Position

Strategic Professor and Head of Clinical Pharmacology
Clinical Pharmacology

Biography

Arduino trained in Clinical Pharmacology, Cardiology and Internal Medicine in Milan, Boston and London. In 2003 he was awarded a PhD at King's College London and was appointed as Senior Lecturer in the Department of Clinical Pharmacology at Flinders University. He was promoted to Associate Professor in 2007 before taking up the Chair of Medicine of Old Age at the University of Aberdeen in 2010. In 2013 he returned to Flinders University as Professor of Clinical Pharmacology and Senior Consultant in Clinical Pharmacology and Internal Medicine. 

Qualifications

MD(Hons), University of Milan, 1991
PhD, King's College London, 2003
MRCP(UK), 2003
FRACP, 2005
FRCP (London), 2009
FRCP (Glasgow), 2010
FRCP (Edinburgh), 2011

Honours, awards and grants

Kathleen Knights, Karen Lillywhite, Gail Easterbrook, John Miners and Arduino Mangoni, Carrick citation for outstanding contributions to student learning "For promotion of safe and effective medication management through an innovative e-learning pharmacology course for Nurse Practitioners in urban, rural and remote areas of Australia". (2007)

Visiting Professor, University of Sassari, Italy (2012, 2014, 2015)

Grants:

2013:  AA Mangoni, BC Lewis, A Rowland. Dimethylarginine dimethylaminohydrolase (DDAH) and angiogenesis modulation: a novel therapeutic target in cancer? Flinders Medical Centre (FMC) Foundation research grant, 1 year, AUD 15,000

2013:  L Mayner, AA Mangoni, RJ Woodman. Are older people on anticholinergic medication at greater risk of hospitalisation during extreme heat conditions? Faculty of Health Sciences research grant, 1 year, AUD 12,000

2013:  A Pilotto, M Mirandola, S Menichelli, I Jansson, M Nordenfelt, M Zoratti, S Maggi, L Ferrucci, AA Mangoni, RJ Woodman, F Pellegrini, A Greco, D Sancarlo, K Kinder, H Kolk, AS Parent, I Kiss, I Petrov. Using Multidimensional Prognostic Indices (MPI) to improve cost-effectiveness of interventions in multimorbid frail older persons. European Commission, Second Health Programme (2008-2013), Ref: 508379, 3 years, EUR 837,572.

2014:  MG Burt, CH Thompson, A Rowland, S Quinn, AA Mangoni. Does variability in glucocorticoid homeostasis affect insulin sensitivity and vascular function? Diabetes Australia, 1 year, $59,843

2015:  AA Mangoni, A Rowland, J Miners, T Chataway, M Michael, MG Burt, D Keating, L Thurgood, M Sorich. Establishment of the Flinders Metabolomic Research facility. Flinders Faculty of Health Sciences Small Grants, AUD 20,000.

2015:  MG Burt, AA Mangoni, L Heilbronn. Determination of the effect of relative hyperglycaemia on markers of cardiovascular risk. Flinders Faculty of Health Sciences Small Grants, AUD 19,000.

Topic Coordinator:

  • MMED8203  Knowledge of Health and Illness 2

Research expertise

  • Cardiovascular medicine and haematology
  • Pharmacology and pharmaceutical sciences

Research interests

Arginine metabolomics in health and disease
Novel DDAH inhibitors as therapeutic agents in models of neurodegeneration
Cardiovascular toxicity of NSAIDs
Pharmacoepidemiology of antimuscarinic drugs and adverse effects in older patients

Supervisory interests

  • Cardiovascular and internal medicine
  • Clinical biochemistry
  • Clinical pharmacology
  • Hypertension/cardiology
  • Pharmacological interventions on cardiovascular function
  • Structure/function of vascular beds

RHD research supervision

Current

Principal supervisor : Pharmacology (3) ;

Associate supervisor : Endocrinology (1) ;

Completion

Principal supervisor : Design of novel DDAH inhibitors (Univ of Aberdeen) (1) ; Methotrexate and markers of cardiovascular risk in rheumatoid arthritis (Univ of Aberdeen) (1) ;

Associate supervisor : Pharmacology (3) ;

