FRIDAY 12th September, 1-2pm, SILC Building
Associate Professor Benjamin Thierry
From Micro-to-Nano: Novel Technologies for Cancer Diagnostics and Prognostics
Ian Wark Research Institute, University of South Australia
The field of diagnostic cancer nanomedicine encompasses, inter alia, the use of nanostructured materials for the detection in vivo (imaging) and ex vivo (molecular biosensing) of tumours. Improved control over the fabrication at the micro/nanoscale of functional diagnostic devices and materials combined with advanced biointerfacial engineering provide tremendous opportunities to positively impact not only on current diagnostic procedures but also to obtain improved mechanistic understanding of biological processes such as the metastatic spreading of solid tumors. A common requirement towards the successful implementation of these approaches in the clinical practice is indeed the need to ensure high level of molecular specificity in interactions with biological entities such as cells and biomarkers. The presentation will illustrate the potential of micro/nano-fabricated devices and materials in cancer diagnostics with a focus on 3 specific applications.
(1) The development of microfluidic systems for the capture and analyses of rare cells (e.g. circulating tumour cells) from biological samples (e.g. blood, lymph nodes).
(2) The use of immuno-targeted nanoscale imaging agents and the importance of understanding their transport in tumor tissues. A specific case-study will be presented based on a handheld magnetometer technology developed for the intraoperative detection of magnetic tracers in sentinel lymph nodes.
(3) The development of a silicon nanowire field effect transistor (SiNW FET) sensing platform for the detection of diagnostic and prognostic cancer markers in serum and lymph nodes.
MONTHLY CNST MEETINGS ARE HELD IN THE SILC BUILDING ON THE LAST FRIDAY OF EVERY MONTH FROM 1pm to 2pm
All are welcome to attend!