MMED2933 Fundamental Neuroscience

2020

4.5

3 x 1-hour lectures weekly
1 x 1.5-hour tutorial weekly
1 x 1-hour on-line exercises weekly
2 x 8-hour project works per semester

1 of MMED2929, MMED2930 has been successfully completed

An understanding of basic cell structure and function is assumed.

Assignments; Tests; Examination (50%)

This topic will provide students with an understanding of the cellular and molecular basis of nervous system function. The material will explore the properties of neurons and other cells in the nervous system that are essential for normal neurotransmission. Topics covered will include key molecular components of neurons and other neural cells, the generation of resting membrane potentials and action potentials in neurons, neurotransmitter synthesis and release, the properties of neurotransmitter receptors and the cellular responses to released neurotransmitters. Subsequent sessions will examine the properties and function of simple neural circuits, the adaptive responses of neurons that contribute to normal function including learning and memory and the key events in nervous system development.

The aim of this topic is to provide students with an understanding of the cellular and molecular basis of nervous system function. The topic will provide fundamental knowledge on the properties of neurons and other cells in the nervous system that underpin normal neurotransmission. It will subsequently examine the features of simple neural circuits, adaptive responses of neurons and key events in the development of the nervous system. This knowledge will allow the students to read and understand much of the neuroscience literature and will provide a strong foundation for further study into advanced aspects of normal nervous system function and the effects of disease.

On successful completion of this topic students will have an understanding of:

• The properties of neurons and other cells in the nervous system that are essential for normal neurotransmission This will include the key molecular components of neurons and other neural cells, the generation of resting membrane potentials and action potentials in neurons, neurotransmitter synthesis and release, the properties of neurotransmitter receptors and neuronal responses to neurotransmitter release

• Tthe properties and function of simple neural circuits

• The adaptive responses of neurons that contribute to normal function including learning and memory

Students will be able to:

• Integrate and apply this knowledge to interpret information on the responses of nerve cells to normal and abnormal stimuli