Dr Nick Spencer

Phone: +61 8 82044241
Email:
Location: School of Medicine (6E:413)
Postal address: GPO Box 2100, Adelaide 5001, South Australia

Research and consultancy

Publications

Refereed journal articles

Arkwright, J., Blenman, N.G., Underhill, I.D., Maunder, S.A., Spencer, N.J., Costa, M., Brookes, S.J., Szczesniak, M.M., & Dinning, P.G., 2011. A fibre optic catheter for simultaneous measurement of longitudinal and circumferential muscular activity in the gastrointestinal tract. Journal of Biophotonics, 4(4), 244-251.

Arkwright, J., Blenman, N.G., Underhill, I.D., Maunder, S.A., Spencer, N.J., Costa, M., Brookes, S.J., Szczesniak, M.M., & Dinning, P.G., 2011. Measurement of muscular activity associated with peristalsis in the human gut using fibre Bragg grating arrays. IEEE Sensors Journal, PP(99).

Dinning, P.G., Arkwright, J., Costa, M., Wiklendt, L., Hennig, G., Brookes, S.J., & Spencer, N.J., 2011. Temporal relationships between wall motion, intraluminal pressure, and flow in the isolated rabbit small intestine. American Journal of Physiology-Gastrointestinal and Liver Physiology, 300, G577-G585.

Kyloh, M.A., Nicholas, S.J., Zagorodnyuk, V.P., Brookes, S.J., & Spencer, N.J., 2011. Identification of the visceral pain pathway activated by noxious colorectal distension in mice. Frontiers in Neuroscience, 5(16), 1-7.

Spencer, N.J., Nicholas, S.J., Robinson, L.V., Kyloh, M.A., Flack, N.C., Brookes, S.J., Zagorodnyuk, V.P., & Keating, D.J., 2011. Mechanisms underlying distension-evoked peristalsis in guinea pig distal colon: is there a role for enterochromaffin cells?. American Journal of Physiology-Gastrointestinal and Liver Physiology, 301(3), G519-G527.

Zagorodnyuk, V.P., Kyloh, M.A., Nicholas, S.J., Peiris, G.H., Brookes, S.J., Chen, B.N., & Spencer, N.J., 2011. Loss of visceral pain following colorectal distension in an endothelin-3 deficient mouse model of Hirschsprung’s disease. Journal of Physiology-London, 589(7), 1691-1706.

Hennig, G.W., Spencer, N.J., Jokela-Willis, S., Bayguinov, P.O., Lee, H., Ritchie, L., Ward, S.M., Smith, T.K., & Sanders, K.M., 2010. ICC-MY coordinate smooth muscle electrical and mechanical activity in the murine small intestine. Neurogastroenterology and Motility, 22(5), e138-e151.

Keating, D.J. & Spencer, N.J., 2010. Release of 5-Hydroxytryptamine From the Mucosa Is Not Required for the Generation or Propagation of Colonic Migrating Motor Complexes. Gastroenterology, 138(2), 659-670.

Nicholas, S.J. & Spencer, N.J., 2010. Peristalsis and fecal pellet propulsion do not require nicotinic, purinergic, 5-HT3, or NK3 receptors in isolated guinea pig distal colon. American Journal of Physiology-Gastrointestinal and Liver Physiology, 298(6), G952-G961.

Zagorodnyuk, V.P., Brookes, S.J., & Spencer, N.J., 2010. Structure-function relationship of sensory endings in the gut and bladder. Autonomic Neuroscience-Basic and Clinical, 153(1), 3-11.

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Refereed journal articles

Arkwright, J., Blenman, N.G., Underhill, I.D., Maunder, S.A., Spencer, N.J., Costa, M., Brookes, S.J., Szczesniak, M.M., & Dinning, P.G., 2011. A fibre optic catheter for simultaneous measurement of longitudinal and circumferential muscular activity in the gastrointestinal tract. Journal of Biophotonics, 4(4), 244-251.

Arkwright, J., Blenman, N.G., Underhill, I.D., Maunder, S.A., Spencer, N.J., Costa, M., Brookes, S.J., Szczesniak, M.M., & Dinning, P.G., 2011. Measurement of muscular activity associated with peristalsis in the human gut using fibre Bragg grating arrays. IEEE Sensors Journal, PP(99).

