Position

NHMRC Principal Research Fellow
Centre for Neuroscience

Biography

I have a research-only role as Head of Molecular and Cellular Physiology within the Centre for Neuroscience. I undertook a post-doc with Prof. Thomas Jentsch at the ZMNH, Hamburg, Germany and was then awarded the TM Ramsay Fellowship at Prince Henry's Institute, Melbourne. I was appointed Group Leader at Flinders University as a BioInnovation SA Research Fellow in 2006. In 2010, I was awarded both a NHMRC Career Development Fellowship (Level 1) and an ARC Future Fellowship and in 2015 I recieved a NHMRC Career Development Fellowship (Level 2).

My research is focused on understanding how cells send out chemical signals to each other and how this is implicated in health and disease. We have published some significant work in this area in leading international journals. These include PLoS Genetics, Molecular Psychiatry (2), Gastroenterology (3), Human Molecular Genetics (3), Journal of Neuroscience (2), Diabetes, Nature Communications (2) and Cell Metabolism.

My lab webpage: Molecular and Cellular Physiology Laboratory

Qualifications

Bachelor of Applied Science (Honours, 1st class)

Ph.D. (Science) University of Adelaide - Department of Physiology

Honours, awards and grants


2004 TM Ramsay Postdoctoral Fellowship - Prince Henry's Institute
2006 Bio Innovation SA Neuroscience Research Fellowship - Flinders University
2007 NHMRC Project Grant (Chief Investigator A)
2009 ARC Discovery Grant (Chief Investigator A)
2010 ARC Future Fellowship Award
2010 NHMRC Career Development Award (Level 1)
2010 Vice Chancellor’s Award for Early Career Researchers, Flinders University
2010 South Australian Young Tall Poppy Award
2010 NHMRC Project Grant (Chief Investigator A)
2012 Australian Society for Medical Research, South Australian Leading Light Award
2013 ARC Discovery Grant (Chief Investigator A)
2014 NHMRC Career Development Award (Level 2)
2015 ARC Linkage Grant (Chief Investigator A)
2015 Professor

Research expertise

  • Biochemistry and cell biology
  • Medical physiology
  • Neurosciences
  • Physiology

Research interests


The focus within my lab is identifying the molecular mechanisms controlling cell signalling and how altered cell signalling relates to human diseases; most especially related to Type 2 Diabetes, metabolism and obesity. I utilise genetic mouse models and human tissue to identify novel genes underlying aspects of these diseases and combine this with cutting edge techniques for the measurement of neurotransmitter and hormone release from single cells. This work is supported with grants from the Australian Research Council, the National Health and Medical Reseaech Council and the Diabetes Australia Research Trust.

Supervisory interests

  • Beta cells
  • Cell signalling
  • Diabetes
  • Exocytosis
  • Insulin secretion
  • Metabolism
  • Neurotransmitters
  • Trafficking
  • Vesicles

RHD research supervision

Current

Principal supervisor : Physiology (3) ; Neuroscience (1) ;

Completion

Principal supervisor : Physiology (3) ;

RHD Student Achievements

  • Heshan Peiris
    Best Student Oral Presentation, Australian Physiology Society Annual Meeting, Sydney 2010 - October 2012
    People’s Choice Award, Flinders University Faculty of Health Sciences Student Research Prize Day - October 2012
  • Kimberley Mackenzie
    Best Student Oral Presentation, Australian Neuroscience Society Annual Meeting, Sydney 2010 - October 2012
    Kathleen V. Russell Prize In Neurobiology, Flinders University Centre for Neuroscience - October 2012
  • Minh-Son To
    Australian Postgraduate Scholarship - October 2012

