre, Brazil. Mar 2005.
  • Llerena, A., Caceres, M.C., Wong, M.L. and Licinio, J. (2005). CYP2C9 and clinical response to antidepressant drugs in Mexican-Americans. 2005 Annual Meeting of the American Society for Clinical Pharmacology and Therapeutics. Orlando, USA. Mar 2005.
  • Wong, M.L. (2005). Diversifying Your Portfolio: Non-Government Sources of Funding. In K30 Module 1: NIH Grant Preparation. Los Angeles, CA, USA. Nov 2005.
  • Wong, M.L. (2005). Endotoxin-Induced Myocarditis: A Newly Discovered, Inflammation-induced heart disease. Pathology, Histology, In Situ Hybridization and Gene Expression Profiling by DNA Chips. In Neuroendocrine Network and Body Homeostasis Meeting, Ribeirao Preto School of Medicine. Ribeirao Preto, Brazil. Aug 2005.
  • Wong, M.L. (2005). Gene Expression as a Probe to Discover New Mechanisms of Antidepressant Action. In Special Lecture at the 20th Korean Society of Biological Psychiatry Annual Meeting. Seoul, South Korea. Sep 2005.
  • Wong, M.L. (2005). How to Write a Scientific Paper. In The 12th Annual Course: The Essentials of Clinical Investigation: Developing a Research Proposal, UCLA General Clinical Research Center. Los Angeles, CA, USA. Jul 2005.
  • Wong, M.L. (2005). Immune Mediators, Depression, and Heart Disease. In Special Lecture, Department of Medicine, University of Dresden. Dresden, Germany. Sep 2005.
  • Wong, M.L. (2004). Pharmacogenomic Approaches to Inflammation and Depression in Hispanics. In Department of Psychiatry Grand Rounds, University of Texas Health Sciences Center. San Antonio, TX, USA. Apr 2004.
  • Wong, M.L. (2004). Pharmacogenomics of Antidepressant Response in Mexican-Americans. In UCLA Auxiliary Fall Meeting. Los Angeles, CA, USA. Nov 2004.
  • Wong, M.L. (2004). Writing and Publishing Research. In UCLA Louis Stokes Alliance for Minority Participation (LSAMP), and the Alliance for Graduate Education and the Professoriate's (AGEP) Summer Transition Program Workshop. Los Angeles, CA, USA. Aug 2004.
  • Wong, M.L., Yildiz, O.A., O'Kirwan, F., Hannestad, J.P., Irizarry, K.J.L., Elashoff, D., et al. (2004). St John's wort and imipramine-induced gene expression profiles reveal novel pharmacogenetic candidates for antidepressant treatment. Pharmacogenetics Research Network Fourth Scientific Meeting. Los Angeles, USA. Mar 2004.
  • Yildiz, O., Hannestad, J., Licinio, J. and Wong, M.L. (2004). Patterns of gene expression in the CNS during systemic inflammation. Society for Neuroscience Annual Meeting 2004. San Diego, USA. Oct 2004.
  • Dunham, A., Earthrow, M., Hunt, S., Niblett, D., Leonard, S., Burton, J., et al. (2004). Exon Sequencing To Identify Variation In Human Genes. International Sanger Institute-Cold Spring Harbor Laboratory Meeting "Pharmacogenomics" Cold Spring Harbor, NY, USA. Nov 2004.
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  • Licinio, J. and Wong, M.L. (2004). Pharmacogenomics of depression. Is there room for further candidate approaches? III Annual Meeting of the International Society of Pharmacogenomics. Santorini, Greece. Oct 2004.
  • Licinio, J., Caglayan, S., Ozata, M., Yildiz, B.O., de Miranda, P.B., O'Kirwan, F., et al. (2004). An experimental therapeutic approach to genetically-based obesity: Leptin replacement therapy resolves morbid obesity, hypogonadism, and diabetes mellitus in leptin-deficient adults. In Poster presentation at the Pharmacogenetics Research Network Fourth Scientific Meeting. Los Angeles, USA. Mar 2004.
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  • Licinio, J., Yildiz, B.O., Caglayan, S., DePaoli, A.M., Ozata, M. and Wong, M.L. (2004). Effects of leptin replacement therapy in humans. 2004 Neuroendocrine Workshop: Neuroendocrinology of Energy Balance. New Orleans, USA. Jun 2004.
