Position/s

Professor Preventive Cancer Biology, Flinders Centre for Cancer Prevention and Control
School of Medicine

Biography

Prof Pamela Sykes has a PhD in Genetics and has worked in the area of molecular genetics in Australia and the US over the last 25 years. Prof Sykes is a Strategic Professor in the area of Preventive Cancer Biology and heads her own research group of staff and post-graduate students studying the biologiical effects of low doses of ionising radiation. Her current research is focussed on studying the protective role of low dose radiation. Some of her current appointments include membership on state and national committees for radiation protection and she is an Associate Editor for the journal Radiation Research.

Qualifications

B.Sc (Hons) PhD, FFSc (RCPA)

Key responsibilities

Undergraduate and post-graduate teaching and supervision
Supervision of low dose radiation research projects

Topic Coordinator:

Topic Lecturer:

Research expertise

  • Genetics
  • Molecular biology
  • Oncology and carcinogenesis

Research interests

We have been using the pKZ1 transgenic mouse chromosomal inversion assay to study the mutagenic effect of very low doses of DNA damaging agents. We demonstrated that very low doses of radiation can protect from endogenous chromosomal inversions suggesting that low doses of radiation can protect from chromosomal damage. Our current research focuses on understanding the mechanism of low dose radiation induced protection from mutation and cancer. We have a number of active projects including:

  • The temporal response for chromosomal inversions after low dose radiation exposure
  • The effect of known chemical radioprotectors on chromosomal inversion in association with low dose radiation.
  • The effect of low dose radiation on DNA methylation levels
  • The role of radiation induced bystander effects after low dose radiation in vivo
  • Intercellular induced apoptosis as a possible mechanism for low dose radiation induced protection from cancer
  • Effect of low dose radiation on prostate cancer progression in a mouse tumour model

Supervisory interests

  • Cancer genetics
  • Epigenetics
  • Molecular biology
  • Molecular genetics
  • Radiobiology

RHD research supervision

Current

Principal supervisor : Radiobiology (3) ;

Associate supervisor : Radiobiology (2) ;

Completion

Associate supervisor : Cancer, radiobiology, mutation research (5) ;

RHD Student Achievements

  • Benjamin Blyth
    Young Investigator award at the Australian Radiation Protection Society national meeting 2010 - October 2010
  • Mark Lawrence
    Competitive student award to attend Australian Radiation Protection Society Conference - October 2010
  • Michelle Newman
    Competitive student award to attend Australian Radiation Protection Society Conference - October 2010
  • Michelle Newman
    Australian Society for Medical Research (SA) "Healthy Aging" research poster award - June 2013

