Position

Strategic Professor in Reproductive Medicine
Flinders Southern Adelaide Clinical School AU

Biography

Professor Tremellen was appointed to the position of Strategic Professor of Reproductive Medicine in 2015 with a vision of improving access to high quality fertility treatment for all individuals wishing to become parents.

He graduated from the University of Adelaide with a medical degree (with honours) and a PhD in the field of reproductive immunology before completing his clinical training in obstetrics, gynaecology and reproductive medicine. His primary research focus is on the impact of nutrition on reproduction.

This research lead to the development of the nutraceutical fertility supplement Menevit™ that has been shown to improve sperm quality and the chances of conception, and is now marketed throughout Australasia by Bayer.

Professor Tremellen is editor of Nutrition, Fertility and Human Reproductive Function (CRC Press), a key textbook that highlights the importance of nutrition in all aspects of male and female reproductive function. He passionately believes that in order to maximise a couple’s chances of achieving their dream of having a healthy child, we must first optimise male and female nutrition and lifestyle before conception.

His other research interests relate to the identification and treatment of premature loss of ovarian reserve, plus investigation of how poor nutrition and obesity combine to trigger inflammation that impairs ovarian function, sperm production and successful implantation of the embryo.

Professor Tremellen has worked at the Uehiro Centre for Practical Ethics at Oxford University and has an interest in analysing the many ethical issues relating to reproductive medicine and associated heath policy. He is on the editorial board of the journal Human Reproduction, has published over 70 original journal articles and book chapters, and holds three patents covering innovations in reproductive medicine.

Qualifications

  • Bachelor of Medicine with honours [MB BS Hons)]
  • Doctor of Philosophy
  • Fellow of the Royal Australian New Zealand College of Obstetricians and Gynaecologists (FRANZCOG)
  • Certified sub-specialist in Reproductive Endocrinology and Infertility (CREI) of the RANZCOG
  • Graduate Certificate in Management

Honours, awards and grants

Fertility Society Australia/ British Fertility Society exchange lecture, 2006

Royal Australian New Zealand College Obstetrics and Gynaecology “Gold Medal” for first placed candidate in the MRANZCOG examination, 2001

Australian Society for Medical Research. Faulding ASMR Prize, 1996

Supervisory interests

  • Ethics in reproductive medicine
  • Impact of nutrition on reproduction
  • Reproductive medicine