Publications

  • Spencer, N.J. and Keating, D.J. (2016). Is There a Role for Endogenous 5-HT in Gastrointestinal Motility? How Recent Studies Have Changed Our Understanding. In Stuart Brierley and Marcello Costa, ed. The Enteric Nervous System: 30 Years Later. Switzerland: Springer, pp. 113-122.
    [10.1007/978-3-319-27592-5_11] [Scopus]
  • Duffield, M., Raghupathi, R. and Keating, D. (2014). Carbon-Fiber Amperometry in the Study of Exocytosis. In Peter Thorn, ed. Exocytosis Methods. New York, United States of America: Humana Press: Springer, pp. 39-54.
    [10.1007/978-1-62703-676-4] [Scopus]
  • Martin, A.M. and Keating, D.J. (2015). Nutrient Sensing by Enterochromaffin Cells in the Colon and Duodenum of Mice. In Gastroenterology. Elsevier. Digestive Disease Week 2015. Washington, DC, USA. May 2015, pp. s1195-s1196.
    [10.1016/S0016-5085(15)34083-X]
  • Peiris, H.D., Duffield, M.D., Fadista, J., Jessup, C.F., Genders, A., McGee, S., et al. (2015). A Novel Screening Approach of Down Syndrome Genes Identifies That RCAN1 Is Overexpressed in Type 2 Diabetic Islets and Causes ß-Cell Mitochondrial Dysfunction. In Diabetes. American Diabetes Association. American Diabetes Association 75th Scientific Sessions. Boston, MA, USA. Jun 2015, pp. A88-A88.
    [10.2337/db15-1-385]
  • Young, R.L., Rayner, C.K., Quyen, N.Q., Wu, T., Burgess, J.E., Lumsden, A.L., et al. (2015). Increased Capacity for Intestinal Serotonin Release in Obese and Diabetic Humans. In Diabetes. American Diabetes Association. American Diabetes Association 75th Scientific Sessions. Boston, MA, USA. Jun 2015, pp. A534-A534.
    [10.2337/db15-1929-2253]
  • Saadipour, K., Lim, Y., Keating, D.J., Wang, Y., Zhong, J.H., Wang, Y.J., et al. (2014). AB INDUCES BACE1 UP-REGULATION AND ENHANCES APP PROCESSING THROUGH CROSS-TALK WITH P75NTR. In Alheimer's & Dementia. Supplement ed. Elsevier. Alzheimer’s Association International Conference. Washington, DC, USA. Jul 2014, pp. P627-P627.
    [10.1016/j.jalz.2014.05.1089]
  • Jackson, J., Papadopulos, A., McCluskey, A., Meunier, F.A., Robinson, P.J. and Keating, D.J. (2013). Small molecules demonstrate that dynamin is a bi-directional modulator of the exocytosis fusion pore. In Proceedings of the Australian Physiological Society. Australian Physiological Society. Australian Physiological Society 2013 Geelong Meeting. Geelong, VIC. Dec 2015.
    [Web Link]
  • Keating, D.J. (2013). Enteroendocrine cell signalling: implications in the GI tract and beyond. In Proceedings of the Australian Physiological Society. Sydney, NSW: Australian Physiological Society. Australian Physiological Society 2013 Geelong Meeting. Geelong, VIC. Dec 2013.
    [Web Link]
  • Peiris, H.D., Duffield, M.D., Jessup, C.F., Kashmir, V., Fadista, J., Genders, A., et al. (2013). RCAN1 is critical for ß-cell mitochondrial function and is overexpressed in human Type 2 diabetes. In Proceedings of the Australian Physiological Society. Australian Physiological Society. Australian Physiological Society 2013 Geelong Meeting. Geelong, VIC. Dec 2013.
    [Web Link]
  • Keating, D.J., Mackenzie, K.D. and Zhou, X.F. (2012). Huntingtin-associated protein 1 (HAP1) regulates exocytosis, vesicle localization and interacts with multiple vesicle proteins. In Proceedings of the Australian Physiological Societye. Australian Physiological Society. Australian Physiological Society 2012 Sydney Meeting. Sydney, NSW. Dec 2012.
