Position

Professor
Biological Sciences

Biography

Prof Brown completed her B.Sc. (Hons.) and her PhD. in the Department of Microbiology and Immunology at Adelaide University under the guidance of Prof Paul Manning and A/Prof Renato Morona. She undertook postdoctoral training with Prof Robert Hancock at the University of British Columbia in Canada for which she was awarded a Canadian Cystic Fibrosis Foundation Postdoctoral Fellowship. Prof Brown returned to Australia in 1993 to work with Prof Ronald Skurray at the University of Sydney. In 2007 she relocated her laboratory to Flinders University where she is currently Professor in Microbiology.

Qualifications

1992 - Ph.D. "Molecular characterisation of the rfb region of Vibrio cholerae O1 (Ogawa)" Department of Microbiology and Immunology, University of Adelaide
1984 - B.Sc. (Hons), "Molecular characterisation of the haemolysin determinant from V. cholerae" Department of Microbiology and Immunology, University of Adelaide
1983 - B.Sc., Department of Microbiology and Immunology, University of Adelaide

Honours, awards and grants

Fellow of the American Society of Microbiology (FAA)

Fellow of the Australian Society of Microbiology (FASM)

Bellberry Research Award 2009

Teaching interests

Prof Brown's teaching interests centre on Microbiology and the application of current molecular techniques.

Topic Coordinator:

  • BIOL3761  Foundations in Microbiology
  • BIOL3782  Advanced Microbiology: Microbial Ecology and Infectious Disease
  • SERC2700  Research Project 1

Topic Lecturer:

Research expertise

  • Biochemistry and cell biology
  • Medical microbiology
  • Microbiology
  • Molecular biology

Research interests

The overall scientific goal of the research undertaken in Prof Brown's laboratory is to determine the complex mechanisms used by bacteria to evade strategies employed by the host for their elimination, including the use of antimicrobial agents. Drug-resistant microorganisms are a major worldwide health issue as a number of important human pathogens have now acquired mechanisms that make them largely resistant to all currently available treatment regimes. One of the most significant resistance mechanisms involves membrane-bound efflux pumps that actively transport toxic antimicrobial compounds from the bacterial cell before they reach their intracellular target. Although many export systems transport a single substrate, or a small group of structurally-related substrates, a number of multidrug resistance (MDR) export systems are involved in the efflux of a wide range of structurally-dissimilar antimicrobial compounds. These MDR pumps are widespread amongst pathogenic bacteria and fungi, parasitic protozoa, and human tumour cells. With her team she is investigating the molecular structures, mechanistic processes and molecular evolution of these efflux pumps. Together with international collaborators, they have provided insights into the controversy of how proteins bind multiple ligands.

Additionally, we have recently developed a range of molecular techniques and model systems to analyse how the bacterium Acinetobacter baumannii has developed into such a successful pathogen.

Supervisory interests

  • Antimicrobials
  • Molecular biology

RHD research supervision

Current

Principal supervisor : Acinetobacter baumannii pathogenesis (3) ; Bacterial multidrug resistance (2) ;

Associate supervisor : Effect of salinity on phytoplankton (1) ;