Publications

  • Mangoni, A.A., Ruxton, K., Mislang, A. and Biganzoli, L. (2016). Chronic Conditions and Cancer in Older Adults. In Bogda Koczwara, ed. Cancer and Chronic Conditions: Addressing the Problem of Multimorbidity in Cancer Patients and Survivors. Singapore: Springer, pp. 421-454.
    [10.1007/978-981-10-1844-2] [10.1007/978-981-10-1844-2_14]
  • Mangoni, A.A., Zinellu, A., Sotgia, S., Rowland, A. and Carru, C. (2016). Methylated Arginines as Biomarkers in Renal Disease. In VB Patel and VR Preedy, ed. Biomarkers in Kidney Disease. Netherlands: Springer Science, pp. 1-30.
    [10.1007/978-94-007-7743-9_19-1]
  • Knights, K. and Mangoni, A. (2015). Drug and Nutrient Interactions in Masters Athletes. In Peter Raeburn, ed. Nutrition and Performance in Masters Athletes. Florida, United States of America: CRC Press/Taylor and Francis, pp. 243-258.
    [Web Link] [Web Link]
  • Mangoni, A.A., Jansen, P. and Jackson, S.H. (2015). Pharmacokinetic and pharmacodynamic studies in older adults. In Antonio Cherubini, Roberto Bernabei, Luigi Ferrucci, Niccolò Marchionni, Stephanie Studenski, Bruno Vellas, ed. Clinical Trials in Older Adults. West Sussex, United Kingdom: John Wiley and Sons, pp. 79-94.
    [Web Link]
  • Mangoni, A. (2014). Drugs acting on the cerebral and peripheral circulations. In J. K. Aronson, ed. Side Effects of Drugs Annual 35. 1st ed. Oxford, United Kingdom: Elsevier, pp. 359-362.
    [10.1016/B978-0-444-62635-6.00019-X] [Scopus]
  • Mangoni, A. (2012). Drugs acting on the cerebral and peripheral circulations. In Side Effects of Drugs Annual 34. N/A: Elsevier, pp. 311-316.
  • Mangoni, A. (2009). Heart Failure. In Jackson S, Jansen P, Mangoni A., ed. Prescribing for Elderly Patients. United Kingdom: Wiley-Blackwell, pp. 125-137.
    [Scopus]
  • Mangoni, A., Jansen, P. and Jackson, S. (2009). Clinical Pharmacology of Ageing. In Jackson S, Jansen P, Mangoni A., ed. Prescribing for Elderly Patients. United Kingdom: Wiley-Blackwell, pp. 1-10.
    [Scopus]
  • Mangoni, A.A. (2009). The emerging role of symmetric dimethylarginine in vascular disease. In Gregory Makowski, ed. Advances in Clinical Chemistry. Burlington: Academic Press, pp. 73-94.
    [10.1016/S0065-2423(09)48003-X] [Scopus]
  • Yiu, D. and Mangoni, A. (2009). Acute Coronary Syndrome. In Jackson S, Jansen P, Mangoni A., ed. Prescribing for Elderly Patients. United Kingdom: Wiley-Blackwell, pp. 111-123.
    [Scopus]
  • Jackson, S., Jansen, P. and Mangoni, A. (Eds.). (2009). Prescribing for Elderly Patients. 1st ed. Chichester, England: Wiley.
  • Mangoni, A.A., Kim, S.W., Hakendorf, P.H., Woodman, R.J. and Mayner, L. (2015). Impact of Anticholinergic Drugs on Adverse Outcomes In Older Hospitalized Patients During Extreme Weather Conditions. In Irish Ageing Studies Review. The International Association of Gerontology and Geriatrics (IAGG-ER). European Region 8th Congress. The Convention Centre Dublin. Apr 2015, pp. abstract 0862.
    [Web Link]
  • Baghdadi, L.R., Woodman, R.J., Shanahan, E.M. and Mangoni, A.A. (2015). Methotrexate, Blood Pressure and Arterial Wave Reflection in Rheumatoid Arthritis. 2015 American College of Rheumatology (ACR)/ARHP Annual Meeting. San Francisco. Nov 2015, pp. Abstract 473.
    [Web Link]
  • Van Dyk, M., McEvoy, M., Mangoni, A. and Rowland, A. (2015). Targeting Arginine Metabolomics in Older Individuals. In Proceedings of the Joint ASCEPT-BPS Scientific Meeting. Joint ASCEPT-BPS Scientific Meeting.
  • Woodman, R.J., Hong, S., Xiao, S. and Mangoni, A.A. (2015). Structural equation models with a binary outcome using STATA and Mplus. 2015 Oceania STATA User’s group meeting. Canberra. Sep 2015.
    [Web Link]
  • Phillips, C., Chee, C., Eaton, V., Woodman, R. and Mangoni, A. (2014). Attitudes and perceptions of junior medical staff toward a ward-based therapeutic drug monitoring service for aminoglycosides. In Antimicrobials 2014 Programme and Book of Abstracts: 15th Annual Scientific Meeting. South Perth, WA: The Australian Society of Antimicrobials. Antimicrobials 2014. Melbourne, VIC. Feb 2014, pp. 111-111.
    [Web Link]
  • Dedigama, M., Mangoni, A. and Phillips, C. (2014). Clinical use of an aminoglycoside ward-based Therapeutic Drug Monitoring (TDM) Service in a tertiary hospital A-220. In Oral Abstract Book, Australasian Society of Clinical and Experimental Pharmacologists and Toxicologiests Scientific Meeting. Eastwood, SA: Australasian Society of Clinical and Experimental Pharmacologists and Toxicologiests. ASCEPT-MPGPCR Joint Scientific Meeting. Melbourne, VIC. Dec 2014.
  • Woodman, R.J., Hong, X., Xiao, S., Mangoni, A.A., wang, S., Chen, J., et al. (2014). A comparison of maximum likelihood and Bayesian estimation approaches to examine the effects of homocysteine and other coronary artery disease (CAD) risk factors on CAD using structural equation modelling. The 10th International Workshop for the Australasian Chapter of the International Society for Bayesian Analysis. The Mantra Legends Hotel, Surfers Paradise, Gold Coast, Australia. Nov 2014.
    [Web Link]
  • shif, M., Rose, A.R., Woodman, R.J., Hakendorf, P.H. and Mangoni, A.A. (2014). Audit of compliance & potential complications of empirical anticoagulation in patients with high probability of pulmonary embolism. In Respirology. Thoracic Society of Australia & New Zealand and the Australian & New Zealand Society of Respiratory Science 2014 Annual Scientific Meetings. Adelaide Convention Centre, Adelaide, SA. Apr 2014, pp. 57.
    [10.1111/resp.12263]
  • Khan, S., Korprasertthaworn, P., Mangoni, A., Polasek, M. and Rowland, A. (2013). In vitro assessment of metabolic drug-drug interactions potentially affecting olanzapine clearance. In Proceedings of the 47th Annual ASCEPT Annual Scientific Meeting. Melbourne, Australia: ASCEPT. 47th ASCEPT Annual Scientific Meeting. Melbourne, Australia. Dec 2003.
  • Van Dyk, M., Mangoni, A. and Rowland, A. (2013). Development of a UPLC-MS Based Approach to Quantify a Panel of Key Arginine Metabolites in Human Serum. In Proceedings of the 47th Annual ASCEPT Annual Scientific Meeting. Melbourne, Australia: ASCEPT. 47th ASCEPT Annual Scientific Meeting. Melbourne, Australia. Dec 2013.
  • Bouteldja, N., Woodman, R.J., Hewitson, C., Domingo, E., Barbara, J. and Mangoni, A. (2012). Age and L-Arginine/ADMA ratio in end-stage renal disease. In J Hypertension. 22nd European Meeting on Hypertension and Cardiovascular protection. London. Apr 2012, pp. 07.190.
    [Web Link]
  • Bouteldja, N., Woodman, R.J., Hewitson, C., Domingo, E., Barbara, J. and Mangoni, A. (2012). Methylated arginines and nitric oxide in end-stage renal disease: relationship with inflammatory and oxidative status. In Cardiovasc Res. Frontiers in CardioVascular Biology. Second Congress of the ESC Council on Basic Cardiovascular Science. Mar 2012.
    [10.1093/cvr/cvr332]
  • Lowry, E., Woodman, R.J., Soiza, R.L. and Mangoni, A.A. (2011). Anticholinergic Risk Scale Score and Physical Function in Older Hospitalised Patients: Implications for Adverse Outcomes. In Basic & Clinical Pharmacology & Toxicology Special Issue: Abstracts of the 10th Congress of the European Association for Clinical Pharmacology and Therapeutics, 26-29 June 2011, Budapest, Hungary. Wiley. 10th Congress of the European Association for Clinical Pharmacology and Therapeutics. Budapest, Hungary. Jul 2011, pp. 72-72.
  • Lowry, E., Woodman, R.J., Soiza, R.L. and Mangoni, A.A. (2011). Drug Burden Index, Physical Function and Adverse Outcomes in Older Hospitalised Patients. In Basic & Clinical Pharmacology & Toxicology Special Issue: Abstracts of the 10th Congress of the European Association for Clinical Pharmacology and Therapeutics, 26-29 June 2011, Budapest, Hungary. Wiley. 10th Congress of the European Association for Clinical Pharmacology and Therapeutics. Budapest, Hungary. Jun 2011, pp. 28-28.
  • Head, G., Mihailidou, S., Duggan, K., Beilin, L.J., Berry, N., Cowley, D., et al. (2009). Relationship between ambulatory and clinic blood pressure: a high blood pressure research council of Australia initiative. In 19th European Meeting on Hypertension. Journal of Hypertension. 19th European Meeting on Hypertension. Milan, Italy. Jun 2009, pp. S3-S3.
  • Head, G., Mihailidou, S., Duggan, K., Beilin, L.J., Berry, N.M., Cowley, D., et al. (2009). Relationship between ambulatory and clinic blood pressure: a high blood pressure research council of Australia initiative. In Abstracts of tne 19th European Meeting on Hypertension. Philadelphia, US: Lippincott Williams & Wilkins. 19th European Meeting on Hypertension. Milan, Italy. Jun 2009, pp. S3-S3.
