Prof Nikolai Petrovsky

Prof. Petrovsky with flu vaccine

Position/s:	Director of Endocrinology Department of Medicine
Phone:	work+61 8 82044572
Email:	nikolai.petrovsky@flinders.edu.au
Location:	School of Medicine (-)
Postal address:	GPO Box 2100, Adelaide 5001, South Australia

Biography

director of endocrinology at flinders medical centre with a conjoint position as professor of medicine at flinders university, nikolai petrovsky is also vice-president and secretary-general of the international immunomics society. active in diabetes, endocrinology and vaccine research, he is the founder of vaxine, a company funded by the us national institutes of health to develop novel vaccine technologies. in 2009 vaxine won the amp innovation award at the telstra business awards and australia's coolest company award from australian anthill magazine. nikolai petrovsky has developed vaccines against influenza, hepatitis b, sting allergy, malaria, japanese encephalitis, rabies and hiv, has authored over 90 papers and chapters and is a regular invited speaker at international vaccine conferences.

Qualifications

Bachelor of Medical Science (University of Tasmania), 1979
Bachelor of Medicine, Bachelor of Surgery (MBBS), University of Tasmania, 1982
Fellowship, Australian Institute of Company Directors (FAICD) 1990
Fellowship, Royal Australasian College of Physicians (FRACP) 1994
PhD, University of Melbourne, 1998
Graduate Certificate in Education Studies, University of Sydney, 2002

Honours, awards and grants

NH&MRC Postgraduate Medical Research Scholarship, 1994
Cleveland Young Investigator Award, Royal Melbourne Hospital, 1995
Edith Moffat Award, Walter and Eliza Hall Institute, 1996
Distinguished Speaker Award, International Immunomics Society, 2005
Flinders University Public Affairs and Alumni Media Award 2005 & 2007
AMP Innovation Award, 2009 Telstra Business Award
AusIndustry Innovation Award, Australian Anthill Company Awards

Key responsibilities

Director of the Department of Diabetes and Endocrinology at Flinders Medical Centre. Actively involved in medical research, supervision of postgraduate research students and teaching of medical curriculum at Flinders University

Teaching

Teaching interests

Diabetes Mellitus
Vaccine development
Biotechnology

Research and consultancy

Research interests

Pathogenesis of type 1 diabetes
Obesity and type 2 diabetes
Vaccine development
Immuno-informatics

Postgraduate research supervision

Supervise PhD, Masters and Honours postgraduate research students

Publications

Refereed journal articles

Barclay, T.G., Ginic-Markovic, M., Johnston, M.R., Cooper, P., & Petrovsky, N., 2012. Observation of the keto tautomer of D-fructose in D2O using 1H NMR spectroscopy. CARBOHYDRATE RESEARCH, 347, 136-141.

Barclay, T.G., Ginic-Markovic, M., Johnston, M.R., Cooper, P., & Petrovsky, N., 2012. Analysis of the hydrolysis of inulin using real time 1H NMR spectroscopy. CARBOHYDRATE RESEARCH, 352, 117-125.

Tan, S., Gordon, D.L., Honda-Okubo, Y., Petrovsky, N., Phillips, P., Huddleston, S.J., & Sadlon, T., 2011. Serological responses following influenza A H1N1 2009 infection in adults. Journal of Infection, 62(5), 388-393.

Barclay, T.G., Ginic-Markovic, M., Cooper, P., & Petrovsky, N., 2010. Inulin - a versatile polysaccharide with multiple pharmaceutical and food chemical uses. Journal of Excipients and Food Chemicals, 1(3), 27-50.

Lobigs, M., Pavy, M., Hall, R.A., Lobigs, P., Cooper, P., Kumiya, T., Toriniwa, H., & Petrovsky, N., 2010. An inactivated Vero cell-grown Japanese encephalitis vaccine formulated with Advax, a novel inulin-based adjuvant, induces protective neutralizing antibody against homologous and heterologous flaviviruses. Journal of General Virology, 91, 1407-1417.

Petrovsky, N., 2010. Immunomodulation with microbial vaccines to prevent type 1 diabetes mellitus. Nature Reviews Endocrinology, 6, 131-138.

Abhary, S., Burdon, K.P., Laurie, K., Thorpe, S., Landers, J.A., Goold, L., Lake, S., Petrovsky, N., & Craig, J., 2010. Aldose reductase gene polymorphisms and diabetic retinopathy susceptibility. Diabetes Care, 33(8), 1834-1836.

Sajkov, D., Petrovsky, N., & Palange, P., 2010. Management of dyspnea in advanced pulmonary arterial hypertension. Current Opinion in Supportive and Palliative Care, 4(2), 76-84.

Abhary, S., Burdon, K.P., Casson, R.J., Goggin, M., Petrovsky, N., & Craig, J., 2010. Association between erythropoietin gene polymorphisms and diabetic retinopathy. Archives of Ophthalmology, 128(1), 102-106.

Abhary, S., Burdon, K.P., Kuot, A., Javadiyan, S., Whiting, M.J., Kasmeridis, N., Petrovsky, N., & Craig, J., 2010. Sequence variation in DDAH1 and DDAH2 genes is strongly and additively associated with serum ADMA concentrations in individuals with type 2 diabetes. PLoS One, 5(3).

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Refereed journal articles

Barclay, T.G., Ginic-Markovic, M., Johnston, M.R., Cooper, P., & Petrovsky, N., 2012. Analysis of the hydrolysis of inulin using real time 1H NMR spectroscopy. CARBOHYDRATE RESEARCH, 352, 117-125.

