Position

Academic Status
College of Medicine and Public Health

Biography

Keryn Williams is an NHMRC Principal Research Fellow in the Department of Ophthalomology and Associate Dean (Research) within the Faculty of Health Sciences.  A graduate of the University of Melbourne, she undertook postdoctoral research at the University of Oxford UK, where she first developed a career-long interest in transplantation immunobiology. On returning to Australia, she began to work in the eye.  She is the scientific director of the Australian Corneal Graft Registry and maintains research interests in corneal transplantation, novel drugs and devices for ophthalmic use, and aberrant ocular angiogenesis.

Qualifications

BSc (Hons) (First Class), University of Melbourne, 1971

PhD, University of Melbourne, 1974

Honours, awards and grants

2010 Peter Bishop Plenary Lecturer
2012 NHMRC "Ten of the Best"

Research interests

Evidence-based outcomes in clinical corneal transplantation
Experimental corneal transplantation
Novel biomaterials for use as ocular implants
Aberrant angiogenesis in the eye

Publications

  • Coster, D.J., Jessup, C.F. and Williams, K.A. (2010). Mechanisms of corneal allograft rejection and the development of new therapies. In Thomas Reinhard and Frank Larkin, ed. Essentials in Ophthalmology. Cornea and external eye disease. Germany: Springer, pp. 13-23.
    [10.1007/978-3-540-85544-6]
  • Coster, D.J. and Williams, K.A. (2009). Outcomes of penetrating keratoplasty. In Frederick S. Brightbill, et al., ed. Corneal surgery : theory, technique and tissue. 4th ed. St. Louis, USA: Elsevier, pp. 553-560.
  • Coster, D.J. and Williams, K.A. (2005). Immunomodulation for corneal transplantation. In Uwe Pleyer and Bartly Mondino, ed. Uveitis and Immunological Disorders. Berlin, Germany: Springer, pp. 35-50.
    [10.1007/3-540-26752-2_4]
  • Williams, K.A., Kelly, M.T., Lowe, M.T., Bartlett, C.M. and Coster, D.J. (2008). Risk factors for full-thickness human corneal graft failure within the Australian Corneal Graft Registry [abstract 31] In Transplantation. Baltimore: Williams & Wilkins Co.. XXII International Congress of The Transplantation Society. Sydney, NSW. Aug 2008, pp. 11-11.
    [10.1097/01.tp.0000332709.42593.50]
  • Parker, D., Klebe, S., Brereton, H.M., Coster, D.J., Anson, D. and Williams, K.A. (2008). Lentivirus-mediated gene transfer to the ovine and human cornea [abstract 30] In Transplantation. Baltimore: Williams & Wilkins Co.. XII International Congress of The Transplantation Society. Sydney, NSW. Aug 2008, pp. 10-11.
    [10.1097/01.tp.0000332708.34969.48]
  • Klebe, S., Parker, D., Clarke, A., Brereton, H.M., Coster, D.J. and Williams, K.A. (2008). Efficacy of a steroid-inducible promoter for lentivirus-mediated transduction of the cornea [abstract 29] In Transplantation. Baltimore,: Williams & Wilkins Co.. XXII International Congress of The Transplantation Society. Sydney, NSW. Aug 2008, pp. 10-10.
    [10.1097/01.tp.0000332706.96851.60]
  • Coster, D.J., Philpott, M. and Williams, K.A. (2008). Donor factors affecting corneal transplantation [abstract 916] In Transplantation. Baltimore: Williams & Wilkins Co.. XXII International Congress of The Transplantation Society. Sydney, NSW. Aug 2008, pp. 319-319.
    [10.1097/01.tp.0000331864.94926.b0]
  • Brice, S., Mortimer, L.A., Tan, C., Anson, D., Brereton, H.M. and Williams, K.A. (2008). Lentiviral gene transfer to the rat cornea [abstract 917] In Transplantation. Baltimore: Williams & Wilkins Co.. XXII International Congress of The Transplantation Society. Sydney, NSW. Aug 2008, pp. 319-319.
    [10.1097/01.tp.0000331865.02551.a3]
  • Parker, D., Kaufmann, C., Brereton, H.M., Anson, D.S., Francis-Staite, L., Coster, D.J., et al. (2007). Lentivirus-mediated gene transfer to the rat, ovine and human cornea. In Asia-ARVO Meeting on Research in Vision and Ophthalmology. Singapore Eye Research Institute. Asia-ARVO Meeting on Research in Vision and Ophthalmology. Suntec City, Singapore. Mar 2007.
  • Parker, D., Kaufmann, C., Brereton, H.M., Anson, D.S., Francis-Staite, L., Jessup, C.F., et al. (2007). Lentivirus-mediated gene transfer to the rat, ovine and human cornea. In The Journal of Gene Medicine: Abstracts from the 5th Australasian Gene Therapy Society Meeting. Wiley InterScience. 5th Meeting of the Australasian Gene Therapy Society. Canberra, ACT. Apr 2007, pp. 533-534.
    [10.1002/jgm.1059] [Web Link]
  • Williams, K.A. (2007). Untangling genetic susceptibility to experimental ROP - with help from the ORIA. In Clinical and Experimental Ophthalmology. Blackwell Publishing Asia. 39th Annual Scientific Congress of RANZCO 2007. Perth, WA. Nov 2007, pp. A8-A8.
    [10.1111/j.1442-9071.2007.01593.x]
  • Brereton, H.M., Sharma, S., Mortimer, L., Tea, M.N., van Wijngaarden, P., Coster, D.J., et al. (2005). Development of antibody fragments for topical treatment of retinal neovascularization. In Proceedings of ComBio2005. Kent Town, SA: Australian Society for Biochemistry and Molecular Biology Inc. ComBio2005. Adelaide, SA. Sep 2005, pp. 133-133.
