Blood flow to the brain is controlled by changes in blood vessel diameter which is fine-tuned by an exquisite interplay between vasodilating agents (that increase vessel diameter) and vasoconstricting agents (that decrease vessel diameter). Blood vessels are comprised of a thin lining of endothelial cells and a few layers of adjacent smooth muscle cells. The endothelium produces nitric oxide, a well-known vasodilating agent that can diffuse to the smooth muscle and cause blood vessel dilation and therefore an increase in blood flow. In many disease states (such as hypertension, diabetes and stroke), nitric oxide bioavailability is compromised, resulting in endothelial dysfunction. Our research team is dedicated to understanding the mechanisms associated with endothelial dysfunction, thereby contributing to the development of therapeutic strategies to improve cerebrovascular health.
Dwinovan J, Colella AD, Chegeni N, Chataway TK, Sokoya EM (2017) Proteomic analysis reveals downregulation of housekeeping proteins in the diabetic vascular proteome. Acta Diabetologica, 54(2):171-190
Sokoya EM (2015) Resveratrol protects endothelial cells from rapid stretch injury and hypoxia in vitro, Current Drug Therapy, 10:56-64
Tajbakhsh S, Aliakbari K, Hussey DJ, Lower KM, Donato AJ, Sokoya EM (2015) Differential telomere shortening in blood versus arteries in an animal model of type 2 diabetes. Journal of Diabetes Research, 2015:153829
Tajbakhsh N, Sokoya EM (2014) Compromised EDH-mediated dilations can be rescued by NS309 in obese Zucker rats. Microcirculation, 21:747-753
Tajbakhsh N, Sokoya EM (2013) Sirtuin 1 and cerebral vascular function in young obese Zucker rats. European Journal of Pharmacology, 721(1-3):43-8
Tajbakhsh N, Sokoya EM (2012) Regulation of cerebral vascular function by sirtuin 1. Microcirculation, 19(4):336-42
Burns AR, Phillips SP, Sokoya EM (2012) Pannexin protein expression in the rat middle cerebral artery. Journal of Vascular Research, 49:101-110