  • Mangoni, A.A., Woodman, R.J. and Knights, K.M. (2009). Use of non-steroidal anti-inflammatory drugs and risk of stroke in Australian Veterans. In Journal of Hypertension. Elsevier. 19th European Meeting on Hypertension. Milan, Italy. Jun 2009, pp. S326-S326.
  • Forrest, A., Ng, D., Mangoni, A.A. and Doogue, M.P. (2008). Analysis of adverse drug reaction documentation in a metropolitan hospital. In Proceddings of the Australian Health and Medical Research Congress 2008. The Australian Health and Medical Research Congress. Brisbane Convention and Exhibition Centre. Nov 2008, pp. 418-419.
  • Lumb, R.S., Mangoni, A.A. and Doogue, M.P. (2008). Serum albumin and total plasma phenytoin concentrations: practical implications for therapeutic drug monitoring. In Proceedings of the Australian Health and Medical Research Congress 2008. 4th Australian Health and Medical Research Congress. Brisbane, QLD. Nov 2008, pp. 419-419.
  • Mangoni, A.A., Doogue, M.P. and Parasca, A. (2008). Determinants of anticholinergic risk score in hospitalized patients. In Proceedings of the Australian Health and Medical Research Congress 2008. The Australian Health and Medical Research Congress. Brisbane Convention and Exhibition Centre, Australia. Nov 2008, pp. 419-420.
  • Mangoni, A.A., Hewitson, C.L., Woodman, R.J., Whiting, M.J., McAteer-Carr, B. and Barbara, J.A.J. (2008). Symmetric dimethylarginine is an independent predictor of intradialytic hypotension. In Frans Van de Werf, ed. European Heart Journal. Oxford Journals. ESC Congress 2008. Munich, Germany. Aug 2008, pp. 482-482.
  • Mangoni, A.A., Tochihara, Y., Whiting, M.J. and Barbara, J.A.J. (2008). Effects of pre-dialysis vs. intra-dialysis administration of folic acid on arterial wave reflections and endothelial function in patients with end-stage renal disease. In Frans Van de werf, ed. Proceedings of ESC Congress 2008. Leuven, Belgium: Oxford Journals. European Society of Cardiology (ESC) Congress 2008. Munich, Germany. Aug 2008, pp. 609-610.
  • Penhall, A., Perry, R., Mangoni, A., De Pasquale, C., Chew, D. and Joseph, M. (2008). Can Speckle Tracking Assist in the Detection of Subclinical Myocardial Changes in Hypertensive Patients? In Abstracts for the Cardiac Society of Australia and New Zealand Annual Scientific Meeting and the International Society for Heart Research, Australasian Section, Annual Scientific Meeting. Elsevier. Cardiac Society of Australia and New Zealand Annual Scientific Meeting and the International Society for Heart Research, Australasian Section, Annual Scientific Meeting. Adelaide, Australia. Aug 2008, pp. S29-S29.
    [10.1016/j.hlc.2008.05.067]
  • Stanke, N., Spurling, L., Mangoni, A.A. and Doogue, M.P. (2008). An audit of medication reconciliation at hospital admission and discharge. In Proceedings of the Australian Health and Medical Research Congress 2008. The Australian Health and Medical Research Congress. Brisbane Convention and Exhibition Centre, Australia. Nov 2008, pp. 419-419.
  • Doogue, M.P., Mangoni, A.A., Grgurinovich, N. and Miners, J.O. (2007). The impact of therapeutic drug monitoring on prescribing of perhexiline. In C G Sobey and S Smid, ed. 2007 Joint Meeting of ASCEPT and SEAWP-RMP. Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists. 41st Annual Scientific Meeting of the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists. Adelaide, SA. Dec 2007, pp. Oral-105-Oral-105.
  • Viggeswarpu, S., Gieroba, Z., Paul, B. and Mangoni, A.A. (2007). Pre-existing comorbidities do not influence the outcome of tilt table test. In Internal Medicine Journal. Blackwell Publishing. Medicine, Aging and Nutrition 2007. Adelaide, SA. Sep 2007, pp. A75-A75.
    [Scopus]
  • Tharakunnel, Z., Mangoni, A.A. and Gieroba, Z. (2007). Variability of systolic blood pressure at which elderly patients experience presyncopal symptoms during tilt table test. In Internal Medicine Journal: Medicine Ageing & Nutrition 2007. Blackwell Publishing. Medicine Ageing & Nutrition 2007. Adelaide, SA. Sep 2007, pp. A76-A76.
    [Scopus]
  • Tharakunnel, Z., Mangoni, A.A. and Gieroba, Z. (2007). Variability of systolic blood pressure at which elderly patients experience presyncopal symptoms during tilt table test. In Conjoint scientific meeting of the ANZSGM, IMSANZ & IANA 2007. Medicine, Ageing and Nutrition 2007. Adelaide, SA. Sep 5007.
  • Perry, R., Yiu, D., Joseph, M., De Pasquale, C., Chew, D., Aylward, P., et al. (2006). High resolution transthoracic echocardiography assessment of the left anterior descending coronary artery: a novel and non-invasive approach to study coronary vasomotion in humans. In Proceedings for the Cardiac Society of Australia and New Zealand 2006 ASM. Journal of the American Society of Echocardiography. Cardiac Society of Australia and New Zealand. Canberra, Australia, pp. 134-138.
  • Paul, B., Gieroba, Z. and Mangoni, A.A. (2006). Effects of Medical Conditions and Medications on Cardiovascular Responsiveness During Tilt Table Testing in the Elderly. In Asia Pacific Geriatric Conference Program. Asia Pacific Geriatric Conference: Preparing for the Ageing Boom - Common Medical Problems in the Older Person. Kuala Lumpur, Malaysia. Apr 2006.
  • Jarmuzewska, E. and Mangoni, A.A. (2005). Pulse pressure is independently associated with peripheral neuropathy in type 2 diabetes. In European Heart Journal. supplement ed. London, UK: Oxford University Press. European Society of Cardiology Congress 2005. Stockholm, Sweden. Sep 2005, pp. 656-657.
  • Yiu, D., Gieroba, Z., Whitehead, C.H., Mangoni, A.A. and Russell, A.E. (2005). A significant drop in systolic blood pressure at 2 minutes predicts a positive tilt table test in elderly patients with a history of unexplained falls. In Heart, Lung and Circulation. Australia2005 CSANZ Annual Scientific Meeting. Perth, WA. Aug 2005, pp. S59.
  • Mangoni, A.A. and Jarmuzewska, E. (2017). Spicing Up the Management of Type 2 Diabetes with Cinnamon. Current Clinical Pharmacology, 12(1) pp. 2-3.
    [10.2174/157488471201170608153024] [Web Link]
  • Mangoni, A.A., Zinellu, A., Sotgia, S. and Carru, C. (2017). Symmetric dimethylarginine, high-density lipoproteins, and cardiovascular risk assessment: are we ready for clinical use? Journal of Laboratory and Precision Medicine, 2(40) pp. 1-4.
    [10.21037/jlpm.2017.06.11]
  • Dawson, J., Dedigama, M., Elliot, D.J., Sorich, M., Mangoni, A.A. and Rowland, A. (2016). Prolonged induction of warfarin metabolism and a paradoxical INR response in a mitral valve replacement patient receiving rifampicin for infective endocarditis. Biomedical Research and Clinical Practice, 1(2) pp. 62-65.
    [10.15761/BRCP.1000112]
  • Mangoni, A.A. (2016). Repurposing Niacin as Antiplatelet Drug. Current Clinical Pharmacology, 11(1) pp. 2-3.
    [10.2174/157488471101160204113351] [Scopus]
  • Mangoni, A.A., Woodman, R.J., Kichenadasse, G., Rowland, A. and Sorich, M. (2016). Anti-VEGF-induced hypertension and cancer outcomes: translating research into clinical practice. Expert Review of Precision Medicine and Drug Development, 1(2) pp. 12 5-127.
    [10.1080/23808993.2016.1155963]
  • Mallarkey, G. and Mangoni, A. (2015). Targeting precision medicine toxicity: recent developments. Therapeutic Advances in Drug Safety, 6(1) pp. 4-14.
    [10.1177/2042098614560737]
  • Kemp, L., Mangoni, A. and Woodman, R. (2014). Online survey on subjective and objective competency in clinical pharmacology skills among final year Australian medical students: a pilot study. Therapeutic Advances in Chronic Disease, 5(6) pp. 274-279.
    [10.1177/2040622314547361] [Scopus]
  • Mangoni, A. (2014). Geriatric medicine in an aging society: up for a challenge? Frontiers in Medicine, 1(10)
    [10.3389/fmed.2014.00010] [Web Link]
  • Mangoni, A. (2014). Harmonization in Pharmacoepidemiological Studies: (Twi)Light at the End of the Tunnel? Current Clinical Pharmacology, 9(2) pp. 91-92.
    [10.2174/1574884709666140403120834] [Scopus]
  • Woodman, R. and Mangoni, A.A. (2013). Adjusting for brachial artery diameter in the analysis of flow-mediated dilatation: Pitfalls of a landmark paper? Atherosclerosis, 228(1) pp. 277-279.
    [10.1016/j.atherosclerosis.2013.01.005] [Scopus]
  • Almalag, H., Mangoni, A.A. and Crilly, M. (2012). Methotrexate and risk of cardiovascular disease. American Journal of Cardiology, 109(9) pp. 1383-1384.
    [10.1016/j.amjcard.2012.01.374] [Scopus]