  • Sharma, S., Brereton, H.M., Coster, D.J. and Williams, K.A. (2004). Stable cell lines as a tool for assaying anti-VEGFR2 antibody specificity. In EXPERIMENTAL EYE RESEARCH. 24-28 OVAL RD, LONDON, ENGLAND, NW1 7DX: ELSEVIER. International Congress of Eye Research, pp. 115.
  • Jessup, C.F., Brereton, H.M., Sykes, P.J., Thiel, M., Coster, D.J. and Williams, K.A. (2004). Modulation of antigen presentation and co-simulation during rat corneal allograft rejection. In EXPERIMENTAL EYE RESEARCH. 24-28 OVAL RD, LONDON, ENGLAND, NW1 7DX: ELSEVIER. International Congress of Eye Reseach.
  • Brereton, H.M., Turner, M.L., Cockerell, E.J., Bodenoch, P.R., Coster, D.J. and Williams, K.A. (2004). The production of antibody fragments for the diagnosis of acanthamoeba keratitis. In Proceedings of ComBio 2004. Kent Town, SA: American Society for Biochemistry and Molecular Biology. ComBio 2004. Perth, WA, pp. 70-70.
  • Brereton, H.M., Farrall, A., Taylor, S., Thiel, M., Coster, D.J. and Williams, K.A. (2004). Penetration of antibody fragments across the cornea and into the posterior segment of the eye. In Proceedings of ComBio 2004. Kent Town, SA: Australian Society for Biochemistry & Molecular Biology Inc. ComBio 2004. Perth, WA, pp. 70-70.
  • Brereton, H.M., Farrall, A., Taylor, S., Coster, D.J. and Williams, K.A. (2004). Penetration of antibody fragments across the cornea and into the posterior segment of the eye. In Experimental Eye Research. London, UK: Elsevier. International Congress of Eye Research, pp. 82.
  • Williams, K.A., Klebe, S., Jessup, C.F., Francis-Staite, L., Brereton, H.M., Anson, D.S., et al. (2004). Strategies for improving experimental corneal graft outcomes. In EXPERIMENTAL EYE RESEARCH. 24-28 OVAL RD, LONDON, ENGLAND, NW1 7DX: ELSEVIER. International Congress of Eye Research.
  • van Wijngaarden, P., Brereton, H.M., Coster, D.J., Gibbins, I.L. and Williams, K.A. (2004). Strain-associated angiogenic heterogeneity amongst inbred rats in a model of oxygen-induced retinopathy. In EXPERIMENTAL EYE RESEARCH. 24-28 OVAL RD, LONDON, ENGLAND, NW1 7DX: ELSEVIER. International Congress of Eye Research.
  • Jessup, C.F., Brereton, H.M., Sykes, P.J., Thiel, M., Coster, D.J. and Williams, K.A. (2003). Ex vivo gene transfer to donor rat corneas (Abstract) In Transplantation Society of Australia and New Zealand. Transplantation Society of Australia and New Zealand. Canberra, ACT. Apr 2002.
  • Williams, K.A. (2003). Annual report from The Australian Corneal Graft Registry (Abstract) In Cornea and Eye Bank 20th Annual Scientific Meeting. Cornea and Eye Bank 20th Annual Scientific Meeting. Adelaide, SA. Mar 2002.
  • Williams, K.A., Klebe, S., Sykes, P.J., Swinburne, S. and Coster, D.J. (2003). Gene Therapy to Prolong Ovine Corneal Allograft Survival (Abstract) In Clinical Immunology. Federation of Clinical Immunology Societies. Paris, France. May 1995, pp. S34.
  • Brereton, H.M., Standfield, S., Hallsworth, P.G., Coster, D.J., Williams, K.A., Teteris, S.A., et al. (2002). Antibody fragments for the treatment and diagnosis of herpetic eye disease. In Proceedings of ComBio 2002. Kent Town, SA: Australian Society for Biochemistry and Molecular Biology Inc. ComBio 2002. Sydney, NSW. Sep 2002.
  • Klebe, S., Coster, D.J., Sykes, P.J., Swinburne, S. and Williams, K.A. (2001). Gene therapy with p40 IL-12 (but not IL-4) prolongs corneal allograft survival in sheep. In 19th Annual Scientific Meeting - Transplantation Society of Australia and New Zealand. Immunology and Cell Biology. Transplantation Society of Australia and New Zealand. Canberra, ACT. Jun 2001, pp. A11-A11.
  • Standfield, S., Sykes, P.J., Stein-Oakley, A., Coster, D.J. and Williams, K.A. (2001). Mediators of Rat Corneal Allograft Rejection (abstract). In 19th Annual Scientific Meeting - Transplantation Society of Australia and New Zealand. Immunology and Cell Biology. 2001 Conference - Transplantation Society of Australia and New Zealand. Canberra, ACT. Apr 2001, pp. A24-A24.
  • Smith, J., Becker, M., O'Rourke, L., Williams, K., Planck, S. and Rosenbaum, J. (2000). Anti-rat ICAM-1 antibody does not influence the course of experimental melanin-induced uveitis. In Investigative Ophthalmology & Visual Science. Association for Research in Vision and Ophthalmology (ARVO) Fort Lauderdale , FL, USA, pp. S374.
  • Smith, J., Hart, P., Coster, D. and Williams, K. (1999). Cellular mechanisms of rat acute anterior uveitis. 17th Congress of Asia-Pacific Academy of Ophthalmology. Manila, Phillipines.
  • Smith, J., Hart, P., Standfield, S., Coster, D. and Williams, K. (1998). Apoptosis of infiltrating inflammatory cells is a prominent feature of acute anterior uveitis in the Fischer 344 rat. In *Ocular Immunology and Inflammation. First International Symposium on Ocular Immunology and Inflammation. Amsterdam, The Netherlands, pp. S45.