Dinning, P.G., Arkwright, J., Costa, M., Wiklendt, L., Hennig, G., Brookes, S.J., & Spencer, N.J., 2011. Temporal relationships between wall motion, intraluminal pressure, and flow in the isolated rabbit small intestine. American Journal of Physiology-Gastrointestinal and Liver Physiology, 300, G577-G585.

Kyloh, M.A., Nicholas, S.J., Zagorodnyuk, V.P., Brookes, S.J., & Spencer, N.J., 2011. Identification of the visceral pain pathway activated by noxious colorectal distension in mice. Frontiers in Neuroscience, 5(16), 1-7.

Spencer, N.J., Nicholas, S.J., Robinson, L.V., Kyloh, M.A., Flack, N.C., Brookes, S.J., Zagorodnyuk, V.P., & Keating, D.J., 2011. Mechanisms underlying distension-evoked peristalsis in guinea pig distal colon: is there a role for enterochromaffin cells?. American Journal of Physiology-Gastrointestinal and Liver Physiology, 301(3), G519-G527.

Zagorodnyuk, V.P., Kyloh, M.A., Nicholas, S.J., Peiris, G.H., Brookes, S.J., Chen, B.N., & Spencer, N.J., 2011. Loss of visceral pain following colorectal distension in an endothelin-3 deficient mouse model of Hirschsprung’s disease. Journal of Physiology-London, 589(7), 1691-1706.

Hennig, G.W., Spencer, N.J., Jokela-Willis, S., Bayguinov, P.O., Lee, H., Ritchie, L., Ward, S.M., Smith, T.K., & Sanders, K.M., 2010. ICC-MY coordinate smooth muscle electrical and mechanical activity in the murine small intestine. Neurogastroenterology and Motility, 22(5), e138-e151.

Keating, D.J. & Spencer, N.J., 2010. Release of 5-Hydroxytryptamine From the Mucosa Is Not Required for the Generation or Propagation of Colonic Migrating Motor Complexes. Gastroenterology, 138(2), 659-670.

Zagorodnyuk, V.P., Brookes, S.J., & Spencer, N.J., 2010. Structure-function relationship of sensory endings in the gut and bladder. Autonomic Neuroscience-Basic and Clinical, 153(1), 3-11.

Nicholas, S.J. & Spencer, N.J., 2010. Peristalsis and fecal pellet propulsion do not require nicotinic, purinergic, 5-HT3, or NK3 receptors in isolated guinea pig distal colon. American Journal of Physiology-Gastrointestinal and Liver Physiology, 298(6), G952-G961.

Jackson, M.W., Spencer, N.J., Reed, J.H., Smith, A.J., & Gordon, T.P., 2009. Potentiation of a functional autoantibody in narcolepsy by a cholinesterase inhibitor. Laboratory Investigation, 89(12), 1332-1339.

Zagorodnyuk, V.P., Brookes, S.J., Spencer, N.J., & Gregory, S.J., 2009. Mechanotransduction and chemosensitivity of two major classes of bladder afferents with endings in the vicinity to the urothelium. Journal of Physiology-London, 587(14), 3523-3538.

Spencer, N.J., Kerrin, A., Singer, C.A., Hennig, G., Gerthoffer, W.T., & McDonnell, O., 2008. Identification of capsaicin-sensitive rectal mechanoreceptors activated by rectal distension in mice. Neuroscience, 153(2), 518-534.

Dickson, E.J., Hennig, G., Heredia, D.J., Lee, H., Bayguinov, P.O., Spencer, N.J., & Smith, T.K., 2008. Polarized intrinsic neural reflexes in response to colonic elongation. Journal of Physiology-London, 586(17), 4225-4240.

Spencer, N.J., Kerrin, A., Zagorodnyuk, V.P., Hennig, G., Muto, M., Brookes, S.J., & McDonnell, O., 2008. Identification of functional intramuscular rectal mechanoreceptors in aganglionic rectal smooth muscle from piebald lethal mice. American Journal of Physiology-Gastrointestinal and Liver Physiology, 294(4), G855-G867.

Dickson, E.J., Spencer, N.J., Hennig, G., Bayguinov, P.O., Ren, J., Heredia, D.J., & Smith, T.K., 2007. An enteric occult reflex underlies accommodation and slow transit in the distal large bowel. Gastroenterology, 132(5), 1912-1924.

smith, T.K., Spencer, N.J., Hennig, G.W., & Dickson, E.J., 2007. Recent advances in enteric neurobiology: multiple sensory interneurons. Neurogastroenterology and Motility, 19(11), 869-878.