Publications

  • Eijkelkamp, B., Hassan, K., Paulsen, I. and Brown, M.H. (2013). The role of efflux pumps in the nosocomial pathogens Staphylococcus aureus and Acinetobacter baumannii. In EW Yu, Q Zhang & MH Brown, ed. Microbial Efflux Pumps: Current Research. Norfolk, UK: Caister Academic Press, pp. 123-142.
    [Web Link]
  • Yu, E., Zhang, Q. and Brown, M.H. (Eds.). (2013). Microbial Efflux Pumps: Current Research. Norfolk, UK: Caister Academic Press.
    [Web Link]
  • Giles, S., Stroeher, U.H. and Brown, M.H. (2016). Measurement of intracellular cAMP levels using the cyclic nucleotide XP enzymatic immunoassay kit. bio-protocol, 6(8)
    [Web Link] [Web Link]
  • Brown, M.H. and Merlino, J. (2010). Biocides in the health industry. Microbiology Australia, 31(4) pp. 158-158.
  • Whiley, H.L., Bentham, R.H. and Brown, M.H. (2017). Legionella persistence in manufactured water systems: pasteurization potentially selecting for thermal tolerance. Frontiers in Microbiology, 8 pp. 1330.
  • Li, L., Hassan, K.A., Brown, M.H. and Paulsen, I. (2016). Rapid multiplexed phenotypic screening identifies drug resistance functions for three novel efflux pumps in Acinetobacter baumannii. Journal of Antimicrobial Chemotherapy, 71(5) pp. 1223-1232.
    [10.1093/jac/dkv460] [Scopus]
  • Chen, M., Monecke, S. and Brown, M.H. (2016). Clonal diversity of methicillin-sensitive Staphylococcus aureus from South Australian wallabies. Onehealth, 2 pp. 31-32.
    [10.1016/j.onehlt.2015.12.001]
  • Chen, M., Boardman, W. and Brown, M.H. (2016). Methicillin resistance gene diversity in staphylococci isolated from captive and free-ranging wallabies. Infection Ecology and Epidemiology, 6 pp. Art: 31507.
    [10.3402/iee.v6.31507]
  • Giles, S., Stroeher, U.H., Eijkelkamp, B.A. and Brown, M.H. (2015). Identification of genes involved in pellicle formation in Acinetobacter baumannii ATCC 17978. BMC Microbiology, 15 pp. Art: 116.
    [10.1186/s12866-015-0440-6]
  • Chen, M., Boardman, W., Smith, I., Goodman, A.E. and Brown, M.H. (2015). Characterisation of ß-lactam resistance mediated by blaZ in staphylococci recovered from captive and wild wallabies. Journal of Global Antibiotic Resistance, 3(3) pp. 184-189.
    [10.1016/j.jgar.2015.05.002] [Scopus]
  • Tong, C.L., Stroeher, U., Brown, M. and Raston, C. (2015). Continuous flow vortex fluidic synthesis of silica xerogel as a delivery vehicle for curcumin. RSC Advances, 5(11) pp. 7953-7958.
    [10.1039/C4RA15109G] [Scopus]
  • Iscla, I., Wray, R., Blount, P., Larkins-Ford, J., Conery, A., Ausubel, F., et al. (2015). A new antibiotic with potent activity targets MscL. JOURNAL OF ANTIBIOTICS, 68 pp. 453-462.
    [10.1038/ja.2015.4] [Scopus]
  • Antiabong, J.F., Ball, A.S. and Brown, M.H. (2015). The effects of iron limitation and cell density on prokaryotic metabolism and gene expression: Excerpts from Fusobacterium necrophorum strain 774 (sheep isolate) Gene, 563 pp. 94-102.
    [10.1016/j.gene.2015.03.017] [Scopus]
  • Eijkelkamp, B., Stroeher, U., Hassan, K., Paulsen, I. and Brown, M.H. (2014). Comparative analysis of surface-exposed virulence factors of Acinetobacter baumannii. BMC Genomics, 15 pp. 1020.
    [Scopus]