  • Smith, J., Hart, P., Standfield, S., Coster, D. and Williams, K. (1998). Experimental melanin-induced uveitis may be prevented by non-depleting anti-CD4 (but not anti-CD8) antibody. In *Experimental Eye Research. XIII International Congress of Eye Research. Paris, France, pp. S71.
  • Smith, J., Coster, D., Hart, P. and Williams, K. (1997). Tumor necrosis factor-alpha receptor P55 (but not P75) and interleukin-4 are mediators of endotoxin-induced uveitis: studies in knock-out mice. In Investigative Ophthalmology & Visual Science. Association for Research in Vision and Ophthalmology (ARVO) Fort Lauderdale , FL, USA, pp. S953.
  • Williams, K., Standfield, S., Smith, J. and Coster, D. (1997). Induction of apoptosis in cells infiltrating rejecting rat corneal allografts. In Investigative Ophthalmology & Visual Science. Association for Research in Vision and Ophthalmology (ARVO) Fort Lauderdale , FL, USA, pp. S1155.
  • Smith, J., Coster, D. and Williams, K. (1996). Phenotype of the inflammatory cell infiltrate in experimental melanin-induced uveitis. First Congress of the Federation of Immunological Societies of Asia-Oceania. Adelaide, Australia.
  • Smith, J., Coster, D. and Williams, K. (1996). Susceptibility of the rodent to experimental melanin-induced uveitis. In *Experimental Eye Research. XII International Congress of Eye Research. Yokohama, Japan, pp. S215.
  • Coster, D.J., Keane, M.C. and Williams, K.A. (2015). Author reply: To PMID 24491643. Ophthalmology, 122(1) pp. e8-e9.
    [10.1016/j.ophtha.2014.07.004]
  • Coster, D.J., Keane, M.C. and Williams, K.A. (2015). Author reply: To PMID 24491643. Ophthalmology, 122(1) pp. e10-e11.
    [10.1016/j.ophtha.2014.06.039]
  • Irani, Y.D., Tian, Y., Wang, M., Klebe, S., McInnes, S.J., Voelcker, N.H., et al. (2015). A novel pressed porous silicon-polycaprolactone composite as a dual-purpose implant for the delivery of cells and drugs to the eye. Experimental Eye Research, 139 pp. 123-131.
    [10.1016/j.exer.2015.08.007] [Scopus]
  • Coster, D.J., Keane, M.C. and Williams, K.A. (2014). Author Reply to PMID 24491643. Ophthalmology, 121(11) pp. e62-e63.
    [Scopus]
  • Coster, D.J., Keane, M.C. and Williams, K.A. (2014). Author Reply to PMID 24491643. Ophthalmology, 121(10) pp. e59-e60.
    [10.1016/j.ophtha.2014.05.035] [Scopus]
  • Klebe, S., Coster, D.J. and Williams, K.A. (2014). Pathological aspects of the failed corneal graft. Diagnostic Histopathology, 21(1) pp. 11-18.
    [10.1016/j.mpdhp.2014.11.003] [Scopus]
  • Irani, Y., McInnes, S., Brereton, H., Williams, K. and Voelcker, N. (2013). Porous silicon as a scaffold for rat oral mucosal epithelial cells and transfer to the eye. EUROPEAN CELLS & MATERIALS, 26(suppl 6) pp. 54.
    [Scopus] [Web Link]
  • McInnes, S., Irani, Y., Lad, H., Williams, K. and Voelcker, N. (2013). Porous silicon films and microparticles as a vehicle for the loading and extended release of infliximab to the eye. EUROPEAN CELLS & MATERIALS, 26(Suppl 6) pp. 98.
    [Scopus] [Web Link]
  • Keane, M., Williams, K. and Coster, D. (2012). Deep anterior lamellar keratoplasty versus penetrating keratoplasty for treating keratoconus (protocol) Cochrane Database of Systematic Reviews, 7
    [10.1002/14651858.CD009700]
  • Klebe, S., Sykes, P.J., Coster, D.J., Krishnan, R. and Williams, K.A. (2001). Prospects for genetic manipulation of donor organs and tissues. Transplantation, 71(9) pp. 1207-1209.
  • Klebe, S., Stirling, J. and Williams, K. (2000). Corneal endothelial cell nuclei are damaged after DNA transfer using a gene gun. Clinical and Experimental Ophthalmology, 28(1) pp. 58-59.
    [10.1046/j.1442-9071.2000.00255.x] [Scopus]
  • Smith, J., Becker, M., O'Rourke, L., Williams, K., Planck, S. and Rosenbaum, J. (2000). Anti-rat ICAM-1 antibody does not influence the course of experimental melanin-induced uveitis: clinical and intravital microscopy studies. FASEB Journal, 14 pp. A1153.
  • Williams, K.A., Lowe, M.T., Bartlett, C.M., Kelly, M.T. and Coster, D.J. (2007). The Australian Corneal Graft Registry 2007 Report.
    [Web Link] [Web Link]
  • Smith, J., Hart, P., Coster, D. and Williams, K. (1998). Experimental melanin-induced uveitis in the Fischer 344 rat. Investigative Ophthalmology & Visual Science Volume 39 Issue 3.
  • Williams, K.A., Coster, D.J. and Klebe, S. (2006). Corneal cells expressing active agents and methods of use thereof. Patent: 20060257382 Australia. Patent owner: Flinders University
  • Thiel, M., Zola, H., Coster, D.J. and Williams, K.A. (2004). Agents and methods for treatment and diagnosis of ocular disorders. Patent: 6773916 United States Patent. Patent owner: Thiel, et al.
  • Jessup, C.F., Brereton, H.M., Coster, D.J. and Williams, K.A. (2004). Ocular tissue modification. Patent: PCT/AU2004/001606 Australia. Patent owner: Flinders University
  • Dawson, A.C., Williams, K.A., Appukuttan, B. and Smith, J.R. (2018). Emerging diagnostic tests for vitreoretinal lymphoma: a review. Clinical and Experimental Ophthalmology,