Publications

  • Tremellen, K.P. (2012). Antioxidant Therapy for the Enhancement of Male Reproductive Health: A Critical Review of the Literature. In Sijo J. Parekattil, Ashok Agarwal, ed. Male Infertility: Contemporary Clinical Approaches, Andrology, ART & Antioxidants. New York: Springer, pp. 389-399.
  • Tremellen, K.P. (2012). Life after Embryo Transfer. In Khaldoun Sharif, Arri Coomarasamy, ed. Assisted Reproductive Techniques: Challenges and Management Options. Online: Wiley Blackwell, pp. 261-266.
  • Tremellen, K.P. (2012). Oxidative Stress and Male Infertility: A Clinical Perspective. In Ashok Agarwal, R. John Aitken, Juan G. Alvarez, ed. Studies on Men's Health and Fertility. New York: Springer, pp. 325-353.
  • Tremellen, K.P. (2011). Pre-treatment hormone assessment to optimize IVF outcomes. In Gab Kovacs, ed. How to Improve your ART Success Rates. Online: Cambridge University Press, pp. 1-6.
  • Tremellen, K.P. and Pearce, K. (Eds.). (2015). Nutrition, Fertility, and Human Reproductive Function. London: CRC Press.
  • Tremellen, K.P. (2014). Social Egg freezing - the answer to a 21st century dilemma. In Proceedings of the 5th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2014) in conjunction with the Fertility Society of Australia Annual Conference. 5th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2014) in conjunction with the Fertility Society of Australia Annual Conference. Brisbane. Apr 2014.
  • Tremellen, K.P. (2014). Probiotica and Gametes - Do the Bacteria in Our Guts Affect our Gametes? In Proceedings of the Scientists in Reproductive Medicine 10th Biennial Conference. www.sirt.org.au: Scientists in Reproductive Technology. Scientists in Reproductive Medicine 10th Biennial Conference, ALPHA 2014. Antalya, Turkey. May 2014.
  • Tremellen, K.P. (2014). Patient centered care in IVF. The role of the GnRHa trigger in preventing OHSS. In Proceedings of the MSD Korean meeting. MSD Korean meeting. Seoul, Korea.
  • Tremellen, K.P. (2013). Role of micronutrients in human fertility. In Proceedings of the 7th Diet and Optimum Health Conference. Linus Pauling Institute. Diet and Optimum Health Conference. Oregon, US. May 2013.
  • Tremellen, K.P. (2012). Serum AMH is a marker of quantitative, not qualitative ovarian reserve. In Proceedings of the European Society for Human Reproduction Annual Meeting, 2012. European Society for Human Reproduction. European Society for Human Reproduction Annual Meeting, 2012. Istanbul, turkey. Jul 2012.
  • Tremellen, K.P. (2011). Sperm oxidative stress and its role in male infertility. In Nordic Society for Reproductive Medicine. Nordic Society for Reproductive Medicine. Stockholm, Sweden.
  • Tremellen, K.P. (2011). The gateway to successful pregnancy is implantation. In Malaysian Reproductive Medicine Congress. Malaysian Society for Assisted Reproductive Technology. Malaysian Reproductive Medicine Congress. Kuala Lumpur.
  • Tremellen, K.P. (2011). Avoidance of weekend oocyte retrievals in GnRH antagonist IVF cycles. In Proceedings of the 27th Annual Meeting of the European Society of Human Reproduction & Embryology. 27th Annual Meeting of the European Society of Human Reproduction & Embryology. Stockholm. Jul 2011.
  • Tremellen, K.P. (2011). Elonva. A new innovation in patient focused therapy. In MSD Korean meeting, 2011. Seoul, KoreaMSD Korean meeting, 2011.
  • Tremellen, K.P. and Thalluri, V. (2015). Influence of Endometriosis on Assisted Reproductive Technology Outcomes: A Systematic Review and Meta-analysis. Obstetrics and Gynecology, 125(6) pp. 1498-1499.
  • Tremellen, K.P. and Thalluri, V. (2013). Impact of adenomyosis on pregnancy rates in IVF treatment. Reproductive Biomedicine Online, 26 pp. 299-300.
  • Tremellen, K.P. and Pearce, K. (2016). METHODS AND COMPOSITIONS FOR EXTENDING REPRODUCTIVE LIFE USING BETA-CRYPTOXANTHIN. Patent: PCT/AU2016/000022 Australia. Patent owner: Flinders Universy
  • Tremellen, K.P., Wilkinson, D. and Savulescu, J. (2016). Is mandating elective single embryo transfer ethically justifiable in young women? Reproductive Biomedicine & Society Online, 1 pp. 81-87.
    [10.1016/j.rbms.2016.02.001]
  • Wilkinson, D., Schaefer, G.O., Tremellen, K.P. and Savulescu, J. (2015). Double trouble: Should double embryo transfer be banned? Theoretical Medicine and Bioethics, 36 pp. 121-139.
    [10.1007/s11017-015-9324-x] [Scopus]
  • Tremellen, K.P., Syedi, N., Tan, S. and Pearce, K. (2015). Metabolic endotoxaemia – a potential novel link between ovarian inflammation and impaired progesterone production. Gynecological Endocrinology, 31(4) pp. 309-312.
