Position

Professor
Human Physiology

Biography

Nick Spencer completed his BSc(Hons) in 1994 and then his PhD in Neurophysiology in 1998 at the Department of Physiology, Monash University, Australia. In 1998, Nick then moved to The University of Nevada School of Medicine, where he spent 10 years, the first 2 years of which were postdoc. In 2002, Nick obtained a 5 year grant with the National Institutes of Health, where he studied the intrinsic neural reflex circuitry in the wall of the gastrointestinal tract. Nick was offered a tenure-track permanent academic position at the University of Nevada in 2007, but instead took up an academic position at Flinders University.

Since arriving at Flinders University 8 years ago, Nick has been a Chief investigator on 12 NH&MRC project grants and 1 ARC project grant (collectively > $6 million AUD). Nick was Chief Investigator A (CIA) on 7 of these 12 NH&MRC project grants, bringing more than $3.5 million into his laboratory. In 2017, he is CIA on two NH&MRC project grants related to silencing visceral pain without opiates.

During his time at Flinders, Nick has been the Course Coordinator of the Bachelor of Medical Science degree for the past 5 years and Coordinator of Medical Neuroanatomy for 2 years. Research in his laboratory is primarily directed to understanding the neurophysiological basis of pain pathways in visceral organs, and the neural mechanisms of transmission in the enteric nervous system. In 2014, he was the inaugural Treasurer of the Australasian Neurogastroenterology and Motility Society (ANGMA) and has organised numerous national and international scientific meetings in Australia. In 2012, he was promoted to Associate Professor and in 2015 was promoted to Professor (level E). In 2016, Nick was elected President of the Australasian Neurogastroenterology & Motility Association (ANGMA).

Qualifications

BSc(Hons), PhD

Honours, awards and grants

2005 Janssen Prize in Gastroenterology, Chicago, U.S.A

2014 Bren Gannon Award: Teaching Excellence

Key responsibilities

2016 - current: President, Australasian Neurogastroenterology & Motility Association (ANGMA)

2014- current: Coordinator of Medical Neuroanatomy, 2nd year Graduate Entry Medical Program

Research expertise

  • Neurosciences

Supervisory interests

  • Colonic motility
  • Enteric electrophysiology
  • Enteric neurotransmission
  • Neuroscience
  • Nociception
  • Pain pathways
  • Pain processing
  • Smooth muscle excitability
  • Spinal afferents
  • Visceral pain

RHD research supervision

Current

Principal supervisor : Enteric neuroscience, colonic motility (1) ;

Associate supervisor : Colonic motility (2) ; Intestinal physiology, diabetes (1) ; Molecular biology, serotonin (1) ;

Completion

Principal supervisor : Colonic motility (1) ;

Associate supervisor : Enteric neuroscience, intestinal physiology (1) ; Uterine smooth muscle (1) ; Enteric neuroscience,sensory neurophysiology (1) ; Down sydrome, diabetes (2) ;

