Position/s

Professor, Head of Discipline
Human Physiology

Associate Dean
Flinders Medical Science and Technology AU

Biography

Simon Brookes was awarded his PhD in 1984 for studies on the nervous system of insects. From this he developed a continuing interest in simple neural circuits.  He did post-doctoral research in the Royal London Hospital, then moved to Flinders University in 1988.  He has been funded by senior research fellowships from the Gastroenterological Society and NHMRC of Australia.  In 2005, he was appointed Professor and Head of Human Physiology at Flinders University.  Simon's research focusses on how nerve cells work together to give coordinated control of the organs of the body and how they go wrong in disease.  His interests range from the molecular level through to the whole organism.  He has worked extensively on 'simple' autonomic and sensory pathways to the gut and has published over 110 papers, chapters and reviews.  He is convenor of the Centre for Neuroscience

Qualifications

BSc (Hons, 1st Class in Psychology and Zoology) University of Bristol (1977-1980)
PhD University of Bristol, (1980-1984)

Honours, awards and grants

1980    Bachelor of Science, Joint Honours in psychology and zoology (first class), awarded by the University of Bristol.
1980    Science Research Council postgraduate scholarship, Dept of Zoology, University of Bristol, UK
1984    PhD, University of Bristol "Studies of two unpaired median neurones in the abdominal ganglia of silkmoth caterpillars"
1986    Wellcome travel award to USA
1992    First Senior Research Fellowship in Digestive Sciences, Gastroenterological Society of Australia 1992-1997.
1995    Sandoz "Neurogastroenterology Award" for best presentation at meeting at Little Brain-Big Brain meeting, Munich
2001    Janssen Award in Basic or Clinical Research in Digestive Sciences, awarded at Digestive Disease Week, Atlanta, GA
2001    Senior Research Fellowship of the National Health and Medical Research Council of Australia
2002    Promotion to Associate Professor (Flinders University, academic status)
2005    Appointed as Professor and Head of Dept of Human Physiology, Flinders University
2012    Appointed, Associate Dean Flinders Medical Science and Technology

Key responsibilities

Associate Dean of Flinders Medical Science and Technology (2012-)
Head of Department (2005-)
Member of Faculty Research Committee
Member of BMedSc Executive Committee
Member BMedSc Exam Board
Chair, BMedSc Course Committee
Editorial boards: Frontiers in Autonomic Neuroscience
Grant Referee; NH&MRC, ARC, FMC Foundation and Faculty Grants Committee
Chair NHMRC Grant Review Panel (2009)
Member NHMRC Grant Review Panel (2001, 2002, 2003, 2008, 2009)
Member NHMRC Senior Fellowships Panel (2011, 2012)

Teaching interests

Physiology,
body systems,
visceral organs,
neuroscience,
sensory physiology,
autonomic nervous system,
gastrointestinal physiology

Topic Lecturer:

  • MDSC2000  Skills for Medical Scientists 2
  • MMED1005  How your body works
  • MMED2931  Human Physiology
  • MMED2932  Integrative Human Physiology
  • MMED2933  Fundamental Neuroscience
  • MMED3931  Advanced Neuroscience
  • MMED8203  Gastrointestinal Block of Graduate Entry Medical Program

Research expertise

  • Medical physiology
  • Neurosciences
  • Physiology

Research interests

Simon's  research interests focus on how nerve cells give rise to sensation and how they control the organs of the body, especially the gastrointestinal tract, ranging from the molecular level through to the behaviour of the whole organism.  He has worked extensively on autonomic control of the gut, especially the enteric nervous system and the extrinsic sensory innervation of the bowel. Since his PhD studies, his interests have focussed on "simple" parts of the nervous system where it is possible to understand at the cellular level, how nerve cells work within circuits to give rise to coordinated behaviour.  His group has  identified the endings of a major class of neurons that mediate pain from the bowel and is attempting to characterise systematically the types of sensory neurons that mediate sensation from the gastrointestinal tract.  Simon has a growing interest in how diseases of the Central Nervous System, such as Parkinson's Disease, affect the simpler, more accessible nerves in the periphery.