  • Irizarry, K., Day, A., Wong, M.L., Lee, C. and Licinio, J. (2004). Identification of functional cSNPs in pharmacogenetic pathways underlying antidepressant treatment response. Pharmacogenetics Research Network Fourth Scientific Meeting. Los Angeles, USA. Mar 2004.
  • Irizarry, K., Day, A., Irizarry, K., Wong, M.L., Licinio, J. and Lee, C. (2003). Identification and integration of diverse genomics signals: building neuroinformatics tools for pharmacogenomics applications. In 2nd annual meeting of the International Society of Pharmacogenomics (ISP) Los Angeles, CA, USA.
  • Licinio, J. and Wong, M.L. (2003). Pharmacogenomics of depression: Search for new targets. In Plenary lecture at "Hot Topics in Pharmacogenomics", the Joint Meeting of the International Society of Pharmacogenomics and the Pacific Rim College of Clinical Pharmacogenetics. Los Angeles, CA, USA. Nov 2003.
  • Licinio, J. and Wong, M.L. (2003). Pharmacogenomics of depression: Search for new targets. NIDA/NIH Symposium "Genomics in Drug Abuse Research" Bethesda, USA. Oct 2003.
  • Licinio, J., Caglayan, S., Ozata, M., Yildiz, B., de Miranda, P., O'Kirwan, F., et al. (2003). An experimental therapeutic approach to genetically-based obesity: leptin replacement therapy resolves morbid obesity, hypogonadism and diabetes mellitus in leptin-deficient adults. In 2nd annual meeting of the International Society of Pharmacogenomics (ISP) Los Angeles, CA, USA.
  • Wong, M.L. (2003). "Meet the Professors" series. In UCLA Interdepartmental Neuroscience Ph.D. Program. Los Angeles, CA, USA. Oct 2003.
  • Wong, M.L., Licinio, J., Yildiz, B., Mantzoros, C., Prolo, P., Kling, M., et al. (2003). Simultaneous and Continuous Plasma and Cerebrospinal Fluid Leptin Concentrations. In Endocrine Society Meeting. Philadelphia, PA, USA. Jun 2003.
  • Licinio, J., Caglayan, S., Ozata, M., Yildiz, B.O., Wagner, A., DePaoli, A.M., et al. (2002). Effects of Recombinant Leptin Therapy in Leptin Deficient Adults. Endocrine Society Meeting "Hot Topics in Endocrinology: The Molecular Basis of Metabolic Regulation" New Orleans, USA. Nov 2002.
  • Licinio, J. and Wong, M.L. (2002). Pharmacogenomic Approaches in Psychiatry. In Plenary Lecture at the 2002 Annual Meeting of the Italian Society for Biological Psychiatry. Naples, Italy. Oct 2002.
  • Licinio, J. and Wong, M.L. (2002). Pharmacogenomics and Pharmacogenetic Approaches to Psychiatry. In Plenary lecture at the Annual Meeting of the Japanese Society for Clinical Pharmacology and Therapeutics. Osaka, Japan. Dec 2002.
  • Licinio, J. and Wong, M.L. (2002). Pharmacogenomics of Major Depression and Antidepressant Treatment. In Plenary Lecture at the Institut Pasteur Euroconference "Pharmacogenomics: The Promise and Reality of Individualized Treatment" Paris, France. Oct 2002.
  • Licinio, J., Caglayan, S., Alvarado, I., Wagner, A.J., DePaoli, A.M., Wong, M.L., et al. (2002). Leptin in Body Weight Regulation. 2002 Annual Meeting of the Society of Biological Psychiatry. Philadelphia, USA. May 2002.
  • Wong, M.L. (2001). Analysis of gene transcription in chronic treatment of prototypic antidepressants and St. John's Wort" In Novartis Pharmaceuticals Corporation. Gaithersburg, MD, USA. Nov 2001.
      • Licinio, J. and Wong, M.L. (Eds.). (2005). Biology of Depression: From Novel Insights to Therapeutic Strategies. Weinheim, Germany: Wiley-VCH Verlag.
      • Licinio, J. and Wong, M.L. (Eds.). (2002). Pharmacogenomics: The Search for Individualized Therapies. Weinheim, Germany: Wiley-VCH Verlag.
