Prof Nikolai Petrovsky

Prof. Petrovsky with flu vaccine
Position/s:Director of Endocrinology
Medicine/General
Phone: +61 8 82044572
Email:
Location: School of Medicine (-)
Postal address: GPO Box 2100, Adelaide 5001, South Australia

Biography

director of endocrinology at flinders medical centre with a conjoint position as professor of medicine at flinders university, nikolai petrovsky is also vice-president and secretary-general of the international immunomics society. active in diabetes, endocrinology and vaccine research, he is the founder of vaxine, a company funded by the us national institutes of health to develop novel vaccine technologies. in 2009 vaxine won the amp innovation award at the telstra business awards and australia's coolest company award from australian anthill magazine. nikolai petrovsky has developed vaccines against influenza, hepatitis b, sting allergy, malaria, japanese encephalitis, rabies and hiv, has authored over 90 papers and chapters and is a regular invited speaker at international vaccine conferences.

Qualifications

  • Bachelor of Medical Science (University of Tasmania), 1979
  • Bachelor of Medicine, Bachelor of Surgery (MBBS), University of Tasmania, 1982
  • Fellowship, Australian Institute of Company Directors (FAICD) 1990
  • Fellowship, Royal Australasian College of Physicians (FRACP) 1994
  • PhD, University of Melbourne, 1998
  • Graduate Certificate in Education Studies, University of Sydney, 2002

Honours, awards and grants

  • NH&MRC Postgraduate Medical Research Scholarship, 1994
  • Cleveland Young Investigator Award, Royal Melbourne Hospital, 1995
  • Edith Moffat Award, Walter and Eliza Hall Institute, 1996
  • Distinguished Speaker Award, International Immunomics Society, 2005
  • Flinders University Public Affairs and Alumni Media Award 2005 & 2007
  • AMP  Innovation Award, 2009 Telstra Business Award
  • AusIndustry Innovation Award, Australian Anthill Company Awards

Key responsibilities

Director of the Department of Diabetes and Endocrinology at Flinders Medical Centre. Actively involved in medical research, supervision of postgraduate research students and teaching of medical curriculum at Flinders University

Teaching

Teaching interests

Diabetes Mellitus
Vaccine development
Biotechnology

Research and supervision

Research interests

  • Pathogenesis of type 1 diabetes
  • Obesity and type 2 diabetes
  • Vaccine development
  • Immuno-informatics

Publications

Refereed journal articles
  • Barclay, T., Constantopoulos, K., Zhang, W., Fujiki, M., Petrovsky, N. and Matisons, J. (2013). Chiral Self-Assembly of Designated Amphiphiles: Influences on Aggregate Morphology. Langmuir, 29(32) pp. 10001-10010. [10.1021/la401987y]
  • Barclay, T.G., Ginic-Markovic, M., Johnston, M., Cooper, P. and Petrovsky, N. (2012). Observation of the keto tautomer of D-fructose in D2O using 1H NMR spectroscopy. Carbohydrate Research, 347(1) pp. 136-141. [10.1016/j.carres.2011.11.003]
  • Fogarty, R., Abhary, S., Javadiyan, S., Kasmeridis, N., Petrovsky, N., Whiting, M., et al. (2012). Relationship between DDAH gene variants and serum ADMA level in individuals with type 1 diabetes. Journal of Diabetes and Its Complications, 26(3) pp. 195-198. [10.1016/j.jdiacomp.2012.03.022]
  • Saade, F., Gorski, S.A. and Petrovsky, N. (2012). Pushing the frontiers of T-cell vaccines: Accurate measurement of human T-cell responses. Expert Review of Vaccines, 11(12) pp. 1459-1470. [10.1586/erv.12.125]
  • Honda-Okubo, Y., Saade, F. and Petrovsky, N. (2012). Advax™, a polysaccharide adjuvant derived from delta inulin, provides improved influenza vaccine protection through broad-based enhancement of adaptive immune responses. Vaccine, 30(36) pp. 5373-5381. [10.1016/j.vaccine.2012.06.021]
  • Li, L., Saade, F. and Petrovsky, N. (2012). The future of human DNA vaccines. Journal of Biotechnology, 162(2) pp. 171-182. [10.1016/j.jbiotec.2012.08.012]
  • Marion, V., Mockel, A., De Melo, C., Obringer, C., Claussmann, A., Simon, A., et al. (2012). BBS-induced ciliary defect enhances adipogenesis, causing paradoxical higher-insulin sensitivity, glucose usage, and decreased inflammatory response . Cell Metabolism, 16(3) pp. 363-377. [10.1016/j.cmet.2012.08.005]
  • Saade, F. and Petrovsky, N. (2012). Technologies for enhanced efficacy of DNA vaccines. Expert Review of Vaccines, 11(2) pp. 189-209. [10.1586/erv.11.188]
  • Barclay, T.G., Ginic-Markovic, M., Johnston, M., Cooper, P. and Petrovsky, N. (2012). Analysis of the hydrolysis of inulin using real time 1H NMR spectroscopy. Carbohydrate Research, 352 pp. 117-125. [10.1016/j.carres.2012.03.001]
  • Gordon, D., Sajkov, D., Woodman, R., Honda-Okubo, Y., Cox, M.M.J., Heinzel, S., et al. (2012). Randomized clinical trial of immunogenicity and safety of recombinant H1N1/2009 pandemic influenza vaccine containing Advax™ polysaccharide adjuvant. Vaccine, 30(36) pp. 5407-5416. [10.1016/j.vaccine.2012.06.009]