    [Web Link]
  • Raghupathi, R., Zelkas, L.E., Duffield, M.D., Spencer, N.J. and Keating, D.J. (2012). Enterochromaffin cells release 5-HT with synaptic kinetics. In Proceedings of the Australian Physiological Society. Australian Physiological Society. Australian Physiological Society 2012 Sydney Meeting. Sydney, NSW. Dec 2012.
    [Web Link]
  • Young, R.L., Lumsden, A.L. and Keating, D.J. (2015). Gut Serotonin is a Regulator of Obesity and Metabolism. Gastroenterology, 149(1) pp. 253-255.
    [10.1053/j.gastro.2015.05.020] [Scopus]
  • Duffield, M.D. and Keating, D.J. (2011). A new 'dual' in the crown for electrochemistry. Journal of Neurochemistry, 119(5) pp. 899-900.
    [10.1111/j.1471-4159.2011.07508.x] [Scopus]
  • Jentsch, T.J., Maritzen, T., Keating, D.J., Zdebik, A.A. and Thevenod, F. (2010). ClC-3 - a granular anion transporter involved in insulin secretion? (Letter to the Editor) Cell Metabolism, 12(4) pp. 307-308.
    [10.1016/j.cmet.2010.08.014] [Scopus]
  • Keating, D. and Spencer, N. (2010). Controversies Involving the Role of 5-Hydroxytryptamine in Generating Colonic Migrating Motor Complexes: What Is Spontaneous? Reply. Gastroenterology, 138(3) pp. 1214-1215.
    [10.1053/j.gastro.2010.01.038] [Scopus]
  • Martin, A.M., Lumsden, A.L., Young, R.L., Jessup, C.F., Spencer, N.J. and Keating, D.J. (2017). Regional differences in nutrient-induced secretion of gut serotonin. Physiological Reports, 5(6) pp. Art: e13199.
    [10.14814/phy2.13199]
  • Martin, A.M., Lumsden, A.L., Young, R.L., Jessup, C.F., Spencer, N.J. and Keating, D.J. (2017). The nutrient-sensing repertoires of mouse enterochromaffin cells differ between duodenum and colon. Neurogastroenterology and Motility, 2017 pp. Art: e13046.
    [10.1111/nmo.13046] [Scopus]
  • Martin, A.M., Young, R.L., Leong, L.E., Rogers, G., Spencer, N.J., Jessup, C.F., et al. (2017). The diverse metabolic roles of peripheral serotonin. Endocrinology,
    [10.1210/en.2016-1839]
  • Rojas-Canales, D., Penko, D., Myo Min, K.K., Parham, K.A., Peiris, G.D., Haberberger, R.V., et al. (2017). Local Sphingosine Kinase 1 Activity Improves Islet Transplantation. Diabetes,
    [10.2337/db16-0837]
  • Han, Y., Lim, Y., Duffield, M.D., Li, H., Liu, J., Abdul Manaph, N.P., et al. (2016). Direct Reprogramming of Mouse Fibroblasts to Neural Stem Cells by Small Molecules. Stem Cells International, 2016 pp. Art: 4304916.
    [10.1155/2016/4304916] [Scopus]
  • Lumsden, A.L., Young, R., Pezos, N. and Keating, D.J. (2016). Huntingtin-associated protein 1: Eutherian adaptation from a TRAK-like protein, conserved gene promoter elements, and localization in the human intestine. BMC Evolutionary Biology, 16(1) pp. Art: 214.
    [10.1186/s12862-016-0780-3] [10.1186/s12862-016-0780-3] [Scopus]
  • Mackenzie, K.D., Lumsden, A.L., Guo, F., Duffield, M.D., Chataway, T.K., Lim, Y., et al. (2016). Huntingtin-associated protein-1 (HAP1) is a synapsin I-binding protein regulating synaptic vesicle exocytosis and synapsin I trafficking. Journal of Neurochemistry,
    [10.1111/jnc.13703]
  • Mccormack, A.M., Chegeni Farahani, N., Chegini, F., Colella, A., Power, J.H., Keating, D.J., et al. (2016). Purification of a-synuclein containing inclusions from human post mortem brain tissue. Journal of Neuroscience Methods, 266 pp. 141-150.
    [10.1016/j.jneumeth.2016.03.016]
