Position

Senior Lecturer
School of Biological Sciences

Biography

After completion of a PhD in latency of herpes simplex virus, at the University of Adelaide, I undertook post-doctoral fellowships at the University of Cambridge and at Northwestern University in Chicago.  In 2001 I returned to Australia to continue herpesvirus-related research at the Inst. of Medical and Veterinary Science, Adelaide.  In July 2007 I accepted an offer to move to Flinders University.

Qualifications

PhD in pathogenesis of herpes simplex virus, University of Adelaide, 1993
BSc (Hons, first class), genetics of wheat and rye, University of Adelaide, 1988.
BSc, University of Adelaide, 1987.

Honours, awards and grants

Recipient of an Australian Federal Government Office of Teaching and Learning Citation Award, worth $10,000, in 2012:

"For inspiring student learning through design and delivery of an engaging, interactive virology program that demonstrates the immense relevance and importance of viruses"

Awarded Fellow of the Australian Society for Microbiology (FASM), 2015.

Key responsibilities

For maintaining and building a high profile for microbiology, in particular, virology, teaching and research at Flinders University.

Teaching interests

I want students to share my passion and enthusiasm for microbiology, and in particular, virology.

Students have recognised the value of studying BIOL2761 Virology through the ever increasing enrolments, which have increased over 500% in the period 2009-2016.

Topic Coordinator:

Topic Lecturer:

  • BIOL1102  Molecular Basis of Life
  • BIOL2722  Disease and Immunology
  • MMED3939  Medical virology, immunology and immunopathogenesis

Research expertise

  • Medical microbiology
  • Microbiology

Research interests

Bacteria are becoming resistant to antibiotics. A strong potential alternative is bacteriophages -"phages" -viruses that infect bacteria. In collaboration with US/Australian company AmpliPhi Biosciences, I am pursuing the use of phages as a treatment for bacterial infections in a number of important medical settings:

-chronic rhinosinusitis: a human trial of this technology commenced in January 2016, in collaboration with ENT surgeon/scientist Prof. PJ Wormald

-diabetic foot ulcer infections

-nasal Staphylococcus aureus decolonization.

I collaborate with the US Army Medical Research Materiel Command to introduce phages into their Combat Wound Infection Control Program.

RHD research supervision

Current

Principal supervisor : Bacteriophage therapy (1) ;

