Prof Neil Sims

Phone: +61 8 82044242
Email:
Location: School of Medicine (6E:139)
Postal address: GPO Box 2100, Adelaide 5001, South Australia

Research and consultancy

Publications

Refereed journal articles

Homkajorn, B., Sims, N.R., & Muyderman, H.C., 2010. Connexin 43 regulates astrocytic migration and proliferation in response to injury. Neuroscience Letters, 486, 197-201.

Muyderman, H.C., Yew, W.P., Homkajorn, B., & Sims, N.R., 2010. Astrocytic responses to DNA delivery using Nucleofection. Neurochemical Research, 35, 1771-1779.

Sims, N.R. & Muyderman, H.C., 2010. Mitochondria, oxidative metabolism and cell death in stroke. Biochimica et Biophysica Acta-Molecular Basis of Disease, 1802(1), 80-91.

Lee, D., Helps, S.C., MacArdle, P.J., Nilsson, M., & Sims, N.R., 2009. Alterations in membrane potential in mitochondria isolated from brain subregions during focal cerebral ischemia and early reperfusion: evaluation using flow cytometry. Neurochemical Research, 34(10), 1857-1866.

Wadey, A.L., Muyderman, H.C., Kwek, P.T., & Sims, N.R., 2009. Mitochondrial glutathione uptake: characterization in isolated brain mitochondria and astrocytes in culture. Journal of Neurochemistry, 109(Suppl. 1), 101-108.

Sims, N.R. & Anderson, M.F., 2008. Isolation of mitochondria from rat brain using Percoll density gradient centrifugation. Nature Protocols, 3(7), 1228-1239.

Helps, S.C. & Sims, N.R., 2007. Inhibition of nitric oxide synthase with 7-nitroindazole does not modify early metabolic recovery following focal cerebral ischemia in rats. Neurochemical Research, 32(4-5), 663-670.

Muyderman, H.C., Wadey, A.L., Nilsson, M., & Sims, N.R., 2007. Mitochondrial glutathione protects against cell death induced by oxidative and nitrative stress in astrocytes. Journal of Neurochemistry, 102(4), 1369-1382.

Thoren, A.E., Helps, S.C., Nilsson, M., & Sims, N.R., 2006. The metabolism of 14C-glucose by neurons and astrocytes in brain subregions following focal cerebral ischemia in rats. Journal of Neurochemistry, 97(4), 968-978.

Rahman, R.M., Nair, S.M., Helps, S.C., Shaw, O.M., Sims, N.R., Rosengren, R.J., & Appleton, I., 2005. (-)-Epigallocatechin gallate as an intervention for the acute treatment of cerebral ischemia. Neuroscience Letters, 382(3), 227-230.

Show all publications

Refereed journal articles

Homkajorn, B., Sims, N.R., & Muyderman, H.C., 2010. Connexin 43 regulates astrocytic migration and proliferation in response to injury. Neuroscience Letters, 486, 197-201.

Muyderman, H.C., Yew, W.P., Homkajorn, B., & Sims, N.R., 2010. Astrocytic responses to DNA delivery using Nucleofection. Neurochemical Research, 35, 1771-1779.

Sims, N.R. & Muyderman, H.C., 2010. Mitochondria, oxidative metabolism and cell death in stroke. Biochimica et Biophysica Acta-Molecular Basis of Disease, 1802(1), 80-91.

Lee, D., Helps, S.C., MacArdle, P.J., Nilsson, M., & Sims, N.R., 2009. Alterations in membrane potential in mitochondria isolated from brain subregions during focal cerebral ischemia and early reperfusion: evaluation using flow cytometry. Neurochemical Research, 34(10), 1857-1866.

Wadey, A.L., Muyderman, H.C., Kwek, P.T., & Sims, N.R., 2009. Mitochondrial glutathione uptake: characterization in isolated brain mitochondria and astrocytes in culture. Journal of Neurochemistry, 109(Suppl. 1), 101-108.

Sims, N.R. & Anderson, M.F., 2008. Isolation of mitochondria from rat brain using Percoll density gradient centrifugation. Nature Protocols, 3(7), 1228-1239.

Helps, S.C. & Sims, N.R., 2007. Inhibition of nitric oxide synthase with 7-nitroindazole does not modify early metabolic recovery following focal cerebral ischemia in rats. Neurochemical Research, 32(4-5), 663-670.

Muyderman, H.C., Wadey, A.L., Nilsson, M., & Sims, N.R., 2007. Mitochondrial glutathione protects against cell death induced by oxidative and nitrative stress in astrocytes. Journal of Neurochemistry, 102(4), 1369-1382.

Thoren, A.E., Helps, S.C., Nilsson, M., & Sims, N.R., 2006. The metabolism of 14C-glucose by neurons and astrocytes in brain subregions following focal cerebral ischemia in rats. Journal of Neurochemistry, 97(4), 968-978.

Rahman, R.M., Nair, S.M., Helps, S.C., Shaw, O.M., Sims, N.R., Rosengren, R.J., & Appleton, I., 2005. (-)-Epigallocatechin gallate as an intervention for the acute treatment of cerebral ischemia. Neuroscience Letters, 382(3), 227-230.

Thoren, A.E., Helps, S.C., Nilsson, M., & Sims, N.R., 2005. Astrocytic function assessed from 1-C-14 - acetate metabolism after temporary focal cerebral ischemia in rats. Journal of Cerebral Blood Flow and Metabolism, 25(4), 440-450.

