Position

Associate Professor
Biological Sciences

Biography

Dr Abbott received her Ph.D from the University of Sydney in 1997 during which she cloned and sequenced the gene for the protease dipeptidyl peptidase 4 (DPP4) in the pre- human genome era. Her discovery of the protease homologues, DPP8 and DPP9 during her post-doctoral studies at the Centenary Institute, Sydney was pivotal to translating selective DPP4 inhibitors such as Sitagliptin safely from the laboratory to the clinic for the treatment of Type 2 diabetes. In 2001, she moved to the School of Biological Sciences, Flinders University, where she has maintained her passion for this family working on their structure and function using DPP inhibitors and DPP substrate discovery to study the role of these proteases in diseases such as cancer, inflammation and metabolism. She is internationally recognized as an expert in the DPP field and is a member of the Flinders Centre for Innovation in Cancer.

Qualifications

BSc, University of Adelaide 1986
PhD, University of Sydney 1997

Graduate Diploma in Education ( Higher Education), Flinders University 2015

Honours, awards and grants

1981 represented the N.T in the National Capital Seminar sponsored by the Queen Elizabeth Silver Jubilee Trust.

1989 awarded Queen Elizabeth Silver Jubilee Trust for Young Australians Scholarship to work in Netherlands

1990 awarded Institute of Molecular Pathology Travel Grant

1990 awarded NATO Travel Grant

1994 awarded Queen Elizabeth Silver Jubilee Trust for Young Australians Scholarship travel grant

1996 awarded Glaxo/Gastroenterological Society of Australia Travel Award

1999 awarded Pharmacia Upjohn/Gastroenterological Society of Australia Senior Travel Award

2006 awarded Australian Academy of Sciences North American Travel Award.

Key responsibilities

Memberships of Boards and other duties

  • Bioinformatics Australia Board 2004-2010

Member of the following societies

  • Gastroenterological Society of Australia 1993-2010
  • Australian Society for Biochemistry and Molecular Biology 1997-2013
  • Australian Society for Medical Research 2002-2010
    • member of State Branch Committee 2002-2005
    • co-convenor of the 2002 State Branch Conference
    • member of the program committee 2003 National conference
  • International Proteolysis Society (IPS) 2001-2016
  • International Society of Computational Biology (ISCB) 2001-2006
  • Australian Society for Medical Research 2002-2016
    • member of ISCB Education Committee
  • AusBiotech-Bioinformatics Australia 2004-2010

Teaching interests

  • Bioinformatics
  • Molecular Biology
  • Molecular Cell Biology
  • Functional Genomics

Topic Coordinator:

Topic Lecturer:

Research expertise

  • Biochemistry and cell biology
  • Clinical sciences
  • Oncology and carcinogenesis

Research interests

My current research mainly focuses on a family of peptidases that are interesting due their heightened expression by activated cells, particularly T cells and hepatic stellate cells, their involvement in cell-extracellular matrix (ECM) interactions and their roles in leukocyte chemotaxis, T cell proliferation, HIV infection and tumor growth (McCaughan et al 2000).

Dipeptidyl Peptidase IV (DPIV)/CD26 is a multifunctional protein which has three unique biological functions (1) an enzyme activity (2) binding to adenosine deaminase (ADA) and (3) T cell activation. The expression of DPIV on the lymphocyte surface is important for lymphocyte function and in the pathogenesis of the human immunodeficiency virus (HIV). Other DPIV-like proteins, with significant sequence homology have been cloned: DP6, DP10 DP8, DP9 and fibroblast activation protein (FAP). The DP6 and DP10 proteins are expressed in the brain and are thought to be involved in signalling processes. FAP has been shown to be important in the pathogenesis of both cancer and cirrhosis of the liver. The identification of these molecules suggests the existence of a highly specialised DPIV-like gene family in which members will probably share gene structure, three-dimensional protein structure and perhaps functions.

Research projects in this lab will involve the examination of the role of these DP8, DP9 and DP10 in human disease.

Long term Goal of this research: The discovery of novel DPIV-like genes will lead to increased understanding of the role of this emerging family in the immune system and in disease pathogenesis. In addition, the discovery of new genes may lead to new targets and inhibitor based therapies for the treatment of such diseases as diabetes, obesity, cancer, inflammatory bowel disease and Alzheimer's Disease.