  • Irani, Y.D., Scotney, P., Klebe, S., Mortimer, L.A., Nash, A. and Williams, K.A. (2017). An Anti-VEGF-B Antibody Fragment Induces Regression of Pre-Existing Blood Vessels in the Rat Cornea. Investigative Ophthalmology and Visual Science, 58(9) pp. 3404-3413.
    [10.1167/iovs.16-21343]
  • Smith, J.R., Todd, S., Ashander, L.M., Charitou, T., Ma, Y., Yeh, S., et al. (2017). Retinal Pigment Epithelial Cells are a Potential Reservoir for Ebola Virus in the Human Eye. Translational Vision Science & Technology, 6(4)
    [10.1167/tvst.6.4.12] [Scopus]
  • Keane, M.C., Galettis, R.A., Mills, R.A., Coster, D.J., Williams, K.A. and Australian Corneal Graft Regis, (2016). A comparison of endothelial and penetrating keratoplasty outcomes following failed penetrating keratoplasty: a registry study. British Journal of Ophthalmology,
    [10.1136/bjophthalmol-2015-307792] [Scopus]
  • Irani, Y.D., Scotney, P., Nash, A. and Williams, K.A. (2016). Species Cross-Reactivity of Antibodies Used to Treat Ophthalmic Conditions. Investigative Ophthalmology and Visual Science, 57(2) pp. 586-591.
    [10.1167/iovs.15-18239] [Scopus]
  • Williams, K.A. and Irani, Y.D. (2016). Gene therapy and gene editing for the corneal dystrophies. Asia-Pacific Journal of Ophthalmology, 5(4) pp. 312-316.
    [10.1097/APO.0000000000000215]
  • McInnes, S.J., Turner, C.T., Al-Bataineh, S.A., Leccardi, M.J.I.A., Irani, Y.D., Williams, K.A., et al. (2015). Surface engineering of porous silicon to optimise therapeutic antibody loading and release. JOURNAL OF MATERIALS CHEMISTRY B, 3(20) pp. 4123-4133.
    [10.1039/c5tb00397k] [Scopus]
  • van Essen, T.H., Roelen, D.L., Williams, K.A. and Jager, M. (2015). Matching for Human Leukocyte Antigens (HLA) in corneal transplantation - to do or not to do. Progress in Retinal and Eye Research, 46 pp. 84-110.
    [10.1016/j.preteyeres.2015.01.001] [Scopus]
  • Coster, D., Lowe, M., Keane, M. and Williams, K. (2014). A Comparison of Lamellar and Penetrating Keratoplasty Outcomes: A Registry Study. Ophthalmology, 121(5) pp. 979-987.
    [10.1016/j.ophtha.2013.12.017] [Scopus]
  • Keane, M., Coster, D., Ziaei, M. and Williams, K. (2014). Deep anterior lamellar keratoplasty versus penetrating keratoplasty for keratoconus. Cochrane Database of Systematic Reviews, 7
    [Scopus]
  • Mills, R., Klebe, S., Coster, D. and Williams, K. (2014). Comparative outcomes of penetrating and component endothelial cell corneal allografts in outbred sheep. CELL TRANSPLANTATION, 23(1) pp. 133-138.
    [10.3727/096368912X659835] [Scopus]
  • Appleby, S.L., Irani, Y., Mortimer, L., Brereton, H., Klebe, S., Keane, M., et al. (2013). Co-expression of a scFv antibody fragment and a reporter protein using lentiviral shuttle plasmid containing a self-processing furin-2A sequence. Journal of Immunological Methods, 397(1-2) pp. 61-65.
    [10.1016/j.jim.2013.08.012] [Scopus]
  • Williams, K., Irani, Y. and Klebe, S. (2013). Novel therapeutic approaches for corneal disease. Discovery Medicine, 15(84) pp. 291-299.
    [Scopus] [Web Link]
  • Tea, M., Michael, M., Brereton, H. and Williams, K. (2013). Stability of small non-coding RNA reference gene expression in the rat retina during exposure to cyclic hyperoxia. Molecular Vision, 19 pp. 501-508.
    [Scopus] [Web Link]
  • Keane, M., Lowe, M.T., Coster, D., Pollock, G. and Williams, K. (2013). The influence of Australian eye banking practices on corneal graft survival. Medical Journal of Australia, 199(4) pp. 275-279.
    [10.5694/mja12.11584] [Scopus] [Web Link]
  • Appleby, S.L., Jessup, C.F., Mortimer, L.A., Brereton, H.M., Coster, D.J., Tan, C.K., et al. (2013). Expression of an anti-CD4 single chain antibody fragment from the donor cornea can prolong corneal allograft survival in inbred rats. British Journal of Ophthalmology, 97(1) pp. 101-105.
    [10.1136/bjophthalmol-2012-302360] [Scopus]
  • Brice, S., Kirk, K.A., Brereton, H., Coster, D. and Williams, K. (2012). The influence of cervical and thoracic lymphadenectomy on corneal allograft rejection in inbred rats. British Journal of Ophthalmology, 96(3) pp. 448-450.
    [10.1136/bjophthalmol-2011-300934] [Scopus]
  • Colella, A., Chegeni Farahani, N., Tea, M., Gibbins, I., Williams, K. and Chataway, T. (2012). Comparison of Stain-Free gels with traditional immunoblot loading control methodology. Analytical Biochemistry, 430(2) pp. 108-110.
    [10.1016/j.ab.2012.08.015] [Scopus]
  • McInnes, S., Irani, Y., Williams, K. and Voelcker, N. (2012). Controlled drug delivery from composites of nanostructured porous silicon and poly(L-lactide) Nanomedicine, 7(7) pp. 995-1016.
    [10.2217/nnm.11.176] [Scopus]
  • Williams, K. and Klebe, S. (2012). Gene therapy for corneal dystrophies and disease, where are we? Current Opinion in Ophthalmology, 23(4) pp. 276-279.
    [10.1097/ICU.0b013e3283541eb6] [Scopus]
  • Kelly, T., Williams, K. and Coster, D. (2011). Corneal transplantation for keratoconus: a registry study. Archives of Ophthalmology, 129(6) pp. 691-697.
    [10.1001/archophthalmol.2011.7] [Scopus]