Publications

  • Blyth, B. and Sykes, P. (2011). Recent advances in low dose radiobiology and implications for cancer risk. In L. Marcu and E. Bezak, ed. Recent Advances and Research Updates in Medical Physics and Radiation Biology. Kerala, India: International Research Promotion Council, pp. 221-234.
  • Blyth, B.J. and Sykes, P.J. (2011). Low dose radiobiology and radiation risk. In L. Marcu and E. Bezak, ed. Recent Advances and Research Updates in Medical Physics and Radiation Biology. Australia: International Research Promotion Council, pp. In press-In press.
  • Sykes, P.J. (2001). Detecting monoclonal immunoglobulin and T-cell receptor gene rearrangements in B- and T-cell malignancies by polymerase chain reaction. In Faguet, G B, ed. Hematologic Malignancies: Methods and Techniques. Totowa, USA: Humana Press, pp. 117-132.
  • Jessup, C.F., Brereton, H.M., Sykes, P.J., Thiel, M., Coster, D.J. and Williams, K.A. (2004). Modulation of antigen presentation and co-simulation during rat corneal allograft rejection. In EXPERIMENTAL EYE RESEARCH. 24-28 OVAL RD, LONDON, ENGLAND, NW1 7DX: ELSEVIER. International Congress of Eye Reseach.
  • Sykes, P.J., Bhat, M., Cormack, J., Morley, A.A. and Hooker, A.M. (2003). Effect of low dose radiation on somatic intrachromosomal recombination in vivo and in vitro (Abstract) In Environmental and Molecular Mutagenesis. New York, NY, USA: WILEY-LISS, INC.. Environmental Mutagenesis: From Mechanisms to Risk Assessment. Miami, USA. May 2003, pp. 208-208.
    [10.1002/em.10148] [Web Link]
  • Sykes, P.J. (2003). Sensitive detection of somatic intrachromosomal recombination in response to low dose radiation exposure - how low can we go? (Abstract) In Ronald Cooper et al, ed. 12th International Congress of Radiation Research Book of Abstracts. Lucas Heights, NSW: AUSTRALIAN INSTITUTE OF NUCLEAR SCIENCE AND ENGINEERING. 12th International Congress of Radiation Research. Brisbane, QLD. Aug 2003, pp. 140.
  • Jessup, C.F., Brereton, H.M., Sykes, P.J., Thiel, M., Coster, D.J. and Williams, K.A. (2003). Ex vivo gene transfer to donor rat corneas (Abstract) In Transplantation Society of Australia and New Zealand. Transplantation Society of Australia and New Zealand. Canberra, ACT. Apr 2002.
  • Hooker, A.M., Morley, A.A., Tilley, W.D. and Sykes, P.J. (2003). Genes associated with cancer can affect somatic intrachromosomal recombination early in carcinogenesis [Abstract] In Environmental and Molecular Mutagenesis. New York, USA: Wiley-Liss, Inc.. Environmental Mutagenesis: From Mechanisms to Risk Assessment. Miami, USA. May 2003, pp. 180-180.
    [10.1002/em.10146]
  • Day, T.K., Hooker, A.M., Morley, A.A. and Sykes, P.J. (2003). Characterisation of an adaptive response in pKZ1 mice after exposure to x-radiation (Abstract) In Cooper, R et al, ed. 12th International Congress of Radiation Research: final program & book of abstracts. Lucas Heights, NSW: Australian Institute of Nuclear Science and Engineering. 12th International Congress of Radiation Research. Brisbane, QLD. Aug 2003, pp. 280.
  • Williams, K.A., Klebe, S., Sykes, P.J., Swinburne, S. and Coster, D.J. (2003). Gene Therapy to Prolong Ovine Corneal Allograft Survival (Abstract) In Clinical Immunology. Federation of Clinical Immunology Societies. Paris, France. May 1995, pp. S34.
  • Brisco, M., Sykes, P.J., Mccallum, B.D., Hughes, E., Latham, S.E. and Morley, A.A. (2001). A simple molecular test to predict outcome in childhood B-lineage acute lymphoblastic leukemia, by quantifying leukemia in marrow at day 14 of induction treatment. In Blood. Washington, DC, USA: American Society of Hematology. 43rd Annual Meeting of the American Society of Hematology. Florida, USA. Dec 2001, pp. A318-A318.
