Position

Lecturer in Synthetic Chemistry
School of Chemical & Physical Sciences

Biography

Justin M. Chalker earned a B.S. in Chemistry and a B.A. in the History and Philosophy of Science at The University of Pittsburgh in 2006. At Pittsburgh, he contributed to the total synthesis of several natural products under the direction of Theodore Cohen. Supported by a Rhodes Scholarship and a National Science Foundation Graduate Research Fellowship, Justin then completed his D.Phil. at the University of Oxford under the supervision of Benjamin Davis where he developed several tools for the site-selective modification of proteins. In 2012, Justin started his independent career as an assistant professor at The University of Tulsa where he established a diverse research program in organic chemistry, biochemistry and material science. In 2015, Justin moved to Flinders University where he is a Lecturer in Synthetic Chemistry and recipient of an ARC Discovery Early Career Researcher Award.

Lab Website: www.chalkerlab.com

Qualifications

Assistant Professor, The University of Tulsa (2012 to 2015)

D.Phil., Organic Chemistry, Oxford University (2011) - Advisor: Prof. Benjamin G. Davis

B.S., Chemistry, University of Pittsburgh (2006) - Advisor: Prof. Theodore Cohen

B.A., History and Philosophy of Science, University of Pittsburgh (2006)

Honours, awards and grants

Vice-Chancellor's Award for Early Career Researchers (2015)

ARC Discovery Early Career Researcher Award (2015)

Fresh Science Finalist (2015)

F1000 Faculty Member of the Year in Chemical Biology (2012)

National Science Foundation Graduate Research Fellowship (2008)

Rhodes Scholarship (2006)

Teaching interests

I am interested in all aspects of organic chemistry and allied fields of biochemistry and chemical biology. Currently I teach second and third year organic chemistry and plan to develop Honours modules related to catalysis, green chemistry, and chemical biology. In these efforts, I aim to inspire students and convince them that organic chemistry is a valuable and interesting academic discipline in and of itself, but also a highly practical science intimately related to a variety of pursuits in biology, energy, materials, and medicine.

Topic Lecturer:

  • CHEM2702  Organic Reactions
  • CHEM3711  Organic Synthesis and Mechanism
  • CHEM3712  Introduction to Polymer Science
  • CPES3700  Research Project (Supervisor)
  • CPES7721  Chemical Biology (Honours Module)
  • CPES8700  Research Project (Supervisor)
  • CTEC3101  Clean Technology (Project Supervisor)

Research expertise

  • Organic chemistry

Research interests

Research in our laboratory falls under the general purview of organic chemistry and its application to problems in chemical synthesis, chemical biology, and material science. One goal in our lab is to design reactions, reagents, and catalysts that streamline the synthesis of valuable materials such as pharmaceuticals and polymers. These efforts are closely linked to our commitment to develop sustainable and environmentally benign chemistry. A second goal in our laboratory is to invent chemical tools that are useful in the interrogation of biological systems. This research provides insight to fundamental biomolecular processes and also provides a foundation for novel therapeutic and diagnostic strategies. Prospective Ph.D. and Honours students are encouraged to contact Dr Chalker directly.

For more on our research, visit our lab's website: www.chalkerlab.com

For links to recent publications and bibliometrics, please follow the Google Scholar or LinkedIn icons at the top of this page.

Supervisory interests

  • Catalysis
  • Chemical biology
  • Functional materials
  • Green chemistry
  • Organic chemistry
  • Organic synthesis
  • Polymers
  • Protein chemistry
  • Sustainable chemistry