Supervisory interests

  • Alzheimer's disease
  • Cancer biology
  • Dipeptidyl peptidases
  • Marine bioprospecting

RHD research supervision

Completion

Principal supervisor : Dicathias Orbita Transcriptomics (1) ; dipeptidyl peptidases (6) ; Cancer Biology (4) ;

Publications

  • Donato, R., El-Merhibia, A., Gundsambuua, B., Maka, K., Formosaa, E., Wang, X., et al. (2011). Studying permeability in a commonly used epithelial cell line: T84 intestinal epithelial cells. In Kursal Tursken, ed. Permeability Barrier. New York, USA: Humana Press, pp. 115-137.
    [10.1007/978-1-61779-191-8_8] [Scopus]
  • Pitman, M.R., Menz, I.I. and Abbott, C.A. (2006). Prediction of dipeptidyl peptidase (DP) 8 structure by homology modelling. In Uwe Lendeckel, Dirk Reinhold, Ute Bank, ed. Advances in Experimental Medicine and Biology. USA: Springer, pp. 33-45.
    [10.1007/0-387-32824-6-4] [Scopus]
  • Abbott, C.A., Yazbeck, R., Geier, M.S., Demuth, H.U. and Howarth, G.S. (2006). Dipeptidyl peptidases and inflammatory bowel disease. In Uwe Lendeckel, Dirk Reinhold, Ute Bank, ed. Advances in Experimental Medicine and Biology. USA: Springer, pp. 155-162.
    [10.1007/0-387-32824-6_16] [Scopus]
  • Sulda, M.L., Abbott, C.A. and Hildebrandt, M. (2006). DPIV/CD26 and FAP in cancer: a tale of contradictions. In Uwe Lendeckel, Dirk Reinhold, Ute Bank, ed. Advances in Experimental Medicine and Biology. USA: Springer, pp. 197-206.
    [Scopus]
  • Wilson, C.H., Tsykin, A., Wilkinson, C.R. and Abbott, C.A. (2006). Experimental Design and Analysis of Microarray Data. In Dilip K Arora, Randy M Berka, Gautam B Singh, ed. Applied Mycology and Biotechnology - Bioinformatics. The Netherlands: Elsevier, pp. 1-37.
    [Scopus]
  • Ajami, K., Abbott, C.A., McCaughan, G.W., Gysbers, V., Kahne, T. and Gorrell, M.D. (2003). Molecular chimeras and mutational analysis in the prolyl oligopeptidase gene family. In Martin Hildebrandt et al., ed. Dipeptidyl Aminopeptodases in Health and Disease. New York: Kluwer Academic / Plenum, pp. 49-55.
    [10.1007/0-306-47920-6_5] [Scopus]
  • Abbott, C.A. and Gorrell, M.D. (2002). The Family of CD26/DPIV and Related Ecopeptidases. In Jurgen Langer & Siegfried Ansorge, ed. Ectopeptidases: CD13/aminopeptidase N and CD26/Dipeptidyl Peptidase IV in Medicine and Biology. New York, NY: Kluwer Academic Publishers, pp. 171-195.
  • Yazbek, R., Abbott, C.A. and Benkendorff, K. (2012). Complementary and Alternative Medicines for Intestinal Mucositis: 'Nutraceuticals' or 'Neutralceuticals'? Multinational Association of Supportive Care in Cancer (MASCC) International Symposium on Supportive Care in Cancer. United States.
  • Yazbek, R., Howarth, G.S., Butler, R.N., Geier, M.S. and Abbott, C.A. (2010). Dipeptidyl peptidase-IV inhibitors and small intestinal adaptation during experimental colitis. Digestive Diseases Week. United States.
  • Yazbek, R., Howarth, G.S., Butler, R.N., Geier, M.S. and Abbott, C.A. (2009). Dipeptidyl peptidase-IV inhibitors and small intestinal adaptation during experimental colitis. Australian Gastroenterology Week. Sydney. Oct 2009.
  • Yazbek, R., Howarth, G.S., Butler, R.N., Geier, M.S. and Abbott, C.A. (2009). Dipeptidyl peptidase-IV inhibitors and small intestinal adaptation during experimental colitis. 6th General Meeting of the International Proteolysis Society.
  • Benkendorff, K., McIver, C., Westley, C.B. and Abbott, C.A. (2008). Anticancer complementary medicines from muricid molluscs. In Human Impacts and Functioning Ecosystems. Christchurch: University of Canterbury. New Zealand Marine Science Society & Australian Marine Science Association combined conference. Christchurch. Jul 2008.
  • McIver, C., Benkendorff, K. and Abbott, C.A. (2007). In vitro evaluation of bioactive muricid extracts and the murex homeopathic remedy in human solid tumors. In SA-ASMR Medical Research Week Scientific Meeting Abstracts. Australian Society for Medical Research. SA-ASMR Medical Research Week Scientific Meeting 2007. Adelaide, SA. Jun 2007, pp. 36-36.