  • Brisco, M., Sykes, P.J., Peach, N., Marshall, G. and Morley, A.A. (2001). In childhood leukemia, resistance to drugs is often already present at diagnosis. In Blood. Washington, DC, USA: American Society of Hematology. 43rd Annual Meeting of the American Society of Hematology. Florida, USA. Dec 2001, pp. 4835-4835.
  • Hooker, A.M., Morley, A.A. and Sykes, P.J. (2001). Effect of c-myc over-expression and loss of MSH-2 expression on somatic intrachromosomal recombination. In Environmental and Molecular Mutagenesis. New York, USA: Wiley-Liss. EMS 2001: A Science Odyssey. San Diego, USA. Mar 2001, pp. 39-39.
  • Klebe, S., Coster, D.J., Sykes, P.J., Swinburne, S. and Williams, K.A. (2001). Gene therapy with p40 IL-12 (but not IL-4) prolongs corneal allograft survival in sheep. In 19th Annual Scientific Meeting - Transplantation Society of Australia and New Zealand. Immunology and Cell Biology. Transplantation Society of Australia and New Zealand. Canberra, ACT. Jun 2001, pp. A11-A11.
  • Standfield, S., Sykes, P.J., Stein-Oakley, A., Coster, D.J. and Williams, K.A. (2001). Mediators of Rat Corneal Allograft Rejection (abstract). In 19th Annual Scientific Meeting - Transplantation Society of Australia and New Zealand. Immunology and Cell Biology. 2001 Conference - Transplantation Society of Australia and New Zealand. Canberra, ACT. Apr 2001, pp. A24-A24.
  • Sykes, P.J., Hooker, A.M., Mccallum, B.D. and Morley, A.A. (2001). Agents which reduce somatic intrachromosomal recombination below spontaneous frequency in the pKZ1 recombination mutagenesis model. In Environmental and Molecular Mutagenesis. New York, USA: Wiley-Liss. EMS 2001: A Science Odyssey. San Diego, USA. Mar 2001, pp. 74-74.
  • Gordon, T., Jovanovich, S., Sykes, P., Bradley, J. and Roberts-Thomson, P. (1989). Molecular cloning of ribosomal P autoantigen and development of a sensitive and specific ELISA using recombinant antigen. Australian Rheumatism Association Meeting. Melbourne, Australia.
  • Klebe, S., Mead, K., Brennan, J.M., Skinner, J.M., Sykes, P.J. and Allen, P.W. (2006). Molecular testing for soft tissue tumours with known translocations (Letter) Pathology, 38(4) pp. 382-383.
    [10.1080/00313020600820930] [10.1080/00313020600820930] [Scopus]
  • Brisco, M., Sykes, P.J., Hughes, E., Story, C., Rice, M.S., Schwarer, A.P., et al. (2001). Molecular relapse can be detected in blood in a sensitive and timely fashion in B-lineage acute lymphoblastic leukemia. Leukemia, 15(11) pp. 1801-1802.
  • Hooker, A.M., Cormack, J., Morley, A.A. and Sykes, P.J. (2003). Effect of low dose radiation on somatic intrachromosomal recombination in vivo and in vitro (Abstract) Cooper, R et al, ed. 12th International Congress of Radiation Research Book of Abstracts, pp. 329.
  • Brisco, M., Sykes, P. and Morley, A. (2010). Method of analysing a marker nucleic acid molecule. Patent: 7785783 USA. Patent owner: Monoquant pty
  • Morley, A.A., Brisco, M. and Sykes, P.J. (2004). Identifcation of clonal cells by repeats in (eg.) T-cell receptor V/D/J genes. Patent: PCT/AU2004/000625 Australia. Patent owner: Flinders University
  • Ormsby, R., Lawrence, M., Blyth, B., Bexis, K., Bezak, E., Murley, J., et al. (2014). Protection from radiation-induced apoptosis by the radioprotector amifostine (WR-2721) is radiation dose dependent. CELL BIOLOGY AND TOXICOLOGY, 30(1) pp. 55-66.
    [10.1007/s10565-014-9268-3]
  • Newman, M., Sykes, P.J., Blyth, B., Bezak, E., Lawrence, M., Morel, K., et al. (2014). A single whole-body low dose X-irradiation does not affect L1, B1 and IAP repeat element DNA methylation longitudinally. PLoS One, 9(3) pp. e93016.
    [10.1371/journal.pone.0093016]
  • Newman, M., Sykes, P.J., Blyth, B., Bezak, E., Lawrence, M., Morel, K., et al. (2014). The methylation of DNA repeat elements is sex-dependent and temporally different in response to X-radiation in radiosensitive and radioresistant mouse strains. Radiation Research, 181(1) pp. 65-75.