Publications

  • Bernardes, G., Chalker, J.M. and Davis, B. (2010). Chemical Protein Modification. In Bruno Pignataro, ed. Ideas in Chemistry and Molecular Sciences: Where Chemistry Meets Life. Weinheim, Germany: Wiley-VCH Verlag GmbH & Co. KGaA, pp. 59-91.
    [Web Link]
  • Crockett, M.P., Evans, A.M., Worthington, M., Albuquerque, I.S., Slattery, A.D., Gibson, C.T., et al. (2016). Sulfur-Limonene Polysulfide: A Material Synthesized Entirely from Industrial By-Products and Its Use in Removing Toxic Metals from Water and Soil. Angewandte Chemie-International Edition, 55 pp. 1714-1718.
    [10.1002/anie.201508708] [Scopus] [Web Link]
  • Chalker, J.M. (2015). Allyl Sulfides: Reactive Substrates for Olefin Metathesis. Australian Journal of Chemistry, 68 pp. 1801-1809.
    [10.1071/CH15311] [Web Link]
  • Britton, J., Chalker, J.M. and Raston, C.L. (2015). Rapid Vortex Fluidics: Continuous Flow Synthesis of Amides and Local Anesthetic Lidocaine. Chemistry-A European Journal, 21(30) pp. 10660-10665.
    [10.1002/chem.201501785] [Scopus] [Web Link]
  • Edwards, G., Culp, P. and Chalker, J.M. (2015). Allyl sulphides in olefin metathesis: catalyst considerations and traceless promotion of ring-closing metathesis. Chemical Communications, 51(3) pp. 515-518.
    [10.1039/C4CC07932A] [Scopus]
  • Moorman, R., Collier, M., Frohock, B., Womble, M. and Chalker, J.M. (2015). Halide inhibition of the copper-catalysed azide-alkyne cycloaddition. Organic and Biomolecular Chemistry, 13(7) pp. 1974-1978.
    [10.1039/C4OB02479F] [Scopus]
  • Moorman, R.M., Kasmani, M.Y., Peeples, C.J. and Chalker, J.M. (2015). Inquiry-Driven Investigation of the Copper-Catalyzed Azide-Alkyne Cycloaddition in the Undergraduate Organic Chemistry Laboratory. The Chemical Educator, 20 pp. 214-219.
    [10.1333/s00897152640a] [Web Link]
  • Pegg, C., Jones, G., Athauda, T., Ozer, R. and Chalker, J.M. (2014). Facile preparation of ammonium alginate-derived nanofibers carrying diverse therapeutic cargo. Chemical Communications, 50 pp. 156-158.
    [Scopus] [Web Link]
  • Edwards, G., Trafford, M., Hamilton, A., Buxton, A., Bardeaux, M. and Chalker, J.M. (2014). Melamine and Melamine-Formaldehyde Polymers as Ligands for Palladium and Application to Suzuki-Miyaura Cross-Coupling Reactions in Sustainable Solvents. The Journal of Organic Chemistry, 79(5) pp. 2094-2104.
    [10.1021/jo402799t] [Scopus] [Web Link]
  • Athauda, T., LePage, W., Chalker, J.M. and Ozer, R. (2014). High density growth of ZnO nanorods on cotton fabric enables access to a flame resistant composite. RSC Advances, 4 pp. 14582-14585.
    [Scopus] [Web Link]
  • Chalker, J.M. (2013). Prospects in the Total Synthesis of Protein Therapeutics. Chemical Biology and Drug Design, 81(1) pp. 122-135.
    [10.1111/cbdd.12007] [Scopus] [Web Link]
  • Hamilton, A., Buxton, A., Peeples, C. and Chalker, J.M. (2013). An Operationally Simple Aqueous Suzuki-Miyaura Cross-Coupling Reaction for an Undergraduate Organic Chemistry Laboratory. Journal of Chemical Education, 90(11) pp. 1509-1513.
    [10.1021/ed4002333] [Scopus] [Web Link]
  • Athauda, T., Ozer, R. and Chalker, J.M. (2013). Investigation of cotton functionalized with ZnO nanorods and its interaction with E. coli. RSC Advances, 3 pp. 10662-10665.
    [Scopus] [Web Link]
  • Chalker, J.M., Lercher, L., Rose, N., Schofield, C. and Davis, B. (2012). Conversion of Cysteine into Dehydroalanine Enables Access to Synthetic Histones Bearing Diverse Post-Translational Modifications. Angewandte Chemie-International Edition, 51(8) pp. 1835-1839.
    [10.1002/anie.201106432] [Scopus]
  • Grayson, E., Bernardes, G., Chalker, J.M., Boutureira, O., Koeppe, J. and Davis, B. (2011). A Coordinated Synthesis and Conjugation Strategy for the Preparation of Homogeneous Glycoconjugate Vaccine Candidates. Angewandte Chemie-International Edition, 50(18) pp. 4127-4132.