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  • Licinio, J. and Wong, M.L. (2014). Launching the 'War on Mental Illness'. MOLECULAR PSYCHIATRY, 19 pp. 1-5.
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  • Licinio, J. and Wong, M.L. (2013). A novel conceptual framework for psychiatry: vertically and horizontally integrated approaches to redundancy and pleiotropism that co-exist with a classification of symptom clusters based on DSM-5. MOLECULAR PSYCHIATRY, 18 pp. 846-848.
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  • Licinio, J. and Wong, M.L. (2013). Research infrastructure: US shutdown should spur other nations. Nature, 503(7475) pp. 198-198.
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  • Chrousos, G.P., Licinio, J. and Wong, M.L. (2012). In memoriam: Wylie Walker Vale, Jr. MOLECULAR PSYCHIATRY, 17(11) pp. 1052-1053.
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  • Ishibashi, K., Berman, S.M., Paz-Filho, G., Lee, B., Robertson, C., Mandelkern, M.A., et al. (2012). Dopamine D2/D3 receptor availability in genetically leptin-deficient patients after long-term leptin replacement. MOLECULAR PSYCHIATRY, 17(4) pp. 352-353.
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  • Licinio, J. and Wong, M.L. (2011). Advances in depression research: 2011. MOLECULAR PSYCHIATRY, 16(7) pp. 686-687.
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  • Licinio, J. and Wong, M.L. (2011). Why does the United States need a national center for new cures? MOLECULAR PSYCHIATRY, 16(9) pp. 882-884.
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  • Licinio, J. and Wong, M.L. (2010). Brain-derived neurotrophic factor in depression: a male problem? MOLECULAR PSYCHIATRY, 15 pp. 227.
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  • Licinio, J. and Wong, M.L. (2010). Pharmacogenomics of antidepressants: what is next? MOLECULAR PSYCHIATRY, 15(5) pp. 445.
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  • Licinio, J., Easteal, S. and Wong, M.L. (2010). Concrete helix recalls smallpox win. Nature, 468(7321) pp. 173-173.
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  • Paz-Filho, G., Wong, M.L. and Licinio, J. (2010). Leptin levels and Alzheimer disease. JAMA-Journal of The American Medical Association, 303(15) pp. 1478.
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  • Mastronardi, C.A., Licinio, J. and Wong, M.L. (2009). A tribute to Dr. Samuel McDonald McCann's life as a scientist, mentor and friend. Physiological Mini Reviews, 4(6) pp. 49-55.
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  • Paz-Filho, G., Esposito, K., Hurwitz, B., Sharma, A., Dong, C., Andreev, V., et al. (2009). Leptin and insulin sensitivity: reply to Oral and Burant. American Journal of Physiology-Endocrinology and Metabolism, 296(2) pp. E396.
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  • Wong, M.L., Arcos-Burgos, M. and Licinio, J. (2008). Frontiers in psychiatric research: Frontiers in genomic research - What the clinician needs to know. Psychiatric Times, 25(7) pp. 44-46.
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  • Schwarz, P.E.H., Reimann, M., Li, J., Bergmann, A., Licinio, J., Wong, M.L., et al. (2007). The Metabolic Syndrome - A Global Challenge for Prevention. HORMONE AND METABOLIC RESEARCH, 39(11) pp. 777-780.
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  • Licinio, J., Mastronardi, C. and Wong, M.L. (2007). Pharmacogenomics of neuroimmune interactions in human psychiatric disorders. Experimental Physiology, 92(5) pp. 807-811.
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  • Bornstein, S.R., Wong, M.L. and Licinio, J. (2006). 150 years of Sigmund Freud: what would Freud have said about the obesity epidemic? MOLECULAR PSYCHIATRY, 11(12) pp. 1070-1072.
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  • Bornstein, S.R., Schuppenies, A., Wong, M.L. and Licinio, J. (2006). Approaching the shared biology of obesity and depression: the stress axis as the locus of gene-environment interactions. MOLECULAR PSYCHIATRY, 11(10) pp. 892-902.
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  • Reichel, A., Schwarz, J., Schulze, J., Licinio, J., Wong, M.L. and Bornstein, S.R. (2005). Depression and anxiety symptoms in diabetic patients on continuous subcutaneous insulin infusion (CSII) MOLECULAR PSYCHIATRY, 10(11) pp. 975-976.