  • Laffy, P.W., Benkendorff, K., Westley, C.B. and Abbott, C.A. (2007). Using molecular approaches to investigate the function of the hypobranchial gland of the marine snail Dicathais orbita. In World Congress of Malacology 2008. World Congress of Malacology. Antwerp, Belgium. Jul 2007.
  • Chen, T., Abbott, C.A., Chegini, F. and Gai, W. (2006). Characterization of a novel dipeptidyl peptidase like protein in human brain and in Alzheimer's neurofibrillary tangles and plaques. In Paul Martin, ed. Proceedings of the Australian Neuroscience Society. Australian Neuroscience Society. 26th Annual Meeting of the Australian Neuroscience Society. Sydney, NSW. Jan 2006, pp. 26-26.
  • Yazbeck, R., Howarth, G.S., Demuth, H.U., Holst, J.J., Marguet, D. and Abbott, C.A. (2006). Inhibition of dipeptidyl peptidase activity in DPIV knock-out and wild type mice decreases disease activity in experimental colitis. In Journal of Gastroenterology and Hepatology. Blacwell Publishers. Australian Gastroenterology Week. Adelaide, SA. Oct 2006, pp. A273-A273.
  • Li, Y., Qin, J., Abbott, C.A., Benkendorff, K. and Li, X. (2006). The impact of spawning on the thermotolerence of Pacific oyster (Crassostrea gigas) in South Australia. In Skretting Australasian Aquaculture Program Abstract. Skretting Australasian Aquaculture 2006: Innovation in Aquaculture. Adelaide, SA. Aug 2006.
  • Laffy, P.W., Benkendorff, K. and Abbott, C.A. (2006). Gene expression within the hypobranchial gland of Dicathais orbita [abstract] In Molluscs 2006: molluscs in research, conservation and the economy: program and abstracts. Sydney, NSW: Malacological Society of Australasia Ltd. Molluscs 2006: Triennial meeting of the Malacological Society of Australia. Wollongong, NSW. Dec 2006, pp. 36-37.
  • Vijayraghavan, V., Soole, K.L. and Abbott, C.A. (2005). Analysis of expression levels of non-phosphorylating NAD(P)H dehydrogenases of Arabidopsis thaliana in response to phosphate. In Associate Professor Clem Robinson, Monash University, ed. Combio 2005 Combined Conference. South Australia, AustraliaCombio 2005 Combined Conference. Adelaide Convention Centre, Adelaide, SA, 25-29 Sep 2005. Sep 2005.
  • Ajami, K., Pitman, M.R., Wilson, C.H., Park, J., Menz, R.I., Starr, A., et al. (2008). Corrigendum to ‘‘Stromal cell-derived factors 1a and 1b, inflammatory protein-10 and interferon-inducible T cell chemo-attractant are novel substrates of dipeptidyl peptidase 8’’ [FEBS Lett. 582 (2008) 819–825] FEBS Letters, 582
    [10.1016/j.febslet.2008.02.066]
  • Abbott, C.A., Baker, E., Sutherland, G. and McCaughan, G.W. (1995). Erratum: Genomic organization, exact localization, and tissue expression of the human CD26 (dipeptidyl peptidase IV) gene (Immunogenetics (1994) 40 (331-338)) Immunogenetics, 42(1) pp. 76-76.
    [10.1007/BF00164993]
  • Esmaeelian, B., Benkendorff, K., Le Leu, R.K. and Abbott, C.A. (2017). Simultaneous assessment of the efficacy and toxicity of marine mollusc derived brominated indoles in an in vivo model for early stage colon cancer. INTEGRATIVE CANCER THERAPIES,
    [10.1177/1534735417699880] [10.1177/1534735417699880.]
  • Munawara, U., Small, A.G., Quach, A., Gorgani, N., Abbott, C.A. and Ferrante, A. (2017). Cytokines regulate complement receptor immunoglobulin expression and phagocytosis of Candida albicans in human macrophages: A control point in anti-microbial immunity. Scientific Reports, 7(1) pp. Art: 4050.
    [10.1038/s41598-017-04325-0] [Scopus]
  • Nurdin, S.U., LeLeu, R., Young, G.P., Stangoulis, J.C.R., Christophersen, C. and Abbott, C.A. (2017). Analysis of the Anti-Cancer effects of Cincau Extract (Premna Oblongifolia Merr) and Other Types of Non-Digestible Fiber using Faecal Fermentation Supernatants and Caco-2 Cells as a Model of the Human Colon. Nutrients, 9(4) pp. Art: 355.
    [10.3390/nu9040355]
  • Yazbek, R., Jaenisch, S.E. and Abbott, C.A. (2017). Potential Disease Biomarkers: Dipeptidyl Peptidase 4 and Fibroblast Activation Protein. PROTOPLASMA,
    [10.1007/s00709-017-1129-5]
  • Wilson, C., Zhang, H.E., Gorrell, M. and Abbott, C.A. (2016). Dipeptidyl peptidase 9 substrates and their discovery: Current progress and the application of mass spectrometry - based approaches. Biological Chemistry, 397 pp. 837-856.