  • Peiris, G.D., Duffield, M.D., Fadista, J., Jessup, C.F., Kashmir, V., Genders, A., et al. (2016). A Syntenic Cross Species Aneuploidy Genetic Screen Links RCAN1 Expression to ß-Cell Mitochondrial Dysfunction in Type 2 Diabetes. PloS Genetics, 12(5) pp. e1006033.
    [10.1371/journal.pgen.1006033] [10.1371/journal.pgen.1006033]
  • Rogers, G., Keating, D.J., Young, R.L., Wong, M.L., Licinio, J. and Wesselingh, S.L. (2016). From gut dysbiosis to altered brain function and mental illness: mechanisms and pathways. MOLECULAR PSYCHIATRY, 21(6) pp. 738-748.
    [10.1038/mp.2016.50] [Scopus]
  • Thorn, P., Zorec, R., Rettig, J. and Keating, D.J. (2016). Exocytosis in non-neuronal cells. Journal of Neurochemistry, 137(6) pp. 849-859.
    [10.1111/jnc.13602] [Scopus]
  • Jackson, J., Papadopulos, , Meunier, F.A., McCluskey, A., Robinson, P.J. and Keating, D.J. (2015). Small molecules demonstrate the role of dynamin as a bi-directional regulator of the exocytosis fusion pore and vesicle release. MOLECULAR PSYCHIATRY, 20(7) pp. 810-819.
    [10.1038/mp.2015.56]
  • Kumar, R.K., Corbett, M., Smith, N.J.C., Jolly, L.A., Tan, C.K., Keating, D.J., et al. (2015). Homozygous mutation of STXBP5L explains an autosomal recessive infantile-onset neurodegenerative disorder. Human Molecular Genetics, 24(7) pp. 2000-2010.
    [10.1093/hmg/ddu614] [Scopus]
  • Papadopulos, A., Gomez, G.A., Martin, S., Jackson, J., Gormal, R.S., Keating, D.J., et al. (2015). Activity-driven relaxation of the cortical actomyosin II network synchronizes Munc18-1-dependent neurosecretory vesicle docking. Nature Communications, 6 pp. Article: 6297.
    [10.1038/ncomms7297] [Scopus]
  • Penko, D., Rojas-Canales, D., Mohanasundaram, D., Peiris, G., Sun, W., Drogemuller, C., et al. (2015). Endothelial progenitor cells enhance islet engraftment, influence beta cell function and modulate islet connexin 36 expression. CELL TRANSPLANTATION, 24(1) pp. 37-48.
    [10.3727/096368913X673423] [Scopus]
  • Raghupathi, R., Jessup, C.F., Lumsden, A.L. and Keating, D.J. (2015). Fusion Pore Size Limits 5-HT Release from Single Enterochromaffin Cell Vesicles. Journal of Cellular Physiology,
    [10.1002/jcp.25256]
  • Spencer, N.J., Sia, T.C., Brookes, S.J., Costa, M. and Keating, D.J. (2015). CrossTalk opposing view: 5-HT is not necessary for peristalsis. Journal of Physiology-London, 593(13) pp. 3229-3231.
    [10.1113/JP270183] [Scopus]
  • Zelkas, L.E., Raghupathi, R., Lumsden, A.L., Martin, A.M., Sun, E.W., Spencer, N.J., et al. (2015). Serotonin-secreting enteroendocrine cells respond via diverse mechanisms to acute and chronic changes in glucose availability. Journal of Nutrition and Metabolism, 12(55) pp. 1-9.
    [10.1186/s12986-015-0051-0]
  • Mackenzie, K.D., Duffield, M.D., Peiris, G.D., Phillips, M.L., Zanin, M.P., Teo, E.H., et al. (2014). Huntingtin-associated protein 1 regulates exocytosis, vesicle docking, readily releasable pool size and fusion pore stability in mouse chromaffin cells. ON-LINE JOURNAL OF PHYSIOLOGY, 592(7) pp. 1505-1518.
    [10.1113/jphysiol.2013.268342] [Scopus]
  • Peiris, G.D., Bonder, C.S., Coates, P.T., Keating, D.J. and Jessup, C.F. (2014). The ß-cell/EC axis: how do islet cells talk to each other? Diabetes, 63(1) pp. 3-11.
    [10.2337/db13-0617] [Scopus]
  • Peiris, G.D., Dubach, D., Jessup, C.F., Unterweger, P., Raghupathi, R., Muyderman, H.C., et al. (2014). RCAN1 Regulates Mitochondrial Function and Increases Susceptibility to Oxidative Stress in Mammalian Cells. Oxidative Medicine and Cellular Longevity, 2014 pp. ArticleID 520316.