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  • Licinio, J. and Wong, M.L. (2005). Depression, antidepressants and suicidality: a critical appraisal. NATURE REVIEWS DRUG DISCOVERY, 4(2) pp. 165-171.
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  • Wong, M.L. and Licinio, J. (2005). Peripheral is Central to the question. MOLECULAR PSYCHIATRY, 10(5) pp. 421-422.
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  • Korenblum, W., Barthel, A., Licinio, J., Wong, M.L., Wolf, O.T., Kirschbaum, C., et al. (2005). Elevated cortisol levels and increased rates of diabetes and mood symptoms in Soviet Union-born Jewish immigrants to Germany. MOLECULAR PSYCHIATRY, 10(11) pp. 974-975.
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  • Flores, D.L., Alvarado, I., Wong, M.L., Licinio, J. and Flockhart, D. (2004). Clinical Implications of Genetic Polymorphism of CYP2D6 in Mexican Americans. Annals of Internal Medicine, 140(11) pp. W-48-W-49.
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  • Kirchheiner, J., Nickchen, K., Bauer, M., Wong, M.L. and Licinio, J. (2004). Pharmacogenetics of antidepressants and antipsychotics: the contribution of allelic variations to the phenotype of drug response. MOLECULAR PSYCHIATRY, 9(5) pp. 442-473.
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  • Licinio, J. and Wong, M.L. (2004). Back to where it all started: monoamines and behavior - from drug responses to genes. MOLECULAR PSYCHIATRY, 9(5) pp. 427.
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  • Licinio, J. and Wong, M.L. (2004). Translational research in psychiatry: pitfalls and opportunities for career development. MOLECULAR PSYCHIATRY, 9(2) pp. 117.
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  • Wong, M.L. and Licinio, J. (2004). From monoamines to genomic targets: a paradigm shift for drug discovery in depression. NATURE REVIEWS DRUG DISCOVERY, 3(2) pp. 136-151.
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  • Licinio, J. and Wong, M.L. (2003). Data from the Northern Finland 1966 Birth Cohort support an association between depression and immune function. MOLECULAR PSYCHIATRY, 8(8) pp. 711-712.
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  • Licinio, J. and Wong, M.L. (2003). Sequence and function in pharmacogenomics. PHARMACOGENOMICS JOURNAL, 3(3) pp. 123-123.
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  • Licinio, J. and Wong, M.L. (2003). Approaches to dissecting mechanisms of adverse drug reactions in psychiatry: clozapine-binding sites in the bone marrow. PHARMACOGENOMICS JOURNAL, 3(4) pp. 189-189.
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  • Licinio, J., Alvarado, I. and Wong, M.L. (2002). Conceptualizing depression. MOLECULAR PSYCHIATRY, 7(5) pp. 429-429.
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  • Licinio, J., Alvarado, I. and Wong, M.L. (2002). Patient-oriented investigation in pharmacogenomics. PHARMACOGENOMICS JOURNAL, 2(3) pp. 137-137.
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  • Licinio, J., Alvarado, I.I. and Wong, M.L. (2002). Autoimmunity in autism. MOLECULAR PSYCHIATRY, 7(4) pp. 329-329.
  • Licinio, J., Yildiz, B. and Wong, M.L. (2002). Depression and cardiovascular disease: co-occurrence or shared genetic substrates? MOLECULAR PSYCHIATRY, 7(10) pp. 1031-1032.
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  • Licinio, J. and Wong, M.L. (2002). Complexity and Pharmacogenomics. PHARMACOGENOMICS JOURNAL, 2(4) pp. 203-203.
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  • Licinio, J. and Wong, M.L. (2002). Brain-derived neurotrophic factor (BDNF) in stress and affective disorders. MOLECULAR PSYCHIATRY, 7(6) pp. 519-519.
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  • Alvarado, I., Wong, M.L. and Licinio, J. (2002). Advances in the pharmacogenomics of adverse drug reactions. PHARMACOGENOMICS JOURNAL, 2 pp. 273.
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  • Licinio, J. and Wong, M.L. (2002). Depression and obesity treatments are life saving. NATURE MEDICINE, 8(12) pp. 1336-1336.
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  • Wong, M.L., Frost, P.J., Hannestad, J.P. and Licinio, J. (2001). Mechanisms of Brain-Body Communication: How the Brain Regulates Disease Susceptibility and Feeling Ill? Biotechnology International III - The Biotech Millenium, pp. 173-180.