    [10.3109/09513590.2014.994602] [Scopus]
  • Tremellen, K.P. and Zander-Fox, D. (2015). Serum anti-Mullerian hormone assessment of ovarian reserve and polycystic ovary syndrome status over the reproductive lifespan. Australian and New Zealand Journal of Obstetrics and Gynaecology, 55 pp. 384-389.
    [10.1111/ajo.12366] [Scopus]
  • Tremellen, K.P. and Savulescu, J. (2015). A discussion supporting presumed consent for posthumous sperm procurement and conception. Reproductive Biomedicine Online, 30 pp. 6-13.
    [Scopus]
  • Robson, S., Campbell, S., McDonald, J., Tremellen, K.P., Carlin, E. and Maybury, G. (2015). Pregnancy and childhood health and developmental outcomes with the use of posthumous human sperm. Human Reproduction, 30(10) pp. 2259-2262.
    [10.1093/humrep/dev191] [Scopus]
  • Pearce, K.L., Gleeson, K. and Tremellen, K.P. (2015). Serum anti-Mullerian hormone production is not correlated with seasonal fluctuations of vitamin D status in ovulatory or PCOS women. Human Reproduction, 30(9) pp. 2171-2177.
    [10.1093/humrep/dev167] [Scopus]
  • Anderson, R.A., Anckaert, E., Bosch, E., Dewailly, D., Dunlop, C.E., Fehr, D., et al. (2015). Prospective study into the value of the automated Elecsys antimullerian hormone assay for the assessment of the ovarian growing follicle pool. Fertility and Sterility, 103(4) pp. 1074-1080.
    [Scopus]
  • Tremellen, K.P. and Savulescu, J. (2014). Ovarian reserve screening: a scientific and ethical analysis. Human Reproduction, 29(12) pp. 2606-2614.
    [Scopus]
  • Russell, P., Hey-Cunningham, A., Berbic, M., Tremellen, K.P., Sacks, G., Gee, A., et al. (2014). Asynchronous glands in the endometrium of women with recurrent reproductive failure. Pathology, 46(4) pp. 325-332.
    [Scopus]
  • Rallis, A. and Tremellen, K.P. (2013). Controlled Ovarian Hyper-stimulation during IVF treatment does not increase the risk of preterm delivery compared to the transfer of frozen–thawed embryos in a natural cycle. Australian and New Zealand Journal of Obstetrics and Gynaecology, 53(2) pp. 165-169.
    [10.1111/ajo.12063] [Scopus]
  • Russell, P., Sacks, G., Tremellen, K.P. and Gee, A. (2013). The distribution of immune cells and macrophages in the endometrium of women with recurrent reproductive failure. III: Further observations and reference ranges. Pathology, 45(4) pp. 393-401.
    [10.1097/PAT.0b013e328361429b] [Scopus]
  • Sermondade, N., Faure, C., Fezeu, L., Shayeb, A.G., Bonde, J.P., Jensen, T.K., et al. (2013). BMI in relation to sperm count: an updated systematic review and collaborative meta-analysis. HUMAN REPRODUCTION UPDATE, 19(3) pp. 221-231.
    [Scopus]
  • Anand-Ivell, R., Tremellen, K.P., Dai, Y., K, H., Yoshida, M., Knight, P.G., et al. (2013). Circulating insulin-like factor 3 (INSL3) in healthy and infertile women. Human Reproduction, 28(11) pp. 3093-3102.
    [Scopus]
  • Iliodromiti, S., Blockeel, C., Tremellen, K.P., Fleming, R., Tournaye, H., Humaidan, P., et al. (2013). Consistent high clinical pregnancy rates and low ovarian hyperstimulation syndrome rates in high-risk patients after GnRH agonist triggering and modified luteal support: a retrospective multicentre study. Human Reproduction, 28(9) pp. 2529-2536.
    [Scopus]
  • Sharkey, D.J., Tremellen, K.P., Jasper, M.J., Gemzell-Danielsson, K. and Robertson, S.A. (2012). Seminal fluid induces leukocyte recruitment and cytokine and chemokine mRNA expression in the human cervix after coitus. Journal of Immunology, 188 pp. 2445-2454.
    [Scopus]
  • Sharkey, D.J., MacPherson, A.M., Tremellen, K.P., Mottershead, D.G., Gilchrist, R.B. and Robertson, S.A. (2012). TGF-b mediates proinflammatory seminal fluid signaling in human cervical epithelial cells. Journal of Immunology, 189(2) pp. 1024-1035.
    [Scopus]
  • Tremellen, K.P. and Russell, P. (2012). The distribution of immune cells and macrophages in the endometrium of women with recurrent reproductive failure. II: adenomyosis and macrophages. JOURNAL OF REPRODUCTIVE IMMUNOLOGY, 93 pp. 58-63.
    [Scopus]
  • Tremellen, K.P. and Pearce, K.L. (2012). Dysbiosis of Gut Microbiota (DOGMA) – A novel theory for the development of Polycystic Ovarian Syndrome. Medical Hypotheses, 79 pp. 104-112.
    [Scopus]
  • Thalluri, V. and Tremellen, K.P. (2012). Ultrasound diagnosed adenomyosis has a negative impact on successful implantation following GnRH antagonist IVF treatment. Human Reproduction, 27(12) pp. 3487-3492.
    [Scopus]