  • Mallarkey, G. and Mangoni, A.A. (2012). Latest drug safety alerts from the 27th International Conference on Pharmacoepidemiology and Therapeutic Risk Management. Therapeutic Advances in Drug Safety, 3(1) pp. 5-11.
    [10.1177/2042098611424178] [Scopus]
  • Mangoni, A.A. and Woodman, R. (2011). Homocysteine and cardiovascular risk: An old foe creeps bac. Journal of The American College of Cardiology, 58(10) pp. 1034-1035.
    [10.1016/j.jacc.2011.05.029] [Scopus]
  • Mallarkey, G. and Mangoni, A. (2010). Pharmacovigilance and pharmacogenetic discussions at WorldPharma 2010. Therapeutic Advances in Drug Safety, 1(1) pp. 7-10.
    [10.1177/2042098610383791]
  • Mangoni, A. (2010). Editorial. Therapeutic Advances in Drug Safety, 1(1) pp. 5-6.
    [10.1177/2042098610381527]
  • Woodman, R. and Mangoni, A. (2010). Is the Aldosterone:Renin Ratio Truly Reproducible? Hypertension, 55 pp. e18.
    [10.1161/HYPERTENSIONAHA.110.149799] [Scopus]
  • Baughman, C., Spurling, L. and Mangoni, A.A. (2008). Provision of warfarin education to hospital inpatients. British Journal of Clinical Pharmacology, 66(3) pp. 416-417.
    [10.1111/j.1365-2125.2008.03242.x] [Scopus]
  • Knights, K.M., Mangoni, A.A. and Miners, J.O. (2007). Authors' reply: Nonselective nonsteroidal anti-inflammatory drugs and increased cardiovascular events: emotional stress could be the explanation. British Journal of Clinical Pharmacology, 63(4) pp. 502-502.
    [10.1111/j.1365-2125.2006.02788.x] [Scopus]
  • Mangoni, A.A. (2007). The impact of advancing age on P-glycoprotein expression and activity: current knowledge and future directions. Expert Opinion on Drug Metabolism and Toxicology, 3(3) pp. 315-320.
    [10.1517/17425255.3.3.315] [Scopus]
  • Lu, T.Y., Kupa, A., Easterbrook, G. and Mangoni, A.A. (2005). Profound wight loss associated with reboxetine use in a 44-year-old woman. British Journal of Clinical Pharmacology, 60(2) pp. 218-220.
    [10.1111/j.1365-2125.2005.02407.x] [Scopus]
  • Jackson, S.H., Mangoni, A.A. and Batty, G.M. (2004). Optimization of drug prescribing. British Journal of Clinical Pharmacology, 57(3) pp. 231-236.
    [10.1046/j.1365-2125.2003.02018.x] [Scopus]
  • Mangoni, A.A. (2004). Diastolic and pulse pressure: the old and the new? Hypertension, 43(3) pp. 531-532.
    [10.1161/01.HYP.0000117154.80362.39] [Scopus]
  • Mangoni, A.A. (2004). Independent commentary on 'Toxicity of nitrazepam in the elderly: a report from the Boston Collaborative Drug Surveillance Program' British Journal of Clinical Pharmacology, 58(7) pp. S852-S853.
    [10.1111/j.1365-2125.2004.02309.x] [Scopus]
  • Mangoni, A.A., Close, J.C., Rodriguez, S., Sherwood, R.A., Bryant, C.A., Swift, C.G., et al. (2004). Acute hypotensive effects of oral cisapride and erythromycin in healthy subjects. British Journal of Clinical Pharmacology, 58(2) pp. 223-224.
    [10.1111/j.1365-2125.2004.02118.x] [Scopus]
  • Mangoni, A.A., Ouldred, E.L., Swift, C.G., Jackson, S.H., Draper, R.P., Sherwood, R.A., et al. (2001). Vascular and Blood Pressure Effects of Folic Acid in Older Patients with Cardiovascular Disease. Journal of the American Geriatrics Society, 49(7) pp. 1003-1004.
    [10.1046/j.1532-5415.2001.49196.x] [Scopus]
  • Awami, S., Doogue, M.P., Calabretto, J.P., Swatman, P., Mangoni, A.A. and Spurling, L.K. (2009). IT support for medication management process in hospitals: An overview. In M Macedo, ed. Proceedings of the IADIS International Conference on e-Health. Algarve, Portugul: International Association for Development of the Information Society. IADIS Multi Conference on Computer Science and Information Systems. Algarve, Portugal. Jun 2009, pp. 59-67.
    [Web Link]
  • Zinellu, A., Sotgiu, E., Fois, A.G., Zinellu, E., Sotgia, S., Ena, S., et al. (2017). Blood global DNA methylation is decreased in non-severe chronic obstructive pulmonary disease (COPD) patients. Pulmonary Pharmacology and Therapeutics, 46 pp. 11-15.
  • Zinellu, A., Sotgia, S., Sotgiu, E., Assaretti, S., Baralla, A., Mangoni, A.A., et al. (2017). Cholesterol lowering treatment restores blood global DNA methylation in chronic kidney disease (CKD) patients. Nutrition Metabolism and Cardiovascular Diseases, 27(9) pp. 822-829.
    [10.1016/j.numecd.2017.06.011] [Scopus] [Web Link]
  • Woodman, R.J., Baghdadi, L.R., Shanahan, E.M. and Mangoni, A.A. (2017). The Temporal Relationship between Arterial Stiffening and Blood Pressure Is Modified by Methotrexate Treatment in Patients with Rheumatoid Arthritis. Frontiers in Physiology, 8 pp. Art: 593.
    [10.3389/fphys.2017.00593]
  • Wilsdon, T., Whittle, S.L., Thynne, T.R. and Mangoni, A.A. (2017). Methotrexate for psoriatic arthritis (Protocol) The Cochrane Library, 2017(7) pp. Art: CD012722.
    [10.1002/14651858.CD012722.]
  • Wilsdon, T., Hendrix, I., Thynne, T.R. and Mangoni, A.A. (2017). Effectiveness of Interventions to Deprescribe Inappropriate Proton Pump Inhibitors in Older Adults. Drugs and Aging,
    [10.1007/s40266-017-0442-1] [Scopus]
  • Tommasi, S., Elliot, D.J., Hulin, J.A., Lewis, B.C., McEvoy, M. and Mangoni, A.A. (2017). Human dimethylarginine dimethylaminohydrolase 1 inhibition by proton pump inhibitors and the cardiovascular risk marker asymmetric dimethylarginine: in vitro and in vivo significance. Scientific Reports, 7(1) pp. Art:03069.
    [10.1038/s41598-017-03069-1] [Scopus]
  • Sotgia, S., Mangoni, A.A., Pintus, G., Carru, C. and Zinellu, A. (2017). Strategies to enhance graphic and results interpretation of a regression-based approach for method comparison studies. Future Science OA,
    [10.4155/fsoa-2017-0004]
  • Rowland, A., Van Dyk, M., Mangoni, A.A., Miners, J.O., McKinnon, R.A., Wiese, M.D., et al. (2017). Kinase inhibitor pharmacokinetics: comprehensive summary and roadmap for addressing interindividual variability in exposure. Expert Opinion on Drug Metabolism and Toxicology, 13(1) pp. 31-49.
    [10.1080/17425255.2016.1229303] [Scopus]
  • Munoz-Torrero, D., Mangoni, A.A., guillou, C., Collina, S., Vanden Eynde, J.J., Rautio, J., et al. (2017). Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes. Molecules, 22(5) pp. Art: 743.
    [10.3390/molecules22050743] [Scopus]
  • Mangoni, A.A., Baghdadi, L.R., Shanahan, E.M., Wiese, M.D., Tommasi, S., Elliot, D.J., et al. (2017). Methotrexate, blood pressure and markers of arterial function in patients with rheumatoid arthritis: a repeated cross-sectional study. Therapeutic Advances in Musculoskeletal Disease,
    [10.1177/1759720X17719850] [Web Link]
  • Mangoni, A.A., Kholmurodova, F., Mayner, L., Hakendorf, P.H. and Woodman, R.J. (2017). Psychotropics, Environmental Temperature, and Hospital Outcomes in Older Medical Patients. JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY, 37(5) pp. 562-568.
    [10.1097/JCP.0000000000000768.]
  • Pasella, S., Pinna, S., Deiana, M., Baralla, A., Dore, S., Mannu, A., et al. (2016). Plasma concentrations of transthyretin in older Sardinians including centenarians. Aging Clinical and Experimental Research, 28(1) pp. 77-82.
    [10.1007/s40520-015-0376-6]
  • Murphy, R.B., Tommasi, S., Lewis, B.C. and Mangoni, A.A. (2016). Inhibitors of the Hydrolytic Enzyme Dimethylarginine Dimethylaminohydrolase (DDAH): Discovery, Synthesis and Development. Molecules, 21(615)
    [10.3390/molecules21050615] [Scopus] [Web Link]
  • Rowland, A., Van Dyk, M., Mangoni, A.A., Miners, J.O., McKinnon, R.A., Weise, M.D., et al. (2016). Kinase inhibitor pharmacokinetics: comprehensive summary and roadmap for addressing inter-individual variability in exposure. Expert Opinion on Drug Metabolism and Toxicology,
    [10.1080/17425255.2016.1229303]
  • Rowland, A., Van Dyk, M., Mangoni, A.A., Miners, J.O., McKinnon, R.A., Wiese, M., et al. (2016). Kinase inhibitor pharmacokinetics: Comprehensive summary and roadmap for addressing inter-individual variability in exposure. Expert Opinion on Drug Metabolism and Toxicology,
    [10.1080/17425255.2016.1229303]
  • Rowland, E., Mangoni, A.A., Hopkins, A., Sorich, M. and Rowland, A. (2016). Optimized Cocktail Phenotyping Study Protocol Using Physiological Based Pharmacokinetic Modeling and In silico Assessment of Metabolic Drug–Drug Interactions Involving Modafinil. Frontiers in Pharmacology, 7 pp. Art: 517.
    [10.3389/fphar.2016.00517]
  • Sorich, M., Kichenadasse, G., Rowland, A., Woodman, R.J. and Mangoni, A.A. (2016). Angiotensin system inhibitors and survival in patients with metastatic renal cell carcinoma treated with VEGF targeted therapy: A pooled secondary analysis of clinical trials. International Journal of Cancer, 138 pp. 2293-2299.