    [10.1002/anie.201006327] [Scopus]
  • Chalker, J.M., Gunnoo, S., Boutureira, O., Gerstberger, S., Fernandez-Gonzalez, M., Bernardes, G., et al. (2011). Methods for converting cysteine to dehydroalanine on peptides and proteins. Chemical Science, 2 pp. 1666-1676.
    [10.1039/c1sc00185j] [Scopus]
  • Chalker, J.M., Bernardes, G. and Davis, B. (2011). A Tag-and-Modify Approach to Site-Selective Protein Modification. ACCOUNTS OF CHEMICAL RESEARCH, 44(9) pp. 730-741.
    [Scopus] [Web Link]
  • Wei, G., Chalker, J.M. and Cohen, T. (2011). Synthesis of (-)-alpha-Kainic Acid via TMSCl-Promoted Pd-Catalyzed Zinc-ene Cyclization of an Allyl Acetate. The Journal of Organic Chemistry, 76(19) pp. 7912-7917.
    [10.1021/jo201341q] [Scopus]
  • Chalker, J.M. and Davis, B. (2010). Chemical mutagenesis: selective post-expression interconversion of protein amino acid residues. Current Opinion in Chemical Biology, 14(6) pp. 781-789.
    [10.1016/j.cbpa.2010.10.007] [Scopus] [Web Link]
  • Lin, Y., Chalker, J.M. and Davis, B. (2010). Olefin Cross-Metathesis on Proteins: Investigation of Allylic Chalcogen Effects and Guiding Principles in Metathesis Partner Selection. Journal of The American Chemical Society, 132(47) pp. 16805-16811.
    [10.1021/ja104994d] [Web Link]
  • Fernandez-Gonzalez, M., Boutureira, O., Bernardes, G., Chalker, J.M., Young, M., Errey, J., et al. (2010). Site-selective chemoenzymatic construction of synthetic glycoproteins using endoglycosidases. Chemical Science, 1(6) pp. 709-715.
    [10.1039/c0sc00265h] [Scopus] [Web Link]
  • Patel, M., Vijayakrishnan, B., Koeppe, J., Chalker, J.M., Doores, K. and Davis, B. (2010). Analysis of the dispersity in carbohydrate loading of synthetic glycoproteins using MALDI-TOF mass spectrometry. Chemical Communications, 46(48) pp. 9119-9121.
    [10.1039/c0cc03420g] [Scopus] [Web Link]
  • Chalker, J.M., Thompson, A. and Davis, B. (2010). Safe and Scalable Preparation of Barluenga's Reagent: (Bis(pyridine) iodonium(I) Tetrafluoroborate) ORGANIC SYNTHESES, 87 pp. 288-298.
    [Scopus] [Web Link] [Web Link]
  • Chalker, J.M., Wood, C. and Davis, B. (2009). A Convenient Catalyst for Aqueous and Protein Suzuki−Miyaura Cross-Coupling. Journal of The American Chemical Society, 131(45) pp. 16346-16347.
    [10.1021/ja907150m] [Scopus] [Web Link]
  • Chalker, J.M., Lin, Y., Boutureira, O. and Davis, B. (2009). Enabling olefin metathesis on proteins: chemical methods for installation of S-allyl cysteine. Chemical Communications, 25 pp. 3714-3716.
    [10.1039/B908004J] [Scopus] [Web Link]
  • Chalker, J.M., Bernardes, G., Lin, Y. and Davis, B. (2009). Chemical Modification of Proteins at Cysteine: Opportunities in Chemistry and Biology. Chemistry an Asian Journal, 4(5) pp. 630-640.
    [10.1002/asia.200800427] [Scopus] [Web Link]
  • Lin, Y., Chalker, J.M. and Davis, B. (2009). Olefin Metathesis for Site-Selective Protein Modification. Chembiochem, 10(6) pp. 959-969.
    [10.1002/cbic.200900002] [Scopus] [Web Link]
  • Bernardes, G., Grayson, E., Thompson, S., Chalker, J.M., Errey, J., El Oualid, F., et al. (2008). From Disulfide- to Thioether-Linked Glycoproteins. Angewandte Chemie-International Edition, 47(12) pp. 2244-2247.
    [10.1002/anie.200704381] [Scopus] [Web Link]
  • Gamblin, D., van Kasteren, S., Bernardes, G., Chalker, J.M., Oldham, N., Fairbanks, A., et al. (2008). Chemical site-selective prenylation of proteins. Molecular BioSystems, 4(6) pp. 558-561.
    [10.1039/b802199f] [Scopus] [Web Link]
  • Gamblin, D., van Kasteren, S., Chalker, J.M. and Davis, B. (2008). Chemical approaches to mapping the function of post-translational modifications. The FEBS Journal, 275(9) pp. 1949-1959.