  • Zander-Fox, D., Tremellen, K.P. and Lane, M. (2011). Single blastocyst embryo transfer maintains comparable pregnancy rates to double cleavage-stage embryo transfer but results in healthier pregnancy outcomes. Australian and New Zealand Journal of Obstetrics and Gynaecology, 51 pp. 406-410.
    [Scopus]
  • Tunc, O., Bakos, H.W. and Tremellen, K.P. (2011). Impact of body mass index on seminal oxidative stress. ANDROLOGIA, 43 pp. 121-128.
    [Scopus]
  • Tremellen, K.P. and Russell, P. (2011). Adenomyosis is a potential cause of recurrent implantation failure during IVF treatment. Australian and New Zealand Journal of Obstetrics and Gynaecology, 51 pp. 280-283.
    [Scopus]
  • Radesic, B. and Tremellen, K.P. (2011). Oocyte maturation employing a GnRH agonist in combination with low-dose hCG luteal rescue minimizes the severity of ovarian hyperstimulation syndrome while maintaining excellent pregnancy rates. Human Reproduction, 26(12) pp. 3437-3442.
    [Scopus]
  • Russell, P., Anderson, L., Lieberman, D., Tremellen, K.P., Yilmaz, H. and Cheerala, B. (2011). The distribution of immune cells and macrophages in the endometrium of women with recurrent reproductive failure I: Techniques. JOURNAL OF REPRODUCTIVE IMMUNOLOGY, 91 pp. 90-102.
    [Scopus]
  • Tunc, O., Thompson, J. and Tremellen, K.P. (2010). Development of the NBT assay as a marker of sperm oxidative stress. INTERNATIONAL JOURNAL OF ANDROLOGY, 33(1) pp. 13-21.
    [10.1111/j.1365-2605.2008.00941.x] [Scopus]
  • Tremellen, K.P. and Tunc, O. (2010). Macrophage activity in semen is significantly correlated with sperm quality in infertile men. INTERNATIONAL JOURNAL OF ANDROLOGY, 33(6) pp. 823-831.
    [10.1111/j.1365-2605.2009.01037.x] [Scopus]
  • Tremellen, K.P. and Kolo, M. (2010). Serum anti-Mullerian hormone is a useful measure of quantitative ovarian reserve but does not predict the chances of live-birth pregnancy. Australian and New Zealand Journal of Obstetrics and Gynaecology, 50(6) pp. 568-572.
    [10.1111/j.1479-828X.2010.01232.x] [Scopus]
  • Tremellen, K.P., Wilkinson, D. and Savulescu, J. (2016). Is mandating elective single embryo transfer ethically justifiable in young women? Reproductive Biomedicine & Society Online, 1 pp. 81-87.
    [10.1016/j.rbms.2016.02.001]
  • Wilkinson, D., Schaefer, G.O., Tremellen, K.P. and Savulescu, J. (2015). Double trouble: Should double embryo transfer be banned? Theoretical Medicine and Bioethics, 36 pp. 121-139.
    [10.1007/s11017-015-9324-x] [Scopus]
  • Tremellen, K.P., Syedi, N., Tan, S. and Pearce, K. (2015). Metabolic endotoxaemia – a potential novel link between ovarian inflammation and impaired progesterone production. Gynecological Endocrinology, 31(4) pp. 309-312.
    [10.3109/09513590.2014.994602] [Scopus]
  • Robson, S., Campbell, S., McDonald, J., Tremellen, K.P., Carlin, E. and Maybury, G. (2015). Pregnancy and childhood health and developmental outcomes with the use of posthumous human sperm. Human Reproduction, 30(10) pp. 2259-2262.
    [10.1093/humrep/dev191] [Scopus]
  • Pearce, K.L., Gleeson, K. and Tremellen, K.P. (2015). Serum anti-Mullerian hormone production is not correlated with seasonal fluctuations of vitamin D status in ovulatory or PCOS women. Human Reproduction, 30(9) pp. 2171-2177.
    [10.1093/humrep/dev167] [Scopus]
  • Anderson, R.A., Anckaert, E., Bosch, E., Dewailly, D., Dunlop, C.E., Fehr, D., et al. (2015). Prospective study into the value of the automated Elecsys antimullerian hormone assay for the assessment of the ovarian growing follicle pool. Fertility and Sterility, 103(4) pp. 1074-1080.
    [Scopus]
  • Tremellen, K.P. and Savulescu, J. (2015). A discussion supporting presumed consent for posthumous sperm procurement and conception. Reproductive Biomedicine Online, 30 pp. 6-13.
    [Scopus]
  • Tremellen, K.P. (2012). Oxidative Stress and Male Infertility: A Clinical Perspective. In Ashok Agarwal, R. John Aitken, Juan G. Alvarez, ed. Studies on Men's Health and Fertility. New York: Springer, pp. 325-353.
  • Tremellen, K.P. (2012). Antioxidant Therapy for the Enhancement of Male Reproductive Health: A Critical Review of the Literature. In Sijo J. Parekattil, Ashok Agarwal, ed. Male Infertility: Contemporary Clinical Approaches, Andrology, ART & Antioxidants. New York: Springer, pp. 389-399.
  • Tremellen, K.P. (2011). Pre-treatment hormone assessment to optimize IVF outcomes. In Gab Kovacs, ed. How to Improve your ART Success Rates. Online: Cambridge University Press, pp. 1-6.

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Location: Flinders Medical Centre
Postal address: GPO Box 2100, Adelaide 5001, South Australia
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