Publications

  • Raghupathi, R., Zelkas, L.E., Duffield, M.D., Spencer, N.J. and Keating, D.J. (2012). Enterochromaffin cells release 5-HT with synaptic kinetics. In Proceedings of the Australian Physiological Society. Australian Physiological Society. Australian Physiological Society 2012 Sydney Meeting. Sydney, NSW. Dec 2012.
    [Web Link]
  • Keating, D. and Spencer, N. (2010). Controversies Involving the Role of 5-Hydroxytryptamine in Generating Colonic Migrating Motor Complexes: What Is Spontaneous? Reply. Gastroenterology, 138(3) pp. 1214-1215.
    [10.1053/j.gastro.2010.01.038] [Scopus]
  • Arkwright, J., Blenman, N.G., Underhill, I.D., Maunder, S.D., Spencer, N.J., Costa, M., et al. (2010). Measurement of the longitudinal and circumferential muscular activity associated with peristalsis using a single fibre grating array. In Proceedings of the SPIE 7653. USA: SPIE - International Society for Optical Engineering. 4th European Workshop on Optical Fibre Sensors. Porto, Portugal. Sep 2010, pp. 765330-765335.
    [10.1117/12.866307] [Scopus]
  • Martin, A.M., Lumsden, A.L., Young, R.L., Jessup, C.F., Spencer, N.J. and Keating, D.J. (2017). The nutrient-sensing repertoires of mouse enterochromaffin cells differ between duodenum and colon. Neurogastroenterology and Motility, 2017 pp. Art: e13046.
    [10.1111/nmo.13046] [Scopus]
  • Martin, A.M., Lumsden, A.L., Young, R.L., Jessup, C.F., Spencer, N.J. and Keating, D.J. (2017). Regional differences in nutrient-induced secretion of gut serotonin. Physiological Reports, 5(6) pp. Art: e13199.
    [10.14814/phy2.13199]
  • Hibberd, T.J., Costa, M., Travis, L.S., Brookes, S.J., Wattchow, D.A., Feng, J., et al. (2017). Neurogenic and myogenic patterns of electrical activity in isolated intact mouse colon. Neurogastroenterology and Motility,
    [10.1111/nmo.13089]
  • Martin, A.M., Young, R.L., Leong, L.E., Rogers, G., Spencer, N.J., Jessup, C.F., et al. (2017). The diverse metabolic roles of peripheral serotonin. Endocrinology,
    [10.1210/en.2016-1839]
  • Sorensen, J., Wiklendt, L.S., Hibberd, T.J., Costa, M. and Spencer, N.J. (2017). Techniques to identify and temporally correlate calcium transients between multiple regions of interest in vertebrate neural circuits. Journal of Neurophysiology, 117(3) pp. 885-902.
    [10.1152/jn.00648.2016.] [Scopus]
  • Spencer, N.J., Kyloh, M.A., Beckett, E.A., Brookes, S.J. and Hibberd, T.J. (2016). Different types of spinal afferent nerve endings in stomach and esophagus identified by anterograde tracing from dorsal root ganglia. Journal of Comparative Neurology, 524(15) pp. 3064-3083.
    [10.1002/cne.24006] [10.1002/cne.24006] [Scopus]
  • Hibberd, T.J., Kestell, G.R., Kyloh, M.A., Brookes, S.J., Wattchow, D.A. and Spencer, N.J. (2016). Identification of different functional types of spinal afferent neurons innervating the mouse large intestine using a novel CGRPalpha transgenic reporter mouse. American Journal of Physiology-Gastrointestinal and Liver Physiology, 310(8) pp. G561-G573.
    [10.1152/ajpgi.00462.2015] [10.1152/ajpgi.00462.2015] [Scopus]
  • Arkwright, J.W., Underhill, I.D., Dodds, K.N., Brookes, S.J., Costa, M., Spencer, N.J., et al. (2016). A composite fibre optic catheter for monitoring peristaltic transit of an intra-luminal bead. Journal of Biophotonics, 9(3) pp. 305-310.
    [10.1002/jbio.201500187] [10.1002/jbio.201500187] [Scopus]
  • Spencer, N.J., Sorensen, J., Travis, L.S., Wiklendt, L.S., Costa, M. and Hibberd, T.J. (2016). Imaging activation of peptidergic spinal afferent varicosities within visceral organs using novel CGRPalpha-mCherry reporter mice. American Journal of Physiology-Gastrointestinal and Liver Physiology, 311(5) pp. G880-G894.
    [10.1152/ajpgi.00250.2016] [10.1152/ajpgi.00250.2016.] [Scopus]
  • Spencer, N.J., Zagorodnyuk, V.P., Brookes, S.J. and Hibberd, T.J. (2016). Spinal afferent nerve endings in visceral organs: recent advances. American Journal of Physiology-Gastrointestinal and Liver Physiology, 311(6) pp. G1056-G1063.
    [10.1152/ajpgi.00319.2016.] [Scopus]
  • Barnes, K.J. and Spencer, N.J. (2015). Can colonic migrating motor complexes occur in mice lacking the endothelin-3 gene? Clinical and Experimental Pharmacology and Physiology, 42(5) pp. 485-495.
    [10.1111/1440-1681.12380] [Scopus]