    [10.1667/RR13460.1]
  • Lawrence, M.D., Blyth, B.J., Ormsby, R.J., Tilley, W.D. and Sykes, P.J. (2013). False-positive TUNEL staining observed in SV40 based transgenic murine prostate cancer models. TRANSGENIC RESEARCH, 22(5) pp. 1037-1047.
    [10.1007/s11248-013-9694-7]
  • Lawrence, M., Ormsby, R., Blyth, B., Bezak, E., England, G., Newman, M., et al. (2013). Lack of high-dose radiation mediated prostate cancer promotion and low-dose radiation adaptive response in the TRAMP mouse model. Radiation Research, 180(4) pp. 376-388.
    [10.1667/RR3381.2]
  • Newman, M.R., Blyth, B.J., Hussey, D.J., Jardine, D.R., Sykes, P.J. and Ormsby, R.J. (2012). Sensitive quantitative analysis of murine LINE1 DNA methylation using high resolution melt analysis. Epigenetics, 7(1) pp. 92-105.
    [10.4161/epi.7.1.18815] [Scopus]
  • Blyth, B.J. and Sykes, P.J. (2011). Radiation-induced bystander effects: what are they are how relevant are they to human radiation exposures? Radiation Research, 176(2) pp. 139-157.
    [10.1667/RR2548.1] [Scopus]
  • Staudacher, A., Blyth, B.J., Lawrence, M.D., Ormsby, R.J., Bezak, E. and Sykes, P.J. (2010). If bystander effects for apoptosis occur in spleen after low dose irradiation in vivo then the magnitude of the effect falls within the range of normal homeostatic apoptosis. Radiation Research, 174 pp. 727-731.
    [10.1667/RR2300.1] [Scopus]
  • Blyth, B.J., Azzam, E.I., Howell, R.W., Ormsby, R.J., Staudacher, A. and Sykes, P.J. (2010). An adoptive transfer method to detect low-dose radiation-induced bystander effects in vivo. Radiation Research, 173(2) pp. 125-137.
    [10.1667/RR1899.1] [10.1667/RR1899.1] [Scopus]
  • Hooker, A.M., Grdina, D.J., Murley, J.S., Blyth, B.J., Ormsby, R.J., Bezak, E., et al. (2009). Low doses of amifostine protect from chromosomal inversions in spleen in vivo when administered after an occupationally relevant X-radiation dose. International Journal of Low Radiation, 6(1) pp. 43-56.
    [10.1504/IJLR.2009.026239] [Scopus]
  • Brisco, M., Latham, S.E., Sutton, R., Hughes, E., Wilczek, V.J., van Zanten, K., et al. (2009). Determining the repertoire of IGH gene rearrangements to develop molecular markers for minimal residual disease in B-lineage acute lymphoblastic leukemia. Journal of Molecular Diagnostics, 11(3) pp. 194-200.
    [10.2353/jmoldx.2009.080047] [10.2353/jmoldx.2009.080047] [Scopus]
  • Morley, A.A., Latham, S.E., Brisco, M., Sykes, P.J., Sutton, R., Hughes, E., et al. (2009). Sensitive and specific measurement of minimal residual disease in acute lymphoblastic leukemia. Journal of Molecular Diagnostics, 11(3) pp. 201-210.
    [10.2353/jmoldx.2009.080048] [10.2353/jmoldx.2009.080048] [Scopus]
  • Sykes, P.J. and Day, T.K. (2007). Requirements for identification of low dose and non-linear mutagenic responses to ionising radiation. Dose-Response, 5(4) pp. 308-314.
    [10.2203/dose-response.07-018.Sykes]
  • Day, T.K., Zeng, G., Hooker, A.M., Bhat, M., Turner, D.R. and Sykes, P.J. (2007). Extremely low doses of X-radiation can induce adaptive responses in mouse prostate. Dose-Response, 5(4) pp. 315-322.
    [10.2203/dose-response.07-019.Day]
  • Day, T.K., Hooker, A.M., Zeng, G. and Sykes, P.J. (2007). Low dose X-radiation adaptive response in spleen and prostate of Atm knockout heterozygous mice. International Journal of Radiation Biology, 83(8) pp. 523-534.
    [10.1080/09553000701420582] [10.1080/09553000701420582] [Scopus]
  • Day, T.K., Zeng, G., Hooker, A.M., Bhat, M., Scott, B., Turner, D.R., et al. (2007). Adaptive response for chromosomal inversions in pKZ1 mouse prostate induced by low doses of X radiation delivered after a high dose. Radiation Research, 167(6) pp. 682-692.
    [10.1667/RR0764.1] [10.1667/RR0764.1] [Scopus]