    [10.1155/2014/520316] [Scopus]
  • Duncan, C., Bica, L., Crouch, P., Caragounis, A., Lidgerwood, G., Parker, S., et al. (2013). Copper modulates the large dense core vesicle secretory pathway in PC12 cells. Metallomics, 5(6) pp. 700-714.
    [10.1039/c3mt20231c] [Scopus]
  • Keating, D.J., Peiris, H., Kyloh, M.A., Brookes, S.J. and Spencer, N.J. (2013). The presence of 5-HT in myenteric varicosities is not due to uptake of 5-HT released from the mucosa during dissection: use of a novel method for quantifying 5-HT immunoreactivity in myenteric ganglia. Neurogastroenterology and Motility, 25(10) pp. 849-853.
    [10.1111/nmo.12189] [Scopus]
  • McGeachie, A., Odell, L., Quan, A., Daniel, J., Chau, N., Hill, T., et al. (2013). The Pyrimidyn Compounds: Dual-Action Small Molecule Pyrimidine-Based Dynamin Inhibitors. ACS Chemical Biology, 8(7) pp. 1507-1518.
    [10.1021/cb400137p] [Scopus]
  • Raghupathi, R., Duffield, M.D., Zelkas, L.E., Meedeniya, A., Brookes, S., Sia, T., et al. (2013). Identification of unique release kinetics of serotonin from guinea-pig and human enterochromaffin cells. Journal of Physiology-London, 591(23) pp. 5959-5975.
    [10.1113/jphysiol.2013.259796] [Scopus]
  • Saadipour, K., Yang, M., Lim, Y., Georgiou, K., Sun, Y., Keating, D., et al. (2013). Amyloid beta1-42 (Abeta42) up-regulates the expression of sortilin via the p75NTR/RhoA signaling pathway. Journal of Neurochemistry, 127(2) pp. 152-162.
    [10.1111/jnc.12383] [Scopus]
  • Zanin, M.P., Mackenzie, K.D., Peiris, H., Pritchard, M.A. and Keating, D.J. (2013). RCAN1 regulates vesicle recycling and quantal release kinetics via effects on calcineurin activity. Journal of Neurochemistry, 124(3) pp. 290-299.
    [10.1111/jnc.12086] [Scopus]
  • Keating, D.J., Winter, M.A., Hemsley, K.M., Mackenzie, K.D., Teo, E.H., Hopwood, J.J., et al. (2012). Exocytosis is impaired in mucopolysaccharidosis IIIA mouse chromaffin cells. Neuroscience, 227 pp. 110-118.
    [10.1016/j.neuroscience.2012.09.034] [Scopus]
  • Rao, J.R., Keating, D.J., Chen, C. and Parkington, H.C. (2012). Adiponectin increases insulin content and cell proliferation in MIN6 cells via PPAR{gamma}-dependent and PPAR{gamma}-independent mechanisms. Diabetes Obesity and Metabolism, 14(11) pp. 983-989.
    [10.1111/j.1463-1326.2012.01626.x] [Scopus]
  • Peiris, H., Raghupathi, R., Jessup, C.F., Zanin, M.P., Mohanasundaram, D., Mackenzie, K.D., et al. (2012). Increased Expression of the Glucose-Responsive Gene, RCAN1, Causes Hypoinsulinemia, {Beta}-Cell Dysfunction, and Diabetes. Endocrinology, 153(11) pp. 5212-5221.
    [10.1210/en.2011-2149] [Scopus]
  • Barreto, S., Bazargan, M., Zotti, M., Hussey, D., Sukocheva, O., Peiris, G., et al. (2011). Galanin receptor 3 - a potential target for acute pancreatitis therapy. Neurogastroenterology and Motility, 23(3) pp. e141-e151.
    [10.1111/j.1365-2982.2010.01662.x] [Scopus]
  • Spencer, N., Nicholas, S., Robinson, L.V., Kyloh, M., Flack, N., Brookes, S., et al. (2011). Mechanisms underlying distension-evoked peristalsis in guinea pig distal colon: is there a role for enterochromaffin cells? American Journal of Physiology-Gastrointestinal and Liver Physiology, 301(3) pp. G519-G527.
    [10.1152/ajpgi.00101.2011] [Scopus]
  • Zanin, M.P., Phillips, M.L., Mackenzie, K.D. and Keating, D.J. (2011). Aging Differentially Affects Multiple Aspects of Vesicle Fusion Kinetics. PLoS One, 6(11 e27820) pp. 1-10.