  • Costa, M., Wiklendt, L.S., Simpson, P.J., Spencer, N.J., Brookes, S.J. and Dinning, P.G. (2015). Neuromechanical factors involved in the formation and propulsion of fecal pellets in the guinea-pig colon. Neurogastroenterology and Motility, 27(10) pp. 1466-1477.
    [10.1111/nmo.12646] [10.1111/nmo.12646] [Scopus]
  • Humenick, A.G., Chen, B.N., Wiklendt, L.S., Spencer, N.J., Zagorodnyuk, V.P., Dinning, P.G., et al. (2015). Activation of intestinal spinal afferent endings by changes in intra-mesenteric arterial pressure. Journal of Physiology-London, 593(16) pp. 3693-3709.
    [10.1113/JP270378] [Scopus]
  • Kuizenga, M.H., Sia, T.C., Dodds, K.N., Wiklendt, L.S., Arkwright, J.W., Thomas, A.C., et al. (2015). Neurally mediated propagating discrete clustered contractions superimposed on myogenic ripples in ex vivo segments of human ileum. American Journal of Physiology-Gastrointestinal and Liver Physiology, 308(1) pp. G1-G11.
    [10.1152/ajpgi.00230.2014] [Scopus]
  • Sharrad, D.F., Hibberd, T.J., Kyloh, M.A., Brookes, S.J. and Spencer, N.J. (2015). Quantitative immunohistochemical co-localization of TRPV1 and CGRP in varicose axons of the murine oesophagus, stomach and colorectum. Neuroscience Letters, 599 pp. 164-171.
    [10.1016/j.neulet.2015.05.020] [Scopus]
  • Spencer, N.J. (2015). Constitutively Active 5-HT Receptors: An Explanation of How 5-HT Antagonists Inhibit Gut Motility in Species Where 5-HT is Not an Enteric Neurotransmitter? Frontiers in Cellular Neuroscience, 18(9) pp. 487-487.
    [10.3389/fncel.2015.00487] [10.3389/fncel.2015.00487] [Scopus]
  • Spencer, N.J., Sia, T.C., Brookes, S.J., Costa, M. and Keating, D.J. (2015). CrossTalk opposing view: 5-HT is not necessary for peristalsis. Journal of Physiology-London, 593(13) pp. 3229-3231.
    [10.1113/JP270183] [Scopus]
  • Zelkas, L.E., Raghupathi, R., Lumsden, A.L., Martin, A.M., Sun, E.W., Spencer, N.J., et al. (2015). Serotonin-secreting enteroendocrine cells respond via diverse mechanisms to acute and chronic changes in glucose availability. Journal of Nutrition and Metabolism, 12(55) pp. 1-9.
    [10.1186/s12986-015-0051-0]
  • Barnes, K., Beckett, E., Brookes, S., Sia, T. and Spencer, N. (2014). Control of intrinsic pacemaker frequency and velocity of colonic migrating motor complexes in mouse. Frontiers in Neuroscience, 8(96) pp. 1-8.
    [10.3389/fnins.2014.00096] [Scopus]
  • Spencer, N., Kyloh, M. and Duffield, M.D. (2014). Identification of different types of spinal afferent nerve endings that encode noxious and innocuous stimuli in the large intestine using a novel anterograde tracing technique. PLoS One, 9(11) pp. e112466.
    [10.1371/journal.pone.0112466] [Scopus]
  • Kyloh, M. and Spencer, N. (2014). A novel anterograde neuronal tracing technique to selectively label spinal afferent nerve endings that encode noxious and innocuous stimuli in visceral organs. Neurogastroenterology and Motility, 26(3) pp. 440-444.
    [10.1111/nmo.12266] [Scopus]
  • Hibberd, T., Spencer, N., Zagorodnyuk, V., Chen, B. and Brookes, S. (2014). Targeted electrophysiological analysis of viscerofugal neurons in the myenteric plexus of guinea-pig colon. Neuroscience, 275 pp. 272-284.
    [10.1016/j.neuroscience.2014.04.066] [Scopus]
  • Herweijer, G., Kyloh, M., Beckett, E., Dodds, K. and Spencer, N. (2014). Characterization of primary afferent spinal innervation of mouse uterus. Frontiers in Neuroscience, 8(202) pp. 1-6.
    [10.3389/fnins.2014.00202] [Scopus]
  • Dinning, P.G., Wiklendt, L.S., Omari, T.I., Arkwright, J.W., Spencer, N.J., Brookes, S.J., et al. (2014). Neural mechanisms of peristalsis in the isolated rabbit distal colon: A neuromechanical loop hypothesis. Frontiers in Neuroscience, 8(75)
    [10.3389/fnins.2014.00075] [Scopus]
  • Dalziel, J., Spencer, N., Dunstan, K., Lynch, A., Haggarty, N., Gopal, P., et al. (2014). An in vitro rat model of colonic motility to determine the effect of b-casomorphin-5 on propagating contractions. Food and Function, 5(11) pp. 2768-2774.
    [10.1039/c4fo00193a] [Scopus]
  • Carbone, S.E., Wattchow, D.A., Spencer, N.J., Hibberd, T.J. and Brookes, S.J. (2014). Damage from dissection is associated with reduced neuro-musclar transmission and gap junction coupling between circular muscle cells of guinea pig ileum, in vitro. Frontiers in Psychology, 5 pp. Art 319.
    [10.3389/fphys.2014.00319] [Scopus]