  • Wong, M.L. and Sternberg, E. (2000). Immunological assays for understanding Neuroimmune interactions. Archives of Neurology, 57(7) pp. 948-952.
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  • Licinio, J. and Wong, M.L. (1999). The role of inflammatory mediators in the biology of major depression: central nervous system cytokines modulate the biological substrate of depressive symptoms, regulate stress-responsive systems, and contribute to neurotoxicity and neuroprotection. MOLECULAR PSYCHIATRY, 4(4) pp. 317-327.
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  • Licinio, J., Prolo, P., McCann, S.M. and Wong, M.L. (1999). Brain iNOS: current understanding and clinical implications. Trends in Molecular Medicine, 5(5) pp. 225-232.
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  • McCann, S.M., Licinio, J., Wong, M.L., Yu, W.H., Karanth, S. and Rettorri, V. (1998). The nitric oxide hypothesis of aging. EXPERIMENTAL GERONTOLOGY, 33(7-8) pp. 813-826.
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  • Prolo, P., Wong, M.L. and Licinio, J. (1998). Molecules in focus: Leptin. International Journal of Biochemistry and Cell Biology, 30(12) pp. 1285-1290.
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  • Licinio, J. and Wong, M.L. (1997). Interleukin 1 receptor antagonist gene expression in rat pituitary in the systemic inflammatory response syndrome: pathophysiological implications. MOLECULAR PSYCHIATRY, 2(2) pp. 99-103.
  • Licinio, J. and Wong, M.L. (1997). Pathways and mechanisms for cytokine signaling of the central nervous system. Journal of Clinical Investigation, 100(12) pp. 2941-2947.
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  • Akiskal, H.S., Bolis, C.L., Cazzullo, C., Costa e Silva, J.A., Gentil, V., Lecrubier, Y., et al. (1996). Dysthymia in neurological disorders. MOLECULAR PSYCHIATRY, 1(6) pp. 478-491.
  • Licinio, J., Wong, M.L. and Gold, P.W. (1996). The hypothalamic-pituitary-adrenal axis in anorexia nervosa. Psychiatry Research, 62(1) pp. 75-83.
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  • Licinio, J. and Wong, M.L. (1996). Interleukin 1 beta and fever. NATURE MEDICINE, 2(12) pp. 1314-1315.
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  • Gold, P.W., Wong, M.L., Chrousos, G.P. and Licinio, J. (1996). Stress system abnormalities in melancholic and atypical depression: molecular, pathophysiological, and therapeutic implications. MOLECULAR PSYCHIATRY, 1(4) pp. 257-264.
  • Gold, P.W., Licinio, J., Wong, M.L. and Chrousos, G.P. (1995). Corticotropin Releasing Hormone in the Pathophysiology of Melancholic and Atypical Depression and in the Mechanism of Action of Antidepressant Drugs. Annals of the New York Academy of Sciences, 771 pp. 716-729.
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  • Wong, M.L., Gold, P.W. and Licinio, J. (1993). In situ hybridization techniques for the localization of interleukin-1 and interleukin-1 receptor antagonist mRNA in brain. Methods in Neurosciences, 16 pp. 81-99.
  • Lipton, R. and Wong, M.L. (1989). Eye tracking disturbance and EEG: A comparison of physiologic markers for schizophrenia and epilepsy. NEUROPSYCHIATRY NEUROPSYCHOLOGY AND BEHAVIORAL NEUROLOGY, 2(1) pp. 61-66.
  • Wong, M.L. (1988). Prefrontal-Type Cognitive Deficits and Chronic Psychiatric Conditions. Archives of General Psychiatry, 45(11) pp. 1054.
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  • Yu, C., Baune, B., Licinio, J. and Wong, M.L. (2017). Single-nucleotide variant proportion in genes: a new concept to explore major depression based on DNA sequencing data. JOURNAL OF HUMAN GENETICS, 62 pp. 577-580.
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  • Yu, C., Baune, B., Licinio, J. and Wong, M.L. (2017). A novel strategy for clustering major depression individuals using whole-genome sequencing variant data. Scientific Reports, 7 pp. Art: 44389.
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  • Yu, C., Arcos-Burgos, M., Licinio, J. and Wong, M.L. (2017). A latent genetic subtype of major depression identified by whole-exome genotyping data in a Mexican-American cohort. Translational Psychiatry, 7(5) pp. Art: e1134.