Spencer, N.J., Bayguinov, P.O., Hennig, G., Park, K.J., Lee, H., Sanders, K.M., & Smith, T.K., 2007. Activation of neural circuitry and Ca2 waves in longitudinal and circular muscle during CMMCs and the consequences of rectal aganglionosis in mice. American Journal of Physiology-Gastrointestinal and Liver Physiology, 292(2), G546-G555.

Lee, H., Hennig, G., Fleming, N.W., Keef, K.D., Spencer, N.J., Ward, S.M., Sanders, K.M., & Smith, T.K., 2007. The mechanism and spread of pacemaker activity through myenteric interstitial cells of cajal in human small intestine. Gastroenterology, 132(5), 1852-1865.

Lee, H., Hennig, G., Fleming, N.W., Keef, K.D., Spencer, N.J., Ward, S.M., Sanders, K.M., & Smith, T.K., 2007. Septal interstitial cells of cajal conduct pacemaker activity to excite muscle bundles in human jejunum. Gastroenterology, 133(3), 907-917.

Park, K.J., Hennig, G., Lee, H., Spencer, N.J., Ward, S.M., Smith, T.K., & Sanders, K.M., 2006. Spatial and temporal mapping of pacemaker activity in interstitial cells of Cajal in mouse ileum in situ. American Journal of Physiology-Cell Physiology, 290(5), C1411-C1427.

Ro, S., Hwang, S.J., Muto, M., Jewett, W.K., & Spencer, N.J., 2006. Anatomic modifications in the enteric nervous system of piebald mice and physiological consequences to colonic motor activity. American Journal of Physiology-Gastrointestinal and Liver Physiology, 290(4), G710-G718.

Spencer, N.J., Dickson, E.J., Hennig, G., & Smith, T.K., 2006. Sensory elements within the circular muscle are essential for mechanotransduction of ongoing peristaltic reflex activity in guinea-pig distal colon. Journal of Physiology-London, 576(2), 519-531.

del Corsso, C., Ostrovskaya, O., McAllister, C.E., Murray, K., Hatton, W.J., Gurney, A.M., Spencer, N.J., & Wilson, S.M., 2006. Effects of aging on Ca2+ signaling in murine mesenteric arterial smooth muscle cells. Mechanisms of Ageing and Development, 127(4), 315-323.

Spencer, N.J., Hennig, G., Dickson, E.J., & Smith, T.K., 2005. Synchronization of enteric neuronal firing during the murine colonic MMC. Journal of Physiology-London, 564(3), 829-847.

Spencer, N.J. & Smith, T.K., 2004. Mechanosensory S-neurons rather than AH-neurons appear to generate a rhythmic motor pattern in guinea-pig distal colon. Journal of Physiology-London, 558(2), 577-596.

Smith, T.K., Oliver, G.R., Hennig, G., O'Shea, D.M., Vanden Berghe, P., Kang, S.H., & Spencer, N.J., 2003. A smooth muscle tone-dependent stretch-activated migrating motor pattern in isolated guinea-pig distal colon. Journal of Physiology-London, 551(3), 955-969.

Spencer, N.J., Sanders, K.M., & Smith, T.K., 2003. Migrating motor complexes do not require electrical slow waves in the mouse small intestine. Journal of Physiology-London, 553(3), 881-893.

Spencer, N.J., Hennig, G., & Smith, T.K., 2003. Stretch-activated neuronal pathways to longitudinal and circular muscle in guinea pig distal colon. American Journal of Physiology-Gastrointestinal and Liver Physiology, 284(2 47-2), G231-G241.

Spencer, N.J. & Greenwood, I.A., 2003. Characterization of properties underlying rhythmicity in mouse portal vein. Autonomic Neuroscience-Basic and Clinical, 104(2), 73-82.

Refereed conference papers

Arkwright, J., Blenman, N.G., Underhill, I.D., Maunder, S.D., Spencer, N.J., Costa, M., Brooks, J.M., Szczesniak, M.M., & Dinning, P., 2010. Measurement of the longitudinal and circumferential muscular activity associated with peristalsis using a single fibre grating array. Proceedings of the SPIE 7653, 765330-765335.

Journal articles

Keating, D.J. & Spencer, N.J., 2010. Controversies Involving the Role of 5-Hydroxytryptamine in Generating Colonic Migrating Motor Complexes: What Is Spontaneous? Reply. Gastroenterology, 138(3), 1214-1215.

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