    [10.1515/hsz-2016-0174] [Scopus]
  • Yang, C.Y., Sierp, M.T., Abbott, C.A., Li, Y. and Qin, J. (2016). Responses to thermal and salinity stress in wild and farmed Pacific oysters Crassostrea gigas. Comparative Biochemistry and Physiology A-Molecular and Integrative Physiology, 201 pp. 22-29.
    [10.1016/j.cbpa.2016.06.024]
  • Benkendorff, K., Rudd, D.A., Nongmaithem, B.D., Liu, L., Young, F.M., Edwards, V.S., et al. (2015). Are the Traditional Medical Uses of Muricidae Molluscs Substantiated by Their Pharmacological Properties and Bioactive Compounds? Marine Drugs, 13 pp. 5237-5275.
    [10.3390/md13085237] [Scopus]
  • Ma, Y., Usuwanthim, K., Munawara, U., Quach, A., Gorgani, N., Abbott, C.A., et al. (2015). Protein kinase Ca regulates the expression of complement receptor Ig in human monocyte-derived macrophages. Journal of Immunology, 194(6) pp. 2855-2861.
    [10.4049/jimmunol.1303477] [Scopus]
  • Yazbeck, R., Lindsay, R., Abbott, C.A., Benkendorff, K. and Howarth, G. (2015). Combined effects of muricid extract and 5-flurouracil on intestinal toxicity in rats. Evidence-based Complementary and Alternative Medicine, 2015 pp. Article: 170858.
    [Scopus]
  • Chen, T., Gai, W.P. and Abbott, C. (2014). Dipeptidyl peptidase 10 (DPP10(789)): a voltage gated potassium channel associated protein is abnormally expressed in Alzheimer's and other neurodegenerative diseases. BioMed Research International, 209398 pp. 1-15.
    [10.1155/2014/209398] [Scopus]
  • Esmaeelian, B., Abbott, C.A., Le Leu, R.K. and Benkendorff, K. (2014). 6-Bromoisatin found in muricid mollusc extracts inhibits colon cancer cell proliferation and induces apoptosis preventing early stage tumor formation in a colorectal cancer rodent model. Marine Drugs, 12(1) pp. 17-35.
    [10.3390/md12010017] [Scopus]
  • Meakin, C., Qin, J., Pogson, L. and Abbott, C. (2014). Thermal tolerance in juvenile King George whiting (Sillaginodes punctata) reduces as fish age and this reduction coincides with migration to deeper colder water. Comparative Biochemistry and Physiology A-Molecular and Integrative Physiology, 172(June) pp. 46-51.
    [10.1016/j.cbpa.2014.02.016] [Scopus]
  • Knez, M., Abbott, C. and Stangoulis, J.C.R. (2014). Changes in the content of fructans and arabinoxylans during baking processes of leavened and unleavened breads. EUROPEAN FOOD RESEARCH AND TECHNOLOGY,
    [10.1007/s00217-014-2273-1] [Scopus]
  • Esmaeelian, B., Benkendorff, K., Johnston, M. and Abbott, C.A. (2013). Purified Brominated Indole Derivatives from Dicathais orbita Induce Apoptosis and Cell Cycle Arrest in Colorectal Cancer Cell Lines. Marine Drugs, 11(10) pp. 3802-3822.
    [10.3390/md11103802] [Scopus]
  • Laffy, P., Benkendorff, K. and Abbott, C.A. (2013). Suppressive subtractive hybridization transcriptomics provides a novel insight into the functional role of the hypobranchial gland in a marine mollusc. Comparative Biochemistry and Physiology Part D: Genomics and Proteomics, 8(2) pp. 111-122.
    [10.1016/j.cbd.2013.01.001] [Scopus]
  • Wilson, C.H., Indarto, D., Doucet, A., Pogson, L.D., Pitman, M., McNicholas, K., et al. (2013). Identifying natural substrates for dipeptidyl peptidases 8 and 9 using terminal amine isotopic labeling of substrates (TAILS) reveals in vivo roles in cellular homeostasis and energy metabolism. Journal of Biological Chemistry, 288(20) pp. 13936-13949.
    [10.1074/jbc.M112.445841] [Scopus]
  • Westley, C.B., Benkendorff, K., McIver, C., Le Leu, R. and Abbott, C.A. (2013). Gastrointestinal and hepatotoxicity assessment of an anticancer extract from muricid molluscs. Evidence-based Complementary and Alternative Medicine, 2013 pp. 837370.
    [10.1155/2013/837370] [Scopus]
  • Wilson, C.H. and Abbott, C.A. (2012). Expression profiling of dipeptidyl peptidase 8 and 9 in breast and ovarian carcinoma cell lines. International Journal of Oncology, 41(3) pp. 919-932.
    [10.3892/ijo.2012.1522] [Scopus]
  • Yazbeck, R., Howarth, G.S., Butler, R.N., Geier, M.S. and Abbott, C.A. (2011). Biochemical and Histological Changes in the Small Intestine of Mice with Dextran Sulfate Sodium Colitis. Journal of Cellular Physiology, 226(12) pp. 3219-3224.
