Position

Dean (Research), Beat Cancer Professor & Matthew Flinders Distinguished Professor
College of Medicine and Public Health

Biography

Welcome to my homepage. A former Flinders School of Medicine PhD graduate, I joined Flinders as Director of the Flinders Centre for Innovation in Cancer in 2011 after 16 years with UniSA and was appointed as a Beat Cancer Professorial Chair for Flinders in 2012. I am now also Dean (Research) for the College of Medicine and Public Health. At UniSA I was the inaugural Director of the Sansom Institute (2005-2009) and Associate Head of the School of Pharmacy and Medical Sciences. An academic pharmacist, I have broad research interests in the pharmacology, pharmaceutical biotechnology and molecular oncology areas. I am a co-inventor of patents relating to cancer chemoprevention (PharmaQest) and the discovery of novel anti-inflammatory compounds. I am currently a Vice-President of the International Pharmaceutical Federation (FIP), which represents more than three million pharmacists and Pharmaceutical Scientists globally.

Qualifications

B Pharm (SAIT)
B Sc (Hons) (Flinders)
PhD (Flinders)

Honours, awards and grants

Current Grants

McKinnon RA. Beat Cancer Professor (Cancer Council SA/ SA Health) 2017-2020

Miners JO, McKinnon RA. The molceular basis of cytochrome P450 ligand bidning. NHMRC Project Grant 2017-1019

Meech R, Mackenzie PI, Downes M, McKinnon RA. A novel metabolic role for UDP glycosyltransferase 8 (UGT8). NHMRC Project Grant. 2015-2017.

Karapetis CS, Sorich MJ, McKinnon RA. Personalised medicine markers of anti-EGFR antibody therapy in metastatic colorectal cancer: accelerating clinical translation with collaborative meta-analyses based on individual-participant data. NHMRC Project Grant. 2015-2017

Watson D, Karapetis C, Young G, Wilson C, Fraser R, Reed R, Sorich M, Ratcliffe J, Woodman R, McKinnon R. Flinders Centre for Gastrointestinal Cancer Prevention. Beat Cancer Project Hospital Package. 2015-2017

Awards/Honours

2017 Matthew Flinders Distinguished Professor

2016 Fellow, Australian Academy of Health and Medical Sciences

2016: Barrie L. Reed Distinguished Lecturer, Monash University

2016: Vice-President, International Pharmaceutical Federation (FIP) (Elected for second term)

2014: Fellow, International Pharmaceutical Federation (FIP)

2014: Chair, FIP Pharmaceutical Sciences World Congress 2014

2012: Vice-President, International Pharmaceutical Federation (FIP)

2011: APSA Medallist

2011: AusBiotech Millis Orator

2010: CSIRO Flagship Fellow

2010: National Facilitator, DIISR Translating Health Discovery Into Clinical Applications SuperScience Project

2010-2011: Member, NHMRC Academy

2008: UniSA Chancellor's Community Engagement Award in collaboration with Chuulangun Aboriginal Corporation.

2006-2010: Member, CSIRO P-Health and Health Sector Advisory Boards

2004-2008: President, Australasian Pharmaceutical Science Association

2001: Fellow, Governor's Leadership Foundation (Leaders Institute of South Australia)

2000: Australian Institute of Political Science Tall Poppy Award

1993: NHMRC C.J. Martin Fellowship

1990: ASCEPT Neville Percy Prize

1988: Flinders University Medal, Peter Meffin Prize, Chancellor's Merit List, Dean's Merit List

1985: Beecham Research Laboratories Mastermind of Australian Hospital Pharmacy (State and National Winner)

1982: SAIT School of Pharmacy: Lipsham Memorial Award, Parke Davis Prize, Sir Eric Scott Prize

Key responsibilities

Director, Flinders Centre for Innovation in Cancer

Dean (Research), College of Medicine and Public Health

Teaching interests

  • Drug discovery and development (Biotechnology)
  • Pharmacology
  • Cancer therapeutics
  • Research

Research expertise

  • Oncology and carcinogenesis
  • Pharmacology and pharmaceutical sciences

Research interests

I have broad interests in the pharmacy and pharmaceutical science discipline including drug discovery and development, pharmacogenomics and the quality use of medicines.

Currently funded projects include:

  • Assessing the value of the confirmatory studies required for the widespread uptake of personalized medicine in the oncology and cardiovascular disciplines (Funding: NHMRC and Heart Foundation)
  • Development of medicines based on traditional idigenous medicine: a collaborative project with the Chuulangun Aboriginal Corporation (Funding: NHMRC, UniSA)
  • Pathophysiology and alternative preventative strategy for breast cancer chemotherapy induced bone loss (Funding: NHMRC)

Supervisory interests

  • Cancer treatment
  • Clinical pharmacology
  • Drug discovery
  • Drug metabolising enzymes, cytochrome P450 and UDP-glucuronosyltransferase
  • Mutagenesis/carcinogenesis, molecular basis of mutation
  • Pharmaceutical biotechnology and natural product drug discovery
  • Pharmaceuticals

RHD research supervision

Current

Principal supervisor : Pharmacy (2) ;

Associate supervisor : Oncology (2) ; Cancer prevention (2) ; Biochemistry (1) ; Pharmacology (4) ; Pharmacy (1) ; Medicinal chemistry (UniSA) (1) ;

Completion

Principal supervisor : Exotoxicology (UniSA) (4) ; Carcinogenesis (UniSA) (2) ; Cancer prevention (UniSA) (2) ; Pharmacy (UniSA) (1) ; Oncology (Flinders) (1) ; Pharmacology (UniSA) (3) ; Medicinal Chemistry (UniSA) (1) ;

Associate supervisor : Ecotoxicology (UniSA) (2) ; Cancer prevention (UniSA) (1) ; Autism (UniSA) (1) ; Biochemistry (UniSA) (1) ; Drug Discovery (UniSA) (2) ; Pharmacology (Flinders) (1) ; Genetics (UniSA) (1) ;

RHD Student Achievements

  • Michael Sorich
    PE Biosystems Prize in Drug Metabolism, Delivery and Pharmacokinetics - December 2001
    APSA Young Investigator Award - December 2003
  • Bradley Simpson
    Finalist, Channel 9 Young Achiever Awards - December 2009
  • Michael Sorich
    Tall Poppy Award - December 2009
  • Phil Gregory
    Tall Poppy Award - December 2009
  • Sasja Beetstra
    Sansom Medal - December 2009
  • Mafalda Dias
    ASCEPT Pharmacogenomics Prize - December 2012
  • Bradley Simpson
    Tall Poppy Award - August 2014
    NHMRC Early Career Fellowship
  • Michael Sorich
    NHMRC CJ Martin Fellowship
  • Michael Ward
    APSA Poster Award
    APSA Oral Prize
  • Sylvie Callegari
    Austrlasian Yeast Group Award