Petrovsky, N., 2010. Immunomodulation with microbial vaccines to prevent type 1 diabetes mellitus. Nature Reviews Endocrinology, 6, 131-138.

Sajkov, D., Petrovsky, N., & Palange, P., 2010. Management of dyspnea in advanced pulmonary arterial hypertension. Current Opinion in Supportive and Palliative Care, 4(2), 76-84.

Abhary, S., Kasmeridis, N., Burdon, K.P., Kuot, A., Whiting, M.J., Yew, W.P., Petrovsky, N., & Craig, J., 2009. Diabetic retinopathy is associated with elevated serum asymmetric and symmetric dimethylarginines. Diabetes Care, 32(11), 2084-2086.

Abhary, S., Burdon, K.P., Gupta, A., Petrovsky, N., & Craig, J., 2009. Diabetic retinopathy is not associated with carbonic anhydrase gene polymorphisms. Molecular Vision, 15, 1179-1184.

Abhary, S., Burdon, K.P., Gupta, A., Lake, S., Selva, D., Petrovsky, N., & Craig, J., 2009. Common sequence variation in the VEGFA gene predicts risk of diabetic retinopathy. Investigative Ophthalmology and Visual Science, 50(12), 5552-5558.

Bracho, G., Zayas, C., Wang, L., Coppel, R., Pérez, O., & Petrovsky, N., 2009. AFCo1, a meningococcal B-derived cochleate adjuvant, strongly enhances antibody and T-cell immunity against Plasmodium falciparum merozoite surface protein 4 and 5. Malaria Journal, 8(1), 1-35.

Yamamoto, K., Ninomiya, Y., Iseki, M., Nakachi, Y., Kanesaki-Yatsuka, Y., Yamanoue, Y., Itoh, T., Nishii, Y., Petrovsky, N., & Okazaki, Y., 2008. 4-Hydroxydocosahexaenoic acid, a potent peroxisome proliferator-activated receptor gamma agonist alleviates the symptoms of DSS-induced colitis. Biochemical and Biophysical Research Communications, 367(3), 566-572.

Petrovsky, N., 2008. Freeing vaccine adjuvants from dangerous immunological dogma. Expert Review of Vaccines, 7(1), 7-10.

Petrovsky, N., Heinzel, S., Honda, Y., & Lyons, A.B., 2007. New-age vaccine adjuvants: friend or foe?. Biopharm International, 20(suppl8), A24-A33.

Petrovsky, N. & Brusic, V., 2006. Bioinformatics for study of autoimmunity. Autoimmunity, 39(8), 635-643.

Arsov, T., Silva, D., O'Bryan, M.K., Sainsbury, A., Lee, N.J., Kennedy, C., Manji, S.S., Nelms, K., Liu, C., Vinuesa, C.G., et al., 2006. Fat Aussie - a new Alstrom syndrome mouse showing a critical role for ALMS1 in obesity, diabetes, and spermatogenesis. Molecular Endocrinology, 20(7), 1610-1622.

Arsov, T., Larter, C.Z., Nolan, C.J., Petrovsky, N., Goodnow, C.C., Teoh, N.C., Yeh, M.M., & Farrell, G.C., 2006. Adaptive failure to high-fat diet characterizes steatohepatitis in Alms1 mutant mice. Biochemical and Biophysical Research Communications, 342(4), 1152-1159.

Petrovsky, N., 2006. Novel human polysaccharide adjuvants with dual Th1 and Th2 potentiating activity. Vaccine, 24(Supp 2), s2/26-s2/29.

Socha, L.A., Gowardman, J., Silva, D., Correcha, M., & Petrovsky, N., 2006. Elevation in interleukin 13 levels in patients diagnosed with systemic inflammatory response syndrome. Intensive Care Medicine, 32(2), 244-250.

Rajapakse, M., Zhang, G.L., Srinivasan, K.N., Schmidt, B., Petrovsky, N., & Brusic, V., 2006. PREDNOD, a prediction server for peptide binding to the H-2g7 haplotype of the non-obese diabetic mouse. Autoimmunity, 39(8), 645-650.

Journal articles

Petrovsky, N., 2008. The vaccines development forum. IDrugs, 11(7), 478-481.

Conference publications

Gordon, D.L., Petrovsky, N., Sadlon, T., Tan, S.D., Honda-Okubo, Y., Phillips, P., & Huddleston, S., 2010. Pattern of serological responses following novel H1N1 2009 Influenza A infection in adults. Proceedings of Annual Scientific Meeting Australian Society for Microbiology, P01.48, 104-104.

Gordon, D.L., Honda-Okubo, Y., Sajkov, D., Woodman, R.J., Petrovsky, N., Heinzel, S., & Cox, M.M., 2010. Immunogenicity and safety of a unique Influenza A (2009 H1N1) vaccine combining recombinant hemagglutinin with a novel polysaccharide adjuvant. Proceedings of Annual Scientific Meeting Australian Society for Microbiology, PP3, 56-56.

Abhary, S., Burdon, K.P., Gupta, A., Petrovsky, N., & Craig, J., 2008. Common sequence variation in the VEGF gene predicts risk of diabetic retinopathy. Clinical and Experimental Ophthalmology, 36(Suppl. 2), A722-A723.

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Professional and community engagement

Expertise for media contact

Vaccine development Expert in development and use of vaccines against diseases including rabies, malaria, hepatitis B, Japanese encephalitis, HIV, Ebola virus etc
Influenza Expert in development and use influenza vaccines
Diabetes mellitus

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