  • Sykes, P.J., Morley, A.A. and Hooker, A.M. (2006). The PKZ1 Recombination Mutation Assay: A Sensitive Assay for Low Dose Studies. Dose-Response, 4(2) pp. 91-105.
    [10.2203/dose-response.05-035.Sykes]
  • Sykes, P.J., Day, T.K., Swinburne, S.J., Lane, J.M., Morley, A.A. and Hooker, A.M. (2006). In Vivo Mutagenic Effect of Very Low Dose Radiation. Dose-Response, 4(4) pp. 309-316.
    [10.2203/dose-response.06-004.Sykes]
  • Zeng, G., Day, T.K., Hooker, A.M., Blyth, B.J., Bhat, M., Tilley, W.D., et al. (2006). Non-linear chromosomal inversion response in prostate after low dose X-radiation exposure. Mutation Research-Fundamental and Molecular Mechanisms of Mutagenesis, 602(1 - 2) pp. 65-73.
    [10.1016/j.mrfmmm.2006.08.002] [10.1016/j.mrfmmm.2006.08.002] [Scopus]
  • Dare, R., Sykes, P.J., Morley, A.A. and Brisco, M. (2006). Effect of age on the repertoire of cytotoxic memory (CD8+CD45RO+) T cells in peripheral blood: The use of rearranged T cell receptor gamma genes as clonal markers. Journal of Immunological Methods, 308(1/2) pp. 1-12.
    [10.1016/j.jim.2005.08.016] [10.1016/j.jim.2005.08.016] [Scopus]
  • Day, T.K., Zeng, G., Hooker, A.M., Bhat, M., Scott, B.R., Turner, D.R., et al. (2006). Extremely low priming doses of X radiation induce an adaptive response for chromosomal inversions in pKZ1 mouse prostate. Radiation Research, 166(5) pp. 757-766.
    [10.1667/RR0689.1] [10.1667/RR0689.1] [Scopus]
  • Jessup, C.F., Brereton, H.M., Sykes, P.J., Thiel, M., Coster, D.J. and Williams, K.A. (2005). Local gene transfer to modulate rat corneal allograft rejection. Investigative Ophthalmology and Visual Science, 46(5) pp. 1675-1681.
    [10.1167/iovs.04-1140] [10.1167/iovs.04-1140] [Scopus]
  • Klebe, S., Coster, D.J., Sykes, P.J., Swinburne, S., Hallsworth, P.G., Scheerlinck, J.Y., et al. (2005). Prolongation of sheep corneal allograft survival by transfer of the gene encoding ovine IL-12-p40 but not IL-4 to donor corneal endothelium. Journal of Immunology, 175(4) pp. 2219-2226.
    [Scopus]
  • Hooker, A.M., Morley, A.A., Tilley, W.D. and Sykes, P.J. (2004). Cancer-associated genes can affect somatic intrachromosomal recombination early in carcinogenesis. Mutation Research-Fundamental and Molecular Mechanisms of Mutagenesis, 550(1-2) pp. 1-10.
    [10.1016/j.mrfmmm.2004.01.003] [10.1016/j.mrfmmm.2004.01.003] [Scopus]
  • Hooker, A.M., Bhat, M., Day, T.K., Lane, J.M., Swinburne, S., Morley, A.A., et al. (2004). The linear no-threshold model does not hold for low-dose ionizing radiation. Radiation Research, 162(4) pp. 447-452.
    [10.1667/RR3228] [10.1667/RR3228] [Scopus]
  • Marshall, G.M., Haber, M., Kwan, E., Zhu, L., Ferrara, D., Chengyuan, X., et al. (2003). Importance of minimal residual disease testing during the second year of therapy for children with acute lymphoblastic leukemia. Journal of Clinical Oncology, 21(4) pp. 704-709.
    [10.1200/JCO.2003.10.080] [10.1200/JCO.2003.10.080] [Scopus]
  • Hooker, A.M., Horne, R., Morley, A.A. and Sykes, P.J. (2002). Dose-dependent increase or decrease of somatic intrachromosomal recombination produced by etoposide. Mutation Research-Fundamental and Molecular Mechanisms of Mutagenesis, 500(1-2) pp. 117-124.
    [10.1016/S0027-5107(02)00007-6] [Scopus]
  • Henry, J.M., Morley, A.A. and Sykes, P.J. (2001). Purging of myeloma cells using all-trans retinoic acid in a mouse model. Experimental Hematology, 29(3) pp. 315-321.
  • Sykes, P.J., Mccallum, B.D., Bangay, M., Hooker, A.M. and Morley, A.A. (2001). Effect of exposure to 900 MHz radiofrequency radiation on intrachromosomal recombination in pKZ1 mice. Radiation Research, 156(5) pp. 495-502.
  • Klebe, S., Bloom, D.C., Sykes, P.J., Williams, K.A. and Coster, D.J. (2001). Gene transfer to ovine corneal endothelium. Clinical and Experimental Ophthalmology, 29 pp. 316-322.