Publications

  • Cortis, L.J., Ward, P.R., McKinnon, R.A. and Koczwara, B. (2016). Breaking the Silos: Integrated Care for Cancer and Chronic Conditions. In Bogda Koczwara, ed. Cancer and Chronic Conditions: Addressing the Problem of Multimorbidity in Cancer Patients and Survivors. Singapore: Springer, pp. 287-314.
    [10.1007/978-981-10-1844-2_10]
  • Cortis, L.J., Ward, P.R., McKinnon, R.A. and Koczwara, B. (2016). Breaking the silos: Integrated care in cancer. In Bogda Koczwara, ed. Cancer and Chronic Conditions: Addressing the Problem of Multimorbidity in Cancer Patients and Survivors. Singapore: Springer, pp. 287-313.
    [10.1007/978-981-10-1844-2_10]
  • Turner, J.P., McKinnon, R.A. and Bell, J.S. (2016). The management of polypharmacy in people with cancer and chronic conditions. In Bogda Koczwara, ed. Cancer and Chronic Conditions: Addressing the Problem of Multimorbidity in Cancer Patients and Survivors. Singapore: Springer, pp. 261-286.
    [10.1007/978-981-10-1844-2_9]
  • McKinnon, R.A. and Ward, M. (2015). Individualised medicine. In Lloyd N. Sansom, ed. Australian Pharmaceutical Formulary. 23rd ed. Australia: Pharmaceutical Society of Australia, pp. 114-118.
  • Ngo, S. and McKinnon, R.A. (2013). PPAR-alpha cloning, expression and characterisation. In MZ Badr & J Youssef, ed. Peroxisome proliferator-activated receptors (PPARS): Protocols and methods. New York, USA: Humana Press, pp. 7-34.
    [10.1007/978-1-62703-155-4_2] [Scopus]
  • McKinnon, R.A. and Ward, M. (2012). Individualised Medicine. In Lloyd N. Sansom, ed. Australian Pharmaceutical Formulary and Handbook: The Everyday Guide to Pharmacy Practice. 22nd ed. Australia: Pharmaceutical Society of Australia, pp. 149-154.
  • Lewis, B.C., Wigley, P. and McKinnon, R.A. (2009). Chemoprevention of non-melanoma skin cancer. In RK Sharma and Rajesh Arora, ed. Herbal Medicine: A Cancer Chemopreventive and Therapeutic Perspictive. 1 ed. Delhi, India: Jaypee Brothers Medical Publishers Pty. Ltd, pp. 473-485.
  • Miners, J. and McKinnon, R.A. (2000). CYP1A. In Levy RH, Thummel KE, Trager WF, Hansten PD, Eichelbaum M, ed. Metabolic Drug Interactions. Philadelphia, United States of America: Lippincott, Wilkins & Wilkins, pp. 61-74.
  • McKinnon, R.A. and Thomson, P. (2017). Innovative Models of PhD Training. In Proceedings of the 6th Pharmaceutical Sciences World Congress. The Hague: FIP. 6th Pharmaceutical Sciences World Congress. Stockholm. Apr 2017.
  • Parajuli, D.R., Franzon, J.A., McKinnon, R.A., Clark, R.A. and Shakib, S. (2017). Comparison of the demographics and clinical characteristics of Heart Failure patients in multidisciplinary clinics with and without a pharmacist involvement. In Heart Lung Circulation. Elsevier. 2017 Cardiac Society of Australia and New Zealand Annual Meeting. Perth. Aug 2017, pp. 43.
  • Phillips, C., Wisdom, A.J., Eaton, V. and McKinnon, R.A. (2016). Hospital pharmacists preparedness to provide contemporary advice on the clinical use of vancomycin: the impact of a targeted continuing education module PO1603. In In Improving Patient Care Through Integration of Education and Practice Book of Abstracts. Penang, Malaysia: Universiti Sains Malaysia. Improving Patient Care Through Integration of Education and Practice. Jan 2016, pp. 39-39.
    [Web Link]
  • Sorich, M., Rowland, A., Dias, M.M., McKinnon, R.A., Kichenadasse, G., Wiese, M., et al. (2015). BRAF V600E and survival benefit of anti-EGFR monoclonal antibody (mAb) therapy for metastatic colorectal cancer (mCRC): A meta-analysis. In Journal of Clinical Oncology. Alexandria, VA: American Society of Oncology. American Society of Clinical Oncology. Chicago. May 2015, pp. e14605.
  • McKinnon, R.A. (2015). Implementation of cell-based therapies in clinical practice. In Proceedings of 54th World Congress of Pharmacy and Pharmaceutical Sciences. The Hague: Federation of International Pharmacists. 54th World Congress of Pharmacy and Pharmaceutical Sciences. Dusseldorf, Germany. Oct 2015, pp. A7.
    [Web Link]
  • Haines, A.Z., Meech, R., McKinnon, R.A. and Mackenzie, P.I. (2015). Epigenetic regulation is a determinant of the cell line specific expression of the UDP glycosyltransferase 3A1 and 3A1 genes. In Proceedings of the 40th FEBS Conference. FEBS. 40th FEBS Conference – The Biochemical Basis of Life. Berlin. Jul 2015, pp. P02-12.
  • Cortis, L.J., Ward, P.R., McKinnon, R.A. and Koczwara, B. (2015). Integrated care in cancer: A literature review. In 2015 Primary Health Care Research Conference. Adelaide: PHCRIS. 2015 Primary Health Care Research Conference. Adelaide. Jul 2015, pp. 91-91.
  • Van Dyk, M., Miners, J., Kichenadasse, G., McKinnon, R. and Rowland, A. (2015). A Novel UPLC-MS Approach For The Quantification Of 13 Clinically Used Kinase Inhibitors. In Proceedings of the Joint ASCEPT-BPS Scientific Meeting. Joint ASCEPT-BPS Scientific Meeting. Hong Kong. May 2015.
  • Chanawong, A., Hu, D.G., Meech, R., McKinnon, R.A. and Mackenzie, P. (2014). Tamoxifen and its active metabolite 4-hydroxytamoxifen, up-regulate androgen-inactivating UDP-glucuronosyltransferases (UGT) 2B15 and 2B17 in breast cancer cells: a novel mechanism of tamoxifen antiestrogenic activity. In Proceedings of ASCEPT-MPGCR Joint Scientific Meeting. ASCEPT. ASCEPT-MPGCR Joint Scientific Meeting. Melbourne. Dec 2014.
  • Fan, C.M., Georgiou, K., McKinnon, R.A., Keefe, D., Howe, P. and Xian, C. (2014). Adverse effects of combination breast cancer chemotherapy on bone and bone marrow. In Osteporosis International. Supplement 5 ed. London: Springer. IOF Regionals - 5h Asia-Pacific Osteoporosis Meeting. Taipei. Nov 2014, pp. 583.
  • Goreham, R., Slattery, A.D., Gibson, C., McKinnon, R.A., Keough, R. and Shapter, J. (2014). Investigating biomechanics of cancer cells using peak-force quantitative nanomechanical atomic force microscopy (PF-QNM AFM). In RACI National Congress. RACI. RACI National COngress. Adelaide. Dec 2014.
  • McKinnon, R.A. (2014). The future of biologicals: biosimilars and antibody drug conjugates. In Medicines Management 2014. Society of Hospital Pharmacists of Australia. Medication Management 2014. Darwin. Sep 2014, pp. 64.
  • McKinnon, R.A. (2014). Unmet needs in drug discovery – what are the challenges? In 74th Federation of International Pharmacists World Congress of Pharmacy and Pharmaceutical Sciences. The Hague: International Pharmaceutical Federation. 74th Federation of International Pharmacists World Congress of Pharmacy and Pharmaceutical Sciences. Bangkok. Aug 2014, pp. A5.
  • Semple, S., Claudie, D., Simpson, B., Smith, N. and McKinnon, R.A. (2014). Locally-driven research on medicinal plants from “Kuuku I’yuâ€쳌 (Northern Kaanju) homelands, Cape York Peninsula, Australia. In R A McKinnon, JA Nicolazzo, ed. 5th Pharmaceutical Sciences World Congress. The Hague: International Pharmaceutical Federation. 5th Pharmaceutical Sciences World Congress. Melbourne. Apr 2014, pp. 1030.
  • Simpson, B., Claudie, D., Smith, N., Mckenzie, R., Stuart, H., Semple, S., et al. (2014). Medicinal plants in socioeconomic context: convergence of Australian Aboriginal and Western perspectives. In New Phytologists Next Generation Scientists Symposium. New Phytologist Trust. New Phytologists Next Generation Scientists Symposium. Norwich, UK. Jul 2014, pp. 79-79.
  • McKinnon, R.A. (2013). 5th Pharmaceutical Science World Congress. In Proceedings of Pharmaceutical Society of Japan. Tokyo: PSJ. 133rd Annual Meeting of the Pharmaceutical Society of Japan. Yokohama. Mar 2013.
  • Callegari, S., Andrews, S., McKinnon, R.A. and de Barros Lopes, M. (2012). Statin-induced mitochondrial toxicity: an insight from yeast. In Proceedings of ComBio. Melbourne: ASBMB. ComBio2012. Adelaide. Sep 2012, pp. 85-85.