    [10.1002/jcp.22682] [Scopus]
  • Yu, D.M., Slaitini, L., Gysbers, V., Riekhoff, A.G.M., Kahne, T., Knott, H.M., et al. (2011). Soluble CD26/Dipeptidyl Peptidase IV Enhances Human Lymphocyte Proliferation In Vitro Independent of Dipeptidyl Peptidase Enzyme Activity and Adenosine Deaminase Binding. Scandinavian Journal of Immunology, 73(2) pp. 102-111.
    [10.1111/j.1365-3083.2010.02488.x] [Scopus]
  • Sulda, M.L., Abbott, C.A., MacArdle, P.J., Hall, R.K. and Kuss, B.J. (2010). Expression and prognostic assessment of dipeptidyl peptidase IV and related enzymes in B-cell chronic lymphocytic leukaemia. Cancer Biology and Therapy, 10(2) pp. 180-189.
    [10.4161/cbt.10.2.12168] [Scopus]
  • Pitman, M.R., Menz, R.I. and Abbott, C.A. (2010). Hydrophilic residues surrounding the S1 and S2 pockets contribute to dimerisation and catalysis in human dipeptidyl peptidase 8 (DP8) Biological Chemistry, 391(8) pp. 959-972.
    [10.1515/BC.2010.111] [Scopus]
  • Westley, C.B., McIver, C., Abbott, C.A., Le Leu, R.K. and Benkendorff, K. (2010). Enhanced acute apoptotic response to azoxymethane-induced DNA damage in the rodent colonic epithelium by Tyrian purple precursors: a potential colorectal cancer chemopreventative. Cancer Biology and Therapy, 9(5) pp. 371-9.
    [10.4161/cbt.9.5.10887] [Scopus]
  • Yazbeck, R., Abbott, C.A. and Howarth, G.S. (2010). The use of GLP-2 and related growth factors in intestinal diseases. Current Opinion in Investigational Drugs, 11(4) pp. 440-446.
    [Scopus]
  • Yazbeck, R., Sulda, M.L., Howarth, G.S., Bleich, A., Raber, K., von Horsten, S.H., et al. (2010). Dipeptidyl Peptidase expression during experimental colitis in mice. Inflammatory Bowel Diseases, 16(8) pp. 1340-1351.
    [10.1002/ibd.21241] [Scopus]
  • Donato, R., Wood, S.A., Saunders, I., Gundsambuu, B., Mak, K.Y., Abbott, C.A., et al. (2009). Regulation of epithelial apical junctions and barrier function by Ga13. Biochimica et Biophysica Acta-Molecular Cell Research, 1793(7) pp. 1228-1235.
    [10.1016/j.bbamcr.2009.04.008] [Scopus]
  • Benkendorff, K., McIver, C. and Abbott, C.A. (2009). Bioactivity of the Murex homeopathic remedy and of extracts from an Australian muricid mollusc against human cancer cells. Evidence-based Complementary and Alternative Medicine, 2011(879585)
    [10.1093/ecam/nep042] [Scopus]
  • Laffy, P.W., Benkendorff, K. and Abbott, C.A. (2009). Trends in molluscan gene sequence similarity: an observation from genes expressed within the hypobranchial gland of Dicathais orbita(Gmelin, 1791) (Neogastropoda: Muricidae) Nautilus, 123(3) pp. 154-158.
    [Scopus]
  • Yu, D.M., Ajami, K., Gall, M., Park, J., lee, C.S., Evans, K.A., et al. (2009). The in vivo expression of dipeptidyl peptidases 8 and 9. Journal of Histochemistry and Cytochemistry, 57(11) pp. 1025-1038.
    [10.1369/jhc.2009.953760] [Scopus]
  • McNicholas, K.B., Chen, T. and Abbott, C.A. (2009). Dipeptidyl peptidase (DP) 6 and DP10: novel proteins implicated in human health and disease. Clinical Chemistry and Laboratory Medicine, 47(3) pp. 262-267.
    [10.1515/CCLM.2009.061] [Scopus]
  • Pitman, M., Sulda, M.L., Kuss, B.J. and Abbott, C.A. (2009). Dipeptidyl peptidase 8 and 9 - guilty by association? Frontiers in Bioscience: Landmark Edition, 14(10) pp. 3619-3633.
    [10.2735/3476] [10.2741/3476] [Scopus]
  • Yazbeck, R., Howarth, G.S. and Abbott, C.A. (2009). Dipeptidyl peptidase inhibitors, an emerging drug class for inflammatory disease? Trends in Pharmacological Sciences, 30(11) pp. 600-607.
    [10.1016/j.tips.2009.08.003] [Scopus]
  • Yazbeck, R., Howarth, G.S. and Abbott, C.A. (2009). Growth factor based therapies and intestinal disease: Is glucagon-like peptide-2 the new way forward? Cytokine and Growth Factor Reviews, 20(2) pp. 175-184.
    [10.1016/j.cytogfr.2009.02.008] [Scopus]
  • Ajami, K., Pitman, M.R., Wilson, C.H., Park, J., Menz, R.I., Starr, A., et al. (2008). Stromal cell-derived factors 1{alpha} and 1{Beta}, inflammatory protein-10 and interferon-inducible T cell chemo-attractant are novel substrates of dipeptidyl peptidase 8. FEBS Letters, 582(5) pp. 819-825.