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  • Yu, C., Baune, B., Wong, M.L. and Licinio, J. (2017). Investigation of copy number variation in subjects with major depression based on whole-genome sequencing data. Journal of Affective Disorders, 220 pp. 38-42.
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  • Yu, C., Baune, B.T., Licinio, J. and Wong, M.L. (2017). Whole-genome single nucleotide variant distribution on genomic regions and its relationship to major depression. Psychiatry Research, 252 pp. 75-79.
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  • Rogers, G., Keating, D.J., Young, R.L., Wong, M.L., Licinio, J. and Wesselingh, S.L. (2016). From gut dysbiosis to altered brain function and mental illness: mechanisms and pathways. MOLECULAR PSYCHIATRY, 21(6) pp. 738-748.
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  • Pasternak, K.I., Timo-Iaria, C., Rodrigues, C.J., Maria, D.A., Duarte, A.J., Paiva, L., et al. (1998). Circumscribed lesion of the medial forebrain bundle area causes structural impairment of lymphoid organs and severe depression of immune function in rats. MOLECULAR PSYCHIATRY, 3(5) pp. 397-404.
    [10.1038/sj.mp.4000426]
  • Loddick, S.A., Wong, M.L., Bongiorno, P.B., Gold, P.W., Licinio, J. and Rothwell, N.J. (1997). Endogenous Interleukin-1 Receptor Antagonist is Neuroprotective. Biochemical and Biophysical Research Communications, 234(1) pp. 211-215.
    [10.1006/bbrc.1997.6436] [Scopus]
  • Licinio, J., Mantzoros, C.S., Negrao, A.B., Cizza, G., Wong, M.L., Bongiorno, P.B., et al. (1997). Human leptin levels are pulsatile and inversely related to pituitary-ardenal function. NATURE MEDICINE, 3(5) pp. 575-579.
    [10.1038/nm0597-575]
  • Wong, M.L., Bongiorno, P.B., Rettori, V., McCann, S.M. and Licinio, J. (1997). Interleukin (IL) 1ß, IL-1 receptor antagonist, IL-10, and IL-13 gene expression in the central nervous system and anterior pituitary during systemic inflammation: Pathophysiological implications. Proceedings of the National Academy of Sciences of the United States of America, 94(1) pp. 227-232.
    [Scopus] [Web Link]
  • Wong, M.L., Bongiorno, P.B., Al-Shekhlee, A., Esposito, A., Khatri, P. and Licinio, J. (1996). IL-1[beta], IL-1 receptor type I and iNOS gene expression in rat brain vasculature and perivascular areas. Neuroreport, 7(15-17) pp. 2445-2448.
    [Scopus] [Web Link]
  • Wong, M.L., Al-Shekhlee, A., Bongiorno, P.B., Esposito, A., Khatri, P., Sternberg, E.M., et al. (1996). Localization of urocortin messenger RNA in rat brain and pituitary. MOLECULAR PSYCHIATRY, 1(4) pp. 307-312.
    [Scopus]
  • Wong, M.L., Khatri, P., Licinio, J., Esposito, A. and Gold, P.W. (1996). Identification of Hypothalamic Transcripts Upregulated by Antidepressants. Biochemical and Biophysical Research Communications, 229(1) pp. 275-279.
    [10.1006/bbrc.1996.1792] [Scopus]
  • Wong, M.L., Rettori, V., Al-Shekhlee, A., Bongiorno, P.B., Canteros, G., McCann, S.M., et al. (1996). Inducible nitric oxide synthase gene expression in the brain during systemic inflammation. NATURE MEDICINE, 2(5) pp. 581-584.
    [10.1038/nm0596-581] [Scopus]
  • Wong, M.L., Xin, W. and Duman, R. (1996). Rat LCR1: Cloning and cellular distribution of a putative chemokine receptor in brain. MOLECULAR PSYCHIATRY, 1(2) pp. 133-140.
    [Scopus]
  • Licinio, J., Bongiorno, P.B., Gold, P.W. and Wong, M.L. (1995). The Gene Encoding for the Novel Transacting Factor PCRH-REB-1 is Constitutively Expressed in Rat Pituitary and in Discrete Brain Regions Containing CRH or CRH Receptors: Pathophysiological Implications. Endocrinology, 136(10) pp. 4709-4712.