  • Balzano, S., Le Lan, C., Ellis, A., Hugo, C., Newton, K., Jamieson, T., et al. (2014). Evaluation of transparent exopolymer particles and microbial communities found post UV-light, multimedia and cartridge filtration pre-treatment in a SWRO plant. Desalination and Water Treatment,
    [10.1080/19443994.2014.950997] [Scopus]
  • Jendyk, J.G., Hemraj, D., Brown, M., Ellis, A. and Leterme, S.C. (2014). Environmental variability and phytoplankton dynamics in a South Australian inverse estuary. Continental Shelf Research,
    [10.1016/j.csr.2014.08.009] [Scopus]
  • Leterme, S.C., Jendyk, J.G., Ellis, A., Brown, M. and Kildea, T. (2014). Annual phytoplankton dynamics in the Gulf Saint Vincent, South Australia in 2011. Oceanologia, 56(4) pp. 757-778.
    [10.5697/oc.56-4.757] [Scopus]
  • Fluman, N., Adler, J., Rotenberg, S., Brown, M.H. and Bibi, E. (2014). Export of a single drug molecule in two transport cycles by a multidrug efflux pump. Nature Communications,
    [10.1038/ncomms5615] [Scopus]
  • Chen, M., Boardman, W., Smith, I., Goodman, A. and Brown, M.H. (2014). Nasal colonisation of Staphylococcus spp among captive and free-ranging wallabies in South Australia. Journal of Veterinary Science & Medical Diagnosis, 3(2)
    [10.4172/2325-9590.1000136]
  • Antiabong, J., Boardman, W., Smith, I., Brown, M.H., Ball, A. and Goodman, A. (2013). Detection of Fusobacterium necrophorum leukotoxin (lkta) gene sequence in the oral cavity of captive Macropods. Journal of Veterinary Science & Medical Diagnosis, 2(2)
    [10.4172/2325-9590.1000114]
  • Antiabong, J., Boardman, W., Adetutu, E., Brown, M.H. and Ball, A. (2013). Does anaerobic bacterial antibiosis decrease fungal diversity in oral necrobacillosis disease? RESEARCH IN VETERINARY SCIENCE, 95(3) pp. 1012-1020.
    [10.1016/j.rvsc.2013.09.008] [Scopus]
  • Antiabong, J.F., Boardman, W., Moore, R.B., Brown, M.H. and Ball, A.S. (2013). The oral microbial community of gingivitis and lumpy jaw in captive macropods. RESEARCH IN VETERINARY SCIENCE, 95(3) pp. 996-1005.
    [10.1016/j.rvsc.2013.08.010] [Scopus]
  • Antiabong, J.F., Boardman, W., Smith, I., Brown, M.H., Ball, A. and Goodman, A. (2013). A molecular survey of a captive wallaby population for periodontopathogens and the co-incidence of Fusobacterium necrophorum subspecies necrophorum with periodontal diseases. Veterinary Microbiology, 163(3-4) pp. 335-343.
    [10.1016/j.vetmic.2013.01.012] [Scopus]
  • Eijkelkamp, B., Stroeher, U., Hassan, K., Elbourne, L., Paulsen, I. and Brown, M.H. (2013). H-NS plays a role in expression of the Acinetobacter baumannii persistence and virulence features. Infection and Immunity, 81(7) pp. 2574-2583.
    [10.1128/IAI.00065-13] [Scopus]
  • Farrugia, D., Elbourne, L., Hassan, K., Eijkelkamp, B., Tetu, S., Brown, M.H., et al. (2013). The complete genome and phenome of a community-acquired Acinetobacter baumannii. PLoS One, 8(3) pp. e58628.
    [10.1371/journal.pone.0058628] [Scopus]
  • Hassan, K., Jackson, S., Penesyan, A., Patching, S., Tetu, S., Eijkelkamp, B., et al. (2013). Transcriptomic and biochemical analyses identify a family of chlohexidine efflux proteins. Proceedings of the National Academy of Sciences of the United States of America, 110(50) pp. 20254-20259.
    [10.1073/pnas.1317052110] [Scopus]