  • Gentilcore, D., Ahmad, S., Jones, K., Greenfield, J., Samocha-Bonet, D., Horowitz, M., et al. (2012). Effects of the amino acid, glutamine, on gastric emptying and the glycaemic response to oral glucose in healthy young subjects. In Neurogastroenterology and Motility. Bologna, Italy: Wiley. Joint International Neurogastroenterology and Motility Meeting. Bologna, Italy. Sep 2012, pp. 170-170.
  • Mubaroka, S., Meech, R., Mackenzie, P., McKinnon, R.A. and Ward, M. (2012). Synergistic Effect of genistein and sodium butyrate on UGT1A8 gene expression, and the PPARγ possible role. In Proceedings of 6th AHMRC. 6th Australian Health and Medical research Congress. Adelaide. Nov 2012, pp. 3198.
  • Simpson, B., Claudie, D., Wang, J., Gerber, J., Smith, N., McKinnon, R.A., et al. (2010). Anti-inflammatory diterpenoids and other secondary metabolites from Dodonaea polyandra; a traditional medicine used by Kaanju people in North Eastern Australia. In Matthias F. Melzig, Herbert Kolodziej, ed. Planta Medica. Planta Medica: Thieme Medical Publishers. 7th Tannin Conference/58th International Congress and Annual Meeting of the Society for Medical Plant and Natural Product Research, pp. 1226-1226.
    [10.1055/s-002-21285]
  • Main, P., Angley, M., Thomas, P., Young, R.L. and McKinnon, R. (2009). Towards individualised treatment of autism, understanding the folate/methionine pathway. In Asia Pacific Autism Conference 2009. Asia Pacific Autism Conference 2009. Sydney, Australia. Aug 2009.
  • Plevin, D., Ward, H.M., Ward, M. and McKinnon, R. (2009). Targeted cancer therapies: clinical practice, pharmacy education and future directions. In 2009 Australasian Pharmaceutical Science conference. 2009 Australasian Pharmaceutical Science Conference. Hobart, TAS.
  • Wang, L.V., Angley, M., Gerber, J.P., Young, R.L., Abarno, D.V., McKinnon, R., et al. (2009). Does urinary indolyl-3-acryloylglycine (IAG) have potential to distinguish autism subtypes. In Asia Pacific Autism Conference 2009. Asia Pacific Autism Conference 2009. Sydney, Australia. Aug 2009.
  • Ngo, S., McKinnon, R.A. and Stupans, I. (2008). Morphological examination and quantification of hepatic peroxisomes in the koala (Phascolarctos cinereus) by electron microscopy. In Comparative Biochemistry and Physiology A-Molecular and Integrative Phsyiology. Elsevier. 25th ESCPB Congress. Ravenna, Italy. Sep 2008, pp. S50-S50.
  • Haddy, C.A., Ward, H.M. and McKinnon, R. (2007). Investigation of Consumer Views of Pharmacogenetics. In APSA Conference. APSA Conference.
  • Sykes, M.J., McKinnon, R. and Miners, J.O. (2007). Computational prediction of metabolism by cytochrome P450 2C9: substrate alignment and docking studies. In C G Sobey and S Smid, ed. 2007 Joint meeting of ASCEPT and SEAWP-RMP. Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists. 41st Annual Scientific Meeting of the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists. Adelaide, SA. Dec 2007, pp. 2-102-2-102.
  • Ward, H.M., Corkindale, D. and McKinnon, R. (2006). A Qualitative Study of the Clinical Adoption of Pharmacogenetics. In APSA Conference. APSA Conference.
  • Wong, Y.C., Young, R.L., Angley, M., McKinnon, R., Berryman, M.J. and Abarno, D.V. (2005). Discrimination of autistic children from healthy controls. In Proceedings of the Joint APSA ASCEPT Annual Meeting 2005. Joint APSA ASCEPT Annual Meeting 2005. Melbourne, VIC. Dec 2005.
  • Wu, A., Young, R.L., Angley, M., McKinnon, R. and Chung, W.K. (2005). Children and Autism: Can the Pharmacist help? In Proceedings of the Joint APSA ASCEPT Annual Meeting 2005. Joint APSA ASCEPT Annual Meeting 2005. Melbourne, VIC. Dec 2005.
  • Wu, A., Young, R.L., Angley, M., Petkov, J., Partington, C., Churches, O., et al. (2005). Establishing an Autism Database. In Proceedings of the Joint APSA ASCEPT Annual Meeting 2005. Joint APSA ASCEPT Annual Meeting 2005. Melbourne, VIC. Dec 2005.
  • Sorich, M.J., Smith, P.A., McKinnon, R.A., Winkler, D.A., Burden, F.R. and Miners, J.O. (2003). Computational prediction of human UDP-glucuronosyltransferase substrate selectivity using multiple-pharmacophore models and classification algoriths. (Abstract) In Davis, EASobey, CG, ed. Proceedings of the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists. Melbourne, VIC, Australia: AUSTRALASIAN SOCIETY OF CLINICAL AND EXPERIMENTAL PHARMACOLOGISTS AND TOXICOLOGISTS. Annual Scientific Meeting of the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists. Sydney, NSW. Nov 2003, pp. 151.
  • Jorgensen, B.R., Smith, P.K., Miners, J.O., Mackenzie, P.I. and McKinnon, R.A. (2002). Towards structural model for UDP glucuronosyltransferase. In The Australian Health and Medical Research Congress. The Australian Health and Medical Research Congress. Melbourne, VIC. Nov 2002, pp. 2113-2113.
  • Smith, P.K., Miners, J.O., Sorich, M.J. and McKinnon, R.A. (2002). In Silico insights: chemical and structural characteristics associated with UDP-glucuronosyltransferases (UGT) substrate selectivity. In The Australian Health and Medical Research Congress. The Australian Health and Medical Research Congress. Melbourne, VIC. Nov 2002, pp. 1103-1103.
  • Smith, P.K., Miners, J.O., Sorich, M.J. and McKinnon, R.A. (2002). QSAR and Pharmacophore Modelling Approaches for the Prediciton of UDP-glucuronosyltransferase Substrate Selectivity and Binding. In William H Cline, ed. XIVth World Congress of Pharmacology - The New Century of Pharmacology. XIVth World Congress of Pharmacology - The New Century of Pharmacology. San Francisco, USA. Jul 2002, pp. A180.
  • McKinnon, R.A. (1997). Olfactory toxicity of acetaminophen in the Cyp1a2(-/-) mouse. In The Toxicologist. Virginia: Society of Toxicology. 36th Society of Toxicology Annual Meeting. USA. Oct 1997, pp. 87.
  • Phillips, C., McKinnon, R.A., Woodman, R.J. and Gordon, D.L. (2017). Junior doctors’ preparedness to prescribe, monitor and treat patients with the antibiotic vancomycin in an Australian teaching hospital. Journal of Educational Evaluation for Health Professions, 14
  • McKinnon, R.A. and Ward, M. (2016). Safety considerations of biosimilars. Australian Prescriber, 39(6) pp. 188-189.
  • McKinnon, R.A. and Ward, M.B. (2016). Biological medicines (biologics) and biosimilars. AUSTRALIAN JOURNAL OF PHARMACY, 97(Art: 1152) pp. 87-91.
    [Web Link] [Web Link]
  • McKinnon, R.A. and Ward, M.B. (2015). Biosimilar Insulins: process, policy and practical interpretations. Australian Pharmacist, 34(12) pp. 38-43.
    [Web Link] [Web Link]
  • Rowland, A., Dias, M.M., Wiese, M.D., Kichenadasse, G., McKinnon, R.A., Karapetis, C.S., et al. (2015). Reply: Comment on ‘Meta-analysis of BRAF mutation as a predictive biomarker of benefit from anti-EGFR monoclonal-antibody therapy for RAS wild-type metastatic colorectal cancer’ British Journal of Cancer,
    [10.1038/bjc.2015.325] [Scopus]
  • Bruno, A., Bates, I. and McKinnon, R.A. (2014). Integrating science into pharmacy education: ideas for the future. 32(1) pp. 56-58.
  • Bruno, A., Galbraith, K. and McKinnon, R.A. (2014). Global Supply of Health Professionals. New England Journal of Medicine, 370(23) pp. 2246.
    [Scopus] [Web Link] [Web Link]
  • Cortis, L.J., McKinnon, R. and Anderson, C. (2013). Palliative care is everyone's business - including pharmacists. American Journal of Pharmaceutical Education, 77(2) pp. 1-2.
    [Scopus] [Scopus] [Web Link]
  • McKinnon, R.A., Ward, M. and Sorich, M. (2013). Pharmacogenomics in a global world series: A roadmap for Australia, prospects and challenges. Current Pharmacogenomics and Personalized Medicine, 11(4) pp. 257-259.
    [10.2174/187569211104140130150639] [Scopus]
  • Ozdemir, V., Llerena, A., McKinnon, R.A., Srivastava, S., Dove, E., Ferguson, L.R., et al. (2013). CPPM 2013 Onward: Building a Socio-Technical GPS for Global Personalized Medicine - A Welcome to Editors-In-Chief Adrián LLerena (Spain) and Ross A. McKinnon (Australia) Current Pharmacogenomics and Personalized Medicine, 11(2) pp. 87-92.