  • Arkwright, J., Dickson, A., Maunder, S.A., Blenman, N.G., Lim, J., O'Grady, G., et al. (2013). The effect of luminal content and rate of occlusion on the interpretation of colonic manometry. Neurogastroenterology and Motility, 25(1) pp. e52-e59.
    [10.1111/nmo.12051] [Scopus]
  • Brookes, S., Spencer, N., Costa, M. and Zagorodnyuk, V. (2013). Extrinsic primary afferent signalling in the gut. Nature Reviews. Gastroenterology and Hepatology, 10(5) pp. 286-296.
    [10.1038/nrgastro.2013.29] [Scopus]
  • Carbone, S., Dinning, P.G., Costa, M., Spencer, N., Brookes, S. and Wattchow, D. (2013). Ascending excitatory neural pathways modulate slow phasic myogenic contractions in the isolated human colon. Neurogastroenterology and Motility, 25(8) pp. 670-676.
    [10.1111/nmo.12129] [Scopus]
  • Costa, M., Dodds, K., Wiklendt, L., Spencer, N., Brookes, S. and Dinning, P. (2013). Neurogenic and myogenic motor activity in the colon of the guinea pig, mouse, rabbit, and rat. American Journal of Physiology-Gastrointestinal and Liver Physiology, 305(10) pp. G749-G759.
    [10.1152/ajpgi.00227.2013] [Scopus]
  • Spencer, N., Nicholas, S., Sia, T.C., Staikopoulos, V., Kyloh, M. and Beckett, E. (2013). By what mechanism does ondansetron inhibit colonic migrating motor complexes: Does it require endogenous serotonin in the gut wall? Neurogastroenterology and Motility, 25(8) pp. 677-685.
    [10.1111/nmo.12136] [Scopus]
  • Travis, L. and Spencer, N. (2013). Imaging stretch-activated firing of spinal afferent nerve endings in mouse colon. Frontiers in Neuroscience, 7(179)
    [10.3389/fnins.2013.00179] [Scopus]
  • Sia, T.C., Whiting, M., Kyloh, M., Nicholas, S.J., Oliver, J., Brookes, S., et al. (2013). 5-HT3 and 5-HT4 antagonists inhibit peristaltic contractions in guinea-pig distal colon by mechanisms independent of endogenous 5-HT. Frontiers in Neuroscience, 7(136)
    [10.3389/fnins.2013.00136] [Scopus]
  • Sia, T.C., Flack, N., Robinson, L., Kyloh, M., Nicholas, S.J., Brookes, S.J., et al. (2013). Is serotonin in enteric nerves required for distension-evoked peristalsis and propulsion of content in guinea-pig distal colon? Neuroscience, 240 pp. 325-335.
    [10.1016/j.neuroscience.2013.02.061] [Scopus]
  • Sia, T.C., Brookes, S., Dinning, P., Wattchow, D. and Spencer, N. (2013). Peristalsis and propulsion of colonic content can occur after blockade of major neuroneuronal and neuromuscular transmitters in isolated guinea pig colon. American Journal of Physiology-Gastrointestinal and Liver Physiology, 305(12) pp. G933-G939.
    [10.1152/ajpgi.00257.2013] [Scopus]
  • Raghupathi, R., Duffield, M.D., Zelkas, L.E., Meedeniya, A., Brookes, S., Sia, T., et al. (2013). Identification of unique release kinetics of serotonin from guinea-pig and human enterochromaffin cells. Journal of Physiology-London, 591(23) pp. 5959-5975.
    [10.1113/jphysiol.2013.259796] [Scopus]
  • Keating, D.J., Peiris, H., Kyloh, M.A., Brookes, S.J. and Spencer, N.J. (2013). The presence of 5-HT in myenteric varicosities is not due to uptake of 5-HT released from the mucosa during dissection: use of a novel method for quantifying 5-HT immunoreactivity in myenteric ganglia. Neurogastroenterology and Motility, 25(10) pp. 849-853.
    [10.1111/nmo.12189] [Scopus]
  • Spencer, N. (2013). Characteristics of colonic migrating motor complexes in neuronal NOS (nNOS) knockout mice. Frontiers in Neuroscience, 7(184)
    [10.3389/fnins.2013.00184] [Scopus]
  • Arkwright, , Blenman, N., Underhill, I., Maunder, S., Spencer, N., Costa, M., et al. (2012). Measurement of muscular activity associated with peristalsis in the human gut using fibre Bragg grating arrays. IEEE Sensors Journal, 12(1) pp. 113-117.
    [10.1109/JSEN.2011.2123883] [Scopus]
  • Carbone, S., Wattchow, D., Spencer, N. and Brookes, S. (2012). Loss of responsiveness of circular smooth muscle cells from the guinea pig ileum is associated with changes in gap junction coupling. American Journal of Physiology-Gastrointestinal and Liver Physiology, 302(12) pp. G1434-G1444.
    [10.1152/ajpgi.00376.2011] [Scopus]
  • Dinning, P.G., Costa, M., Brookes, S. and Spencer, N. (2012). Neurogenic and myogenic motor patterns of rabbit proximal, mid and distal colon. American Journal of Physiology-Gastrointestinal and Liver Physiology, 303(1) pp. G83-G92.
    [10.1152/ajpgi.00429.2011] [Scopus]