  • La Vars, S., Johnston, M., Hayles, J., Gascooke, J., Brown, M., Leterme, S.C., et al. (2013). 29Si{1H} CP-MAS NMR comparison and ATR-FTIR spectroscopic analysis of the diatoms Chaetoceros muelleri and Thalassiosira pseudonana grown at different salinities. Analytical and Bioanalytical Chemistry, 405(10) pp. 3359-3365.
    [10.1007/s00216-013-6746-z] [Scopus]
  • Leterme, S.C., Prime, E., Mitchell, J., Brown, M. and Ellis, A. (2013). Diatom adaptability to environmental change: a case study of two Cocconeis species from high-salinity areas. Diatom Research, 28(1) pp. 29-35.
    [10.1080/0269249X.2012.734530] [Scopus]
  • Smith, R.J., Jeffries, T.C., Roudnew, B., Seymour, J., Fitch, A.J., Simons, K.L., et al. (2013). Confined aquifers as viral reservoirs. Environmental Microbiology Reports, 5(5) pp. 725-730.
    [10.1111/1758-2229.12072] [Scopus]
  • Antiabong, J., Jardine, D., Boardman, W., Brown, M.H. and Ball, A. (2013). A molecular ecological approach to the detection and designation of the etiological agents of a model polymicrobial disease. JOURNAL OF VETERINARY DIAGNOSTIC INVESTIGATION, 25(4) pp. 467-472.
    [10.1177/1040638713493628] [Scopus]
  • Antiabong, J., Boardman, W., Smith, I., Brown, M.H., Ball, A. and Goodman, A. (2013). "Cycliplex PCR" confirmation of Fusobacterium necrophorum isolates from captive wallabies: A rapid and accurate approach. Anaerobe, 19(1) pp. 44-49.
    [10.1016/j.anaerobe.2012.12.003] [Scopus]
  • Smith, R.J., Jeffries, T.C., Roudnew, B., Fitch, A.J., Seymour, J., Delpin, M.W., et al. (2012). Metagenomic comparison of microbial communities inhabiting confined and unconfined aquifer ecosystems. Environmental Microbiology, 14(1) pp. 240-253.
    [10.1111/j.1462-2920.2011.02614.x] [Scopus]
  • Eijkelkamp, B.A., Stroeher, U., Hassan, K., Papadimitrious, M.S., Paulsen, I. and Brown, M.H. (2011). Adherence and motility characteristics of clinical Acinetobacter baumannii isolates. FEMS Microbiology Letters, 323(1) pp. 44-51.
    [10.1111/j.1574-6968.2011.02362.x] [Scopus]
  • Hassan, K.A., Brzoska, A.J., Wilson, N.L., Eijkelkamp, B.A., Brown, M.H. and Paulsen, I. (2011). Roles of DHA2 family transporters in drug resistance and iron homeostasis in Acinetobacter spp. Journal of Molecular Microbiology and Biotechnology, 20(2) pp. 116-124.
    [10.1159/000325367] [Scopus]
  • Peters, K., Brooks, B., Schumacher, M., Skurray, R., Brennan, R. and Brown, M.H. (2011). A single acidic residue can guide binding site selection but does not govern QacR cationic-drug affinity. PLoS One, 6(1) pp. e15974.
    [10.1371/journal.pone.0015974] [Scopus]
  • Eijkelkamp, B.A., Hassan, K., Paulsen, I. and Brown, M.H. (2011). Development of a high-throughput cloning strategy for characterization of Acinetobacter baumannii drug transporter proteins. Journal of Molecular Microbiology and Biotechnology, 20(4) pp. 211-219.
    [10.1159/000329836] [Scopus]
  • Eijkelkamp, B.A., Hassan, K.A., Paulsen, I. and Brown, M.H. (2011). Investigation of the human pathogen Acinetobacter baumannii under iron limiting conditions. BMC Genomics, 12 pp. 126.
    [10.1186/1471-2164-12-126] [Scopus]
  • Baltzer, S. and Brown, M.H. (2011). Antimicrobial peptides - promising alternatives to conventional antibiotics. Journal of Molecular Microbiology and Biotechnology, 20(4) pp. 228-235.
    [10.1159/000331009] [Scopus]
  • Hassan, K., Baltzer, S., Paulsen, I. and Brown, M.H. (2010). Pumping out biocides: a cause for concern. Microbiology Australia, 31(4) pp. 178-181.