    [10.1002/ijc.29972] [Scopus]
  • Sorich, M., Rowland, A., Kichenadasse, G., Woodman, R.J. and Mangoni, A.A. (2016). Risk factors of proteinuria in renal cell carcinoma patients treated with VEGF inhibitors: a secondary analysis of pooled clinical trial data. British Journal of Cancer, 114(12) pp. 1313-1317.
    [10.1038/bjc.2016.147] [Scopus]
  • Sotgia, S., Arru, D., Sotgiu, E., Mangoni, A.A., Forteschi, M., Pintus, G., et al. (2016). Simultaneous determination of the main amino thiol and thione in human whole blood by CE and LC. Bioanalysis, 8(9) pp. 945-951.
    [10.4155/bio-2015-0002] [Scopus]
  • Sotgia, S., Mangoni, A.A., Forteschi, M., Murphy, R.B., Elliot, D.J., Sotgiu, E., et al. (2016). Identification of the Main Intermediate Precursor of L-Ergothioneine Biosynthesis in Human Biological Specimens. Molecules, 21(10) pp. Art: 1298.
    [10.3390/molecules21101298]
  • Woodman, R.J., Wood, K.M., kunnel, A., Dedigama, M., Pegoli, M., Soiza, R.L., et al. (2016). Patterns of Drug Use and Serum Sodium Concentrations in Older Hospitalized Patients: A Latent Class Analysis Approach. Drugs - Real World Outcomes,
    [10.1007/s40801-016-0094-1]
  • Zinellu, A., Fois, A.G., Sotgia, S., Sotgiu, E., Zinellu, E., Bifulco, F., et al. (2016). Arginines Plasma Concentration and Oxidative Stress in Mild to Moderate COPD. PLoS One, 11(8) pp. Art: e0160237.
    [10.1371/journal.pone.0160237]
  • Zinellu, A., Fois, A.G., Sotgia, S., Zinellu, E., Bifulco, F., Pintus, G., et al. (2016). Plasma protein thiols: an early marker of oxidative stress in asthma and chronic obstructive pulmonary disease. EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, 46(2) pp. 181-188.
    [10.1111/eci.12582] [Scopus]
  • Zinellu, A., Sotgia, S., Mangoni, A.A., Sotgiu, E., Ena, S., Arru, D., et al. (2016). Effects of Ramipril and Telmisartan on Plasma Concentrations of Low Molecular Weight and Protein Thiols and Carotid Intima Media Thickness in Patients with Chronic Kidney Disease. DISEASE MARKERS, 2016 pp. Art: 1821596.
    [10.1155/2016/1821596]
  • Zinellu, A., Sotgia, S., Mangoni, A.A., Sotgiu, E., Ena, S., Satta, A.E., et al. (2016). Effect of cholesterol lowering treatment on plasma markers of endothelial dysfunction in chronic kidney disease. Journal of Pharmaceutical and Biomedical Analysis, 129 pp. 383-388.
    [10.1016/j.jpba.2016.07.025]
  • Rowland, A., Karapetis, C.S., Mangoni, A.A., Wiese, M., Kichenadasse, G., McKinnon, R.A., et al. (2016). Clinical translation of predictive markers for anti-EGFR monoclonal antibody therapy in metastatic colorectal cancer. Translational Cancer Research, 5(Suppl 1) pp. S31-S34.
    [10.21037/tcr.2016.05.19]
  • Alder, S., Caslake, R. and Mangoni, A.A. (2016). Practical advice for prescribing in old age. MEDICINE, 41(1) pp. 9-12.
    [10.1016/j.mpmed.2016.10.004] [Scopus]
  • Burt, M.G., Manglesdorf, B.L., Stranks, S.N. and Mangoni, A.A. (2016). Relationship between Vitamin D Status and Autonomic Nervous System Activity. Nutrients, 8(9) pp. Art: 565.
    [10.3390/nu8090565] [Scopus]
  • Da Boit, M., Sibson, R., Meakin, J.R., Aspden, R.M., Thies, F., Mangoni, A.A., et al. (2016). Sex differences in the response to resistance exercise training in older people. Physiological Reports, 4(12) pp. Art: e12834.
    [10.14814/phy2.12834]
  • Da Boit, M., Sibson, R., Sivasubramaniam, S., Meakin, J.R., Greig, C.A., Aspden, R.M., et al. (2016). Sex differences in the effect of fish oil supplementation on the adaptive response to resistance exercise training in older people: a randomized control trial. American Journal of Clinical Nutrition,
    [10.3945/ajcn.116.140780] [10.3945/ajcn.116.140780.]
  • Forteschi, M., Zinellu, A., Assaretti, S., Mangoni, A.A., Pintus, G., Carru, C., et al. (2016). An isotope dilution capillary electrophoresis/tandem mass spectrometry (CE-MS/MS) method for the simultaneous measurement of choline, betaine, and dimethylglycine concentrations in human plasma. Analytical and Bioanalytical Chemistry,
    [10.1007/s00216-016-9848-6] [Scopus]
  • Gabb, G.M., Mangoni, A.A., Anderson, C., Cowley, D., Dowden, J.S., Golledge, J., et al. (2016). Guideline for the diagnosis and management of hypertension in adults — 2016. MJA Medical Journal of Australia, 205(2) pp. 85-89.
    [10.5694/mja16.00526] [Scopus]
  • Grion, A.M., Gallo, U., Tinjala, D.D., Daragjati, J., Loreggian, M., Cardaci, G., et al. (2016). A New Computer-Based Tool to Reduce Potentially Inappropriate Prescriptions in Hospitalized Geriatric Patients. Drugs and Aging, 33(4) pp. 267-275.
    [10.1007/s40266-015-0340-3] [10.1007/s40266-015-0340-3.] [Scopus] [Web Link]
  • Mangoni, A.A. and Pilotto, A. (2016). New drugs and patient-centred end-points in old age: setting the wheels in motion. Expert Review of Clinical Pharmacology, 9(1) pp. 81-89.
    [10.1586/17512433.2016.1100074]
  • Mangoni, A.A., Kim, S.W., Hakendorf, P.H., Mayner, L. and Woodman, R.J. (2016). Heat Waves, Drugs with Anticholinergic Effects, and Outcomes in Older Hospitalized Adults. Journal of the American Geriatrics Society, 64(5) pp. 1091-1096.
    [10.1111/jgs.14100] [Scopus]
  • Mangoni, A.A. and Ruxton, K. (2016). Using patient-centered end-points in older adults participating in clinical trials. Geriatric Care, 2(5893) pp. 20-21.
    [10.4081/gc.2016.5893]
  • Zinellu, A., Sotgia, S., Scanu, B., Arru, D., Cossu, A., Posadino, A.M., et al. (2015). N- and S-homocysteinylation reduce the binding of human serum albumin to catechins. European Journal of Nutrition,
    [10.1007/s00394-015-1125-5] [Scopus]
  • Zinellu, A., Sotgia, S., Mangoni, A., Sanna, M., Satta, A. and Carru, C. (2015). Impact of cholesterol lowering treatment on plasma kynurenine and tryptophan concentrations in chronic kidney disease: relationship with oxidative stress improvement. Nutrition Metabolism and Cardiovascular Diseases,
    [10.1016/j.numecd.2014.11.004]
  • Van Dyk, M., Mangoni, A.A., McEvoy, M., Attia, J.R., Sorich, M. and Rowland, A. (2015). Targeted arginine metabolomics: A rapid, simple UPLC-QToF-MSE based approach for assessing the involvement of arginine metabolism in human disease. Clinica Chimica Acta, 447 pp. 59-65.
    [10.1016/j.cca.2015.05.014] [Scopus]
  • Tommasi, S., Zanato, C., Lewis, B.C., Nair, P.C., Dall'Angelo, S., Zanda, M., et al. (2015). Arginine analogues incorporating carboxylate bioisosteric functions are micromolar inhibitors of human recombinant DDAH-1. Organic and Biomolecular Chemistry, 13 pp. 11315-11330.
    [10.1039/C5OB01843A] [10.1039/c5ob01843a]
  • Baghdadi, L., Woodman, R., Shanahan, E. and Mangoni, A. (2015). The Impact of Traditional Cardiovascular Risk Factors on Cardiovascular Outcomes in Patients with Rheumatoid Arthritis: A Systematic Review and Meta-Analysis. PLoS One, 10(2) pp. Art: e0117952.
    [10.1371/journal.pone.0117952] [Scopus] [Web Link]
  • Ruxton, K., Woodman, R.J. and Mangoni, A.A. (2015). Drugs with anticholinergic effects and cognitive impairment, falls and all-cause mortality in older adults: A systematic review and meta-analysis. British Journal of Clinical Pharmacology, 80(2) pp. 209-220.
    [10.1111/bcp.12617]
  • Reeve, E., Wiese, M. and Mangoni, A. (2015). Alterations in drug disposition in older adults. Expert Opinion on Drug Metabolism and Toxicology, 11(4) pp. 491-508.
    [10.1517/17425255.2015.1004310] [Scopus] [Web Link]
  • Phillips, C., Chee, C.T., Eaton, V., Woodman, R.J. and Mangoni, A.A. (2015). Doctors' perspectives towards a bedside aminoglycoside therapeutic drug monitoring service: a collaboration between pharmacy and clinical pharmacology. Journal of Pharmacy Practice and Research, 45(2) pp. 159-165.
    [10.1002/jppr.1079] [Web Link]
  • Tommasi, S., Zanato, C., Carabeo, R., Mangoni, A.A., Dall'Angelo, S. and Zanda, M. (2015). An Efficient Route to N-Monosubstituted Guanidino-Lactams. SYNTHESIS-STUTTGART, 47(16)
    [10.1055/s-0034-1378845] [Scopus] [Web Link]
  • Kouladjian, L., Gnjidic, D., Chen, T., Mangoni, A. and Hilmer, S. (2014). Drug Burden Index in older adults: theoretical and practical issues. Clinical Interventions in Aging, 9 pp. 1503-1515.
    [10.2147/CIA.S66660] [Scopus]
  • McEvoy, M., Schofield, P., Smith, W., Agho, K., Mangoni, A., Soiza, R., et al. (2014). Memory impairment is associated with serum methylarginines in older adults. Current Alzheimer Research, 11(1) pp. 97-106.
    [10.2174/15672050113106660178] [Scopus]
  • Rowland, A. and Mangoni, A. (2014). Cytochrome P450 and ischemic heart disease: current concepts and future directions. Expert Opinion on Drug Metabolism and Toxicology, 10(2) pp. 191-213.