  • Hibberd, T., Zagorodnyuk, V., Spencer, N. and Brookes, S. (2012). Viscerofugal neurons recorded from guinea-pig colonic nerves after organ culture. Neurogastroenterology and Motility, 24(11) pp. 1041-e548.
    [10.1111/j.1365-2982.2012.01979.x] [Scopus]
  • Hibberd, T.J., Zagorodnyuk, V.P., Spencer, N.J. and Brookes, S.J. (2012). Identification and mechanosensitivity of viscerofugal neurons. Neuroscience, 225 pp. 118-129.
    [10.1016/j.neuroscience.2012.08.040] [Scopus]
  • Spencer, N., Kyloh, M., Wattchow, D., Thomas, A., Sia, T.C., Brookes, S.J., et al. (2012). Characterization of motor patterns in isolated human colon: are there differences in patients with slow-transit constipation? American Journal of Physiology-Gastrointestinal and Liver Physiology, 302(1) pp. G34-G43.
    [10.1152/ajpgi.00319.2011] [Scopus]
  • Zagorodnyuk, V., Kyloh, M., Brookes, S., Nicholas, S. and Spencer, N. (2012). Firing patterns and functional roles of different classes of spinal afferents in rectal nerves during colonic migrating motor complexes in mouse colon. American Journal of Physiology-Gastrointestinal and Liver Physiology, 303(3) pp. G404-G411.
    [10.1152/ajpgi.00047.2012] [Scopus]
  • Arkwright, , Blenman, N., Underhill, I., Maunder, S., Spencer, N., Costa, M., et al. (2011). A fibre optic catheter for simultaneous measurement of longitudinal and circumferential muscular activity in the gastrointestinal tract. Journal of Biophotonics, 4(4) pp. 244-251.
    [10.1002/jbio.201000056] [Scopus]
  • Dinning, P., Arkwright, , Costa, M., Wiklendt, L., Hennig, G., Brookes, S., et al. (2011). Temporal relationships between wall motion, intraluminal pressure, and flow in the isolated rabbit small intestine. American Journal of Physiology-Gastrointestinal and Liver Physiology, 300 pp. G577-G585.
    [10.1152/ajpgi.00532.2010] [Scopus]
  • Kyloh, M., Nicholas, S., Zagorodnyuk, V., Brookes, S. and Spencer, N. (2011). Identification of the visceral pain pathway activated by noxious colorectal distension in mice. Frontiers in Neuroscience, 5(16)
    [10.3389/fnins.2011.00016] [Scopus]
  • Spencer, N., Nicholas, S., Robinson, L.V., Kyloh, M., Flack, N., Brookes, S., et al. (2011). Mechanisms underlying distension-evoked peristalsis in guinea pig distal colon: is there a role for enterochromaffin cells? American Journal of Physiology-Gastrointestinal and Liver Physiology, 301(3) pp. G519-G527.
    [10.1152/ajpgi.00101.2011] [Scopus]
  • Zagorodnyuk, V., Kyloh, M., Nicholas, S., Peiris, G., Brookes, S., Chen, B., et al. (2011). Loss of visceral pain following colorectal distension in an endothelin-3 deficient mouse model of Hirschsprung's disease. Journal of Physiology-London, 589(7) pp. 1691-1706.
    [10.1113/jphysiol.2010.202820] [Scopus]
  • Zagorodnyuk, V.P. and Spencer, N.J. (2011). Localization of the Sensory Neurons and Mechanoreceptors Required for Stretch-Evoked Colonic Migrating Motor Complexes in Mouse Colon. Frontiers in Physiology, 2(Article: 98)
    [10.3389/fphys.2011.00098] [Scopus]
  • Zarate, N. and Spencer, N.J. (2011). Chronic constipation: Lessons from animal studies. Best Practice and Research in Clinical Gastroenterology, 25 pp. 59-71.
    [10.1016/j.bpg.2010.12.003] [Scopus]
  • Hennig, G.W., Spencer, N.J., Jokela-Willis, S., Bayguinov, P.O., Lee, H.T., Ritchie, L., et al. (2010). ICC-MY coordinate smooth muscle electrical and mechanical activity in the murine small intestine. Neurogastroenterology and Motility, 22(5) pp. e138-e151.
    [10.1111/j.1365-2982.2009.01448.x] [Scopus]
  • Zagorodnyuk, V.P., Brookes, S.J. and Spencer, N.J. (2010). Structure-function relationship of sensory endings in the gut and bladder. Autonomic Neuroscience-Basic and Clinical, 153(1) pp. 3-11.
    [10.1016/j.autneu.2009.07.018] [Scopus]
  • Nicholas, S.J. and Spencer, N.J. (2010). Peristalsis and fecal pellet propulsion do not require nicotinic, purinergic, 5-HT3, or NK3 receptors in isolated guinea pig distal colon. American Journal of Physiology-Gastrointestinal and Liver Physiology, 298(6) pp. G952-G961.
    [10.1152/ajpgi.00457.2009] [Scopus]
  • Keating, D.J. and Spencer, N.J. (2010). Release of 5-Hydroxytryptamine From the Mucosa Is Not Required for the Generation or Propagation of Colonic Migrating Motor Complexes. Gastroenterology, 138(2) pp. 659-670.
    [10.1053/j.gastro.2009.09.020] [Scopus]