Show all publications

Refereed journal articles
  • Barclay, T., Constantopoulos, K., Zhang, W., Fujiki, M., Petrovsky, N. and Matisons, J. (2013). Chiral Self-Assembly of Designated Amphiphiles: Influences on Aggregate Morphology. Langmuir, 29(32) pp. 10001-10010. [10.1021/la401987y]
  • Fogarty, R., Abhary, S., Javadiyan, S., Kasmeridis, N., Petrovsky, N., Whiting, M., et al. (2012). Relationship between DDAH gene variants and serum ADMA level in individuals with type 1 diabetes. Journal of Diabetes and Its Complications, 26(3) pp. 195-198. [10.1016/j.jdiacomp.2012.03.022]
  • Barclay, T.G., Ginic-Markovic, M., Johnston, M., Cooper, P. and Petrovsky, N. (2012). Observation of the keto tautomer of D-fructose in D2O using 1H NMR spectroscopy. Carbohydrate Research, 347(1) pp. 136-141. [10.1016/j.carres.2011.11.003]
  • Barclay, T.G., Ginic-Markovic, M., Johnston, M., Cooper, P. and Petrovsky, N. (2012). Analysis of the hydrolysis of inulin using real time 1H NMR spectroscopy. Carbohydrate Research, 352 pp. 117-125. [10.1016/j.carres.2012.03.001]
  • Honda-Okubo, Y., Saade, F. and Petrovsky, N. (2012). Advax™, a polysaccharide adjuvant derived from delta inulin, provides improved influenza vaccine protection through broad-based enhancement of adaptive immune responses. Vaccine, 30(36) pp. 5373-5381. [10.1016/j.vaccine.2012.06.021]
  • Gordon, D., Sajkov, D., Woodman, R., Honda-Okubo, Y., Cox, M.M.J., Heinzel, S., et al. (2012). Randomized clinical trial of immunogenicity and safety of recombinant H1N1/2009 pandemic influenza vaccine containing Advax™ polysaccharide adjuvant. Vaccine, 30(36) pp. 5407-5416. [10.1016/j.vaccine.2012.06.009]
  • Li, L., Saade, F. and Petrovsky, N. (2012). The future of human DNA vaccines. Journal of Biotechnology, 162(2) pp. 171-182. [10.1016/j.jbiotec.2012.08.012]
  • Saade, F., Gorski, S.A. and Petrovsky, N. (2012). Pushing the frontiers of T-cell vaccines: Accurate measurement of human T-cell responses. Expert Review of Vaccines, 11(12) pp. 1459-1470. [10.1586/erv.12.125]
  • Saade, F. and Petrovsky, N. (2012). Technologies for enhanced efficacy of DNA vaccines. Expert Review of Vaccines, 11(2) pp. 189-209. [10.1586/erv.11.188]
  • Marion, V., Mockel, A., De Melo, C., Obringer, C., Claussmann, A., Simon, A., et al. (2012). BBS-induced ciliary defect enhances adipogenesis, causing paradoxical higher-insulin sensitivity, glucose usage, and decreased inflammatory response . Cell Metabolism, 16(3) pp. 363-377. [10.1016/j.cmet.2012.08.005]
  • Girard, D. and Petrovsky, N. (2011). Alström syndrome: insights into the pathogenesis of metabolic disorders. Nature Reviews Endocrinology, 7 pp. 77-88. [10.1038/nrendo.2010.210]
  • Cooper, P. and Petrovsky, N. (2011). Delta inulin: A novel, immunologically active, stable packing structure comprising ß-D-[2 ? 1] poly(fructo-furanosyl) ad-glucose polymers . Glycobiology, 21(5) pp. 595-606. [10.1093/glycob/cwq201]
  • Colby Layton, R., Petrovsky, N., Gigliotti, A.P., Pollock, Z., Knight, J., Donart, N., et al. (2011). Delta inulin polysaccharide adjuvant enhances the ability of split-virion H5N1 vaccine to protect against lethal challenge in ferrets. Vaccine, 29(37) pp. 6242-6251. [10.1016/j.vaccine.2011.06.078]
  • Tan, S., Gordon, D., Honda-Okubo, Y., Petrovsky, N., Phillips, P., Huddleston, S., et al. (2011). Serological responses following influenza A H1N1 2009 infection in adults. Journal of Infection, 62(5) pp. 388-393. [10.1016/j.jinf.2011.03.002]