  • Ni, L., Jensen, S., Tonthat, N.K., Berg, T., Kwong, S., Guan, F.H.X., et al. (2009). The Staphylococcus aureus pSK41 plasmid-encoded ArtA protein is a master regulator of plasmid transmission genes and contains a RHH motif used in alternate DNA-binding modes. Nucleic Acids Research, 37(20) pp. 6970-6983.
    [10.1093/nar/gkp756] [Scopus]
  • Peters, K.M., Sharbeen, G., Theis, T., Skurray, R.A. and Brown, M.H. (2009). Biochemical characterization of the multidrug regulator QacR distinguishes residues that are crucial to multidrug binding and induction of qacA transcription. Biochemistry, 48(41) pp. 9794-9800.
    [10.1021/bi901102h] [Scopus]
  • Hassan, K.A., Xu, Z., Watkins, R.E., Brennan, R.G., Skurray, R.A. and Brown, M.H. (2009). Optimized production and analysis of the staphylococcal multidrug efflux protein QacA. Protein Expression and Purification, 64(2) pp. 118-124.
    [10.1016/j.pep.2008.11.009] [Scopus]
  • Hassan, K., Soulhani, T., Skurray, R.A. and Brown, M.H. (2008). Analysis of tryptophan residues in the staphylococcal multidrug transporter QacA reveals long-distance functional associations of residues on opposite sides of the membrane. Journal of Bacteriology, 190(7) pp. 2441-2449.
    [10.1128/JB.01864-07] [Scopus]
  • Hardie, K.M., Schuman, J., Brown, M.H., Skurray, R.A., Brennan, R.G. and Schumacher, M.A. (2008). QacR-cation recognition is mediated by a redundancy of residues capable of charge neutralization. Biochemistry, 47(31) pp. 8122-8129.
    [10.1021/bi8008246] [Scopus]
  • Wu, J., Hassan, K.A., Skurray, R.A. and Brown, M.H. (2008). Functional analyses reveal an important role for tyrosine residues in the staphylococcal multidrug efflux protein QacA. BMC Microbiology, 8
    [10.1186/1471-2180-8-147] [Scopus]
  • Theis, T., Skurray, R.A. and Brown, M.H. (2007). Identification of suitable internal controls to study expression of a Staphylococcus aureus multidrug resistance system by quantitative real-time PCR. Journal of Microbiological Methods, 70(2) pp. 355-362.
    [10.1016/j.mimet.2007.05.011] [Scopus]
  • Hassan, K.A., Skurray, R.A. and Brown, M.H. (2007). Transmembrane Helix 12 of the Staphylococcus aureus Multidrug Transporter QacA Lines the Bivalent Cationic Drug Binding Pocket. Journal of Bacteriology, 189(24) pp. 9131-9134.
    [10.1128/JB.01492-07] [Scopus]
  • Hassan, K.A., Skurray, R.A. and Brown, M.H. (2007). Active export proteins mediating drug resistance in staphylococci. Journal of Molecular Microbiology and Biotechnology, 12(3-4) pp. 180-196.
    [10.1159/000099640] [Scopus]
  • Hassan, K.A., Robinson, K.L., Smith, A., Gibson, J., Skurray, R.A. and Brown, M.H. (2006). Glycine-rich transmembrane helix 10 in the staphylococcal tetracycline transporter TetA(K) lines a solvent-accessible channel. Biochemistry, 45(51) pp. 15661-15669.
    [10.1021/bi0614380] [Scopus]
  • Hassan, K.A., Galea, M., Wu, J., Mitchell, B.A., Skurray, R.A. and Brown, M.H. (2006). Functional effects of intramembranous proline substitutions in the staphylococcal multidrug transporter QacA. FEMS Microbiology Letters, 263(1) pp. 76-85.
    [10.1111/j.1574-6968.2006.00411.x] [Scopus]
  • Xu, Z., O'Rourke, B.A., Skurray, R.A. and Brown, M.H. (2006). Role of transmembrane segment 10 in efflux mediated by the staphylococcal multidrug transport protein QacA. Journal of Biological Chemistry, 281(2) pp. 792-799.