    [10.2174/1875692111311020001] [Scopus]
  • Anderson, C., Plevin, D. and McKinnon, R.A. (2012). Educating our students about pharmaceutical care for those living with cancer. American Journal of Pharmaceutical Education, 76(7) pp. Article 119.
    [Scopus] [Web Link] [Web Link]
  • McKinnon, R.A. and Sorich, M.J. (2012). Personalising Medicine. Are we there yet? AQ (Australian Quarterly) 83(4) pp. 3-8.
    [Web Link] [Web Link]
  • McKinnon, R.A. and Hay, S. (2012). Meeting the challenge of translating Australia's medical research. AQ (Australian Quarterly) 83(3) pp. 9-15.
    [Web Link] [Web Link]
  • Manasse, H., Marriott, J. and McKinnon, R. (2012). The future of pharmacy education - how are we creating it? International Pharmacy Journal, 28(1) pp. 12-14.
  • McKinnon, R. and Anderson, C. (2011). Transforming Pharmaceutical Education to Accelerate the Acceptance and Implementation of Personalized Medicine. American Journal of Pharmaceutical Education, 75(6) pp. article: 107.
    [10.5688/ajpe756107] [Scopus] [Web Link]
  • McKinnon, R.A. (2011). Getting to grips with burns. Pharmacy News, September pp. 35-38.
  • McKinnon, R.A. (2011). Translating health discovery into clinical applications: an Australian perspective. Australasian Biotechnology, 21(3) pp. 13-14.
    [Scopus] [Web Link] [Web Link]
  • Ngo, S., Stupans, I. and McKinnon, R.A. (2010). Correlation between peroxisome proliferation and up-regulation of cytochrome P450 CYP4A and peroxisomal beta-oxidation fatty acyl CoA oxidases (AOX) in the koala (Phascolarctos Cinereus) Gene Expression to Genetical Genomics, 3 pp. 1-6.
    [10.4137/GGG.S3368]
  • Moridani, M., Maitland-van der Zee, A.H., Sasaki, H., McKinnon, R., Fleckenstein, L. and Shah, V. (2009). AAPS–FIP Summary Workshop Report: Pharmacogenetics in Individualized Medicine: Methods, Regulatory, and Clinical Applications. AAPS - American Association of Pharmaceutical Scientists, 11(2) pp. 214-216.
    [10.1208/s12248-009-9097-0] [Scopus]
  • McKinnon, R. and Lu, C. (2009). Biosimilars are not (bio)generics. Australian Prescriber, 32(6) pp. 146-147.
    [Scopus]
  • Buckley, P. and McKinnon, R.A. (2004). Pharmacogenomics, ethics and the community. Australian Pharmacist, 23(1) pp. 22-24.
  • McKinnon, R.A. and Buckley, P. (2004). Pharmacogenomics – SNiPs, chips and the future of drug therapy. Australian Pharmacist, 22(11) pp. 852-853.
  • McKinnon, R.A. and Foster, T.S. (2015). How do Clinicians in the JAPAC Region View Biosimilars?
    [Web Link]
  • McKinnon, R.A. (2013). Anti-inflammatory compounds. Patent: 13/509,194 USA. Patent owner: Susan J Semple, Bradley S Simpson, Ross Allan McKinnon, David Claudie, Jacobus P Gerber, Jiping Wang, George Moreton
  • Semple, S., Simpson, B., McKinnon, R.A., Claudie, D., Gerber, J., Wang, J., et al. (2013). Anti-inflammatory compounds. Patent: 2010317657 Australia. Patent owner: University of South Australia, Chuulangun Aborifinal Corporation
  • Semple, S., Simpson, B., McKinnon, R.A., Claudie, D., Gerber, J., Wang, J., et al. (2012). Anti-inflammatory compounds. Patent: 2499123 Europe. Patent owner: University of South Australia, Chuulangun Aboriginal Corporation
  • Semple, S., Simpson, B., Claudie, D., Wang, J., Smith, N. and McKinnon, R.A. (2011). Anti-inflammatory extract. Patent: 2011057327 World. Patent owner: University of South Australia, Chuulangun Aboriginal Corporation
  • McKinnon, R.A., Sorich, M. and Ward, M. (2007). Chromatographic analysis of nucleic acids. Patent: 2007019619 World. Patent owner: University of South Australia
  • McKinnon, R.A. and McManus, M.E. (1995). Function and localization of cytochromes P450 involved in the metabolic activation of food-derived heterocyclic amines. In Proceedings of the 23rd International Princess Takamatsu Symposium. New Jersey: Princeton Scientific Publishing. 23rd International Princess Takamatsu Symposium. Tokyo, pp. 143-153.
  • Phillips, C., McKinnon, R.A., Woodman, R.J. and Gordon, D.L. (2017). Junior doctors’ preparedness to prescribe, monitor and treat patients with the antibiotic vancomycin in an Australian teaching hospital. Journal of Educational Evaluation for Health Professionals, 14(13)
    [10.3352/jeehp.2017.14.13]
  • Phillips, C., McKinnon, R.A., Woodman, R.J. and Gordon, D.L. (2017). Sustained improvement in vancomycin dosing and monitoring post implementation of guidelines: results of a three-year follow-up after a multifaceted intervention. JOURNAL OF INFECTION AND CHEMOTHERAPY,
  • Phillips, C., Wisdom, A., McKinnon, R.A., Woodman, R.J. and Gordon, D.L. (2017). Interventions targeting the prescribing and monitoring of vancomycin for hospitalized patients: A systematic review protocol. Infectious Diseases and Therapy,
  • Phillips, C., Wisdom, A., McKinnon, R.A., Woodman, R.J. and Gordon, D.L. (2017). Interventions targeting the prescribing and monitoring of vancomycin for hospitalized patients: a systematic review protocol. Infectious Diseases and Therapy,
  • Rowland, A., Van Dyk, M., Mangoni, A.A., Miners, J.O., McKinnon, R.A., Wiese, M.D., et al. (2017). Kinase inhibitor pharmacokinetics: comprehensive summary and roadmap for addressing interindividual variability in exposure. Expert Opinion on Drug Metabolism and Toxicology, 13(1) pp. 31-49.
    [10.1080/17425255.2016.1229303] [Scopus]
  • Wijayakumara, D.D., Mackenzie, P.I., McKinnon, R.A., Hu, D.G. and Meech, R. (2017). Regulation of UDP-Glucuronosyltransferases UGT2B4 and UGT2B7 by MicroRNAs in Liver Cancer Cellss. Journal of Pharmacology and Experimental Therapeutics,
    [10.1124/jpet.116.239707]
  • Parajuli, D.R., Franzon, J.A., McKinnon, R.A., Shakib, S. and Clark, R.A. (2017). Role of the pharmacist for improving self-care and outcomes in heart failure. Current Heart Failure Reports, 14(2) pp. 78-86.
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  • Hopkins, A.M., Rowland, A., Kichenadasse, G., Wiese, M., Gurney, H., McKinnon, R.A., et al. (2017). Predicting response and toxicity to immune checkpoint inhibitors using routinely available blood and clinical markers. British Journal of Cancer, 117(7) pp. 913-920.
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  • Phillips, C., Wisdom, A.J., Eaton, V., Woodman, R.J. and McKinnon, R.A. (2016). The impact of a pilot continuing professional development module on hospital pharmacists' preparedness to provide contemporary advice on the clinical use of vancomycin. Springer Plus, 5(331)
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  • Ndi, C., Sykes, M.J., Claudie, D.J., McKinnon, R.A., Semple, S.J. and Simpson, B.S. (2016). Anti-proliferative aporphine alkaloids from Litsea glutinosa and ethnopharmacological relevance to Kuuku I’yu traditional medicine. Australian Journal of Chemistry, 69(2) pp. 145-151.
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  • Rowland, A., Van Dyk, M., Mangoni, A.A., Miners, J.O., McKinnon, R.A., Weise, M.D., et al. (2016). Kinase inhibitor pharmacokinetics: comprehensive summary and roadmap for addressing inter-individual variability in exposure. Expert Opinion on Drug Metabolism and Toxicology,
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  • Simpson, B.S., Bulone, V., Semple, S.J., Booker, G.W., McKinnon, R.A. and Weinstein, P. (2016). Arid awakening: New opportunities for Australian plant natural product research. Rangeland Journal,
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  • Rowland, A., Dias, M.M., Wiese, M., Kichenadasse, G., McKinnon, R.A., Karapetis, C.S., et al. (2016). Meta-analysis comparing the efficacy of anti-EGFR monoclonal antibody therapy between KRAS G13D and other KRAS mutant metastatic colorectal cancer tumours. European Journal of Cancer, 55(3) pp. 122-130.