  • Kelly, T., Coster, D. and Williams, K. (2011). Repeat penetrating keratoplasty in patients with keratoconus. Ophthalmology, 118(8) pp. 1538-1542.
    [10.1016/j.ophtha.2011.01.002] [Scopus]
  • Chen, C.S.W., Lee, A., Campbell, B., Paine, M., Lee, T.F., Fraser, C., et al. (2011). Study of the efficacy of intravenous tissue plasminogen activator in central retinal artery occlusion. International Journal of Stroke, 6 pp. 87-89.
    [10.1111/j.1747-4949.2010.00545.x] [Scopus]
  • Lowe, M.T., Keane, M.C., Coster, D.J. and Williams, K.A. (2011). The Outcome of Corneal Transplantation in Infants, Children, and Adolescents. Ophthalmology, 118(3) pp. 492-497.
    [10.1016/j.ophtha.2010.07.006] [Scopus]
  • Klebe, S., van Wijngaarden, P., Melville, T., Lipsett, J., De Smet, H.R., Coster, D.J., et al. (2010). Exposure to cyclic oxygen sufficient for development of oxygen-induced retinopathy does not induce bronchopulmonary dysplasia in rats. Experimental Lung Research, 36(3) pp. 175-182.
    [10.3109/01902140903258904] [Scopus]
  • Kashanian, S., Harding, F.J., Irani, Y., Klebe, S., Marshall, K.A., Loni, A., et al. (2010). Evaluation of mesoporous silicon/polycaprolactone composites as ophthalmic implants. Acta Biomaterialia, 6(9) pp. 3566-3572.
    [10.1016/j.actbio.2010.03.031] [Scopus]
  • Low, S.P., Williams, K.A., Canham, L. and Voelcker, N.H. (2010). Generation of reactive oxygen species from porous silicon microparticles in cell culture medium. Journal of Biomedical Materials Research Part A, 93(3) pp. 1124-1131.
    [10.1002/jbm.a.32610] [Scopus]
  • van Wijngaarden, P., Brereton, H.M., Coster, D.J. and Williams, K.A. (2010). Hereditary influences in oxygen-induced retinopathy in the rat. Documenta Ophthalmologica, 120 pp. 87-97.
    [10.1007/s10633-009-9196-3] [Scopus]
  • Williams, K.A., Kelly, T.L., Lowe, M.T. and Coster, D.J. (2010). The Influence of Rejection Episodes in Recipients of Bilateral Corneal Grafts. American Journal of Transplantation, 10 pp. 921-930.
    [10.1111/j.1600-6143.2009.03002.x] [Scopus]
  • Williams, K.A. and Coster, D.J. (2010). Gene therapy for diseases of the cornea - a review. Clinical and Experimental Ophthalmology, 38 pp. 93-103.
    [10.1111/j.1442-9071.2009.02179.x] [Scopus]
  • Parker, D.G., Coster, D.J., Brereton, H.M., Hart, P., Koldej, R., Anson, D., et al. (2010). Lentivirus-mediated gene transfer of interleukin 10 to the ovine and human cornea. Clinical and Experimental Ophthalmology, 38(4) pp. 405-413.
    [10.1111/j.1442-9071.2010.02261.x] [Scopus]
  • Coster, D.J., Jessup, C.F. and Williams, K.A. (2009). Mechanisms of corneal allograft rejection and regional immunosuppression. Eye, 23 pp. 1894-1897.
    [10.1038/eye.2009.17] [Scopus]
  • Irani, Y., Brereton, H.M., Tilton, R.G., Coster, D.J. and Williams, K.A. (2009). Production of scFv antibody fragments from a hybridoma with functional activity against human vascular endothelial growth factor. Hybridoma, 28(3) pp. 205-209.
    [10.1089/hyb.2009.0001] [Scopus]
  • Klebe, S., Coster, D.J. and Williams, K.A. (2009). Rejection and acceptance of corneal allografts. Current Opinion in Organ Transplantation, 14(1) pp. 4-9.
    [10.1097/MOT.0b013e32831af1d7] [Scopus]
  • Low, S.P., Voelcker, N.H., Canham, L.T. and Williams, K.A. (2009). The biocompatibility of porous silicon in tissues of the eye. Biomaterials, 30(15) pp. 2873-2880.
    [10.1016/j.biomaterials.2009.02.008] [Scopus]
  • Williams, K.A., Brereton, H.M. and Coster, D.J. (2009). Prospects for genetic modulation of corneal graft survival. Eye, 23(10) pp. 1904-1909.
    [10.1038/eye.2008.378] [Scopus]
  • Parker, D., Brereton, H.M., Klebe, S., Coster, D.J. and Williams, K.A. (2009). A steroid-inducible promoter for the cornea. British Journal of Ophthalmology, 93(9) pp. 1255-1259.
    [10.1136/bjo.2009.159137] [10.1136/bjo.2009.169433] [Scopus] [Web Link]
  • Tea, M.N., Fogarty, R.D., Brereton, H.M., Michael, M.Z., Van der Heok, M.B., Tsykin, A., et al. (2009). Gene expression microarray analysis of early oxygen-induced retinopathy in the rat. Journal of Ocular Biology, Diseases, and Informatics, 2(4) pp. 190-201.
    [10.1007/s12177-009-9041-7] [Scopus]
  • Thiel, M., Kaufmann, C., Coster, D.J. and Williams, K.A. (2009). Antibody-based immunosuppressive agents for corneal transplantation. Eye, 23(10) pp. 1962-1965.
    [10.1038/eye.2008.384] [Scopus]
  • Parker, D., Brereton, H.M., Coster, D.J. and Williams, K.A. (2009). The potential of viral vector-mediated gene transfer to prolong corneal allograft survival. Current Gene Therapy, 9(1) pp. 33-44.
    [10.2174/156652309787354621] [Scopus]
  • Irani, Y., Tea, M.N., Tilton, R.G., Coster, D.J., Williams, K.A. and Brereton, H.M. (2008). PCR amplification of the functional immunoglobulin heavy chain variable gene from a hybridoma in the presence of two aberrant transcripts. Journal of Immunological Methods, 336(2) pp. 246-250.
    [10.1016/j.jim.2008.04.014] [Scopus]