Supervisory interests

  • Autonomic nerves, internal organs, blood vessels and skin
  • Cell biology
  • Enteric nervous system
  • Neuroscience
  • Sensory nerves, pain
  • Sensory neurobiology of the gastrointestinal tract

RHD research supervision

Current

Principal supervisor : smooth muscle biology (1) ;

Completion

Associate supervisor : enteric nervous system (1) ;

Publications

  • Bharucha, A. and Brookes, S. (2012). Neurophysiologic Mechanisms of Human Large Intestinal Motility. In Leonard R Johnson, ed. Physiology of the Gastrointestinal Tract. 5th ed. Boston, USA: Academic Press, pp. 977-1022.
    [10.1016/B978-0-12-382026-6.00036-1]
  • Cook, I., Brookes, S. and Dinning, P. (2010). Colonic Motor and Sensory Function and Dysfunction. In Feldman M, Friedman LS, and Brandt LJ, ed. Sleisenger and Fordtran's Gastrointestinal and Liver Disease. 9th ed. Philadelphia: Saunders, pp. 1659-1674.
  • Cook, I.J., Brookes, S.J. and Dinning, P.G. (2010). Sensory and Motor Function of the Colon and Dysfunction. In Sleisenger And Fordtran's Gastrointestinal and Liver Disease. 9 ed. Philadelphia: Elsevier, pp. 1660-1674.
  • Costa, M. and Brookes, S.J. (2009). Neuropeptides: enteric nervous system. In Larry R. Squire, ed. Encyclopedia of Neuroscience. Oxford, UK: Academic Press, pp. 899-906.
  • Grundy, D. and Brookes, S.J. (2009). Mechanosensory Transduction. In Squire, LR, ed. Encyclopedia of Neuroscience. USA: Elsevier, pp. 697-702.
  • Brookes, S.J., Zagorodnyuk, V.P. and Costa, M. (2005). Mechanotransduction by vagal tension receptors in the upper gut. In Bradley J. Undem and Daniel Weinreich, ed. Advances in Vagal Afferent Neurobiology. Boca Raton, Florida, USA: CRC Press, pp. 147-166.
  • Brookes, S.J. and Costa, M. (2004). Functional neuroanatomy. In Robin Spiller, David Grundy, ed. PATHOPHYSIOLOGY OF THE ENTERIC NERVOUS SYSTEM. Malden, Mass.: Blackwell Publishing, pp. 3-12.
  • Brookes, S.J. and Costa, M. (2002). Cellular organisation of the mammalian enteric nervous system. In Simon Brookes and Marcello Costa, ed. Innervation of the gastrointestinal tract. London, UK: Taylor and Francis, pp. 393-467.
  • Cook, I.J. and Brookes, S.J. (2002). Motility of the large intestine. In Mark Feldman, Lawrence S. Friedman, Marvin H. Sleisenger, ed. Sleisenger and Fordtran's gastrointestinal and liver disease: pathophysiology, diagnosis, management. 7th ed. Philadelphia, USA: Elsevier Saunders, pp. 1679-1691.
  • Grundy, D. and Brookes, S.J. (2012). Neural Control of Gastrointestinal Function. California, USA: Morgan & Claypool.
  • Brookes, S.J. (2013). The presence of 5-HT in myenteric varicosities is not due to uptake of 5-HT released from the mucosa during dissection: use of a novel method for quantifying 5-HT immunoreactivity in myenteric ganglia. Neurogastroenterology and Motility, 25(10) pp. 849-853.
  • Zagorodnyuk, V.P., Gibbins, I.L., Costa, M., Brookes, S.J. and Nicholas, S.J. (2008). How many sensors in the bladder? Physiology News, 73 pp. 18-20.
  • Shea-Donohue, T., Cook, I.J., De Giorgio, R., Tonini, M., Dent, J., Costa, M., et al. (2005). A teaching module on irritable bowel syndrome. Neurogastroenterology and Motility, 17(suppl3) pp. 20-40.
    [10.1111/j.1365-2982.2005.00713.x] [10.1111/j.1365-2982.2005.00713.x] [Scopus]
  • Zagorodnyuk, V., Brookes, S., Spencer, N. and Yuan, S.Y. (2013). Hydrogen peroxide activates high threshold intramural vascular mechanoreceptors via TRPA1 but not TRPV1 channels in the guinea pig bladder. Proceedings of the Australian Neuroscience Society. 23 pp. 56-56.
  • Yuan, S.Y., Costa, M. and Brookes, S. (2000). Ascending excitatory and descending inhibitory pathways to the guinea pig pyloric sphincter. Proceedings of the Australian Neuroscience Society. 11 pp. 96-96.
  • Rainsford, T., Costa, M., Yuan, S.Y. and Brookes, S. (2000). Correlation between smooth muscle electrical activity and spatiio-temporal motor events in the guinea-pig small intestine. Proceedings of the Australian Physiological and Pharmacological Society. 31(2) pp. 105-105.