    [10.1210/en.136.10.4709]
  • Licinio, J., Gold, P.W. and Wong, M.L. (1995). A molecular mechanism for stress-induced alterations in susceptibility to disease. Lancet, 346(8967) pp. 104-106.
    [10.1016/S0140-6736(95)92119-2] [Scopus]
  • Wong, M.L., Bongiorno, P.B., Gold, P.W. and Licinio, J. (1995). Localization of Interleukin-1ß Converting Enzyme mRNA in Rat Brain Vasculature: Evidence that the Genes Encoding the Interleukin-1 System Are Constitutively Expressed in Brain Blood Vessels. Pathophysiological implications. NeuroImmunoModulation, 2(3) pp. 141-148.
    [10.1159/000096884] [Scopus]
  • Wong, M.L., Loddick, S., Bongiorno, P., Gold, P., Rothwell, N. and Licinio, J. (1995). Focal cerebral ischemia induces CRH mRNA in rat cerebral cortex and amygdala. Neuroreport, 6(13) pp. 1785-1788.
    [Scopus]
  • Wong, M.L. and Licinio, J. (1994). Localization of Interleukin 1 Type I receptor mRNA in Rat Brain. NeuroImmunoModulation, 1(2) pp. 110-115.
    [10.1159/000097143] [Scopus]
  • Licinio, J., Wong, M.L., Altemus, M., Bongiorno, P.B., Bernat, A., Brabant, G., et al. (1994). Pulsatility of 24-hour concentrations of circulating interleukin-1-alpha in healthy women: analysis of integrated basal levels, discrete pulse properties, and correlation with simultaneous interleukin-2 concentrations. NeuroImmunoModulation, 1(4) pp. 242-250.
    [10.1159/000097172] [Scopus]
  • Wong, M.L. and Licinio, J. (1994). Localization of stem cell factor mRNA in adult rat hippocampus. NeuroImmunoModulation, 1(3) pp. 181-187.
    [Scopus]
  • Wong, M.L., Licinio, J., Pasternak, K.I. and Gold, P.W. (1994). Localization of corticotropin-releasing hormone (CRH) receptor mRNA in adult rat brain by in situ hybridization histochemistry. Endocrinology, 135(5) pp. 2275-2278.
    [10.1210/en.135.5.2275] [Scopus]
  • Licinio, J., Wong, M.L., Altemus, M., Bongiorno, P.B., Bernat, A., Tamarkin, L., et al. (1993). Twenty-four hour concentrations of circulating interleukin-2 in healthy women exhibit episodic fluctuations: analysis of integrated basal levels and discrete pulse properties. Endocrine, 1 pp. 120-128.
  • Wong, M.L., Licinio, J., Gold, P.W. and Glowa, J. (1993). Activity-induced anorexia in rats does not affect hypothalamic neuropeptide gene expression chronically. International Journal of Eating Disorders, 13(4) pp. 399-405.
    [10.1002/1098-108X(199305)13:4<399::AID-EAT2260130408>3.0.CO;2-J]
  • Wong, M.L., Smith, M.A., Licinio, J., Doi, S.Q., Weiss, S.R.B., Post, R.M., et al. (1993). Differential effects of kindled and electrically induced seizures on a glutamate receptor (GluR1) gene expression. Epilepsy Research, 14(3) pp. 221-227.
    [10.1016/0920-1211(93)90046-A] [Scopus]
  • Xin, W., Terwilliger, R., Rimland, J., Wong, M.L., Nestler, E. and Duman, R. (1993). Characterization and functional expression of a somatostatin receptor coupled to adenylyl cyclase. Molecular and Cellular Neuroscience, 4(3) pp. 259-266.
    [10.1006/mcne.1993.1033] [Scopus]
  • Licinio, J., Wong, M.L. and Gold, P.W. (1992). Neutrophil-activating peptide-1/interleukin-8 mRNA is localized in rat hypothalamus and hippocampus. Neuroreport, 3(9) pp. 753-756.
    [Scopus] [Web Link]
  • Wong, M.L., Weiss, S.R.B., Gold, P.W., Doi, S.Q., Banerjee, S., Licinio, J., et al. (1992). Induction of constitutive heat shock protein 73 mRNA in the dentate gyrus by seizures. Molecular Brain Research, 13(1-2) pp. 19-25.