  • Smith, J.R., Rosenbaum, J.T. and Williams, K.A. (2008). Experimental melanin-induced uveitis: experimental model of human acute anterior uveitis. Ophthalmic Research, 40(3-4) pp. 136-140.
    [10.1159/000119864] [Scopus]
  • Williams, K.A., Lowe, M.T., Bartlett, C.M., Kelly, M.T. and Coster, D.J. (2008). Risk factors for human corneal graft failure within the Australian corneal graft registry. Transplantation, 86(12) pp. 1720-1724.
    [10.1097/TP.0b013e3181903b0a] [Scopus]
  • Brereton, H.M., Chamberlain, D., Yang, R., Tea, M.N., McNeil, S., Coster, D.J., et al. (2007). Single chain antibody fragments for ocular use produced at high levels in a commercial wheat variety. Journal of Biotechnology, 129(3) pp. 539-546.
    [10.1016/j.jbiotec.2007.01.008] [Scopus]
  • Caudle, L.E., Williams, K.A. and Pesudovs, K. (2007). The eye sensation scale: an ophthalmic pain severity measure. Optometry and Vision Science, 84(8) pp. 752-762.
    [10.1097/OPX.0b013e31812f7690] [Scopus] [PubMed]
  • Holmstrom, G., van Wijngaarden, P., Coster, D.J. and Williams, K.A. (2007). Genetic susceptibility to retinopathy of prematurity: the evidence from clinical and experimental animal studies. British Journal of Ophthalmology, 91(12) pp. 1704-1708.
    [10.1136/bjo.2007.117283] [Scopus] [Web Link]
  • Parker, D., Kaufmann, C., Brereton, H.M., Anson, D.S., Francis-Staite, L., Jessup, C.F., et al. (2007). Lentivirus-mediated gene transfer to the rat, ovine and human cornea. Gene Therapy, 14(9) pp. 760-767.
    [10.1038/sj.gt.3302921] [Scopus] [Web Link]
  • Williams, K.A. and Coster, D.J. (2007). The immunobiology of corneal transplantation. Transplantation, 84(7) pp. 806-813.
    [10.1097/01.tp.0000285489.91595.13] [Scopus]
  • van Wijngaarden, P., Brereton, H.M., Coster, D.J. and Williams, K.A. (2007). Genetic influences on susceptibility to oxygen-induced retinopathy. Investigative Ophthalmology and Visual Science, 48(4) pp. 1761-1766.
    [10.1167/iovs.06-0531] [Scopus]
  • van Wijngaarden, P., Brereton, H.M., Gibbins, I.L., Coster, D.J. and Williams, K.A. (2007). Kinetics of strain-dependent differential gene expression in oxygen-induced retinopathy in the rat. Experimental Eye Research, 85(4) pp. 508-517.
    [10.1016/j.exer.2007.07.001] [Scopus]
  • van Wijngaarden, P., Brereton, H.M., Coster, D.J. and Williams, K.A. (2007). Stability of housekeeping gene expression in the rat retina during exposure to cyclic hyperoxia. Molecular Vision, 13 pp. 1508-1515.
    [Scopus] [Web Link] [Web Link]
  • Low, S.P., Williams, K.A., Canham, L.T. and Voelcker, N.H. (2006). Evaluation of mammalian cell adhesion on surface-modified porous silicon. Biomaterials, 27(26) pp. 4538-4546.
    [10.1016/j.biomaterials.2006.04.015] [Scopus]
  • Williams, K.A., Esterman, A.J., Bartlett, C.M., Holland, H.K., Hornsby, N.B. and Coster, D.J. (2006). How effective is penetrating corneal transplantation? Factors influencing long-term outcome in multivariate analysis. Transplantation, 81(6) pp. 896-901.
    [10.1097/01.tp.0000185197.37824.35] [Scopus]
  • van Wijngaarden, P., Coster, D.J., Brereton, H.M., Gibbins, I.L. and Williams, K.A. (2005). Strain-dependent differences in oxygen-induced retinopathy in the inbred rat. Investigative Ophthalmology and Visual Science, 46(4) pp. 1445-1452.
    [10.1167/iovs.04-0708] [Scopus]
  • Brereton, H.M., Taylor, S.D., Farrall, A., Hocking, D., Thiel, M., Tea, M.N., et al. (2005). Influence of format on in vitro penetration of antibody fragments through porcine cornea. British Journal of Ophthalmology, 89(9) pp. 1205-1209.
    [10.1136/bjo.2005.066225] [Scopus]
  • Coster, D.J. and Williams, K.A. (2005). The impact of corneal allograft rejection on the long-term outcome of corneal transplantation. American Journal of Ophthalmology, 140(6) pp. 1112-1122.
    [10.1016/j.ajo.2005.07.024] [Scopus]
  • Coster, D.J., Jessup, C.F. and Williams, K.A. (2005). Mechanisms of corneal allograft rejection. The Ocular Surface, 3(4) pp. S165-S168.
    [10.1097/01.TP.0000147196.79546.69] [Scopus] [Scopus]
  • Jessup, C.F., Brereton, H.M., Coster, D.J. and Williams, K.A. (2005). In vitro adenovirus mediated gene transfer to the human cornea. British Journal of Ophthalmology, 89(6) pp. 658-661.
    [10.1136/bjo.2004.061754] [Scopus]
  • Jessup, C.F., Brereton, H.M., Sykes, P.J., Thiel, M., Coster, D.J. and Williams, K.A. (2005). Local gene transfer to modulate rat corneal allograft rejection. Investigative Ophthalmology and Visual Science, 46(5) pp. 1675-1681.
    [10.1167/iovs.04-1140] [Scopus]
  • Klebe, S., Coster, D.J., Sykes, P.J., Swinburne, S., Hallsworth, P.G., Scheerlinck, J.P.Y., et al. (2005). Prolongation of sheep corneal allograft survival by transfer of the gene encoding ovine IL-12-p40 but not IL-4 to donor corneal endothelium. Journal of Immunology, 175(4) pp. 2219-2226.
    [Scopus]
  • Thiel, M., Steiger, J.U., O'Connell, P., Lehnert, A., Coster, D.J. and Williams, K.A. (2005). Local or short-term systemic costimulatory molecule blockade prolongs rat corneal allograft survival. Clinical and Experimental Ophthalmology, 33(2) pp. 176-180.