    [10.1074/jbc.M508676200] [Scopus]
  • Saidijam, M., Giulia, B., Ren, Q., Xu, Z., Hoyle, C.J., Palmer, S.L., et al. (2006). Microbial drug efflux proteins of the major facilitator superfamily. Current Drug Targets, 7(7) pp. 793-811.
    [10.2174/138945006777709575] [Scopus]
  • Bayer, A.S., Kupferwasser, L.I., Brown, M.H., Skurray, R.A., Grkovic, S., Jones, T., et al. (2006). Low-level resistance of staphylococcus aureus to thrombin-induced platelet microbicidal protein 1 in vitro associated with qacA gene carriage is independent of multidrug efflux pump activity. Antimicrobial Agents and Chemotherapy, 50(7) pp. 2448-2454.
    [10.1128/AAC.00028-06] [Scopus]
  • Grkovic, S., Hardie, K.M., Brown, M.H. and Skurray, R.A. (2003). Interactions of the QacR multidrug-binding protein with structurally diverse ligands: implications for the evolution of the binding pocket. Biochemistry, 42(51) pp. 15226-15236.
    [10.1021/bi035447+] [Scopus]
  • Grkovic, S., Brown, M.H., Hardie, K.M., Firth, N. and Skurray, R.A. (2003). Stable low-copy-number Staphylococcus aureus shuttle vectors. Microbiology-SGM, 149(3) pp. 785-794.
    [10.1099/mic.0.25951-0] [Scopus]
  • Grkovic, S., Brown, M.H. and Skurray, R.A. (2002). Regulation of bacterial drug export systems. Microbiology and Molecular Biology Reviews, 66(4) pp. 671-701.
    [10.1128/MMBR.66.4.671-701.2002] [Scopus]
  • Schumacher, M.A., Miller, M.C., Grkovic, S., Brown, M.H., Skurray, R.A. and Brennan, R.G. (2002). Structural basis for cooperative DNA binding by two dimers of the multidrug-binding protein QacR. EMBO Journal, 21(5) pp. 1210-1218.
    [10.1093/emboj/21.5.1210] [Scopus]
  • Schumacher, M.A., Miller, M.C., Grkovic, S., Brown, M.H., Skurray, R.A. and Brennan, R.G. (2001). Structural Mechanisms of QacR Induction and Multidrug Recognition. Science, 294(5549) pp. 2158-2163.
    [10.1126/science.1066020] [Scopus]
  • Grkovic, S., Brown, M.H. and Skurray, R.A. (2001). Transcriptional regulation of multidrug efflux pumps in bacteria. Seminars in Cell and Developmental Biology, 12(3) pp. 225-237.
    [10.1006/scdb.2000.0248] [Scopus]
  • Brown, M.H. and Skurray, R.A. (2001). Staphylococcal multidrug efflux protein QacA. Journal of Molecular Microbiology and Biotechnology, 3(2) pp. 163-170.
    [Scopus]
  • Grkovic, S., Brown, M.H., Schumacher, M.A., Brennan, R.G. and Skurray, R.A. (2001). The Staphylococcal QacR Multidrug Regulator Binds a Correctly Spaced Operator as a Pair of Dimers. Journal of Bacteriology, 183(24) pp. 7102-7109.
    [10.1128/JB.183.24.7102-7109.2001] [Scopus]
  • Eijkelkamp, B., Stroeher, U., Hassan, K., Elbourne, L., Paulsen, I. and Brown, M.H. (2013). H-NS plays a role in expression of the Acinetobacter baumannii persistence and virulence features. Infection and Immunity, 81(7) pp. 2574-2583.
    [10.1128/IAI.00065-13] [Scopus]
  • Farrugia, D., Elbourne, L., Hassan, K., Eijkelkamp, B., Tetu, S., Brown, M.H., et al. (2013). The complete genome and phenome of a community-acquired Acinetobacter baumannii. PLoS One, 8(3) pp. e58628.
    [10.1371/journal.pone.0058628] [Scopus]