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  • Fan, C.M., Georgiou, K., McKinnon, R., Keefe, D., Howe, P. and Xian, C. (2016). Combination chemotherapy with cyclophosphamide, epirubicin and 5-fluorouracil causes trabecular bone loss, bone marrow cell depletion and marrow adiposity in female rats. Journal of Bone and Mineral Metabolism, 34(3) pp. 277-290.
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  • Ali, S., Humphreys, K.J., McKinnon, R.A. and Michael, M.Z. (2015). Impact of Histone Deacetylase Inhibitors on microRNA Expression and Cancer Therapy: A Review. Drug Development Research, 76(6) pp. 296-317.
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  • Wijayakumara, D.D., Hu, D.G., Meech, R., McKinnon, R.A. and Mackenzie, P.I. (2015). Regulation of human UGT2B15 and UGT2B17 by miR-376c in prostate cancer cell lines. Journal of Pharmacology and Experimental Therapeutics, 354(3) pp. 417-425.
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  • Sorich, M., Wiese, M., Rowland, A., Kichenadasse, G., McKinnon, R.A. and Karapetis, C. (2015). Extended RAS mutations and anti-EGFR monoclonal antibody survival benefit in metastatic colorectal cancer: a meta-analysis of randomized controlled trials. Annals of Oncology, 26(1) pp. 13-21.
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  • Chanawong, A., Hu, D.G., Meech, R., Mackenzie, P. and McKinnon, R.A. (2015). Induction of UDP-glucuronoslytransferase 2B15 gene expression by the major active metabolites of tamoxifen, 4-hydroxytamoxifen and endoxifen, in breast cancer cells. Drug Metabolism and Disposition, 43 pp. 889-897.
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  • Heinemann, L., Khatami, H., McKinnon, R.A. and Home, P. (2015). An Overview of Current Regulatory Requirements for Approval of Biosimilar Insulins. Diabetes Technology & Therapeutics, 17(7) pp. 497-526.
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  • Mohamed, H., Sorich, M., Kowalski, S., McKinnon, R.A., Proudman, S., Cleland, L., et al. (2015). The role and utility of measuring red blood cell methotrexate polyglutamate concentrations in inflammatory arthropathies - a systematic review. European Journal of Clinical Pharmacology,
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  • Rowland, A., Dias, M.M., Wiese, M.D., Kichenadasse, G., McKinnon, R.A., Karapetis, C.S., et al. (2015). Meta-analysis of BRAF mutation as a predictive biomarker of benefit from anti-EGFR monoclonal antibody therapy for RAS wild-type metastatic colorectal cancer. British Journal of Cancer, 112(12) pp. 1888-1894.
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  • Nandurkar, H., Chong, B.H., Salem, H., Gallus, A.S., Ferro, V. and McKinnon, R.A. (2014). Low-molecular-weight heparin biosimilars: potential implications for clinical practice. Internal Medicine Journal, 44(5) pp. 497-500.
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  • Dias, M., Ward, H., Sorich, M. and McKinnon, R.A. (2014). Exploration of the perceptions, barriers and drivers of pharmacogenomics practice among hospital pharmacists in Adelaide, South Australia. PHARMACOGENOMICS JOURNAL, 14(3) pp. 235-240.
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  • Sorich, M., Rowland, A., McKinnon, R.A. and Wiese, M. (2014). CYP2C19 Genotype Has a Greater Effect on Adverse Cardiovascular Outcomes Following Percutaneous Coronary Intervention and in Asian Populations Treated With Clopidogrel: A Meta-Analysis. Circulation Cardiovascular Genetics, 7(6) pp. 895-902.
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  • Humphreys, K., McKinnon, R.A. and Michael, M. (2014). miR-18a inhibits CDC42 and plays a tumour suppressor role in colorectal cancer cells. PLoS One, 9(11) pp. e112288.
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  • Hu, D.G., Meech, R., McKinnon, R.A. and Mackenzie, P. (2014). Transcriptional regulation of human UDP-glucuronosyltransferase genes. Drug Metabolism Reviews, 46(4) pp. 421-458.
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  • Simpson, B., Claudie, D., Smith, N., McKinnon, R.A. and Semple, S. (2013). Learning from Both Sides: Experiences and Opportunities in the Investigation of Australian Aboriginal Medicinal Plants. JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES, 16(2) pp. 259-271.
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  • Ngo, S., Stupans, I. and McKinnon, R.A. (2013). Generic substitution in the treatment of epilepsy: patient attitudes and perceptions. Epilepsy and Behavior, 26(1) pp. 64-66.
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  • Anderson, C., Ward, H., Corkindale, D., Ward, M., Sorich, M.J. and McKinnon, R. (2012). Pharmacogenomics and personalized medicine: Consumer perspectives, lessons learned in Australia and beyond. Current Pharmacogenomics and Personalized Medicine, 10(2) pp. 170-177.
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  • Callegari, S., Gregory, P.A., Sykes, M., Bellon, J., Andrews, S., McKinnon, R., et al. (2012). Polymorphisms in the mitochondrial ribosome recycling factor EF-G2mt/MEF2 compromise cell respiratory function and increase atorvastatin toxicity. PloS Genetics, 8(6) pp. e1002755.
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  • Dias, M., Depala, K., Ward, H.M., Ward, M., Sorich, M.J., Anderson, C., et al. (2012). Reforming pharmaceutical education to enhance the global uptake of pharmacogenomics and personalised medicine. Current Pharmacogenomics and Personalized Medicine, 10(3) pp. 231-238.
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  • Dias, M., McKinnon, R.A. and Sorich, M.J. (2012). The impact of the UGT1A1*28 allele on response to irinotecan: a systematic review and meta-analysis. Pharmacogenomics, 13(8) pp. 889-899.
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  • El Merhibi, A., Ngo, S., Marchant, C., Height, T., Stupans, I. and McKinnon, R.A. (2012). Cytochrome P450 CYP3A in marsupials: Cloning and identification of the first CYP3A subfamily member, isoform 3A70 from Eastern gray kangaroo (Macropus giganteus) Gene, 506(2) pp. 423-428.
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  • Ibrahim, R., McKinnon, R.A. and Ngo, S. (2012). Knowledge and perceptions of community patients about generic medicines. Journal of Pharmacy Practice and Research, 42(4) pp. 283-286.
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  • Simpson, B.S., Claudie, D., Smith, N., McKinnon, R.A. and Semple, S. (2012). Rare, seven-membered cyclic ether labdane diterpenoid from Dodonaea polyandra. Phytochemistry, 84 pp. 141-146.
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  • Sorich, M.J. and McKinnon, R.A. (2012). Personalized medicine: potential, barriers and contemporary issues. Current Drug Metabolism, 13(7) pp. 1000-1006.
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  • Simpson, B., Claudie, D., Smith, N., Gerber, J., McKinnon, R. and Semple, S. (2011). Flavonoids from the leaves and stems of Dodonaea polyandra: A Northern Kaanju medicinal plant. Phytochemistry, 72 pp. 1883-1888.
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  • Simpson, B., Claudie, D., Gerber, J., Pyke, S., Wang, J., McKinnon, R.A., et al. (2011). In Vivo Activity of Benzoyl Ester Clerodane Diterpenoid Derivatives from Dodonaea polyandra. Journal of Natural Products, 74(4) pp. 650-657.
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  • Callegari, S., McKinnon, R.A., Andrews, S. and de Barros Lopes, M. (2011). The MEF2 gene is essential for yeast longevity, with a dual role in cell respiration and maintenance of mitochondrial membrane potential. FEBS Letters, 585(8) pp. 1140-1146.
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  • El-Merhibi, A., Ngo, S., Crittenden, T., Marchant, C., Stupans, I. and McKinnon, R. (2011). Cytochrome P450 CYP3A in marsupials: Cloning and characterisation of the second identified CYP3A subfamily member, isoform 3A78 from koala (Phascolarctos cinereus) Comparative Biochemistry and Physiology C-Toxicology and Pharmacology, 154(4) pp. 367-376.