    [10.1016/j.febslet.2008.02.005] [Scopus]
  • Li, Y., Qin, J., Abbott, C.A., Li, X. and Benkendorff, K. (2007). Synergistic impacts of heat shock and spawning on the physiology and immune health of Crassostrea gigas: An explanation for summer mortality in pacific oysters. American Journal of Physiology-Regulatory Integrative and Comparative Physiology, 293(6) pp. R2353-R2362.
    [10.1152/ajpregu.00463.2007] [Scopus]
  • Chen, T., Ajami, K., McCaughan, G.W., Gai, W., Gorrell, M. and Abbott, C.A. (2006). Molecular characterization of a novel dipeptidyl peptidase like 2-short form (DPL2-s) that is highly expressed in the brain and lacks dipeptidyl peptidase activity. Biochimica et Biophysica Acta-Proteins and Proteomics, 1764(2) pp. 33-43.
    [10.1016/j.bbapap.2005.09.013] [Scopus]
  • Sanderson, M.P., Abbott, C.A., Tada, H., Seno, M., Dempsey, P.J. and Dunbar, A.J. (2006). Hydrogen oeroxide and endothelin-1 are novel activators of betacellulin ectodomain shedding. Journal of Cellular Biochemistry, 99(2) pp. 609-623.
    [10.1002/jcb.20968] [Scopus]
  • Geier, M.S., Tenikoff, D., Yazbeck, R., McCaughan, G.W., Abbott, C.A. and Howarth, G.S. (2005). Development and resolution of experimental colitis in mice with targeted deletion of dipeptidyl peptidase IV. Journal of Cellular Physiology, 204(2) pp. 687-692.
    [10.1002/jcp.20333] [Scopus]
  • Ajami, K., Abbott, C.A., McCaughan, G.W. and Gorrell, M.D. (2004). Dipeptidyl peptidase 9 has two forms, a broad tissue distribution, cytoplasmic localization and DPIV-like peptidase activity. Biochimica et Biophysica Acta-Gene Structure and Expression, 1679(1) pp. 18-28.
    [10.1016/j.bbaexp.2004.03.010] [Scopus]
  • Chen, T., Smyth, D.R. and Abbott, C.A. (2004). CD26. Journal of Biological Regulators and Homeostatic Agents, 18(1) pp. 47-54.
    [Scopus]
  • Abbott, C.A. (2003). Meeting Review: 11th Intelligient Systems for Molecular Biology 2003. Comparative and Functional Genomics, 4(6) pp. 654-659.
    [10.1002/cfg.336] [Scopus]
  • Abbott, C.A., Chen, T., Ajami, K., McCaughan, G.W. and Gorrell, M.D. (2003). Dipeptidyl peptidase IV gene family : the DPIV family. Advances in Experimental Medicine and Biology, 524 pp. 79-86.
    [Scopus]
  • Shackel, N., McGuinness, P.H., Abbott, C.A., Gorrell, M.D. and McCaughan, G.W. (2003). Novel differential gene expression in human cirrhosis detected by suppression subtractive hybridization. Hepatology, 38(3) pp. 577-588.
    [10.1053/jhep.2003.50376] [Scopus]
  • Shackel, N.A., McGuinness, P.H., Abbott, C.A., Gorrell, M.D. and McCaughan, G.W. (2002). Insights into the pathobiology of hepatitis C virus-associated cirrhosis : analysis of intrahepatic differential gene expression. American Journal of Pathology, 160(2) pp. 641-654.
    [Scopus]
  • Wang, M., Gorrell, M.D., Abbott, C.A., Jaggi, R., Marguet, D. and Dickinson, R.G. (2002). Hepatic covalent adduct formation with zomepirac in the CD26-deficient mouse. Journal of Gastroenterology and Hepatology, 17(1) pp. 66-71.
    [10.1046/j.1440-1746.2002.02662.x] [Scopus]
  • Abbott, C.A., McCaughan, G.W., Levy, M.T., Church, W.B. and Gorrell, M. (2001). Binding to human dipeptidyl peptidase IV by adenosine deaminase and antibodies that inhibit ligand binding involves overlapping, discontinuous sites on a predicted b propeller domain. European Journal of Biochemistry, 266(3) pp. 798-810.
    [10.1046/j.1432-1327.1999.00902.x]
  • Abbott, C.A., Yu, D.M., Woollatt, E., Sutherland, G., McCaughan, G.W. and Gorrell, M. (2001). Cloning, expression and chromosomal localization of a novel human dipeptidyl peptidase (DPP) IV homolog, DPP8. European Journal of Biochemistry, 267 pp. 6140-6150.
    [10.1046/j.1432-1327.2000.01617.x]
  • Shackel, N.A., McGuninness, P.H., Abbott, C.A., Gorrell, M.D. and McCaughan, G.W. (2001). Identification of novel molecules and pathogenic pathways in primary biliary cirrhosis: cDNA array analysis on intraheptic differrential gene expression. Gut, 49 pp. 565-576.
    [10.1136/gut.49.4.565] [Scopus]