  • Lobigs, M., Pavy, M., Hall, R.A., Lobigs, P., Cooper, P., Kumiya, T., et al. (2010). An inactivated Vero cell-grown Japanese encephalitis vaccine formulated with Advax, a novel inulin-based adjuvant, induces protective neutralizing antibody against homologous and heterologous flaviviruses. Journal of General Virology, 91 pp. 1407-1417. [10.1099/vir.0.019190-0]
  • Barclay, T.G., Ginic-Markovic, M., Cooper, P. and Petrovsky, N. (2010). Inulin - a versatile polysaccharide with multiple pharmaceutical and food chemical uses. Journal of Excipients and Food Chemicals, 1(3) pp. 27-50. [Link]
  • Abhary, S., Burdon, K.P., Laurie, K., Thorpe, S., Landers, J.A., Goold, L., et al. (2010). Aldose reductase gene polymorphisms and diabetic retinopathy susceptibility. Diabetes Care, 33(8) pp. 1834-1836. [10.2337/dc09-1893]
  • Abhary, S., Burdon, K.P., Kuot, A., Javadiyan, S., Whiting, M.J., Kasmeridis, N., et al. (2010). Sequence variation in DDAH1 and DDAH2 genes is strongly and additively associated with serum ADMA concentrations in individuals with type 2 diabetes. PLoS One, 5(3) pp. e9462. [10.1371/journal.pone.0009462]
  • Abhary, S., Burdon, K.P., Casson, R.J., Goggin, M., Petrovsky, N. and Craig, J. (2010). Association between erythropoietin gene polymorphisms and diabetic retinopathy. Archives of Ophthalmology, 128(1) pp. 102-106. [Link]
  • Petrovsky, N. (2010). Immunomodulation with microbial vaccines to prevent type 1 diabetes mellitus. Nature Reviews Endocrinology, 6 pp. 131-138. [doi:10.1038/nrendo.2009.273]
  • Sajkov, D., Petrovsky, N. and Palange, P. (2010). Management of dyspnea in advanced pulmonary arterial hypertension. Current Opinion in Supportive and Palliative Care, 4(2) pp. 76-84.
  • Abhary, S., Burdon, K.P., Gupta, A., Lake, S., Selva, D., Petrovsky, N., et al. (2009). Common sequence variation in the VEGFA gene predicts risk of diabetic retinopathy. Investigative Ophthalmology and Visual Science, 50(12) pp. 5552-5558. [doi:10.1167/iovs.09-3694]
  • Abhary, S., Burdon, K.P., Gupta, A., Petrovsky, N. and Craig, J. (2009). Diabetic retinopathy is not associated with carbonic anhydrase gene polymorphisms. Molecular Vision, 15 pp. 1179-1184. [Link]
  • Abhary, S., Kasmeridis, N., Burdon, K.P., Kuot, A., Whiting, M.J., Yew, W.P., et al. (2009). Diabetic retinopathy is associated with elevated serum asymmetric and symmetric dimethylarginines. Diabetes Care, 32(11) pp. 2084-2086. [doi:10.2337/dc09-0816]
  • Bracho, G., Zayas, C., Wang, L., Coppel, R., Pérez, O. and Petrovsky, N. (2009). AFCo1, a meningococcal B-derived cochleate adjuvant, strongly enhances antibody and T-cell immunity against Plasmodium falciparum merozoite surface protein 4 and 5. Malaria Journal, 8(1) pp. 1-35. [doi:10.1186/1475-2875-8-35]
  • Petrovsky, N. (2008). Freeing vaccine adjuvants from dangerous immunological dogma. Expert Review of Vaccines, 7(1) pp. 7-10. [doi:10.1586/14760584.7.1.7]
  • Yamamoto, K., Ninomiya, Y., Iseki, M., Nakachi, Y., Kanesaki-Yatsuka, Y., Yamanoue, Y., et al. (2008). 4-Hydroxydocosahexaenoic acid, a potent peroxisome proliferator-activated receptor gamma agonist alleviates the symptoms of DSS-induced colitis. Biochemical and Biophysical Research Communications, 367(3) pp. 566-572. [doi:10.1016/j.bbrc.2007.12.188]