Anderson, M.F., Nilsson, M., & Sims, N.R., 2004. Glutathione monoethylester prevents mitochondrial glutathione depletion during focal cerebral ischemia. Neurochemistry International, 44(3), 153-159.

Anderson, M.F., Nilsson, M., Eriksson, P.S., & Sims, N.R., 2004. Glutathione monoethyl ester provides neuroprotection in a rat model of stroke. Neuroscience Letters, 354(2), 163-165.

Muyderman, H.C., Nilsson, M., & Sims, N.R., 2004. Highly selective and prolonged depletion of mitochondrial glutathione in astrocytes markedly increases sensitivity to peroxynitrite. Journal of Neuroscience, 24(37), 8019-8028.

Sims, N.R., Nilsson, M., & Muyderman, H.C., 2004. Mitochondrial glutathione: a modulator of brain cell death. Journal of Bioenergetics and Biomembranes, 36(4), 329-333.

Zaidan, E., Nilsson, M., & Sims, N.R., 2004. Increased mitochondrial permeability in response to intrastriatal N-methyl-D-aspartate : detection based on accumulation of radiolabel from[3h]deoxyglucose. Neurochemical Research, 29(3), 609-616.

Lee, D., Helps, S.C., Gibbins, I.L., Nilsson, M., & Sims, N.R., 2003. Losses of NG2 and NeuN immunoreactivity but not astrocytic markers during early reperfusion following severe focal cerebral ischemia. Brain Research, 989(2), 221-230.

Willoughby, J.O., Mackenzie, L., Broberg, I.M., Thoren, A.E., Medvedev, A., Sims, N.R., & Nilsson, M., 2003. Fluorocitrate-mediated astroglial dysfunction causes seizures. Journal of Neuroscience Research, 74(1), 160-166.

Anderson, M.F. & Sims, N.R., 2002. The effects of focal ischemia and reperfusion on the glutathione content of mitochondria from rat brain subregions. Journal of Neurochemistry, 81(3), 541-549.

Sims, N.R. & Anderson, M.F., 2002. Mitochondrial contributions to tissue damage in stroke. Neurochemistry International, 40(6), 511-526.

Conference publications

Sims, N.R., 2006. Astrocytic susceptibility to ischemia and oxidative stress [Abstract]. Journal of Neurochemistry: 7th Biennial Meeting of the Asian Pacific Society for Neurochemistry, 98(S1), 94-94.

Muyderman, H.C., Wadey, A.L., Nilsson, M., & Sims, N.R., 2005. Selective modulation of mitochondrial glutathione alters susceptibility to oxidative stress in astrocytes. Society for Neuroscience 35th Annual Meeting.

Thoren, A.E., Helps, S.C., Nilsson, M., & Sims, N.R., 2004. Oxidative metabolism of 14C-glucose by astrocytes and neurons following temporary focal cerebral ischemia. Neuroscience 2004 Abstract: 342. Ischemia: Cell and Molecular Mechanisms II Poster.

Muyderman, H.C., Nilsson, M., & Sims, N.R., 2004. Highly selective and prolonged depletion of mitochondrial glutathione in astrocytes markedly increases sensitivity to peroxynitrite. Proceedings of the Australian Neuroscience Society.

Helps, S.C. & Sims, N.R., 2004. Inhibition of nitric oxide synthase does not improve early metabolic recovery following focal cerebral ischemia. Proceedings of the Australian Neuroscience Society.

Helps, S.C. & Sims, N.R., 2003. Selectivy alterations in energy-related metabolites following focal cerebral ischaemia in the rat (Poster). Proceedings of the Australian Neuroscience Society, 14.

Lee, D., Helps, S.C., Gibbins, I.L., Nilsson, M., & Sims, N.R., 2003. Losses of NG2 and NeuN immunoreactivity but not astrocytic markers during early reperfusion following severe focal cerebral ischaemia (Abstract). Proceedings of the Australian Neuroscience Society, 14, Oral 4-4.

Muyderman, H.C., Nilsson, M., & Sims, N.R., 2003. Depletion of mitochondrial glutathione increases the susceptibility for nitric oxide and peroxynitrite in astrocytes in primary culture (Poster). Proceedings of the Australian Neuroscience Society, 14.

Thoren, A.E., Nilsson, M., & Sims, N.R., 2003. Oxidative metabolism in astrocytes following cerebral ischaemia (Poster). Proceedings of the Australian Neuroscience Society, 14.

Thoren, A.E., Sims, N.R., & Nilsson, M., 2002. Assessment of astrocyte metabolic activity in brain subregions. 22nd Annual Meeting Australian Neuorscience Society, 13.

Lee, D., Sims, N.R., Helps, S.C., & Nilsson, M., 2002. Changes in NG2 immunoreactivity following temporary focal cerebral ischaemia. GLIA, 38(suppl1).

Sims, N.R. & Anderson, M.F., 2001. Mitochondrial contributions to tissue damage in cerebral ischaemia. Proceedings of the Australian Neuroscience Society, 12, 12-12.

Other public research outputs

Thoren, A.E., Nilsson, M., & Sims, N.R., 2003. Oxidative metabolism in astrocytes following cerebral ischaemia (Abstract). Society for Neuroscience Annual Meeting Abstract viewer/planner (electronic).

Show selected publications

Professional and community engagement

Expertise for media contact

  • Brain Biochemistry molecular basis of brain diseases, particularly stroke and related cerebrovascular disease; nerve cell death;astrocytes and their role in disease; oxidative damage; mitochondria;neurotransmitters; energy metabolism

Subject/s

  • Biochemistry
  • Brain
  • Metabolism
  • Stroke


inspiring achievement