    [10.1111/j.1742-4658.2008.06347.x] [Scopus] [Web Link]
  • Lin, Y., Chalker, J.M., Floyd, N., Bernardes, G. and Davis, B. (2008). Allyl Sulfides Are Privileged Substrates in Aqueous Cross-Metathesis: Application to Site-Selective Protein Modification. Journal of The American Chemical Society, 130(30) pp. 9642-9643.
    [10.1021/ja8026168] [Scopus] [Web Link]
  • Bernardes, G., Chalker, J.M., Errey, J. and Davis, B. (2008). Facile Conversion of Cysteine and Alkyl Cysteines to Dehydroalanine on Protein Surfaces: Versatile and Switchable Access to Functionalized Proteins. Journal of The American Chemical Society, 130(15) pp. 5052-5053.
    [10.1021/ja800800p] [Scopus] [Web Link]
  • Chalker, J.M., Yang, A., Deng, K. and Cohen, T. (2007). Two Syntheses of (-)-Kainic Acid via Highly Stereoselective Zinc-ene Cyclizations. Organic Letters, 9(19) pp. 3825-3828.
    [Scopus] [Web Link]
  • Deng, K., Chalker, J.M., Yang, A. and Cohen, T. (2005). Allyl Sulfones as Precursors to Allylzincs in the Palladium-Catalyzed Zinc-ene Cyclization: Highly Efficient Synthesis of Enantiopure (-)-Erythrodiene. Organic Letters, 7(17) pp. 3637-3640.
    [Scopus] [Web Link]
  • Crockett, M.P., Evans, A.M., Worthington, M., Albuquerque, I.S., Slattery, A.D., Gibson, C.T., et al. (2016). Sulfur-Limonene Polysulfide: A Material Synthesized Entirely from Industrial By-Products and Its Use in Removing Toxic Metals from Water and Soil. Angewandte Chemie-International Edition, 55 pp. 1714-1718.
    [10.1002/anie.201508708] [Scopus] [Web Link]
  • Chalker, J.M. (2015). Allyl Sulfides: Reactive Substrates for Olefin Metathesis. Australian Journal of Chemistry, 68 pp. 1801-1809.
    [10.1071/CH15311] [Web Link]
  • Edwards, G., Culp, P. and Chalker, J.M. (2015). Allyl sulphides in olefin metathesis: catalyst considerations and traceless promotion of ring-closing metathesis. Chemical Communications, 51(3) pp. 515-518.
    [10.1039/C4CC07932A] [Scopus]
  • Britton, J., Chalker, J.M. and Raston, C.L. (2015). Rapid Vortex Fluidics: Continuous Flow Synthesis of Amides and Local Anesthetic Lidocaine. Chemistry-A European Journal, 21(30) pp. 10660-10665.
    [10.1002/chem.201501785] [Scopus] [Web Link]
  • Moorman, R., Collier, M., Frohock, B., Womble, M. and Chalker, J.M. (2015). Halide inhibition of the copper-catalysed azide-alkyne cycloaddition. Organic and Biomolecular Chemistry, 13(7) pp. 1974-1978.
    [10.1039/C4OB02479F] [Scopus]
  • Moorman, R.M., Kasmani, M.Y., Peeples, C.J. and Chalker, J.M. (2015). Inquiry-Driven Investigation of the Copper-Catalyzed Azide-Alkyne Cycloaddition in the Undergraduate Organic Chemistry Laboratory. The Chemical Educator, 20 pp. 214-219.
    [10.1333/s00897152640a] [Web Link]
  • Athauda, T., LePage, W., Chalker, J.M. and Ozer, R. (2014). High density growth of ZnO nanorods on cotton fabric enables access to a flame resistant composite. RSC Advances, 4 pp. 14582-14585.
    [Scopus] [Web Link]
  • Edwards, G., Trafford, M., Hamilton, A., Buxton, A., Bardeaux, M. and Chalker, J.M. (2014). Melamine and Melamine-Formaldehyde Polymers as Ligands for Palladium and Application to Suzuki-Miyaura Cross-Coupling Reactions in Sustainable Solvents. The Journal of Organic Chemistry, 79(5) pp. 2094-2104.
    [10.1021/jo402799t] [Scopus] [Web Link]
  • Pegg, C., Jones, G., Athauda, T., Ozer, R. and Chalker, J.M. (2014). Facile preparation of ammonium alginate-derived nanofibers carrying diverse therapeutic cargo. Chemical Communications, 50 pp. 156-158.
    [Scopus] [Web Link]
  • Athauda, T., Ozer, R. and Chalker, J.M. (2013). Investigation of cotton functionalized with ZnO nanorods and its interaction with E. coli. RSC Advances, 3 pp. 10662-10665.
    [Scopus] [Web Link]