Publications

  • Speck, P.G. (2013). Antibiotics: Avert an impending crisis. Nature, 496(7444) pp. 169.
    [Scopus] [Web Link] [Web Link]
  • Speck, P.G., Callen, D.F. and Longnecker, R. (2003). Absence of the Epstein-Barr virus genome in breast cancer-derived cell lines. Journal of The National Cancer Institute, 95(16) pp. 1253-1254.
    [10.1093/jnci/djg041] [Scopus]
  • Speck, P.G. and Smithyman, T. (2016). Safety and efficacy of phage therapy via the intravenous route. FEMS Microbiology Letters, 363(3)
  • Carlson-Jones, J.A.P., Paterson, J.S., Newton, K., Smith, R.J., Dann, L.M., Speck, P.G., et al. (2016). Enumerating Virus-Like Particles and Bacterial Populations in the Sinuses of Chronic Rhinosinusitis Patients Using Flow Cytometry. PLoS One, 11(5) pp. Art: e0155003.
    [Scopus]
  • AlFaris, E.A. and Speck, P.G. (2016). Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy, 12(1)
  • Green, T.J., Speck, P.G., geng, L., Raftos, D., Beard, M.R. and Helbig, K. (2015). Oyster viperin retains direct antiviral activity and its transcription occurs via a signalling pathway involving a heat-stable haemolymph protein. Journal of General Virology, 96(12) pp. 3587-3597.
    [Scopus]
  • Green, T., Raftos, D., Speck, P.G. and Montagnani, C. (2015). Antiviral immunity in marine molluscs. Journal of General Virology, 96(9) pp. 2471-2482.
    [Scopus]
  • Dang, V.T., Benkendorff, K., Green, T. and Speck, P.G. (2015). Marine snails and slugs: a great place to look for antiviral drugs. Journal of Virology, 89(16) pp. 8114-8118.
    [Scopus]
  • Green, T., Montagnani, C., Bekendorff, K., Robinson, N. and Speck, P. (2014). Ontogeny and water temperature influences the antiviral response of the Pacific oyster Crassostrea gigas. Fish and Shellfish Immunology, 36(1) pp. 151-157.
    [10.1016/j.fsi.2013.10.026] [Scopus]
  • Green, T., Bekendorff, K., Robinson, N., raftos, D. and Speck, P. (2014). Anti-viral gene induction is absent upon secondary encounter with double-stranded RNA in the Pacific oyster, Crassostrea gigas. Fish and Shellfish Immunology, 39 pp. 492-497.
    [Scopus] [Web Link]
  • Drilling, A., Morales, S., Jardeleza, C., Vreugde, S., Speck, P.G. and Wormald, P. (2014). Bacteriophage reduces biofilm of Staphylococcus aureus ex vivo isolates from chronic rhinosinusitis patients. American Journal of Rhinology & Allergy, 28 pp. 3-11.
    [Scopus]
  • Drilling, A., Morales, S., Boase, S., Jervis-Bardy, J., James, C., Jardeleza, C., et al. (2014). Safety and efficacy of topical bacteriophage and ethylenediaminetetraacetic acid treatment of Staphylococcus aureus infection in a sheep model of sinusitis. International Forum of Allergy and Rhinology, 4 pp. 176-186.
    [Scopus]
  • Drilling, A., Coombs, G., Tan, H., Pearson, J., Boase, S., Psaltis, A., et al. (2014). Cousins, siblings, or copies: the genomics of recurrent Staphylococcus aureus infections in chronic rhinosinusitis. International Forum of Allergy and Rhinology,
    [Scopus]
  • Green, T., Robinson, N., Chataway, T., Benkendorff, K., O'Connor, W. and Speck, P. (2014). Evidence that the major hemolymph protein of the Pacific oyster, Crassostrea gigas, has antiviral activity against herpesviruses. ANTIVIRAL RESEARCH, 110 pp. 168-174.
    [10.1016/j.antiviral.2014.08.010] [Scopus]
  • Dann, L., Mitchell, J.G., Speck, P., Newton, K., Jeffries, T. and Paterson, J. (2014). Virio- and Bacterioplankton Microscale Distributions at the Sediment-Water Interface. PLoS One, 9(7) pp. e102805.
    [Scopus]
  • Dang, V.T., Benkendorff, K., Corbeil, S., Williams, L., Hoad, J., Crane, M., et al. (2013). Immunological changes in response to herpesvirus infection in abalone Haliotis laevigata and Haliotis rubra hybrids. Fish and Shellfish Immunology, 34(2) pp. 688-691.
    [10.1016/j.fsi.2012.11.023] [Scopus]
  • Smith, R.J., Jeffries, T.C., Roudnew, B., Seymour, J., Fitch, A.J., Simons, K.L., et al. (2013). Confined aquifers as viral reservoirs. Environmental Microbiology Reports, 5(5) pp. 725-730.
    [10.1111/1758-2229.12072] [Scopus]
  • Dang, V., Speck, P.G. and Benkendorff, K. (2012). Influence of elevated temperatures on the immune response of abalone, Haliotis rubra. Fish and Shellfish Immunology, 32(5) pp. 732-740.
    [10.1016/j.fsi.2012.01.022] [Scopus]
  • Dang, V., Benkendorff, K. and Speck, P.G. (2011). In vitro antiviral activity against herpes simplex virus in the abalone Haliotis laevigata. Journal of General Virology, 92(3) pp. 627-637.
    [10.1099/vir.0.025247-0] [Scopus]
  • Dang, V., Li, Y., Speck, P.G. and Benkendorff, K. (2011). Effects of micro and macroalgal diet supplementations on growth and immunity of greenlip abalone, Haliotis laevigata. Aquaculture, 320(1-2) pp. 91-98.
    [10.1016/j.aquaculture.2011.08.009] [Scopus]
  • Dang, V., Speck, P.G., Doroudi, M., Smith, B. and Benkendorff, K. (2011). Variation in the antiviral and antibacterial activity of abalone Haliotis laevigata, H. rubra and their hybrid in South Australia. Aquaculture, 315(3-4) pp. 242-249.