  • Jackson, M.W., Spencer, N.J., Reed, J.H., Smith, A.J.F. and Gordon, T.P. (2009). Potentiation of a functional autoantibody in narcolepsy by a cholinesterase inhibitor. Laboratory Investigation, 89(12) pp. 1332-1339.
    [10.1038/ajg.2009.492_23] [10.1038/labinvest.2009.108] [Scopus]
  • Zagorodnyuk, V.P., Brookes, S.J., Spencer, N.J. and Gregory, S.J. (2009). Mechanotransduction and chemosensitivity of two major classes of bladder afferents with endings in the vicinity to the urothelium. Journal of Physiology-London, 587(14) pp. 3523-3538.
    [10.1113/jphysiol.2009.172577] [Scopus]
  • Spencer, N.J., Kerrin, A., Singer, C.A., Hennig, G., Gerthoffer, W.T. and McDonnell, O. (2008). Identification of capsaicin-sensitive rectal mechanoreceptors activated by rectal distension in mice. Neuroscience, 153(2) pp. 518-534.
    [10.1016/j.neuroscience.2008.02.054] [Scopus]
  • Dickson, E.J., Hennig, G., Heredia, D.J., Lee, H.T., Bayguinov, P.O., Spencer, N.J., et al. (2008). Polarized intrinsic neural reflexes in response to colonic elongation. Journal of Physiology-London, 586(17) pp. 4225-4240.
    [10.1113/jphysiol.2008.155630] [Scopus]
  • Spencer, N.J., Kerrin, A., Zagorodnyuk, V.P., Hennig, G., Muto, M., Brookes, S.J., et al. (2008). Identification of functional intramuscular rectal mechanoreceptors in aganglionic rectal smooth muscle from piebald lethal mice. American Journal of Physiology-Gastrointestinal and Liver Physiology, 294(4) pp. G855-G867.
    [10.1152/ajpgi.00502.2007] [Scopus]
  • Dickson, E.J., Spencer, N.J., Hennig, G., Bayguinov, P.O., Ren, J., Heredia, D.J., et al. (2007). An enteric occult reflex underlies accommodation and slow transit in the distal large bowel. Gastroenterology, 132(5) pp. 1912-1924.
    [10.1053/j.gastro.2007.02.047] [Scopus]
  • smith, T.K., Spencer, N.J., Hennig, G.W. and Dickson, E.J. (2007). Recent advances in enteric neurobiology: multiple sensory interneurons. Neurogastroenterology and Motility, 19(11) pp. 869-878.
    [10.1111/j.1365-2982.2007.01019.x] [Scopus]
  • Spencer, N.J., Bayguinov, P.O., Hennig, G., Park, K.J., Lee, H.T., Sanders, K.M., et al. (2007). Activation of neural circuitry and Ca2 waves in longitudinal and circular muscle during CMMCs and the consequences of rectal aganglionosis in mice. American Journal of Physiology-Gastrointestinal and Liver Physiology, 292(2) pp. G546-G555.
    [10.1152/ajpgi.00352.2006] [Scopus]
  • Lee, H.T., Hennig, G., Fleming, N.W., Keef, K.D., Spencer, N.J., Ward, S.M., et al. (2007). The mechanism and spread of pacemaker activity through myenteric interstitial cells of cajal in human small intestine. Gastroenterology, 132(5) pp. 1852-1865.
    [10.1053/j.gastro.2007.02.049] [Scopus]
  • Lee, H.T., Hennig, G., Fleming, N.W., Keef, K.D., Spencer, N.J., Ward, S.M., et al. (2007). Septal interstitial cells of cajal conduct pacemaker activity to excite muscle bundles in human jejunum. Gastroenterology, 133(3) pp. 907-917.
    [10.1053/j.gastro.2007.06.024] [Scopus]
  • Park, K.J., Hennig, G., Lee, H.T., Spencer, N.J., Ward, S.M., Smith, T.K., et al. (2006). Spatial and temporal mapping of pacemaker activity in interstitial cells of Cajal in mouse ileum in situ. American Journal of Physiology-Cell Physiology, 290(5) pp. C1411-C1427.
    [10.1152/ajpcell.00447.2005] [Scopus]
  • Ro, S., Hwang, S.J., Muto, M., Jewett, W.K. and Spencer, N.J. (2006). Anatomic modifications in the enteric nervous system of piebald mice and physiological consequences to colonic motor activity. American Journal of Physiology-Gastrointestinal and Liver Physiology, 290(4) pp. G710-G718.
    [10.1152/ajpgi.00420.2005] [Scopus]
  • Spencer, N.J., Dickson, E.J., Hennig, G. and Smith, T.K. (2006). Sensory elements within the circular muscle are essential for mechanotransduction of ongoing peristaltic reflex activity in guinea-pig distal colon. Journal of Physiology-London, 576(2) pp. 519-531.
    [10.1113/jphysiol.2006.109561] [Scopus] [PubMed]
  • del Corsso, C., Ostrovskaya, O., McAllister, C.E., Murray, K., Hatton, W.J., Gurney, A.M., et al. (2006). Effects of aging on Ca2+ signaling in murine mesenteric arterial smooth muscle cells. Mechanisms of Ageing and Development, 127(4) pp. 315-323.
    [Scopus]
  • Spencer, N.J., Hennig, G., Dickson, E.J. and Smith, T.K. (2005). Synchronization of enteric neuronal firing during the murine colonic MMC. Journal of Physiology-London, 564(3) pp. 829-847.