    [10.1371/journal.pone.0027820] [Scopus]
  • Wen, P., Osborne, S., Zanin, M., Low, P., Wang, H.T., Schoenwaelder, S., et al. (2011). Phosphatidylinositol(4,5)bisphosphate coordinates actin-mediated mobilization and translocation of secretory vesicles to the plasma membrane of chromaffin cells. Nature Communications, 2 pp. 491.
    [10.1038/ncomms1500] [Scopus]
  • Keating, D.J. and Spencer, N.J. (2010). Release of 5-Hydroxytryptamine From the Mucosa Is Not Required for the Generation or Propagation of Colonic Migrating Motor Complexes. Gastroenterology, 138(2) pp. 659-670.
    [10.1053/j.gastro.2009.09.020] [Scopus]
  • Keating, D.J., Rychkov, G. and Roberts, M. (2009). The contribution of voltage-gated Ca2+ currents to K+ channel activation during ovine adrenal chromaffin cell development. International Journal of Developmental Neuroscience, 27(4) pp. 357-363.
    [10.1016/j.ijdevneu.2009.03.003] [Scopus]
  • Pfeffer, C., Stein, V., Keating, D.J., Maier, H., Rinke, I., Rudhard, Y., et al. (2009). NKCC1-dependent GABAergic excitation drives synaptic network maturation during early hippocampal development. Journal of Neuroscience, 29(11) pp. 3419-3430.
    [10.1523/JNEUROSCI.1377-08.2009] [Scopus]
  • Feng, D.D., Zhao, Y.F., Luo, Z., Keating, D.J. and Chen, C. (2008). Linoleic acid induces Ca2+-induced inactivation of voltage-dependent Ca2+ currents in rat pancreatic beta-cells. Journal of Endocrinology, 196(2) pp. 377-384.
    [10.1677/JOE-07-0426] [Scopus]
  • Keating, D.J. (2008). Mitochondrial dysfunction, oxidative stress, regulation of exocytosis and their relevance to neurodegenerative diseases. Journal of Neurochemistry, 104(2) pp. 298-305.
    [10.1111/j.1471-4159.2007.04997.x] [Scopus]
  • Keating, D.J., Dubach, D., Zanin, M.P., Yu, Y., Martin, K., Zhao, Y.F., et al. (2008). DSCR1/RCAN1 regulates vesicle exocytosis and fusion pore kinetics: implications for Down syndrome and Alzheimer's disease. Human Molecular Genetics, 17(7) pp. 1020-1030.
    [10.1093/hmg/ddm374] [Scopus]
  • Maritzen, T., Keating, D.J., Neagoe, I., Zdebik, A.A. and Jentsch, T.J. (2008). Role of the vesicular chloride transporter ClC-3 in neuroendocrine tissue. Journal of Neuroscience, 28(42) pp. 10587-10598.
    [10.1523/JNEUROSCI.3750-08.2008] [Scopus]
  • Yu, Y., Chu, P.Y., Bowser, D.N., Keating, D.J., Dubach, D., Harper, I., et al. (2008). Mice deficient for the chromosome 21 ortholog Itsn1 exhibit vesicle-trafficking abnormalities. Human Molecular Genetics, 17(21) pp. 3281-3290.
    [10.1093/hmg/ddn224] [Scopus]
  • Quan, A., McGeachie, A.B., Keating, D.J., van Dam, E.M., Rusak, J., Chau, N., et al. (2007). Myristyl trimethyl ammonium bromide and octadecyl trimethyl ammonium bromide are surface-active small molecule dynamin inhibitors that block endocytosis mediated by dynamin I or dynamin II. Molecular Pharmacology, 72(6) pp. 1425-1439.
    [10.1124/mol.107.034207] [Scopus]
  • Yang, S.K., Parkington, H.C., Epelbaum, J., Keating, D.J. and Chen, C. (2007). Somatostatin decreases voltage-gated Ca2+ currents in GH3 cells through activation of somatostatin receptor 2. American Journal of Physiology-Endocrinology and Metabolism, 292(6) pp. E1863-E1870.
    [10.1152/ajpendo.00047.2007] [Scopus]
  • Feng, D.D., Luo, Z., Roh, S.G., Hernandez, M., Tawadros, N., Keating, D., et al. (2006). Reduction in Voltage-Gated K+ Currents in Primary Cultured Rat Pancreatic beta-Cells by Linoleic Acids. Endocrinology, 147(2) pp. 674-682.