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  • Milic, N., Ngo, S., Marchant, C., Height, T. and McKinnon, R.A. (2011). Pulmonary cytochrome P450 enzymes belonging to the CYP4B subfamily from an Australian marsupial, the tammar wallaby (Macropus eugenii) Comparative Biochemistry and Physiology C-Toxicology and Pharmacology, 153(1) pp. 60-66.
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  • Sorich, M., Vitry, A., Ward, M., Horowitz, J. and McKinnon, R. (2010). Prasugrel vs. clopidogrel for cytochrome P450 2C19-genotyped subgroups: integration of the TRITON-TIMI 38 trial data. Journal of Thrombosis and Haemostasis, 8(8) pp. 1678-1684.
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  • Simpson, B., Claudie, D., Smith, N., Wang, J., McKinnon, R.A. and Semple, S. (2010). Evaluation of the anti-inflammatory properties of Dodonaea polyandra, a Kaanju traditional medicine. JOURNAL OF ETHNOPHARMACOLOGY, 132(1) pp. 340-343.
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  • Plevin, D., Ward, H.M., Ward, M.B., Sorich, M.J. and McKinnon, R.A. (2010). Pharmacists' Role in Targeted Cancer Therapy in Australia and Implications for Pharmacy Education. American Journal of Pharmaceutical Education, 74(9)
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  • Haddy, C.A., Ward, H.M., Angley, M. and McKinnon, R.A. (2010). Consumers' views of pharmacogenetics: A qualitative study. Research in Social and Administrative Pharmacy, 6(3) pp. 221-231.
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  • Wang, L.V., Angley, M., Sorich, M.J., Young, R.L., McKinnon, R. and Gerber, J.P. (2010). Is there a role for routinely screening children with Autism Spectrum Disorder for Creatine Deficiency Syndrome? Autism Research, 3 pp. 268-272.
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  • Callegari, S., McKinnon, R., Andrews, S. and de Barros Lopes, M. (2010). Atorvastatin-induced cell toxicity in yeast is linked to disruption of protein isoprenylation. FEMS YEAST RESEARCH, 10(2) pp. 188-198.
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  • Mittal, R., Harris, L., McKinnon, R. and Sorich, M. (2009). Partial charge calculation method affects CoMFA QSAR prediction accuracy. Journal of Chemical Information and Modeling, 49(3) pp. 704-709.
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  • Leong, E., Semple, S., Angley, M., Siebert, W., Petkov, J. and McKinnon, R. (2009). Complementary and alternative medicines and dietary interventions in multiple sclerosis: what is being used in South Australia and why? Complementary Therapies in Medicine, 17(4) pp. 216-223.
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  • Kong, S., Ngo, S., McKinnon, R. and Stupans, I. (2009). Cloning and expression of the koala (Phascolarctos cinereus) liver cytochrome P450 reductase. Comparative Biochemistry and Physiology C-Toxicology and Pharmacology, 150(1) pp. 1-9.
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  • Mittal, R., McKinnon, R. and Sorich, M. (2009). Comparison datasets for benchmarking QSAR methodologies in lead optimization. Journal of Chemical Information and Modeling, 49(7) pp. 1810-1820.
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  • Ward, M., Sorich, M., Evans, A. and McKinnon, R. (2009). Cytochrome P450 3: Impact of drug-drug interactions. Journal of Pharmacy Practice and Research, 39(1) pp. 55-58.
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  • Wang, L.V., Angley, M., Gerber, J.P., Young, R.L., Abamo, D.V., McKinnon, R., et al. (2009). Is urinary indolyl-3-acryloylglycine a biomarker for autism with gastrointestinal symptoms? Biomarkers, 14(8) pp. 596-603.
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  • Mittal, R., McKinnon, R. and Sorich, M. (2009). The effect of molecular fields, lattice spacing and analysis options on CoMFA predictive ability. QSAR & COMBINATORIAL SCIENCE, 28(6-7) pp. 637-644.
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  • Beetstra, S., Suthers, G., Dhillon, V., Salisbury, C., Turner, J., Altree, M., et al. (2008). Methionine-dependence phenotype in the de novo pathway in BRCA1 and BRCA2 mutation carriers with and without breast cancer. Cancer Epidemiology Biomarkers and Prevention, 17(10) pp. 2565-2571.
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  • Jones, B., El-Merhibi, A., Ngo, S., Stupans, I. and McKinnon, R. (2008). Hepatic cytochrome P450 enzymes belonging to the CYP2C subfamily from an Australian marsupial, the koala (Phascolarctos cinereus) Comparative Biochemistry and Physiology C-Toxicology and Pharmacology, 148(3) pp. 230-237.
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  • McKinnon, R., Sorich, M. and Ward, M. (2008). Cytochrome P450 Part 1: Multiplicity and function. Journal of Pharmacy Practice and Research, 38(1) pp. 55-57.
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  • Mittal, R., McKinnon, R. and Sorich, M. (2008). Effect of steric molecular field settings on CoMFA predictivity. Journal of Molecular Modeling, 14(1) pp. 59-67.
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  • Sorich, M.J., Smith, P.A., Miners, J.O., Mackenzie, P.I. and McKinnon, R. (2008). Recent advances in the in silico modelling of UDP Glucuronosyltransferase Substrates. Current Drug Metabolism, 9(1) pp. 60-69.
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  • Sykes, M.J., McKinnon, R. and Miners, J.O. (2008). Prediction of metabolism by cytochrome P450 2C9: Alignment and docking studies of a validated database of substrates. Journal of Medicinal Chemistry, 51(4) pp. 780-791.
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  • Ward, M., Sorich, M. and McKinnon, R. (2008). Cytochrome P450 Part 2: Genetics of inter-individual variability. Journal of Pharmacy Practice and Research, 38(3) pp. 226-229.
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  • Ward, M., Kotasek, D. and McKinnon, R.A. (2008). Investigation of HTR3C mutations for association with 5HT3 receptor antagonist anti-emetic efficacy. Pharmacogenomics, 9(8) pp. 1027-1033.
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  • Corkindale, D., Ward, H.M. and McKinnon, R. (2007). Low adoption of pharmacogenetic testing: an exploration and explanation of the reasons in Australia. Personalized Medicine, 4(2) pp. 191-199.
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  • Angley, M., Semple, S.J., Hewton, C., Paterson, F. and McKinnon, R.A. (2007). Children and autism 2: management with complementary medicines and dietary interventions. Australian Family Physician, 36(10) pp. 827-830.
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  • Angley, M., Young, R.L., Ellis, D., Chan, W. and McKinnon, R. (2007). Children and autism: Part 1 - recognition and pharmacological management. Australian Family Physician, 36(9) pp. 741-744.
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  • McKinnon, R.A., Ward, M. and Sorich, M. (2007). A critical analysis of barriers to the implementation of pharmacogenomics into clinical practice. Therapeutics and Clinical Risk Management, 3(5) pp. 751-759.
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  • Angley, M., McKinnon, R., Young, R.L. and Evans, A. (2006). Children and autism: can the pharmacist help? Australian Pharmacist, 25(6) pp. 468-472.
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  • Toy, A., Anderson, B., McKinnon, R.A. and Gilbert, A. (2006). Possible role for clinical pharmacists in identifying pharmacogenomic interventions. Journal of Pharmacy Practice and Research, 36(1) pp. 35-39.
  • Sorich, M.J., McKinnon, R., Miners, J.O. and Smith, P.A. (2006). The Importance of Local Chemical Structure for Chemical Metabolism by Human Uridine 5'-Diphosphate-Glucuronosyltransferase. Journal of Chemical Information and Modeling, 46(6) pp. 2692-2697.