    [10.1111/j.1442-9071.2005.00974.x] [Scopus]
  • Turner, M.L., Cockerell, E.J., Brereton, H.M., Badenoch, P.R., Tea, M.N., Coster, D.J., et al. (2005). Antigens of selected Acanthamoeba species detected with monoclonal antibodies. International Journal For Parasitology, 35(9) pp. 981-990.
    [10.1016/j.ijpara.2005.03.015] [Scopus]
  • Williams, K.A., Brereton, H.M., Farrall, A., Standfield, S., Taylor, S.D., Kirk, L., et al. (2005). Topically applied antibody fragments penetrate into the back of the rabbit eye. Eye, 19(8) pp. 910-913.
    [10.1038/sj.eye.6701669] [Scopus]
  • Williams, K.A., Standfield, S., Smith, J.R. and Coster, D.J. (2005). Corneal graft rejection occurs despite Fas ligand expression and apoptosis of infiltrating cells. British Journal of Ophthalmology, 89(5) pp. 632-638.
    [10.1136/bjo.2003.040675] [Scopus]
  • van Wijngaarden, P., Coster, D.J. and Williams, K.A. (2005). Inhibitors of ocular neovascularization: promises and potential problems. JAMA-Journal of The American Medical Association, 293(12) pp. 1509-1513.
    [10.1001/jama.293.12.1509] [Scopus]
  • Williams, K.A., Jessup, C.F. and Coster, D.J. (2004). Gene therapy approaches to prolonging corneal allograft survival. Expert Opinion on Biological Therapy, 4(7) pp. 1059-1071.
    [10.1517/14712598.4.7.1059] [Scopus]
  • Thiel, M., Coster, D.J. and Williams, K.A. (2003). The potential of antibody-based immunosuppressive agents for corneal transplantation. Immunology and Cell Biology, 81(2) pp. 93-105.
    [10.1046/j.0818-9641.2002.01145.x] [Scopus]
  • Mayne, G.C., Borowicz, R.A., Greeneklee, K.V.L., Finlay-Jones, J.J., Williams, K.A. and Hart, P. (2003). Centrifugation facilitates transduction of green fluorescent protein in human monocytes and macrophages by adenovirus at low multiplicity of infection. Journal of Immunological Methods, 278(1-2) pp. 45-56.
    [10.1016/S0022-1759(03)00229-1] [Scopus]
  • Coster, D.J. and Williams, K.A. (2003). Management of high-risk corneal grafts. Eye, 17(8) pp. 996-1002.
    [10.1038/sj.eye.6700634] [Scopus]
  • Mills, R.A., Coster, D.J. and Williams, K.A. (2002). Effect of immunosuppression on outcome measures in a model of rat limbal transplantation. Investigative Ophthalmology and Visual Science, 43(3) pp. 647-655.
    [Scopus]
  • Thiel, M., Coster, D.J., Mavrangelos, C., Zola, H. and Williams, K.A. (2002). An economical 20 litre bench-top fermenter. Protein Expression and Purification, 26(1) pp. 14-18.
    [10.1016/S1046-5928(02)00527-2] [Scopus]
  • Thiel, M., Coster, D.J., Standfield, S., Brereton, H.M., Mavrangelos, C., Zola, H., et al. (2002). Penetration of engineered antibody fragments into the eye. Clinical and Experimental Immunology, 128(1) pp. 67-74.
    [10.1046/j.1365-2249.2002.01808.x] [Scopus]
  • Klebe, S., Sykes, P.J., Krishnan, R. and Williams, K.A. (2001). Prolongation of sheep allograft survival by ex-vivo transfer of the gene encoding interleukin 10. Transplantation, 71(9) pp. 1214-1220.
    [Scopus]
  • Klebe, S., Bloom, D.C., Sykes, P.J., Williams, K.A. and Coster, D.J. (2001). Gene transfer to ovine corneal endothelium. Clinical and Experimental Ophthalmology, 29 pp. 316-322.
    [10.1046/j.1442-9071.2001.00440.x] [Scopus]
  • Henderson, T.R., Coster, D.J. and Williams, K.A. (2001). The long-term outcome of limbal allografts - the search for surviving cells. British Journal of Ophthalmology, 85 pp. 604-609.
    [Scopus]
  • Thiel, M., Morlet, N., Schulz, D.O., Edelhauser, H.F., Dart, J.K., Coster, D.J., et al. (2001). A simple corneal perfusion chamber for drug penetration and toxicity studies. British Journal of Ophthalmology, 85 pp. 450-453.
    [Scopus]
  • Thiel, M., Takano, T., Hawksworth, N.R., Coster, D.J. and Williams, K.A. (2001). Low-dose, short-term treatment with anti-CD4 monoclonal antibody prolongs corneal allograft survival. Transplantation Proceedings, 33 pp. 635-636.
    [Scopus]
  • Smith, J., Hart, P., Standfield, S., Coster, D., Wing, S. and Williams, K. (2000). Apoptosis is a prominent feature of acute anterior uveitis in the Fischer 344 rat. British Journal of Ophthalmology, 84(2) pp. 205-211.
    [10.1136/bjo.84.2.205] [Scopus]
  • Smith, J., O'Rourke, L., Becker, M., Cao, M., Williams, K., Planck, S., et al. (2000). Anti-rat ICAM-1 antibody does not influence the course of experimental melanin-induced uveitis. Current Eye Research, 21(5) pp. 906-912.
    [10.1076/ceyr.21.5.906.5537] [Scopus]
  • Smith, J., Hart, P., Parish, C., Standfield, S., Coster, D. and Williams, K. (1999). Experimental melanin-induced uveitis in the Fischer 344 rat is inhibited by anti-CD4 monoclonal antibody, but not by mannose-6-phosphate. Clinical and Experimental Immunology, 115(1) pp. 64-71.
    [10.1046/j.1365-2249.1999.00765.x] [Scopus]
  • Williams, K., Standfield, S., Mills, R., Takano, T., Larkin, D., Krishnan, R., et al. (1999). A new model of orthotopic penetrating corneal transplantation in the sheep: graft survival, phenotypes of graft-infiltrating cells and local cytokine production. Australian and New Zealand Journal of Ophthalmology, 27(2) pp. 127-135.