    [10.1016/j.aquaculture.2011.03.005] [Scopus]
  • Elson, K., Ribeiro, R., Perelson, A.S., Simmons, A. and Speck, P.G. (2004). The life span of ganglionic glia in murine sensory ganglia estimated by uptake of bromodeoxyuridine. Experimental Neurology, 186(1) pp. 99-103.
    [10.1016/j.expneurol.2003.10.017] [Scopus]
  • Elson, K., Simmons, A. and Speck, P.G. (2004). Satellite cell proliferation in murine sensory ganglia in response to scarification of the skin. Glia, 45(1) pp. 105-109.
    [10.1002/glia.10294] [Scopus]
  • Carbone, F.R. and Speck, P.G. (2003). Hide and seek: the immunology of HSV persistence. Immunity, 18(5) pp. 583-584.
    [10.1016/S1074-7613(03)00121-3] [Scopus]
  • Elson, K., Speck, P.G. and Simmons, A. (2003). Herpes simplex virus infection of murine sensory ganglia induces proliferation of neuronal satellite cells. Journal of General Virology, 84(5) pp. 1079-1084.
    [10.1099/vir.0.19035-0] [Scopus]
  • Grubor-Bauk, B., Simmons, A., Mayrhofer, G. and Speck, P.G. (2003). Impaired clearance of herpes simplex virus type 1 from mice lacking CD1d or NKT cells expressing the semivariant V alpha 14-J alpha 281 TCR. Journal of Immunology, 170(3) pp. 1430-1434.
    [Scopus]
  • Speck, P.G., ikeda, M., ikeda, A., Lederman, H. and Longnecker, R. (2002). Signal transduction through the B cell antigen receptor is normal in ataxia-telangiectasia B lymphocytes. Journal of Biological Chemistry, 277(6) pp. 4123-4127.
    [10.1074/jbc.M110109200] [Scopus]
  • AlFaris, E.A. and Speck, P.G. (2016). Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy, 12(1)
  • Carlson-Jones, J.A.P., Paterson, J.S., Newton, K., Smith, R.J., Dann, L.M., Speck, P.G., et al. (2016). Enumerating Virus-Like Particles and Bacterial Populations in the Sinuses of Chronic Rhinosinusitis Patients Using Flow Cytometry. PLoS One, 11(5) pp. Art: e0155003.
    [Scopus]
  • Speck, P.G. and Smithyman, T. (2016). Safety and efficacy of phage therapy via the intravenous route. FEMS Microbiology Letters, 363(3)
  • Dang, V.T., Benkendorff, K., Green, T. and Speck, P.G. (2015). Marine snails and slugs: a great place to look for antiviral drugs. Journal of Virology, 89(16) pp. 8114-8118.
    [Scopus]
  • Green, T., Raftos, D., Speck, P.G. and Montagnani, C. (2015). Antiviral immunity in marine molluscs. Journal of General Virology, 96(9) pp. 2471-2482.
    [Scopus]
  • Green, T.J., Speck, P.G., geng, L., Raftos, D., Beard, M.R. and Helbig, K. (2015). Oyster viperin retains direct antiviral activity and its transcription occurs via a signalling pathway involving a heat-stable haemolymph protein. Journal of General Virology, 96(12) pp. 3587-3597.
    [Scopus]
  • Dann, L., Mitchell, J.G., Speck, P., Newton, K., Jeffries, T. and Paterson, J. (2014). Virio- and Bacterioplankton Microscale Distributions at the Sediment-Water Interface. PLoS One, 9(7) pp. e102805.
    [Scopus]
  • Drilling, A., Coombs, G., Tan, H., Pearson, J., Boase, S., Psaltis, A., et al. (2014). Cousins, siblings, or copies: the genomics of recurrent Staphylococcus aureus infections in chronic rhinosinusitis. International Forum of Allergy and Rhinology,
    [Scopus]
  • Drilling, A., Morales, S., Boase, S., Jervis-Bardy, J., James, C., Jardeleza, C., et al. (2014). Safety and efficacy of topical bacteriophage and ethylenediaminetetraacetic acid treatment of Staphylococcus aureus infection in a sheep model of sinusitis. International Forum of Allergy and Rhinology, 4 pp. 176-186.
    [Scopus]
  • Green, T., Bekendorff, K., Robinson, N., raftos, D. and Speck, P. (2014). Anti-viral gene induction is absent upon secondary encounter with double-stranded RNA in the Pacific oyster, Crassostrea gigas. Fish and Shellfish Immunology, 39 pp. 492-497.
    [Scopus] [Web Link]

Professional and community engagement

Chair, National Scientific Advisory Committee, Virology Division, Australian Society for Microbiology, 2012-2014
Secretary, Australasian Society for Virology.

As Secretary of AVS I have initiated and driven a push to bring this society together with other professional societies, such as the Australian Society for Microbiology, the Australian Society for Immunology, the Australian Society for Clinical Immunology and Alllergy, the Australasian Society for Antimicrobials, and the Australian Society for Infectious Diseases, on key issues of policy and public advocacy. Together this umbrella group represents over 5000 scientists and clinicians. This group has made numerous public statements and representations to government on matters such as antimicrobial policy and vaccination.

Chair, Local Organizing Committee, Australasian Society for Virology Biennial Scientific Meeting, Adelaide, December 2017.

Expertise for media contact

Subject Titles

  • Vaccination
  • Viruses

Contact

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Phone: +61 8 82012765
Email:
Location: Biological Sciences (328)
Postal address: GPO Box 2100, Adelaide 5001, South Australia
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