  • Yuan, S.Y., Costa, M. and Brookes, S. (2000). Effects of piroxicam on the slow waves in the circular muscle of the guinea-pig gastric antrum and duodenum. Proceedings of the Australian Physiological and Pharmalogical Society. 31(2) pp. 71-71.
  • Yuan, S.Y., Costa, M. and Brookes, S. (1999). Neuronal transmission to the pyloric sphincter of the guinea pig. Proceedings of the Australian Neuroscience Society. 10 pp. 164-164.
  • Yuan, S.Y., Brookes, S. and Costa, M. (1996). Inhibitory and excitatory neurotransmission to the isolated guinea-pig lower esophageal sphincter. Proceedings of the Australian Neuroscience Society. 7 pp. 81-81.
  • Yuan, S.Y., Brookes, S. and Costa, M. (1995). Electrophysiological study of enteric reflexes to the circular muscle of the isolated guinea-pig stomach. Proceedings of the Australian Pharmacological Society. 26 pp. 196-196.
  • Berthoud, H.R., Blackshaw, L.A., Brookes, S.J. and Grundy, D. (2004). Neuroanatomy of extrinsic afferents supplying the gastrointestinal tract. In Neurogastroenterology and Motility. Blackwell Publishing. Enteric Nervous System 2003. Calgary, Canada, pp. 28-33.
    [10.1111/j.1743-3150.2004.00471.x] [10.1111/j.1743-3150.2004.00471.x] [Scopus]
  • Yuan, S., Gregory, S.J., Brookes, S.J. and Costa, M. (2004). Enteric neuronal pathways across the gastro-duodenal junction in the guinea-pig. In Proc. Aust. Neurosci. Soc. ANS Conference, pp. 31.
  • Yuan, S., Gregory, S.J., Brookes, S.J. and Costa, M. (2003). Transition pattern of pacemaker activity in the guinea pig gastro-duodenal junction. In Neurogastroenterology & Motility. 19th International Symposium on Gastrointestinal Motility. Barcelona, Spain. Oct 2003, pp. 40-41.
  • Yuan, S., Brookes, S.J. and Costa, M. (2002). Pattern of pacemaker activity in the circular and longitudinal muscle layers of the guinea pig gastro-duodenal junction. In Proceedings of the Australian Heath & Medical Research Congress. NHMRC. 2002 Australian Heath & Medical Research Congress. Melbourne, VIC. Nov 2002, pp. 1125-1125.
  • Yuan, S.Y., Hennig, G., Costa, M. and Brookes, S. (1999). Neuronal pathways and transmission to the pyloric sphincter of the guinea pig. In Neurogastroenterology and Motility. 302 ed. 17th International Symposium on Gastrointestinal Motility. Belgium.
  • Yuan, S.Y., Brookes, S. and Costa, M. (1998). Neuronal pathways and transmission to the gastroesophageal junction of the guinea pig. In Neurogatroenterology and Motility. 16th International Symposium on Gastrointestinal Motility, pp. 110-110.
  • Yuan, S.Y., Brookes, S. and Costa, M. (1997). Neurotransmission to the gastric sling muscle of the guinea-pig. In Journal of the Autonomic Nervous System. Inaugural Conference of the International Society for Autonomic Neuroscience in Australia, pp. 150-150.
  • De Fontgalland, D., Brookes, S., Gibbins, I., Sia, T. and Wattchow, D. (2014). The neurochemical changes in the innervation of human colonic mesenteric and submucosal blood vessels in Ulcerative colitis and Crohn's disease. Neurogastroenterology and Motility, 26(5) pp. 731-744.
  • Brookes, S., Spencer, N., Costa, M. and Zagorodnyuk, V. (2013). Extrinsic primary afferent signalling in the gut. Nature Reviews. Gastroenterology and Hepatology, 10(5) pp. 286-296.
    [10.1038/nrgastro.2013.29]
  • Arkwright, J., Dickson, A., Maunder, S.A., Blenman, N.G., Lim, J., O'Grady, G., et al. (2013). The effect of luminal content and rate of occlusion on the interpretation of colonic manometry . Neurogastroenterology and Motility, 25(1) pp. e52-e59.
    [10.1111/nmo.12051]
  • Carbone, S., Dinning, P.G., Costa, M., Spencer, N., Brookes, S. and Wattchow, D. (2013). Ascending excitatory neural pathways modulate slow phasic myogenic contractions in the isolated human colon. Neurogastroenterology and Motility, 25(8) pp. 670-676.