  • McCaughan, G.W., Gorrell, M., Bishop, G., Abbott, C.A., Shackel, N.A., McGuinness, P.H., et al. (2000). Molecular pathogenesis of liver disease: an approach to hepatic inflammation, cirrhosis and liver transplant tolerance. IMMUNOLOGICAL REVIEWS, 174(1) pp. 172-191.
    [10.1034/j.1600-065X.2000.174001172.x]
  • Abbott, C.A., McCaughan, G.W. and Gorrell, M. (1999). Two highly conserved glutamic acid residues in the predicted b propeller domain of dipeptidyl peptidase IV are required for its enzyme activity. FEBS Letters, 458 pp. 278-284.
    [10.1016/S0014-5793(99)01166-7]
  • Levy, M.T., McCaughan, G.W., Abbott, C.A., Park, J.E., Cunningham, A.M., Muller, E., et al. (1999). Fibroblast Activation Protein: A Cell Surface Dipeptidyl Peptidase and Gelatinase Expressed by Stellate Cells at the Tissue Remodelling Interface in Human Cirrhosis. Hepatology, 29(6) pp. 1768-1778.
    [10.1002/hep.510290631]
  • Abbott, C.A., Gorrell, M., Kobayashi, Y., Kawasaki, T., Liddle, C., Bishop, G., et al. (1995). Increased serum levels of dipeptidyl peptidase IV (CD26) in rats undergoing liver regeneration. International Hepatology Communications, 4(3) pp. 165-174.
    [10.1016/0928-4346(95)00242-1]
  • Munawara, U., Small, A.G., Quach, A., Gorgani, N., Abbott, C.A. and Ferrante, A. (2017). Cytokines regulate complement receptor immunoglobulin expression and phagocytosis of Candida albicans in human macrophages: A control point in anti-microbial immunity. Scientific Reports, 7(1) pp. Art: 4050.
    [10.1038/s41598-017-04325-0] [Scopus]
  • Yazbek, R., Jaenisch, S.E. and Abbott, C.A. (2017). Potential Disease Biomarkers: Dipeptidyl Peptidase 4 and Fibroblast Activation Protein. PROTOPLASMA,
    [10.1007/s00709-017-1129-5]
  • Laffy, P., Benkendorff, K. and Abbott, C.A. (2013). Suppressive subtractive hybridization transcriptomics provides a novel insight into the functional role of the hypobranchial gland in a marine mollusc. Comparative Biochemistry and Physiology Part D: Genomics and Proteomics, 8(2) pp. 111-122.
    [10.1016/j.cbd.2013.01.001] [Scopus]
  • Wilson, C.H., Indarto, D., Doucet, A., Pogson, L.D., Pitman, M., McNicholas, K., et al. (2013). Identifying natural substrates for dipeptidyl peptidases 8 and 9 using terminal amine isotopic labeling of substrates (TAILS) reveals in vivo roles in cellular homeostasis and energy metabolism. Journal of Biological Chemistry, 288(20) pp. 13936-13949.
    [10.1074/jbc.M112.445841] [Scopus]
  • Wilson, C.H. and Abbott, C.A. (2012). Expression profiling of dipeptidyl peptidase 8 and 9 in breast and ovarian carcinoma cell lines. International Journal of Oncology, 41(3) pp. 919-932.
    [10.3892/ijo.2012.1522] [Scopus]
  • Yazbeck, R., Howarth, G.S., Butler, R.N., Geier, M.S. and Abbott, C.A. (2011). Biochemical and Histological Changes in the Small Intestine of Mice with Dextran Sulfate Sodium Colitis. Journal of Cellular Physiology, 226(12) pp. 3219-3224.
    [10.1002/jcp.22682] [Scopus]
  • Yu, D.M., Slaitini, L., Gysbers, V., Riekhoff, A.G.M., Kahne, T., Knott, H.M., et al. (2011). Soluble CD26/Dipeptidyl Peptidase IV Enhances Human Lymphocyte Proliferation In Vitro Independent of Dipeptidyl Peptidase Enzyme Activity and Adenosine Deaminase Binding. Scandinavian Journal of Immunology, 73(2) pp. 102-111.
    [10.1111/j.1365-3083.2010.02488.x] [Scopus]
  • Westley, C.B., McIver, C., Abbott, C.A., Le Leu, R.K. and Benkendorff, K. (2010). Enhanced acute apoptotic response to azoxymethane-induced DNA damage in the rodent colonic epithelium by Tyrian purple precursors: a potential colorectal cancer chemopreventative. Cancer Biology and Therapy, 9(5) pp. 371-9.
    [10.4161/cbt.9.5.10887] [Scopus]
  • Yazbeck, R., Abbott, C.A. and Howarth, G.S. (2010). The use of GLP-2 and related growth factors in intestinal diseases. Current Opinion in Investigational Drugs, 11(4) pp. 440-446.
    [Scopus]
  • Yazbeck, R., Sulda, M.L., Howarth, G.S., Bleich, A., Raber, K., von Horsten, S.H., et al. (2010). Dipeptidyl Peptidase expression during experimental colitis in mice. Inflammatory Bowel Diseases, 16(8) pp. 1340-1351.
    [10.1002/ibd.21241] [Scopus]