  • Klebe, S., Sykes, P.J., Krishnan, R. and Williams, K.A. (2001). Prolongation of sheep allograft survival by ex-vivo transfer of the gene encoding interleukin 10. Transplantation, 71(9) pp. 1214-1220.
  • Brisco, M., Sykes, P.J., Hughes, E., Neoh, S.H., Snell, L., Dolman, G., et al. (2001). Comparison of methods for assessment of minimal residual disease in childhood B-lineage acute lymphoblastic leukemia. Leukemia, 15(1) pp. 385-390.
  • Gordon, T., Jovanovich, S., Sykes, P., Bradley, J. and Roberts-Thomson, P. (1990). Detection of autoantibodies to ribosomal P protein using recombinant autoantigen in a quantitative immunoassay. Rheumatology International, 10(3) pp. 99-102.
    [Web Link]
  • Newman, M., Sykes, P.J., Blyth, B., Bezak, E., Lawrence, M., Morel, K., et al. (2014). The methylation of DNA repeat elements is sex-dependent and temporally different in response to X-radiation in radiosensitive and radioresistant mouse strains. Radiation Research, 181(1) pp. 65-75.
    [10.1667/RR13460.1]
  • Ormsby, R., Lawrence, M., Blyth, B., Bexis, K., Bezak, E., Murley, J., et al. (2014). Protection from radiation-induced apoptosis by the radioprotector amifostine (WR-2721) is radiation dose dependent. CELL BIOLOGY AND TOXICOLOGY, 30(1) pp. 55-66.
    [10.1007/s10565-014-9268-3]
  • Newman, M., Sykes, P.J., Blyth, B., Bezak, E., Lawrence, M., Morel, K., et al. (2014). A single whole-body low dose X-irradiation does not affect L1, B1 and IAP repeat element DNA methylation longitudinally. PLoS One, 9(3) pp. e93016.
    [10.1371/journal.pone.0093016]
  • Lawrence, M., Ormsby, R., Blyth, B., Bezak, E., England, G., Newman, M., et al. (2013). Lack of high-dose radiation mediated prostate cancer promotion and low-dose radiation adaptive response in the TRAMP mouse model. Radiation Research, 180(4) pp. 376-388.
    [10.1667/RR3381.2]
  • Lawrence, M.D., Blyth, B.J., Ormsby, R.J., Tilley, W.D. and Sykes, P.J. (2013). False-positive TUNEL staining observed in SV40 based transgenic murine prostate cancer models. TRANSGENIC RESEARCH, 22(5) pp. 1037-1047.
    [10.1007/s11248-013-9694-7]
  • Newman, M.R., Blyth, B.J., Hussey, D.J., Jardine, D.R., Sykes, P.J. and Ormsby, R.J. (2012). Sensitive quantitative analysis of murine LINE1 DNA methylation using high resolution melt analysis. Epigenetics, 7(1) pp. 92-105.
    [10.4161/epi.7.1.18815] [Scopus]
  • Blyth, B.J. and Sykes, P.J. (2011). Radiation-induced bystander effects: what are they are how relevant are they to human radiation exposures? Radiation Research, 176(2) pp. 139-157.
    [10.1667/RR2548.1] [Scopus]
  • Blyth, B.J., Azzam, E.I., Howell, R.W., Ormsby, R.J., Staudacher, A. and Sykes, P.J. (2010). An adoptive transfer method to detect low-dose radiation-induced bystander effects in vivo. Radiation Research, 173(2) pp. 125-137.
    [10.1667/RR1899.1] [10.1667/RR1899.1] [Scopus]
  • Staudacher, A., Blyth, B.J., Lawrence, M.D., Ormsby, R.J., Bezak, E. and Sykes, P.J. (2010). If bystander effects for apoptosis occur in spleen after low dose irradiation in vivo then the magnitude of the effect falls within the range of normal homeostatic apoptosis. Radiation Research, 174 pp. 727-731.
    [10.1667/RR2300.1] [Scopus]
  • Sykes, P.J. (2001). Detecting monoclonal immunoglobulin and T-cell receptor gene rearrangements in B- and T-cell malignancies by polymerase chain reaction. In Faguet, G B, ed. Hematologic Malignancies: Methods and Techniques. Totowa, USA: Humana Press, pp. 117-132.

Professional and community engagement

Member, South Australian Radiation Protection Committee
Associate Editor. Radiation Research

Contact

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Phone: +61 8 82044379
Email:
Location: Flinders Centre for Innovation in Cancer (3L:100)
Postal address: GPO Box 2100, Adelaide 5001, South Australia
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