    [10.1046/j.1440-1606.1999.00171.x] [Scopus]
  • Smith, J., Hart, P. and Williams, K. (1998). Basic pathogenic mechanisms operating in experimental models of acute anterior uveitis. Immunology and Cell Biology, 76(6) pp. 497-512.
    [10.1046/j.1440-1711.1998.00783.x] [Scopus]
  • Smith, J., Hart, P., Coster, D. and Williams, K. (1998). Uveal mast cells are not required for rodent uveitis. Ophthalmic Research, 30(6) pp. 388-393.
    [10.1159/000055500] [Scopus]
  • Smith, J., Hart, P., Coster, D. and Williams, K. (1998). Mice deficient in tumor necrosis factor receptors p55 and p75, interleukin-4, or inducible nitric oxide synthase are susceptible to endotoxin-induced uveitis. Investigative Ophthalmology & Visual Science, 39(3) pp. 658-661.
  • Williams, K.A., Brereton, H.M., Aggarwal, R., Sykes, P.J., Turner, D.R., Russ, G.R., et al. (1995). Use of DNA polymorphisms and the polymerase chain reaction to examine the survival of a human limbal stem cell allograft. American Journal of Ophthalmology, 120(3) pp. 342-350.
    [Scopus]
  • Williams, K., Standfield, S., Wing, S., Barras, C., Mills, R., Comacchio, R., et al. (1992). Patterns of corneal graft rejection in the rabbit and reversal of rejection with monocional antibodies. Transplantation, 54(1) pp. 38-43.
    [Scopus]
  • Williams, K.A., Keane, M.C., Galettis, R.A., Jones, V.J., Mills, R.A. and Coster, D.J. (2015). The Australian Corneal Graft Registry. Adelaide: Flinders University.
  • Williams, K., Lowe, M.T., Keane, M., Jones, V., Loh, R. and Coster, D. (2012). The Australian Corneal Graft Registry 2012 Report.
    [Web Link] [Web Link]
  • Williams, K.A., Hornsby, N.B., Bartlett, C.M., Holland, H.K., Esterman, A.J. and Coster, D.J. (2004). The Australian Corneal Graft Registry 2004 Report. Adelaide, SA: SNAP PRINTING.
  • Dawson, A.C., Williams, K.A., Appukuttan, B. and Smith, J.R. (2018). Emerging diagnostic tests for vitreoretinal lymphoma: a review. Clinical and Experimental Ophthalmology,
  • Smith, J.R., Todd, S., Ashander, L.M., Charitou, T., Ma, Y., Yeh, S., et al. (2017). Retinal Pigment Epithelial Cells are a Potential Reservoir for Ebola Virus in the Human Eye. Translational Vision Science & Technology, 6(4)
    [10.1167/tvst.6.4.12] [Scopus]
  • Irani, Y.D., Scotney, P., Klebe, S., Mortimer, L.A., Nash, A. and Williams, K.A. (2017). An Anti-VEGF-B Antibody Fragment Induces Regression of Pre-Existing Blood Vessels in the Rat Cornea. Investigative Ophthalmology and Visual Science, 58(9) pp. 3404-3413.
    [10.1167/iovs.16-21343]
  • Williams, K.A. and Irani, Y.D. (2016). Gene therapy and gene editing for the corneal dystrophies. Asia-Pacific Journal of Ophthalmology, 5(4) pp. 312-316.
    [10.1097/APO.0000000000000215]
  • Irani, Y.D., Scotney, P., Nash, A. and Williams, K.A. (2016). Species Cross-Reactivity of Antibodies Used to Treat Ophthalmic Conditions. Investigative Ophthalmology and Visual Science, 57(2) pp. 586-591.
    [10.1167/iovs.15-18239] [Scopus]
  • Keane, M.C., Galettis, R.A., Mills, R.A., Coster, D.J., Williams, K.A. and Australian Corneal Graft Regis, (2016). A comparison of endothelial and penetrating keratoplasty outcomes following failed penetrating keratoplasty: a registry study. British Journal of Ophthalmology,
    [10.1136/bjophthalmol-2015-307792] [Scopus]
  • McInnes, S.J., Turner, C.T., Al-Bataineh, S.A., Leccardi, M.J.I.A., Irani, Y.D., Williams, K.A., et al. (2015). Surface engineering of porous silicon to optimise therapeutic antibody loading and release. JOURNAL OF MATERIALS CHEMISTRY B, 3(20) pp. 4123-4133.
    [10.1039/c5tb00397k] [Scopus]
  • Coster, D.J., Jessup, C.F. and Williams, K.A. (2010). Mechanisms of corneal allograft rejection and the development of new therapies. In Thomas Reinhard and Frank Larkin, ed. Essentials in Ophthalmology. Cornea and external eye disease. Germany: Springer, pp. 13-23.
    [10.1007/978-3-540-85544-6]
  • Coster, D.J. and Williams, K.A. (2009). Outcomes of penetrating keratoplasty. In Frederick S. Brightbill, et al., ed. Corneal surgery : theory, technique and tissue. 4th ed. St. Louis, USA: Elsevier, pp. 553-560.
  • Coster, D.J. and Williams, K.A. (2005). Immunomodulation for corneal transplantation. In Uwe Pleyer and Bartly Mondino, ed. Uveitis and Immunological Disorders. Berlin, Germany: Springer, pp. 35-50.
    [10.1007/3-540-26752-2_4]

Expertise for media contact

Subject Titles

  • Eyes

Interests

  • Experimental Eye Research (corneal transplantation, ocular inflammation, ocular immunology, eye banking, Australian Corneal Graft Registry)

Contact

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Phone: +61 8 82045047
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Location: Flinders Medical Centre (5D:212)
Postal address: GPO Box 2100, Adelaide 5001, South Australia
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