    [10.1210/en.2005-0225] [Scopus]
  • Keating, D., Chen, C. and Pritchard, M.A. (2006). Alzheimer's disease and endocytic dysfunction: Clues from the Down syndrome-related proteins, DSCR1 and ITSN1. Ageing Research Reviews, 5(4) pp. 388-401.
    [10.1016/j.arr.2005.11.001] [Scopus]
  • Han, X.F., Zhu, Y.L., Hernandez, M., Keating, D. and Chen, C. (2005). Ghrelin reduces voltage-gated potassium currents in GH3 cells via cyclic GMP pathways. Endocrine, 28(2) pp. 217-224.
    [10.1385/ENDO:28:2:217] [Scopus]
  • Keating, D. and Chen, C. (2005). Activin A stimulates catecholamine secretion from rat adrenal chromaffin cells: a new physiological mechanism. Journal of Endocrinology, 186(2) pp. R1-R5.
    [10.1677/joe.1.06301] [Scopus]
  • Keating, D., Rychkov, G.Y., Giacomin, P.R. and Roberts, M.L. (2005). Oxygen-sensing pathway for SK channels in the ovine adrenal medulla. Clinical and Experimental Pharmacology and Physiology, 32(10) pp. 882-887.
    [10.1111/j.1440-1681.2010.04279.x] [Scopus]
  • Yang, S.K., Parkington, H.C., Blake, A.D., Keating, D. and Chen, C. (2005). Somatostatin increases voltage-gated K+ currents in GH3 cells through activation of multiple somatostatin receptors. Endocrinology, 146(11) pp. 4975-4984.
    [10.1210/en.2005-0696#sthash.YdUIJo3A.dpuf] [Scopus]
  • Zhao, Y.F., Keating, D., Hernandez, M., Feng, D.D., Zhu, Y. and Chen, C. (2005). Long-term inhibition of protein tyrosine kinase impairs electrophysiologic activity and a rapid component of exocytosis in pancreatic B-cells. Journal of Molecular Endocrinology, 35(1) pp. 49-59.
    [10.1677/jme.1.01779] [Scopus]
  • Keating, D., Rychkov, G.Y., Adams, M.B., Holgert, H., McMillen, I.C. and Roberts, M.L. (2004). Opioid receptor stimulation suppresses the adrenal medulla hypoxic response in sheep by actions on Ca2+ and K+ channels. Journal of Physiology-London, 555(2) pp. 489-502.
    [10.1113/jphysiol.2003.056176] [Scopus]
  • Boettger, T., Rust, M.B., Maier, H., Seidenbecher, T., Schweizer, M., Keating, D., et al. (2003). Loss of K-Cl co-transporter KCC3 causes deafness, neurodegeneration and reduced seizure threshold. EMBO Journal, 22(20) pp. 5422-5434.
    [10.1093/emboj/cdg519] [Scopus]
  • Keating, D., Rychkov, G. and Roberts, M.L. (2001). Oxygen sensitivity in the sheep adrenal medulla: role of SK channels. American Journal of Physiology-Cell Physiology, 281 pp. C1434-C1441.
    [Scopus]
  • Jackson, J., Papadopulos, , Meunier, F.A., McCluskey, A., Robinson, P.J. and Keating, D.J. (2015). Small molecules demonstrate the role of dynamin as a bi-directional regulator of the exocytosis fusion pore and vesicle release. MOLECULAR PSYCHIATRY, 20(7) pp. 810-819.
    [10.1038/mp.2015.56]
  • Kumar, R.K., Corbett, M., Smith, N.J.C., Jolly, L.A., Tan, C.K., Keating, D.J., et al. (2015). Homozygous mutation of STXBP5L explains an autosomal recessive infantile-onset neurodegenerative disorder. Human Molecular Genetics, 24(7) pp. 2000-2010.
    [10.1093/hmg/ddu614] [Scopus]
  • Papadopulos, A., Gomez, G.A., Martin, S., Jackson, J., Gormal, R.S., Keating, D.J., et al. (2015). Activity-driven relaxation of the cortical actomyosin II network synchronizes Munc18-1-dependent neurosecretory vesicle docking. Nature Communications, 6 pp. Article: 6297.
    [10.1038/ncomms7297] [Scopus]
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