    [10.1111/nmo.12129]
  • Costa, M., Dodds, K., Wiklendt, L., Spencer, N., Brookes, S. and Dinning, P. (2013). Neurogenic and myogenic motor activity in the colon of the guinea pig, mouse, rabbit, and rat. American Journal of Physiology-Gastrointestinal and Liver Physiology, 305(10) pp. G749-G759.
    [10.1152/ajpgi.00227.2013]
  • Costa, M., Wiklendt, L., Arkwright, J.W., Omari, T., Brookes, S.J.H. and Dinning, P.G. (2013). An experimental method to identify neurogenic and myogenic active mechanical states of intestinal motility. Frontiers in Systems Neuroscience, 7(7) pp. 1-18.
    [10.3389/fnsys.2013.00007]
  • Sia, T.C., Whiting, M., Kyloh, M., Nicholas, S.J., Oliver, J., Brookes, S., et al. (2013). 5-HT3 and 5-HT4 antagonists inhibit peristaltic contractions in guinea-pig distal colon by mechanisms independent of endogenous 5-HT. Frontiers in Neuroscience, 7(136)
    [10.3389/fnins.2013.00136] [PubMed]
  • Sharrad, D., Chen, B.N. and Brookes, S. (2013). Neurochemical coding compared between varicose axons and cell bodies of myenteric neurons in the guinea-pig ileum. Neuroscience Letters, 534 pp. 171-176.
    [10.1016/j.neulet.2012.10.049]
  • Sharrad, D., de Vries, E. and Brookes, S. (2013). Selective expression of alpha-synuclein-immunoreactivity in vesicular acetylcholine transporter-immunoreactive axons in the guinea-pig rectum and human colon. Journal of Comparative Neurology, 521(3) pp. 657-676.
    [10.1002/cne.23198]
  • Sharrad, D.F., Gai, W. and Brookes, S. (2013). Selective coexpression of synaptic proteins, {alpha}-synuclein, cysteine string protein-{alpha}, synaptophysin, synaptotagmin-1, and synaptobrevin-2 in vesicular acetylcholine transporter-immunoreactive axons in the guinea pig ileum. Journal of Comparative Neurology, 521(11) pp. 2523-2537.
    [10.1002/cne.23296] [Web Link]
  • Sia, T.C., Brookes, S., Dinning, P., Wattchow, D. and Spencer, N. (2013). Peristalsis and propulsion of colonic content can occur after blockade of major neuroneuronal and neuromuscular transmitters in isolated guinea pig colon. American Journal of Physiology-Gastrointestinal and Liver Physiology, 305(12) pp. G933-G939.
    [10.1152/ajpgi.00257.2013] [PubMed]
  • Sia, T.C., Flack, N., Robinson, L., Kyloh, M., Nicholas, S.J., Brookes, S.J., et al. (2013). Is serotonin in enteric nerves required for distension-evoked peristalsis and propulsion of content in guinea-pig distal colon? Neuroscience, 240 pp. 325-335.
    [10.1016/j.neuroscience.2013.02.061]
  • Raghupathi, R., Duffield, M.D., Zelkas, L.E., Meedeniya, A., Brookes, S., Sia, T., et al. (2013). Identification of unique release kinetics of serotonin from guinea-pig and human enterochromaffin cells. Journal of Physiology-London, 591(23) pp. 5959-5975.
    [10.1113/jphysiol.2013.259796]
  • Carbone, S., Wattchow, D., Spencer, N. and Brookes, S. (2012). Loss of responsiveness of circular smooth muscle cells from the guinea pig ileum is associated with changes in gap junction coupling. American Journal of Physiology-Gastrointestinal and Liver Physiology, 302(12) pp. G1434-G1444.
    [10.1152/ajpgi.00376.2011]
  • Arkwright, , Blenman, N., Underhill, I., Maunder, S., Spencer, N., Costa, M., et al. (2012). Measurement of muscular activity associated with peristalsis in the human gut using fibre Bragg grating arrays. IEEE Sensors Journal, 12(1) pp. 113-117.
    [10.1109/JSEN.2011.2123883] [Scopus]
  • Dinning, P.G., Costa, M., Brookes, S. and Spencer, N. (2012). Neurogenic and myogenic motor patterns of rabbit proximal, mid and distal colon. American Journal of Physiology-Gastrointestinal and Liver Physiology, 303(1) pp. G83-G92.
    [10.1152/ajpgi.00429.2011]
  • Zagorodnyuk, V., Kyloh, M., Brookes, S., Nicholas, S. and Spencer, N. (2012). Firing patterns and functional roles of different classes of spinal afferents in rectal nerves during colonic migrating motor complexes in mouse colon. American Journal of Physiology-Gastrointestinal and Liver Physiology, 303(3) pp. G404-G411.