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  • Ngo, S., McKinnon, R.A. and Stupans, I. (2006). Cloning and expression of koala liver CYP4A (Phascolarctos cinereus) Gene, 376(1) pp. 123-132.
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  • Lim, Y.Z., Angley, M., Tait, P.A., Young, R.L. and McKinnon, R. (2006). Immunisation and autism: sifting myth from reality. Australian Pharmacist, 25(7) pp. 554-558.
  • Dias, M., Mittal, R., McKinnon, R.A. and Sorich, M. (2006). Systematic statistical comparison of CoMSIA molecular fields for computer-aided lead optimization. Journal of Chemical Information and Modeling, 46(5) pp. 2015-2021.
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  • Beetstra, S., Salisbury, C., Turner, J., Altree, M., McKinnon, R.A., Suthers, G., et al. (2006). Lymphocytes of BRCA1 and BRCA2 germ-line mutation carriers, with or without breast cancer, are not abnormally sensitive to the chromosome damaging effect of moderate folate. Carcinogenesis, 27(3) pp. 517-524.
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  • Mackenzie, P.I., Gregory, P.A., Lewinsky, R., Yasmin, S.N., Height, T., McKinnon, R.A., et al. (2005). Polymorphic variations in the expression of the chemical detoxifying UDP glucuronosytransferases. Toxicology and Applied Pharmacology, 207(Issue 2 SUPPL.) pp. S77-S83.
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  • Sorich, M.J., Miners, J.O., McKinnon, R.A. and Smith, P.A. (2004). Multiple pharmacophores for the investigation of human UDP-glucuronosyltransferase isoform substrate selectivity. Molecular Pharmacology, 65(2) pp. 301-308.
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  • Sorich, M.J., McKinnon, R.A., Miners, J.O., Winkler, D.A. and Smith, P.A. (2004). Rapid prediction of chemical metabolism by human UDP-glucuronosyltransferase isoforms using quantum chemical descriptors derived with the electronegativity equalization method. Journal of Medicinal Chemistry, 47(21) pp. 5311-5317.
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  • Miners, J.O., Smith, P.A., Sorich, M.J., McKinnon, R.A. and Mackenzie, P.I. (2004). Predicating Human Drug Glucuronidation Parameters: Application of In Vitro and InSilico Modeling Approaches. Annual Review of Pharmacology and Toxicology, 44 pp. 1-25.
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  • Boye, S., Kerdpin, O., Elliot, D.J., Miners, J.O., Kelly, L., McKinnon, R.A., et al. (2004). Optimizing bacterial expression of catalytically active human cytochromes P450: comparison of CYP2C8 and CYP2C9. Xenobiotica, 34(1) pp. 49-60.
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  • Smith, P.A., Sorich, M.J., McKinnon, R.A. and Miners, J.O. (2003). Pharmacophore and quantitative structure-activity relationship modeling: complementary approaches for the rationalization and prediction of UDP-glucuronosyltransferase 1A4 substrate selectivity. Journal of Medicinal Chemistry, 46(9) pp. 1617-1626.
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  • Smith, P.A., Sorich, M.J., McKinnon, R.A. and Miners, J.O. (2003). In silico insights: chemical and structural characteristics associated with uridine diphosphate-glucuronosyltransferase substrate selectivity. Clinical and Experimental Pharmacology and Physiology, 30(11) pp. 836-840.
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  • Ngo, S.N.T., McKinnon, R.A. and Stupans, I. (2003). The effects of Eucalyptus terpenes on hepatic cytochrome P450 CYP4A, peroxisomal Acyl CoA oxidase (AOX) and peroxisome proliferator activated receptor alpha (PPARalpha) in the common brush tail possum (Trichosurus vulpecula) Comparative Biochemistry and Physiology C-Toxicology and Pharmacology, 136(2) pp. 165-173.
  • Ngo, S.N.T., McKinnon, R.A. and Stupans, I. (2003). Identification and cloning of two forms of koala liver peroxisomal fatty Acyl CoA Oxidase from the koala (Phascolarctos Cinereus) Gene, 309(2) pp. 91-99.
  • Sorich, M.J., Miners, J.O., McKinnon, R.A., Winkler, D.A., Burden, F.R. and Smith, P.A. (2003). Comparison of linear and nonlinear classification algorithms for the prediction of drug and chemical metabolism by human UDP-glucuronosyltransferase isoforms. Journal of Chemical Information and Computer Sciences, 43(6) pp. 2019-2024.
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  • McKinnon, R.A. and Ward, M. (2003). The emergence of pharmacogenomics. Journal of Pharmacy Practice and Research, 33(2) pp. 133-137.
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  • Kong, S., McKinnon, R.A., Mojarrabi, B. and Stupans, I. (2002). Absence of type 1 11beta-hydroxysteroid dehydrogenase enzyme in koala liver. Comparative Biochemistry and Physiology C-Toxicology and Pharmacology, 131(1) pp. 39-50.
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  • Miners, J.O., Mackenzie, P.I. and McKinnon, R.A. (2002). Genetic polymorphisms of UDP-glucuronosyltransferases and their functional significance. Toxicology, 181-182 pp. 453-456.
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  • Sorich, M.J., Smith, P.A., McKinnon, R.A. and Miners, J.O. (2002). Pharmacophore and quantitative structure activity relationship modelling of UDP-glucuronosyltransferase 1A1 (UGT1A1) substrates. Pharmacogenetics, 12(8) pp. 635-645.
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  • Stupans, I., Jones, B. and McKinnon, R.A. (2001). Xenobiotic metabolism in Australian marsupials. Comparative Biochemistry and Physiology C-Toxicology and Pharmacology, 128(3) pp. 367-376.
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  • McKinnon, R.A. (2000). Cytochrome P450 1: Multiplicity and function. Journal of Pharmacy Practice and Research, 30(2) pp. 54-56.
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  • Ngo, S.N.T., Kong, S., Kirlich, A., McKinnon, R.A. and Stupans, I. (2000). Cytochrome P450 4A, peroxisomal enzymes and nicotinamide cofactors in koala liver. Comparative Biochemistry and Physiology C-Toxicology and Pharmacology, 127(3) pp. 327-334.
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  • Liapis, P., Pass, G.J., McKinnon, R.A. and Stupans, I. (2000). Characterisation of tolbutamide hydroxylase activity in the common brushtail possum, (Trichosurus vulpecula) and koala (Phascolarctos cinereus): inhibition by the Eucalyptus terpene 1,8-cineole. Comparative Biochemistry and Physiology C-Toxicology and Pharmacology, 127(3) pp. 351-357.
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  • Mackenzie, P., Miners, J. and McKinnon, R.A. (2000). Polymorphisms in UDP glucuronosyltransferase genes: functional consequences and clinical relevance. Clinical Chemistry and Laboratory Medicine, 38(9) pp. 889-892.
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  • Dalton, T., Miller, M., Wu, X., Menon, A., Ciancolo, E., McKinnon, R.A., et al. (2000). Refining the mouse chromosomal location of Cdm, the major gene associated with susceptibility to cadmium-induced testicular necrosis. Pharmacogenetics, 10(2) pp. 141-151.
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  • Stupans, I., Kong, S., Kirlich, A., Murray, M., Bailey, E., Jones, B., et al. (1999). Hepatic microsomal enzyme activity in the koala and tammar wallaby: high 17b-hydroxysteroid oxidoreductase activity in koala liver microsomes. Comparative Biochemistry and Physiology C-Toxicology and Pharmacology, 123(1) pp. 67-73.
  • Stupans, I., Kong, S., Kirlich, A., McKinnon, R.A. and Murray, M. (1999). Testosterone dehydrogenase activity in koala liver: characterisation of cofactor and steroid substrate differences. Comparative Biochemistry and Physiology C-Toxicology and Pharmacology, 125(2) pp. 245-250.
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  • Stupans, I., Kirlich, A. and McKinnon, R.A. (1998). Human thiopurine methyltransferase: no evidence of activation by its substrates. Life Sciences, 62(4) pp. 343-350.