    [10.1517/17425255.2014.859675] [Scopus]
  • Sotgia, S., Zinellu, A., Mangoni, A., Pinto, G., Attia, J., Carru, C., et al. (2014). Clinical and Biochemical Correlates of Serum L-Ergothioneine Concentrations in Community-Dwelling Middle-Aged and Older Adults. PLoS One, 9(1) pp. e84918.
    [10.1371/journal.pone.0084918] [Scopus]
  • Sumukadas, D., McMurdo, M., Mangoni, A. and Guthrie, B. (2014). Temporal trends in anticholinergic medication prescription in older people: repeated cross-sectional analysis of population prescribing data. Age and Ageing, 43(4) pp. 515-521.
    [10.1093/ageing/aft199] [Scopus] [Web Link]
  • Tay, H., Soiza, R. and Mangoni, A. (2014). Minimizing anticholinergic drug prescribing in older hospitalized patients: a full audit cycle. Therapeutic Advances in Drug Safety, 5(3) pp. 121-128.
    [10.1177/2042098614523638] [Scopus] [Web Link]
  • Asif, M., Soiza, R., McEvoy, M. and Mangoni, A.A. (2013). Asymmetric Dimethylarginine: A Possible Link between Vascular Disease and Dementia. Current Alzheimer Research, 10(4) pp. 347-356.
    [10.2174/1567205011310040001] [Scopus]
  • Bostock, C., Soiza, R. and Mangoni, A. (2013). Associations between different measures of anticholinergic drug exposure and Barthel Index in older hospitalized patients. Therapeutic Advances in Drug Safety, 4(6) pp. 235-245.
    [10.1177/2042098613500689] [Scopus]
  • Bouteldja, N., Woodman, R., Hewitson, C., Domingo, E., Barbara, J. and Mangoni, A. (2013). Methylated arginines and nitric oxide in end-stage renal disease: impact of inflammation, oxidative stress and haemodialysis. Biomarkers, 18(4) pp. 357-364.
    [10.3109/1354750X.2013.795608] [Scopus] [Web Link]
  • Crilly, M., Mangoni, A. and Knights, K. (2013). Aldosterone glucuronidation inhibition as a potential mechanism for arterial dysfunction associated with chronic celecoxib and diclofenac use in patients with rheumatoid arthritis. Clinical and Experimental Rheumatology, 31(5) pp. 691-698.
    [Scopus] [Web Link]
  • Greig, M., Rochow, S., Crilly, M. and Mangoni, A.A. (2013). Routine pharmacological venous thromboembolism prophylaxis in frail older hospitalised patients: where is the evidence? Age and Ageing, 42(4) pp. 428-434.
    [10.1093/ageing/aft041] [Scopus]
  • Jarchow-Macdonald, A.A. and Mangoni, A.A. (2013). Prescribing patterns of proton pump inhibitors in older hospitalized patients in a Scottish health board. Geriatrics and Gerontology International, 13(4) pp. 1002-1009.
    [10.1111/ggi.12047] [Scopus]
  • McEvoy, M.A., Schofield, P.W., Smith, W.T., Agho, K., Mangoni, A.A., Soiza, R.L., et al. (2013). Serum Methylarginines and Spirometry-Measured Lung Function in Older Adults. PLoS One, 8(5) pp. e58390.
    [10.1371/journal.pone.0058390] [Scopus]
  • Mangoni, A., Zinellu, A., Carru, C., Attia, J. and McEvoy, M. (2013). Transsulfuration Pathway Thiols and Methylated Arginines: The Hunter Community Study. PLoS One, 8(1) pp. e54870.
    [10.1371/journal.pone.0054870] [Scopus]
  • Mangoni, A., van Munster, B., Woodman, R. and de Rooij, S. (2013). Measures of Anticholinergic Drug Exposure, Serum Anticholinergic Activity, and All-cause Postdischarge Mortality in Older Hospitalized Patients With Hip Fractures. American Journal of Geriatric Psychiatry, 21(8) pp. 785-793.
    [10.1016/j.jagp.2013.01.012] [Scopus]
  • Mangoni, A.A., Jansen, P. and Jackson, S. (2013). Under-representation of older adults in pharmacokinetic and pharmacodynamic studies: A solvable problem? Expert Review of Clinical Pharmacology, 6(1) pp. 35-39.
    [10.1586/ecp.12.75] [Scopus]
  • Mangoni, A.A., Zinellu, A., Carru, C., Attia, J. and McEvoy, M. (2013). Serum thiols and cardiovascular risk scores: a combined assessment of transsulfuration pathway components and substrate/product ratios. Journal of Translational Medicine, 11(1) pp. 99.
    [10.1186/1479-5876-11-99] [Scopus]
  • McEvoy, M., Schofield, P., Smith, W., Agho, K., Mangoni, A.A., Soiza, R., et al. (2013). Serum methylarginines and incident depression in a cohort of older adults. Journal of Affective Disorders, 151(2) pp. 493-499.
    [10.1016/j.jad.2013.06.033] [Scopus]
  • Mangoni, A., Stockley, C. and Woodman, R. (2013). Effects of red wine on established markers of arterial structure and function in human studies: current knowledge and future research directions. Expert Review of Clinical Pharmacology, 6(6) pp. 613-625.
    [10.1586/17512433.2013.841077] [Scopus]
  • Hamzat, H., Sun, H., Ford, J., Macleod, J., Soiza, R. and Mangoni, A.A. (2012). Inappropriate prescribing of proton pump inhibitors in older patients. Drugs and Aging, 29(8) pp. 681-690.
    [10.1007/BF03262283] [Scopus]
  • Head, G., McGrath, B., Mihailidou, A., Nelson, M., Schlaich, M., Stowasser, M., et al. (2012). Ambulatory blood pressure monitoring in Australia: 2011 consensus position statement. Journal of Hypertension, 30(2) pp. 253-266.
    [10.1097/HJH.0b013e32834de621] [Scopus]
  • Mangoni, A.A. (2012). Predicting and detecting adverse drug reactions in old age: challenges and opportunities. Expert Opinion on Drug Metabolism and Toxicology, 8(5) pp. 527-530.
    [10.1517/17425255.2012.665874] [Scopus]
  • Lowry, E., Woodman, R., Soiza, R., Hilmer, S. and Mangoni, A. (2012). Drug Burden Index, Physical Function, and Adverse Outcomes in Older Hospitalized Patients. Journal of Clinical Pharmacology, 52(10) pp. 1584-1591.
    [10.1177/0091270011421489] [Scopus]
  • Koshoedo, S., Soiza, R., Purkayastha, R. and Mangoni, A.A. (2012). Anticholinergic drugs and functional outcomes in older patients undergoing orthopaedic rehabilitation. American Journal of Geriatric Pharmocotherapy, 10(4) pp. 251-257.
    [10.1016/j.amjopharm.2012.06.003] [Scopus]
  • Jackson, S., Jansen, P. and Mangoni, A.A. (2012). Off-label prescribing in older patients. Drugs and Aging, 29(6) pp. 427-434.
    [10.2165/11633520-000000000-00000] [Scopus]
  • Crilly, M. and Mangoni, A. (2011). Non-steroidal anti-inflammatory drug (NSAID) related inhibition of aldosterone glucuronidation and arterial dysfunction in patients with rheumatoid arthritis: a cross-sectional clinical study. BMJ Open, 1(1) pp. e000076.
    [10.1136/bmjopen-2011-000076] [Scopus]
  • Head, G., McGrath, B., Mihailidou, A., Nelson, M., Schlaich, M., Stowasser, M., et al. (2011). Ambulatory blood pressure monitoring. Australian Family Physician, 40(11) pp. 877-880.
    [Scopus] [Web Link]
  • Jarmuzewska, E. and Mangoni, A.A. (2011). Electrophysiological and clinical study of type-2 diabetic patients with short duration of disease and normal generalized nerve conductions. Panminerva Medica, 53(1) pp. 1-11.
    [Scopus] [Web Link]
  • Lowry, E., Woodman, R., Soiza, R. and Mangoni, A.A. (2011). Clinical and demographic factors associated with antimuscarinic medication use in older hospitalized patients. Hospital Practice, 39(1) pp. 30-36.
    [10.3810/hp.2011.02.371]
  • Thanigaimani, S., Kichenadasse, G. and Mangoni, A.A. (2011). The Emerging Role of Vascular Endothelial Growth Factor (VEGF) in Vascular Homeostasis: Lessons from Recent Trials with Anti-VEGF Drugs. Current Vascular Pharmacology, 9 pp. 358-380.
    [10.2174/157016111795495503] [Scopus]
  • Nguyen, N.Q., Grgurinovich, N., Bryant, L.K., Burgstad, C., Chapman, M., Holloway, R.H., et al. (2011). Plasma erythromycin concentrations predict feeding outcomes in critically ill patients with feed intolerance. Critical Care Medicine, 39(4) pp. 868-871.
    [10.1097/CCM.0b013e318206d57b] [Scopus]
  • Mangoni, A.A., Crilly, M. and Knights, K. (2011). Cardiovascular toxicity of nonsteroidal anti-inflammatory drugs: Moving beyond cyclooxygenase selectivity. Expert Review of Clinical Pharmacology, 4(3) pp. 299-302.
    [10.1586/ecp.11.12] [Scopus]
  • Mangoni, A.A. (2011). Assessing the adverse effects of antimuscarinic drugs in older patients: Which way forward? Expert Review of Clinical Pharmacology, 4(5) pp. 531-533.
    [10.1586/ecp.11.44] [Scopus]
  • Mangoni, A. and Knights, K. (2011). Farmaci antinfiammatori non steroidei e rischio di ictus nell'età  avanzata: controversie e opportunità  (Non-steroidal anti-inflammatory drugs and risk of stroke in older patients: current controversies and research directions) Giornale Italiano Di Cardiologia (Italian Journal of Cardiology) 12(5) pp. 341-349.
    [10.1714/643.7499] [Scopus]