    [10.1113/jphysiol.2005.083600] [Scopus]
  • Spencer, N.J. and Smith, T.K. (2004). Mechanosensory S-neurons rather than AH-neurons appear to generate a rhythmic motor pattern in guinea-pig distal colon. Journal of Physiology-London, 558(2) pp. 577-596.
    [10.1113/jphysiol.2004.063586] [Scopus]
  • Smith, T.K., Oliver, G.R., Hennig, G., O'Shea, D.M., Vanden Berghe, P., Kang, S.H., et al. (2003). A smooth muscle tone-dependent stretch-activated migrating motor pattern in isolated guinea-pig distal colon. Journal of Physiology-London, 551(3) pp. 955-969.
    [10.1113/jphysiol.2003.049163] [Scopus]
  • Spencer, N.J., Hennig, G. and Smith, T.K. (2003). Stretch-activated neuronal pathways to longitudinal and circular muscle in guinea pig distal colon. American Journal of Physiology-Gastrointestinal and Liver Physiology, 284(2 47-2) pp. G231-G241.
    [10.1152/ajpgi.00291.2002] [Scopus]
  • Spencer, N.J., Sanders, K.M. and Smith, T.K. (2003). Migrating motor complexes do not require electrical slow waves in the mouse small intestine. Journal of Physiology-London, 553(3) pp. 881-893.
    [10.1113/jphysiol.2003.049700] [Scopus]
  • Spencer, N.J. and Greenwood, I.A. (2003). Characterization of properties underlying rhythmicity in mouse portal vein. Autonomic Neuroscience-Basic and Clinical, 104(2) pp. 73-82.
    [10.1016/S1566-0702(02)00292-8] [Scopus]
  • Hibberd, T.J., Costa, M., Travis, L.S., Brookes, S.J., Wattchow, D.A., Feng, J., et al. (2017). Neurogenic and myogenic patterns of electrical activity in isolated intact mouse colon. Neurogastroenterology and Motility,
    [10.1111/nmo.13089]
  • Martin, A.M., Lumsden, A.L., Young, R.L., Jessup, C.F., Spencer, N.J. and Keating, D.J. (2017). Regional differences in nutrient-induced secretion of gut serotonin. Physiological Reports, 5(6) pp. Art: e13199.
    [10.14814/phy2.13199]
  • Martin, A.M., Lumsden, A.L., Young, R.L., Jessup, C.F., Spencer, N.J. and Keating, D.J. (2017). The nutrient-sensing repertoires of mouse enterochromaffin cells differ between duodenum and colon. Neurogastroenterology and Motility, 2017 pp. Art: e13046.
    [10.1111/nmo.13046] [Scopus]
  • Martin, A.M., Young, R.L., Leong, L.E., Rogers, G., Spencer, N.J., Jessup, C.F., et al. (2017). The diverse metabolic roles of peripheral serotonin. Endocrinology,
    [10.1210/en.2016-1839]
  • Sorensen, J., Wiklendt, L.S., Hibberd, T.J., Costa, M. and Spencer, N.J. (2017). Techniques to identify and temporally correlate calcium transients between multiple regions of interest in vertebrate neural circuits. Journal of Neurophysiology, 117(3) pp. 885-902.
    [10.1152/jn.00648.2016.] [Scopus]
  • Arkwright, J.W., Underhill, I.D., Dodds, K.N., Brookes, S.J., Costa, M., Spencer, N.J., et al. (2016). A composite fibre optic catheter for monitoring peristaltic transit of an intra-luminal bead. Journal of Biophotonics, 9(3) pp. 305-310.
    [10.1002/jbio.201500187] [10.1002/jbio.201500187] [Scopus]
  • Hibberd, T.J., Kestell, G.R., Kyloh, M.A., Brookes, S.J., Wattchow, D.A. and Spencer, N.J. (2016). Identification of different functional types of spinal afferent neurons innervating the mouse large intestine using a novel CGRPalpha transgenic reporter mouse. American Journal of Physiology-Gastrointestinal and Liver Physiology, 310(8) pp. G561-G573.
    [10.1152/ajpgi.00462.2015] [10.1152/ajpgi.00462.2015] [Scopus]
  • Spencer, N.J., Kyloh, M.A., Beckett, E.A., Brookes, S.J. and Hibberd, T.J. (2016). Different types of spinal afferent nerve endings in stomach and esophagus identified by anterograde tracing from dorsal root ganglia. Journal of Comparative Neurology, 524(15) pp. 3064-3083.
    [10.1002/cne.24006] [10.1002/cne.24006] [Scopus]
  • Spencer, N.J., Sorensen, J., Travis, L.S., Wiklendt, L.S., Costa, M. and Hibberd, T.J. (2016). Imaging activation of peptidergic spinal afferent varicosities within visceral organs using novel CGRPalpha-mCherry reporter mice. American Journal of Physiology-Gastrointestinal and Liver Physiology, 311(5) pp. G880-G894.
    [10.1152/ajpgi.00250.2016] [10.1152/ajpgi.00250.2016.] [Scopus]
  • Spencer, N.J., Zagorodnyuk, V.P., Brookes, S.J. and Hibberd, T.J. (2016). Spinal afferent nerve endings in visceral organs: recent advances. American Journal of Physiology-Gastrointestinal and Liver Physiology, 311(6) pp. G1056-G1063.
    [10.1152/ajpgi.00319.2016.] [Scopus]