Professional and community engagement

Justin regularly egages in science outreach through appearances on TV and radio, public lectures, school visits, online science mentorship, and interactive scienc shows. If you are interested in an outreach partnership, please contact Justin

Recent Events and activities:

ABC Catalyst episode on mercury pollution (2016)

Scope Network Ten segment on converting waste into polymers that capture pollution [from 19:10] (2016)

• The Heavy Metals Lab at MONA in Hobart - a collaboration between artists and scientists to increase awareness about pollution (2016)

Science and Maths Academy at Flinders University - invited speaker. (2016)

• Keynote speaker for the RACI Year 12 Merit Ceremony for South Australia (2016)

ABC Radio segment on new technologies to capture mercury (2015)

• RACI Science Alive Chemistry Show at the Royal Adelaide Showground (3 day Chemistry show, more than 25,000 in audience) (2015)

Fresh Science - Stories of discovery from early-career researchers in Australia. (2015)

First Lego League mentor - Virtual conferences about STEM with grade 5-8 team from Jesup Community Schools in Waterloo, IA. (2015)

Students on the Beamlines - Mentor for inquiry-driven science project at the Canadian Light Source, in conjunction with high school project leaders at Evan Hardy Collegiate Institute in Saskatoon Canada. (2015-2016)

Contact

Add to address book
Phone: +61 8 82012268
Email:
Location: Physical Sciences Building (3109)
Postal address: GPO Box 2100, Adelaide 5001, South Australia
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