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  • McKinnon, R.A. and Nebert, D.W. (1998). Cytochrome P450 knockout mice: new toxicological models. Clinical and Experimental Pharmacology and Physiology, 25(10) pp. 783-788.
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  • Genter, M.B., Liang, H.C., Gu, J., Ding, X., Negishi, M., McKinnon, R.A., et al. (1998). Role of Cyp2a5 and 2g1 in acetaminophen metabolism and toxicity in the olfactory mucosa of the Cyp1a2 (-/-) mouse. Biochemical Pharmacology, 55(11) pp. 1819-1826.
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  • Windmill, K., McKinnon, R.A., Zhu, X., Gaedigk, A., Grant, D.M. and McManus, M.E. (1997). The role of xenobiotic metabolising enzymes in arylamine toxicity and carcinogenesis: functional and localization studies. Mutation Research-Fundamental and Molecular Mechanisms of Mutagenesis, 376(1) pp. 153-160.
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  • Liang, H.C., McKinnon, R.A. and Nebert, D.W. (1997). Sensitivity of CYP1A1 mRNA inducibility by dioxin is the same for Cyp1a2 (+/+) wild-type and Cyp1a2 (-/-) null mutant mice. Biochemical Pharmacology, 54(10) pp. 153-160.
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  • Puga, A., Nebert, D.W., McKinnon, R.A. and Menon, A. (1997). Genetic polymorphisms in human drug-metabolising enzymes: potential uses of reverse genetics to identify genes of toxicological relevance. CRITICAL REVIEWS IN TOXICOLOGY, 27(2) pp. 199-222.
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  • Liang, H.C., Huang, L.H., McKinnon, R.A., Duffy, J.J., Potter, S.S., Puga, A., et al. (1996). Cypla2(-/-) null mutant mice develop normally but show deficient drug metabolism. Proceedings of the National Academy of Sciences of the United States of America, 93(4) pp. 1671-1676.
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  • McKinnon, R.A. and McManus, M.E. (1996). Localization of cytochromes P450 in human tissues: implications for chemical toxicity. Pathology, 28(2) pp. 148-155.
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  • Nebert, D.W., McKinnon, R.A. and Puga, A. (1996). Human drug-metabolizing enzyme polymorphisms: effects on risk of toxicity and cancer. DNA AND CELL BIOLOGY, 15(4) pp. 273-280.
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  • McKinnon, R.A., Burgess, W.M., Hall, P.D.L.M., Sarah, R.T.J., Gonzalez, F.J. and McManus, M.E. (1995). Characterization of CYP3A gene subfamily expression in human gastrointestinal tissues. Gut, 39(2) pp. 259-267.
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  • McKinnon, R.A. and Nebert, D.W. (1994). Possible role of cytochrome P450 in systemic lupus erythematosis. Lupus, 3(6) pp. 473-478.
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  • McKinnon, R.A., Burgess, W.M., Gonzalez, F.J., Gasser, R. and McManus, M.E. (1994). Species-specific expression of CYP4B1 in rabbit and human gastrointestinal tissues. Pharmacogenetics, 4(5) pp. 260-270.
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  • Nebert, D.W. and McKinnon, R.A. (1994). Cytochrome P450: Evolution and functional variability. Progress in Liver Diseases, 12 pp. 63-97.
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  • McKinnon, R.A., Burgess, W., Gonzalez, F. and McManus, M. (1993). Metabolic differences in colon mucosal cells. Mutation Research-Fundamental and Molecular Mechanisms of Mutagenesis, 290(1) pp. 27-33.
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  • McKinnon, R.A., Burgess, W., Hall, P.D.L.M., Abdul-Aziz, Z. and McManus, M. (1992). Metabolism of food-derived heterocyclic amines in human and rabbit tissues by P4503A proteins in the presence of flavonoids. Cancer Research, 52(Suppl 7) pp. 2108-2113.
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  • Burnet, R., Radden, H., Easterbrook, G. and McKinnon, R.A. (1991). Premenstrual Syndrome and Spironolactone. Australian and New Zealand Journal of Obstetrics and Gynaecology, 31(4) pp. 366-368.
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  • McKinnon, R.A., Hall, P.D.L.M., Quattrochi, L., Tukey, R. and McManus, M. (1991). Localization of CYP1A1 and CYP1A2 messenger RNA in normal human liver and in hepatocellular carcinoma by in situ hybridization. Hepatology, 14(5) pp. 848-856.
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  • McManus, M. and McKinnon, R.A. (1991). Measurement of cytochrome P450 activation of xenobiotics using the Ames Salmonella test. Methods in Enzymology, 206 pp. 501-509.
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  • Phillips, C., McKinnon, R.A., Woodman, R.J. and Gordon, D.L. (2017). Sustained improvement in vancomycin dosing and monitoring post implementation of guidelines: results of a three-year follow-up after a multifaceted intervention. JOURNAL OF INFECTION AND CHEMOTHERAPY,
  • Sorich, M., Wiese, M., Rowland, A., Kichenadasse, G., McKinnon, R.A. and Karapetis, C. (2015). Extended RAS mutations and anti-EGFR monoclonal antibody survival benefit in metastatic colorectal cancer: a meta-analysis of randomized controlled trials. Annals of Oncology, 26(1) pp. 13-21.
    [10.1093/annonc/mdu378] [Scopus] [PubMed] [Web Link]
  • Hu, D.G., Mackenzie, P., Lu, L., Meech, R. and McKinnon, R.A. (2015). Induction of human UDP-glucuronosyltransferase 2B7 gene expression by cytotoxic anticancer drugs in liver cancer HepG2 cells. Drug Metabolism and Disposition, 43(5) pp. 660-668.
    [10.1124/dmd.114.062380] [Scopus]
  • Chanawong, A., Hu, D.G., Meech, R., Mackenzie, P. and McKinnon, R.A. (2015). Induction of UDP-glucuronoslytransferase 2B15 gene expression by the major active metabolites of tamoxifen, 4-hydroxytamoxifen and endoxifen, in breast cancer cells. Drug Metabolism and Disposition, 43 pp. 889-897.
    [10.1124/dmd.114.062935] [Scopus]
  • Cortis, L.J., Ward, P.R., McKinnon, R.A. and Koczwara, B. (2016). Breaking the Silos: Integrated Care for Cancer and Chronic Conditions. In Bogda Koczwara, ed. Cancer and Chronic Conditions: Addressing the Problem of Multimorbidity in Cancer Patients and Survivors. Singapore: Springer, pp. 287-314.
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  • Turner, J.P., McKinnon, R.A. and Bell, J.S. (2016). The management of polypharmacy in people with cancer and chronic conditions. In Bogda Koczwara, ed. Cancer and Chronic Conditions: Addressing the Problem of Multimorbidity in Cancer Patients and Survivors. Singapore: Springer, pp. 261-286.
    [10.1007/978-981-10-1844-2_9]
  • Cortis, L.J., Ward, P.R., McKinnon, R.A. and Koczwara, B. (2016). Breaking the silos: Integrated care in cancer. In Bogda Koczwara, ed. Cancer and Chronic Conditions: Addressing the Problem of Multimorbidity in Cancer Patients and Survivors. Singapore: Springer, pp. 287-313.
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  • Ngo, S. and McKinnon, R.A. (2013). PPAR-alpha cloning, expression and characterisation. In MZ Badr & J Youssef, ed. Peroxisome proliferator-activated receptors (PPARS): Protocols and methods. New York, USA: Humana Press, pp. 7-34.
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  • Lewis, B.C., Wigley, P. and McKinnon, R.A. (2009). Chemoprevention of non-melanoma skin cancer. In RK Sharma and Rajesh Arora, ed. Herbal Medicine: A Cancer Chemopreventive and Therapeutic Perspictive. 1 ed. Delhi, India: Jaypee Brothers Medical Publishers Pty. Ltd, pp. 473-485.
  • Miners, J. and McKinnon, R.A. (2000). CYP1A. In Levy RH, Thummel KE, Trager WF, Hansten PD, Eichelbaum M, ed. Metabolic Drug Interactions. Philadelphia, United States of America: Lippincott, Wilkins & Wilkins, pp. 61-74.

Professional and community engagement

Vice-President, International Pharmaceutical Federation (FIP) and Member of the Bureau and Council
Director, Australian Institute of Policy and Science
Member, Editorial Board of The Pharmacogenomics Journal

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