  • Smith, R.J., Jeffries, T.C., Roudnew, B., Fitch, A.J., Seymour, J., Delpin, M.W., et al. (2012). Metagenomic comparison of microbial communities inhabiting confined and unconfined aquifer ecosystems. Environmental Microbiology, 14(1) pp. 240-253.
    [10.1111/j.1462-2920.2011.02614.x] [Scopus]
  • Eijkelkamp, B.A., Hassan, K., Paulsen, I. and Brown, M.H. (2011). Development of a high-throughput cloning strategy for characterization of Acinetobacter baumannii drug transporter proteins. Journal of Molecular Microbiology and Biotechnology, 20(4) pp. 211-219.
    [10.1159/000329836] [Scopus]
  • Eijkelkamp, B.A., Hassan, K.A., Paulsen, I. and Brown, M.H. (2011). Investigation of the human pathogen Acinetobacter baumannii under iron limiting conditions. BMC Genomics, 12 pp. 126.
    [10.1186/1471-2164-12-126] [Scopus]
  • Peters, K., Brooks, B., Schumacher, M., Skurray, R., Brennan, R. and Brown, M.H. (2011). A single acidic residue can guide binding site selection but does not govern QacR cationic-drug affinity. PLoS One, 6(1) pp. e15974.
    [10.1371/journal.pone.0015974] [Scopus]
  • Eijkelkamp, B.A., Stroeher, U., Hassan, K., Papadimitrious, M.S., Paulsen, I. and Brown, M.H. (2011). Adherence and motility characteristics of clinical Acinetobacter baumannii isolates. FEMS Microbiology Letters, 323(1) pp. 44-51.
    [10.1111/j.1574-6968.2011.02362.x] [Scopus]
  • Ni, L., Jensen, S., Tonthat, N.K., Berg, T., Kwong, S., Guan, F.H.X., et al. (2009). The Staphylococcus aureus pSK41 plasmid-encoded ArtA protein is a master regulator of plasmid transmission genes and contains a RHH motif used in alternate DNA-binding modes. Nucleic Acids Research, 37(20) pp. 6970-6983.
    [10.1093/nar/gkp756] [Scopus]
  • Hardie, K.M., Schuman, J., Brown, M.H., Skurray, R.A., Brennan, R.G. and Schumacher, M.A. (2008). QacR-cation recognition is mediated by a redundancy of residues capable of charge neutralization. Biochemistry, 47(31) pp. 8122-8129.
    [10.1021/bi8008246] [Scopus]
  • Hassan, K., Soulhani, T., Skurray, R.A. and Brown, M.H. (2008). Analysis of tryptophan residues in the staphylococcal multidrug transporter QacA reveals long-distance functional associations of residues on opposite sides of the membrane. Journal of Bacteriology, 190(7) pp. 2441-2449.
    [10.1128/JB.01864-07] [Scopus]

Professional and community engagement

Journal Editor/ Reviews
Senior Editor of the Journal of Molecular Microbiology and Biotechnology
Reviewer for multiple scientific journals
Reviewer for granting agencies including; Australian Research Council (ARC), National Health and Medical Research Council of Australia (NHMRC), British Society for Antimicrobial Chemotherapy, Israel Science Fund, New Zealand Health Council, United States National Science Foundation (NSF)

Professional Society Memberships/Committees

South Australian Branch of the Australian Society for Microbiology (Committee Member)

Adelaide Protein Group (Committee Member)

American Society for Microbiology (Member; FAA)

American Society for Microbiology (Ambassador to Australia)

Australian Society for Microbiology (Member; FASM)

Australian Society for Biochemistry and Molecular Biology (Member)

Contact

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Phone: +61 8 82012747
Email:
Location: Biological Sciences (221)
Postal address: GPO Box 2100, Adelaide 5001, South Australia
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