    [10.1016/0169-328X(92)90040-I] [Scopus]
  • Paciotti, G.F., Baron, D., Licinio, J., Tamarkin, L., Wong, M.L., Gold, P.W., et al. (1992). Novel enzyme immunoassays for the detection of the cytokines interleukn 1-a and interleukin 2 in the circulation of normal subjects: 24-hour profiles. Progress in Neuroendocrinimmunology, 5(1) pp. 21-30.
  • Licinio, J., Wong, M.L. and Gold, P.W. (1991). Localization of Interleukin-1 Receptor Antagonist mRNA in Rat Brain. Endocrinology, 129(1) pp. 562-564.
    [10.1210/endo-129-1-562]
  • Licinio, J., Wong, M.L. and Gold, P.W. (1991). In situ hybridization histochemistry: A simple and rapid method for the study of peptide gene expression in circulating white blood cells. INTERNATIONAL JOURNAL OF METHODS IN PSYCHIATRIC RESEARCH, 1(2) pp. 101-104.
  • Nussenzveig, I., Sircar, R., Wong, M.L., Frusciante, M., Javitt, D. and Zukin, S. (1991). Polyamine effects upon N-methyl-D-aspartate receptor functioning: differential alteration by glutamate and glycine sites antagonists. Brain Research, 561(2) pp. 285-291.
    [Scopus]
  • Wong, M.L., Lewis, M.D. and Licinio, J. (2015). Translational research in endocrinology and neuroimmunology applied to depression . In Vale, Nuno, ed. Biomedical Chemistry: Current Trends and Developments. Berlin, Germany: De Gruyter, pp. 119-131.
    [10.1515/9783110468755-004] [Scopus]
  • Paz-Filho, G., Wong, M.L. and Licinio, J. (2009). Circadian Rhythms of the HPA Axis and Stress. In Chrousos G., ed. Adrenal Physiology and Diseases. n/a: Endotext, pp. Chapter 27.
  • Blauner, S., Bond, C., Burguieres, P.J., Wong, M.L., Licinio, J. and Flores, D.L. (2005). The Experience of Depression. In Julio Licinio & Ma-Li Wong, ed. Biology of Depression: From Novel Insights to Therapeutic Strategies. Weinheim, Germany: Wiley-VCH Verlag, pp. 1023-1034.
  • Wong, M.L. (2005). History and Epidemiology of Depression. In Julio Licinio and Ma-Li Wong, ed. Biology of Depression: From Novel Insights to Therapeutic Strategies. Weinheim, Germany: Wiley-VCH Verlag, pp. 653-667.
  • Wong, M.L. (2005). Major Depression and Animal Models. In Julio Licinio and Ma-Li Wong, ed. Biology of Depression: From Novel Insights to Therapeutic Strategies. Weinheim, Germany: Wiley-VCH Verlag, pp. 669-688.
  • Wong, M.L. (2005). Pharmacogenetics and Pharmacogenomics of Antidepressant Drug Action. In Julio Licinio and Ma-Li Wong, ed. Biology of Depression: From Novel Insights to Therapeutic Strategies. Weinheim, Germany: Wiley-VCH Verlag, pp. 855-877.
  • Licinio, J. and Wong, M.L. (2003). Cytokine Pathways in the Brain. In Ziad Kronfol, ed. Neurobiological Foundation of Aberrant Behaviors Volume 7: Cytokines and Mental Health. New York, USA: Springer-Verlag, pp. 39-53.
    [10.1007/978-1-4615-0323-1_3]
  • Akiskal, H.S., Cazzullo, C., Gentil, V., Lecrubier, Y., Licinio, J., Linden, M., et al. (1996). Dysthymia in Neurological Disorders. Geneva, Switzerland: World Health Organization.
    [Web Link]
  • Licinio, J. and Wong, M.L. (Eds.). (2005). Biology of Depression: From Novel Insights to Therapeutic Strategies. Weinheim, Germany: Wiley-VCH Verlag.
  • Licinio, J. and Wong, M.L. (Eds.). (2002). Pharmacogenomics: The Search for Individualized Therapies. Weinheim, Germany: Wiley-VCH Verlag.

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Subject Titles

  • Psychiatry
  • Research

Interests

  • Major depression

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