  • Lowry, E., Woodman, R.J., Soiza, R.L. and Mangoni, A.A. (2011). Associations Between the Anticholinergic Risk Scale Score and Physical Function: Potential Implications for Adverse Outcomes in Older Hospitalized Patients. Journal of the American Medical Directors Association, 12(8) pp. 565-572.
    [10.1016/j.jamda.2011.03.006] [Scopus]
  • Bostock, C.V., Soiza, R.L. and Mangoni, A.A. (2010). Association between prescribing of antimuscarinic drugs and antimuscarinic adverse effects in older people. Expert Review of Clinical Pharmacology, 4 pp. 441-452.
    [10.1586/ecp.10.34] [Scopus]
  • Head, G., Mahailidou, A.S., Duggan, K., Beilin, L.J., Berry, N.M., Brown, M.A., et al. (2010). Definition of ambulatory blood pressure targets for diagnosis and treatment of hypertension in relation to clinic blood pressure: prospective cohort study. British Medical Journal, 340(c1104)
    [10.1136/bmj.c1104] [Scopus]
  • Paul, B., Whiting, M.J., De Pasquale, C.G. and Mangoni, A.A. (2010). Acute effects of 5-methyltetrahydrofolate on endothelial function and asymmetric dimethylarginine in patients with chronic heart failure. Nutrition Metabolism and Cardiovascular Diseases, 20(5) pp. 341-349.
    [10.1016/j.numecd.2009.04.008] [Scopus]
  • Mangoni, A.A., Woodman, R.J., Gilbert, A. and Knights, K.M. (2010). Use of non-steroidal anti-inflammatory drugs and risk of ischemic and hemorrhagic stroke in the Australian veteran communtiy. Pharmacoepidemiology and Drug Safety, 19(5) pp. 490-498.
    [10.1002/pds.1945] [Scopus]
  • Mangoni, A.A., Woodman, R.J., Gaganis, P., Gilbert, A. and Knights, K.M. (2010). Use of non-steroidal anti-inflammatory drugs and risk of incident myocardial infarction and heart failure, and all-cause mortality in the Australian veteran community. British Journal of Clinical Pharmacology, 69(6) pp. 689-700.
    [10.1111/j.1365-2125.2010.03627.x] [Scopus]
  • Mangoni, A.A., Reid, D.M. and Knights, K.M. (2010). Non-steroidal anti-inflammatory drugs and atherothrombotic risk in older patients: where do we stand? Age and Ageing, 39 pp. 530-533.
    [10.1093/ageing/afq099] [Scopus]
  • Knights, K.M., Mangoni, A.A. and Miners, J.O. (2010). Defining the COX inhibitor selectivity of NSAIDS: implications for understanding toxicity. Expert Review of Clinical Pharmacology, 3(6) pp. 769-776.
    [10.1586/ECP.10.120] [10.1586/ecp.10.120] [Scopus]
  • Wadham, C. and Mangoni, A.A. (2009). Dimethylarginine dimethylaminohydrolase regulation: a novel therapeutic target in cardiovascular disease. Expert Opinion on Drug Metabolism and Toxicology, 5(3) pp. 303-319.
    [10.1517/17425250902785172] [Scopus]
  • Paul, B., Hewitson, C.L., Woodman, R.J. and Mangoni, A.A. (2009). Analysis of short-term reproducibility of arterial vasoreactivity by pulse-wave analysis after pharmacological challenge. Clinical and Experimental Pharmacology and Physiology, 36(1) pp. 49-54.
    [10.1111/j.1440-1681.2008.05033.x] [Scopus]
  • Parasca, A., Doogue, M.P., Woodman, R.J. and Mangoni, A.A. (2009). Hypoalbuminaemia and impaired renal function are associated with increased anticholinergic drug prescribing. International Journal of Clinical Practice, 63(7) pp. 1110-1114.
    [10.1111/j.1742-1241.2009.02067.x] [Scopus] [Web Link] [Web Link]
  • Jarmuzewska, E., Rocchi, R., Guidoni, A. and Mangoni, A.A. (2008). ACE inhibitor-based treatment and antihypertensive effects in patients with type 2 diabetes. Panminerva Medica, 50(3) pp. 207-216.
    [Scopus] [Web Link]
  • Mangoni, A.A. and Jackson, S.H. (2008). Vascular risk factors and Dementia. CME Geriatric Medicine, 10(1) pp. 8-13.
    [Scopus]
  • Mangoni, A.A., Hewitson, C.L., Woodman, R.J., Whiting, M.J., McAteer-Carr, B. and Barbara, J.A.J. (2008). Symmetric dimethylarginine is an independent predictor of intradialytic hypotension. American Journal of Hypertension, 21(8) pp. 955-959.
    [10.1038/ajh.2008.214] [Scopus]
  • Perry, R., Joseph, M., De Pasquale, C.G., Chew, D.P., Yiu, D., Aylward, P.E., et al. (2008). High-resolution transthoracic echocardiography of the left anterior descending coronary artery: a novel noninvasive assessment of coronary vasoreactivity. Journal of The American Society of Echocardiography, 21(2) pp. 134-138.
    [10.1016/j.echo.2007.05.019] [Scopus]
  • Tochihara, Y., Whiting, M.J., Barbara, J.A.J. and Mangoni, A.A. (2008). Effects of pre- vs. intra-dialysis folic acid on arterial wave reflections and endothelial function in patients with end-stage renal disease. British Journal of Clinical Pharmacology, 66(5) pp. 717-722.
    [10.1111/j.1365-2125.2008.03262.x] [Scopus]
  • Nguyen, N., Mangoni, A., Fraser, R., Chapman, M., Bryant, L., Burgstad, C., et al. (2007). Prokinetic therapy with erythromycin has no significant impact on blood pressure and heart rate in critically ill patients. British Journal of Clinical Pharmacology, 63(4) pp. 498-500.
    [10.1111/j.1365-2125.2006.02772.x] [Scopus]
  • Jarmuzewska, E., Ghidoni, A. and Mangoni, A.A. (2007). Hypertension and Sensorimotor Peripheral Neuropathy in type 2 diabetes. European Neurology, 57(2) pp. 91-95.
    [10.1159/000098058] [Scopus]
  • Hewitson, C.L., Whiting, M.J., Barbara, J.A.J. and Mangoni, A.A. (2007). Acute effects of haemodialysis on biochemical modulators of endothelial function. Journal of Internal Medicine, 262(5) pp. 571-580.
    [10.1111/j.1365-2796.2007.01848.x] [Scopus]
  • Ellington, C.M., Grgurinovich, N., Miners, J.O. and Mangoni, A.A. (2007). Quality of requests for serum digoxin concentrations: experience from an Australian Regional Health Service. British Journal of Clinical Pharmacology, 63(5) pp. 623-627.
    [10.1111/j.1365-2125.2006.02802.x] [Scopus]
  • Paul, B., Gieroba, Z. and Mangoni, A.A. (2007). Influence of comorbidities and medication use on tilt table test outcome in elderly patients. Pace-Pacing and Clinical Electrophysiology, 30(4) pp. 540-543.
    [10.1111/j.1540-8159.2007.00705.x] [Scopus]
  • To, T., Spurling, L., Mangoni, A.A. and Eaton, V. (2007). Using personal digital assistants for a pharmacist intervention monitoring database: cost analysis. Journal of Pharmacy Practice and Research, 37(1) pp. 30-32.
    [Scopus] [Web Link]
  • Dhesi, J.K., Allain, T.J., Mangoni, A.A. and Jackson, S.H.D. (2006). The implications of a growing evidence base for drug use in elderly patients. Part 4. Vitamin D and bisphosphonates for fractures and osteoporosis. British Journal of Clinical Pharmacology, 61(5) pp. 521-528.
    [10.1111/j.1365-2125.2006.02612.x] [Scopus]
  • Hart, S.R., Mangoni, A.A., Swift, C.G. and Jackson, S.H. (2006). Effect of methionine loading on pulse wave analysis in elderly volunteers. Postgraduate Medical Journal, 82(970) pp. 524-527.
    [10.1136/pgmj.2005.044610] [Scopus]
  • Hart, S.R., Mangoni, A.A., Swift, C.G. and Jackson, S.H. (2006). Lack of Significant Effects of Methionine Loading on Endothelial Function in Elderly Volunteers. Heart, Lung and Circulation, 15(6) pp. 358-361.
    [10.1016/j.hlc.2006.08.001] [Scopus]
  • Jarmuzewska, E.A., Rocchi, R. and Mangoni, A.A. (2006). Predictors of impaired blood pressure homeostasis during acute and sustained orthostasis in patients with type 2 diabetes. Panminerva Medica, 48(1) pp. 67-72.
    [Scopus]
  • Knights, K.M., Mangoni, A.A. and Miners, J.O. (2006). Non-selective nonsteroidal anti-inflammatory drugs and cardiovascular events: is aldosterone the silent partner in crime? British Journal of Clinical Pharmacology, 61(6) pp. 738-740.
    [10.1111/j.1365-2125.2006.02678.x] [Scopus]
  • Yiu, D., Gieroba, Z., Hall, K.L., Mackintosh, S., Russell, A.E. and Mangoni, A.A. (2006). An early drop in systolic blood pressure predicts a positive tilt table test in elderly patients with unexplained falls or syncope. Age and Ageing, 35(2) pp. 183-185.
    [10.1093/ageing/afj043] [Scopus]
  • Pathansali, R., Mangoni, A.A., Creagh-Brown, B., Lan, Z.C., Ngow, G.L., Yuan, X.F., et al. (2006). Effects of folic acid supplementation on psychomotor performance and hemorheology in healthy elderly subjects. Archives of Gerontology and Geriatrics, 43(1) pp. 127-137.
    [10.1016/j.archger.2005.10.002] [Scopus]
  • Mangoni, A.A. and Jackson, S.H.D. (2006). The implications of a growing evidence base for drug use in elderly patients. Part 3. Beta-adrenoceptor blockers in heart failure and thrombolytics in acute myocardial infarction. British Journal of Clinical Pharmacology, 61(5) pp. 513-520.
    [10.1111/j.1365-2125.2006.02611.x] [Scopus]
  • Mangoni, A.A. and Jackson, S.H. (2006). The implications of a growing evidence base for drug use in elderly patients. Part 2. ACE inhibitors and angiotension receptor blockers in heart failure and high cardiovascular risk patients. British Journal of Clinical Pharmacology, 61(5) pp. 502-512.