Expertise for media contact

Subject Titles

  • Biochemistry
  • Biotechnology
  • Molecular Biology

Interests

  • Bioinformatics
  • Molecular Biology (cloning and characterisation of novel genes)
  • Biotechnology (structure/function studies in dipeptidyl peptidase family for inhibitor design)
  • Cell Biology (study of dipeptidyl peptidase family)
  • Inflammatory Bowel Diseases (using animal models to further characterise IBD)

Contact

Add to address book
Phone: +61 8 82013836, +61 8 82012078
Email:
Location: Biological Sciences (333B)
Postal address: GPO Box 2100, Adelaide 5001, South Australia

Further information

Current students:
Miss Lisa Pogson
Mr Robert Qiao

Ms Arphaphorn Dokphut

Ms Nguyen Ngoc Thuan Nguyen

BSc Honours Alumuni
2002 Tong Chen
2002 Dave Greig (Biotechnology)
2003 Yvonne Tan Hsiao Wei
2003 Mark Geier
2004 Melissa Pitman
2004 Claire Wilson
2004 Roger Yazbeck
2005 Melanie Sulda
2006 Alex Staudacher -
2008 Kym McNicholas- Research Assistant FMC, Adelaide
2009 Andrew Lorbeer (Biotechnology) -co-supervised Karen Burke Da Silvia
2010 Tanya Blazewizc (Biotechnology) -co-supervised Karen Burke Da Silvia
2010 Hayley Rumble- co supervised with Dr Michael Michael
2010 (Kent) Ching-Yao Yang - co supervised with Assoc Prof Jian Qin
2011 Lisa Pogson
2013-14 Robert Qiao

2016-17 Cassie Hoepner-co-supervised Karen Burke Da Silvia

Masters of Biotechnology Alumuni
2006 Dr Dono Indarto

2009 Ruoyang Wang

2013/2014 Kalyani Suryavanshi
2013/204 Charndeep Chahal

PhD Alumuni:

2015: Dr Usma Munawara

2014: Dr Babak Esmeelian

2014: Dr Dono Indarto -Lecturer at Physiology Department,Faculty of Medicine, Sebelas Maret University, Indonesia.
2013:Dr Nurdin Samsara- Lecturer at Department of Agricultural Product Technology, Lumpung University, Indonesia.
2012: Dr Maresa Bruhn-2013 Research Assistant QEH, Adelaide
2012:Dr Patrick Laffy- 2013 Post-doc AIMS, Townsville, Australia
2012:Dr Claire Wilson- 2012 Post-Doc at Center for Cancer Biology, Adelaide. 2014-2018 NHMRC Biomedical Research Fellow,UniSA.
2010:Dr Melanie Sulda: 2010-Post-Doc, Department of Haematology, FU, 2011-Post-Doc fellowship at Uni of Texas-MDA Anderson Cancer Centre, US. 2013- Research Associate FMC
2010:Dr Rino Donato: 2010 Post-Doc, Gastroenterology, Queen Elizabeth Hospital, Adelaide
2009: Dr Roger Yazbeck: 2009 -10 Post-Doc Gastroenterology, WCHl, Adelaide; 2011-2014 NHMRC Biomedical Research Fellow UniSA. CMRK Research Fellow at Flinders 2015-2019.
2009: Dr Melissa Pitman: since 2008 Post Doc at Center for Cancer Biology, Adelaide.
2008: Dr Tong Chen- 2008 -2009 research assistant Flinders University ; 2010-11 Alzheimers Association post-doc fellowship in Abbott Laboratory. 2012- Research Assistant FMC
2005: Dr Michael Sanderson- 2005- Post-Doc Germany

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