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Phone: +61 8 82044241
Email:
Location: Flinders Medical Centre (6E:417)
Postal address: GPO Box 2100, Adelaide 5001, South Australia

Further information

CURRENT EXTERNAL FEDERAL FUNDING- AUSTRALIA -

2017-2020. National Health & Medical Research Council (NH&MRC) - project grant 105277 ($637,356 AUD)
Title
: A novel technique for prolonged silencing of visceral pain without opiates.
N.J Spencer (CIA), S.J. Brookes (CIBA) :- Flinders University.
Aim: To use a harmless virus to selectively silence the pain pathway to a specific organ, without side effecs of opiates.

2016-2018. National Health & Medical Research Council (NH&MRC) - project grant 105277 ($548,289 AUD)
Title
: Importance of CGRP alpha in pain processing from the large intestine.
N.J Spencer (CIA), S.J. Brookes (CIBA) :- Flinders University.
Aim: Understanding how the CGRP alpha gene modulates pain pathways from the lower gastrointestinal tract.

RECENTLY EXPIRED

2014-2016. National Health & Medical Research Council (NH&MRC) - project grant 1067335 ($570,558 AUD)
Title: Imaging the activation of spinal afferent nerve endings that detect pain inthe colorectum.
N.J Spencer (CIA), S.J. Brookes (CIB) & V.P. Zagorodnyuk (CIC):– Flinders University.
Aim: Understanding how inflammatory bowel disease causes hypersensitivity of colonic sensory nerve endings and increased abdominal pain.

2014-2016. National Health & Medical Research Council (NH&MRC) – project grant 1067317 ($342,111 AUD)
Title: Use of a novel technique to identify the sensory nerve endings that detect painful stimuli in the upper gastrointestinal tract and characterize their mechanisms of activation.
N.J Spencer (CIA) & V.P. Zagorodnyuk (CIB): – Flinders University.
Aim: To determine how inflammation of the colon leads to hypersensitivity of spinal afferent nerve endings that underlie pain perception.

2012-2014 National Health & Medical Research Council (NH&MRC) – project grant ($551,500 AUD).
Title: Imaging the activation of spinal afferent nerve endings that detect pain in the colorectum.
N.J Spencer (CIA - sole CI): – Flinders University.
Aim: Determine mechanisms underlying transduction of visceral pain in the large intestine.

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