    [10.1111/j.1365-2125.2006.02610.x] [Scopus]
  • Mangoni, A.A. and Jackson, S.H. (2006). The implications of a growing evidence base for drug use in elderly patients. Part 1. Statins for primary and secondary cardiovascular prevention. British Journal of Clinical Pharmacology, 61(5) pp. 494-501.
    [10.1111/j.1365-2125.2006.02609.x] [Scopus]
  • Mangoni, A.A. (2006). Folic acid, inflammation, and atherosclerosis: False hopes or the need for better trials? Clinica Chimica Acta, 367(1-2) pp. 11-19.
    [10.1016/j.cca.2005.11.016] [Scopus]
  • Mangoni, A.A. (2006). Endothelial Function and Cardiovascular Disease: The Role of Folic Acid. Letters in Drug Design and Discovery, 3(2) pp. 112-117.
    [10.2174/157018006775789784] [Scopus]
  • Mangoni, A.A., Sherwood, R.A., Asonganyi, B., Swift, C.G., Thomas, S. and Jackson, S.H. (2005). Short-term oral folic acid supplementation enhances endothelial function in patients with type 2 diabetes. American Journal of Hypertension, 18(2) pp. 220-226.
    [10.1016/j.amjhyper.2004.08.036] [Scopus]
  • Jarmuzewska, E. and Mangoni, A.A. (2005). Pulse pressure is independently associated with sensorimotor peripheral neuropathy in patients with type 2 diabetes. Journal of Internal Medicine, 258(1) pp. 38-44.
    [10.1111/j.1365-2796.2005.01500.x] [Scopus]
  • Mangoni, A.A. (2005). Cardiovascular Drug Therapy in Elderly Patients : Specific age-related pharmacokinetic, pharmacodynamic and therapeutic considerations. Drugs and Aging, 22(11) pp. 913-941.
    [10.2165/00002512-200522110-00003] [Scopus]
  • Mangoni, A.A. and Jackson, S.H. (2004). Age-related changes in pharmacokinetics and pharmacodynamics: basic principles and practical applications. British Journal of Clinical Pharmacology, 57(1) pp. 6-14.
    [10.1046/j.1365-2125.2003.02007.x] [Scopus]
  • Ford, G.A., Bryant, C.A., Mangoni, A.A. and Jackson, S.H. (2004). Stroke, dementia, and drug delivery. British Journal of Clinical Pharmacology, 57(1) pp. 15-26.
    [10.1046/j.1365-2125.2003.01939.x] [Scopus]
  • Mangoni, A.A., Kinirons, M.T., Swift, C.G. and Jackson, S.H. (2003). Impact of age on QT interval and QT dispersion in healthy subjects: a regression analysis. Age and Ageing, 32(3) pp. 326-331.
    [10.1093/ageing/32.3.326] [Scopus]
  • Mangoni, A.A., Ouldred, E.L., Allain, T.J., Close, J.C., Hilton, D., Swift, C.G., et al. (2003). Paradoxical Vasodilation During Lower Body Negative Pressure in Patients with Vasodepressor Carotid Sinus Syndrome. Journal of the American Geriatrics Society, 51(6) pp. 853-857.
    [10.1046/j.1365-2389.2003.51269.x] [Scopus]
  • Mangoni, A.A., Arya, R., Ford, E., Asonganyi, B., Sherwood, R.A., Ouldred, E.L., et al. (2003). Effects of folic acid supplementation on inflammatory and thrombogenic markers in chronic smokers. A randomised controlled trial. Thrombosis Research, 110(1) pp. 13-17.
    [10.1016/S0049-3848(03)00295-0] [Scopus]
  • Mangoni, A.A. and Jackson, S.H. (2003). Antihypertensive treatment and the prevention of stroke and dementia in elderly patients. British Journal of Cardiology, 10(1) pp. HB 15-HB 19.
  • Manyemba, J., Mangoni, A.A., Pettingale, K.W. and Jackson, S.H. (2003). Determinants of failure to prescribe target doses of angiotensin-converting enzyme inhibitors for heart failure. European Journal of Heart Failure, 5(5) pp. 693-696.
    [10.1016/S1388-9842(03)00055-2] [Scopus]
  • Moore, A., Mangoni, A.A., Lyons, D. and Jackson, S.H. (2003). The cardiovascular system in the ageing patient. British Journal of Clinical Pharmacology, 56(3) pp. 254-260.
    [10.1046/j.0306-5251.2003.01876.x] [Scopus]
  • Legos, J.J., Mangoni, A.A., Read, S.J., Campbell, C.A., Irving, E.A., Roberts, J., et al. (2002). Programmable microchip monitoring of post-stroke pyrexia: effects of aspirin and paracetamol on temperature and infarct size in the rat. Journal of Neuroscience Methods, 113(2) pp. 159-166.
    [10.1016/S0165-0270(01)00488-5] [Scopus]
  • Mangoni, A.A. and Jackson, S.H. (2002). Homocysteine and cardiovascular disease: Current evidence and future prospects . American Journal of Medicine, 112(7) pp. 556-565.
    [10.1016/S0002-9343(02)01021-5] [Scopus] [Web Link]
  • Mangoni, A.A., Koelling, T.M., Meyer, G.S., Akins, C.W. and Fifer, M.A. (2002). Outcome following mitral valve replacement in patients with mitral stenosis and moderately reduced left ventricular ejection fraction. European Journal of Cardio-Thoracic Surgery, 22(1) pp. 90-94.
    [10.1016/S1010-7940(02)00218-X] [Scopus]
  • Mangoni, A.A., Sherwood, R.A., Swift, C.G. and Jackson, S.H. (2002). Folic acid enhances endothelial function and reduces blood pressure in smokers: a randomized controlled trial. Journal of Internal Medicine, 252(6) pp. 497-503.
    [10.1046/j.1365-2796.2002.01059.x] [Scopus]
  • Mangoni, A.A., DiSalvo, T.G., Vlahakes, G.J., Polanczyk, C.A. and Fifer, M.A. (2001). Outcome following isolated tricuspid valve replacement. European Journal of Cardio-Thoracic Surgery, 19(1) pp. 68-73.
    [10.1016/S1010-7940(00)00598-4] [Scopus]
  • Woodman, R.J., Baghdadi, L.R., Shanahan, E.M. and Mangoni, A.A. (2017). The Temporal Relationship between Arterial Stiffening and Blood Pressure Is Modified by Methotrexate Treatment in Patients with Rheumatoid Arthritis. Frontiers in Physiology, 8 pp. Art: 593.
    [10.3389/fphys.2017.00593]
  • Tommasi, S., Elliot, D.J., Hulin, J.A., Lewis, B.C., McEvoy, M. and Mangoni, A.A. (2017). Human dimethylarginine dimethylaminohydrolase 1 inhibition by proton pump inhibitors and the cardiovascular risk marker asymmetric dimethylarginine: in vitro and in vivo significance. Scientific Reports, 7(1) pp. Art:03069.
    [10.1038/s41598-017-03069-1] [Scopus]
  • Sotgia, S., Mangoni, A.A., Pintus, G., Carru, C. and Zinellu, A. (2017). Strategies to enhance graphic and results interpretation of a regression-based approach for method comparison studies. Future Science OA,
    [10.4155/fsoa-2017-0004]
  • Rowland, A., Van Dyk, M., Mangoni, A.A., Miners, J.O., McKinnon, R.A., Wiese, M.D., et al. (2017). Kinase inhibitor pharmacokinetics: comprehensive summary and roadmap for addressing interindividual variability in exposure. Expert Opinion on Drug Metabolism and Toxicology, 13(1) pp. 31-49.
    [10.1080/17425255.2016.1229303] [Scopus]
  • Munoz-Torrero, D., Mangoni, A.A., guillou, C., Collina, S., Vanden Eynde, J.J., Rautio, J., et al. (2017). Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes. Molecules, 22(5) pp. Art: 743.
    [10.3390/molecules22050743] [Scopus]
  • Wilsdon, T., Hendrix, I., Thynne, T.R. and Mangoni, A.A. (2017). Effectiveness of Interventions to Deprescribe Inappropriate Proton Pump Inhibitors in Older Adults. Drugs and Aging,
    [10.1007/s40266-017-0442-1] [Scopus]
  • Mangoni, A.A., Zinellu, A., Sotgia, S., Rowland, A. and Carru, C. (2016). Methylated Arginines as Biomarkers in Renal Disease. In VB Patel and VR Preedy, ed. Biomarkers in Kidney Disease. Netherlands: Springer Science, pp. 1-30.
    [10.1007/978-94-007-7743-9_19-1]
  • Mangoni, A.A., Ruxton, K., Mislang, A. and Biganzoli, L. (2016). Chronic Conditions and Cancer in Older Adults. In Bogda Koczwara, ed. Cancer and Chronic Conditions: Addressing the Problem of Multimorbidity in Cancer Patients and Survivors. Singapore: Springer, pp. 421-454.
    [10.1007/978-981-10-1844-2] [10.1007/978-981-10-1844-2_14]
  • Mangoni, A.A., Jansen, P. and Jackson, S.H. (2015). Pharmacokinetic and pharmacodynamic studies in older adults. In Antonio Cherubini, Roberto Bernabei, Luigi Ferrucci, Niccolò Marchionni, Stephanie Studenski, Bruno Vellas, ed. Clinical Trials in Older Adults. West Sussex, United Kingdom: John Wiley and Sons, pp. 79-94.
    [Web Link]
  • Mangoni, A.A. (2009). The emerging role of symmetric dimethylarginine in vascular disease. In Gregory Makowski, ed. Advances in Clinical Chemistry. Burlington: Academic Press, pp. 73-94.
    [10.1016/S0065-2423(09)48003-X] [Scopus]

Professional and community engagement


Editor-in-Chief: Therapeutic Advances in Drug Safety
Associate Editor: Age & Ageing
Review Editor: British Journal of Clinical Pharmacology
Executive Member of the National Blood Pressure and Vascular Disease Advisory Committee: review and update of Australian Hypertension Guidelines
SIGN (Scottish Intercollegiate Guidelines Network) Working Group: Management of Chronic Pain
Clinical Pharmacology Consultant for Bellberry Human Research Ethics Committee


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