  • Petrovsky, N., Heinzel, S., Honda, Y. and Lyons, A.B. (2007). New-age vaccine adjuvants: friend or foe? Biopharm International, 20(suppl8) pp. A24-A33.
  • Arsov, T., Larter, C.Z., Nolan, C.J., Petrovsky, N., Goodnow, C.C., Teoh, N.C., et al. (2006). Adaptive failure to high-fat diet characterizes steatohepatitis in Alms1 mutant mice. Biochemical and Biophysical Research Communications, 342(4) pp. 1152-1159. [doi:10.1016/j.bbrc.2006.02.032]
  • Arsov, T., Silva, D., O'Bryan, M.K., Sainsbury, A., Lee, N.J., Kennedy, C., et al. (2006). Fat Aussie - a new Alstrom syndrome mouse showing a critical role for ALMS1 in obesity, diabetes, and spermatogenesis. Molecular Endocrinology, 20(7) pp. 1610-1622. [doi:10.1210/me.2005-0494]
  • Socha, L.A., Gowardman, J., Silva, D., Correcha, M. and Petrovsky, N. (2006). Elevation in interleukin 13 levels in patients diagnosed with systemic inflammatory response syndrome. Intensive Care Medicine, 32(2) pp. 244-250. [doi:10.1007/s00134-005-0020-6]
  • Rajapakse, M., Zhang, G.L., Srinivasan, K.N., Schmidt, B., Petrovsky, N. and Brusic, V. (2006). PREDNOD, a prediction server for peptide binding to the H-2g7 haplotype of the non-obese diabetic mouse. Autoimmunity, 39(8) pp. 645-650. [doi:10.1080/08916930601062494]
  • Petrovsky, N. (2006). Novel human polysaccharide adjuvants with dual Th1 and Th2 potentiating activity. Vaccine, 24(Supp 2) pp. s2/26-s2/29. [doi:10.1016/j.vaccine.2005.01.107]
Journal articles
  • Barclay, T.G., Ginic-Markovic, M., Cooper, P.D. and Petrovsky, N. (2012). The chemistry and sources of fructose and their effect on its utility and health implications. Journal of Excipients and Food Chemicals, 3(2) pp. 67-82. [Link]
  • Petrovsky, N. (2008). The vaccines development forum. IDrugs, 11(7) pp. 478-481.
Conference publications
  • Gordon, D.L., Petrovsky, N., Sadlon, T., Tan, S.D., Honda-Okubo, Y., Phillips, P., et al. (2010). Pattern of serological responses following novel H1N1 2009 Influenza A infection in adults. In Proceedings of Annual Scientific Meeting Australian Society for Microbiology. AustraliaAnnual Scientific Meeting Australian Society for Microbiology. Sydney. Jul 2010, pp. 104-104.
  • Gordon, D.L., Honda-Okubo, Y., Sajkov, D., Woodman, R.J., Petrovsky, N., Heinzel, S., et al. (2010). Immunogenicity and safety of a unique Influenza A (2009 H1N1) vaccine combining recombinant hemagglutinin with a novel polysaccharide adjuvant. In Proceedings of Annual Scientific Meeting Australian Society for Microbiology. The Australian Society for Microbiology Annual Scientific Meeting. Sydney. Jul 2010, pp. 56-56.
  • Abhary, S., Burdon, K.P., Gupta, A., Petrovsky, N. and Craig, J. (2008). Common sequence variation in the VEGF gene predicts risk of diabetic retinopathy. In Charles N J McGhee, Victoria Cartwright (Managing Editor), ed. Clinical and Experimental Ophthalmology. Australia: Wiley-Blackwell Publishing Asia. RANZCO 40th Annual Scientific Congress. Melbourne. Nov 2008, pp. A722-A723. [doi:10.1111/j.1442-9071.2008.01850.x]

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Professional and community engagement

Expertise for media contact

  • Vaccine development Expert in development and use of vaccines against diseases including rabies, malaria, hepatitis B, Japanese encephalitis, HIV, Ebola virus etc
  • Influenza Expert in development and use influenza vaccines
  • Diabetes mellitus


inspiring achievement