    [10.1152/ajpgi.00047.2012]
  • Spencer, N., Kyloh, M., Wattchow, D., Thomas, A., Sia, T.C., Brookes, S.J., et al. (2012). Characterization of motor patterns in isolated human colon: are there differences in patients with slow-transit constipation? American Journal of Physiology-Gastrointestinal and Liver Physiology, 302(1) pp. G34-G43.
    [10.1152/ajpgi.00319.2011]
  • Hibberd, T.J., Zagorodnyuk, V.P., Spencer, N.J. and Brookes, S.J. (2012). Identification and mechanosensitivity of viscerofugal neurons. Neuroscience, 225 pp. 118-129.
    [10.1016/j.neuroscience.2012.08.040]
  • Hibberd, T., Zagorodnyuk, V., Spencer, N. and Brookes, S. (2012). Viscerofugal neurons recorded from guinea-pig colonic nerves after organ culture. Neurogastroenterology and Motility, 24(11) pp. 1041-e548.
    [10.1111/j.1365-2982.2012.01979.x]
  • Arkwright, , Blenman, N., Underhill, I., Maunder, S., Spencer, N., Costa, M., et al. (2011). A fibre optic catheter for simultaneous measurement of longitudinal and circumferential muscular activity in the gastrointestinal tract. Journal of Biophotonics, 4(4) pp. 244-251.
    [10.1002/jbio.201000056] [Scopus]
  • Dinning, P., Arkwright, , Costa, M., Wiklendt, L., Hennig, G., Brookes, S., et al. (2011). Temporal relationships between wall motion, intraluminal pressure, and flow in the isolated rabbit small intestine. American Journal of Physiology-Gastrointestinal and Liver Physiology, 300 pp. G577-G585.
    [10.1152/ajpgi.00532.2010] [Scopus]
  • Dinning, P.G., Arkwright, J.W., Costa, M., Wiklendt, L.S., Hennig, G.W., Brookes, S.J., et al. (2011). Temporal relationships between wall motion, intraluminal pressure, and flow in the isolated rabbit small intestine. American Journal of Physiology-Gastrointestinal and Liver Physiology, 300 pp. G577-G585.
  • Kyloh, M., Nicholas, S., Zagorodnyuk, V., Brookes, S. and Spencer, N. (2011). Identification of the visceral pain pathway activated by noxious colorectal distension in mice. Frontiers in Neuroscience, 5(16)
    [10.3389/fnins.2011.00016] [Scopus]
  • Lynn, P.A. and Brookes, S.J. (2011). Function and morphology correlates of rectal nerve mechanoreceptors innervating the guinea pig internal anal sphincter. Neurogastroenterology and Motility, 23(1) pp. 241-250.
    [10.1111/j.1365-2982.2010.01593.x] [Scopus]
  • Lynn, P.A. and Brookes, S.J. (2011). Pudendal afferent innervation of the guinea pig external anal sphincter. Neurogastroenterology and Motility, 23(9) pp. 871-e343.
    [10.1111/j.1365-2982.2011.01741.x] [Scopus]
  • Spencer, N., Nicholas, S., Robinson, L.V., Kyloh, M., Flack, N., Brookes, S., et al. (2011). Mechanisms underlying distension-evoked peristalsis in guinea pig distal colon: is there a role for enterochromaffin cells? American Journal of Physiology-Gastrointestinal and Liver Physiology, 301(3) pp. G519-G527.
    [10.1152/ajpgi.00101.2011] [Scopus]
  • Zagorodnyuk, V., Kyloh, M., Nicholas, S., Peiris, G., Brookes, S., Chen, B., et al. (2011). Loss of visceral pain following colorectal distension in an endothelin-3 deficient mouse model of Hirschsprung's disease. Journal of Physiology-London, 589(7) pp. 1691-1706.
    [10.1113/jphysiol.2010.202820] [Scopus]
  • Hennig, G., Gregory, S.J., Brookes, S.J. and Costa, M. (2010). Non-peristaltic patterns of motor activity in the guinea-pig proximal colon . Neurogastroenterology and Motility, 22(6) pp. e207-e217.
    [10.1111/j.1365-2982.2009.01453.x] [10.1111/j.1365-2982.2009.01453.x] [Scopus]
  • O'Dea, C.J., Brookes, S.J. and Wattchow, D.A. (2010). The efficacy of treatment of patients with severe constipation or recurrent pseudo-obstruction with pyridostigmine. Colorectal Disease, 12(6) pp. 540-548.
    [10.1111/j.1463-1318.2009.01838.x] [10.1111/j.1463-1318.2009.01838.x] [Scopus]
  • Zagorodnyuk, V.P., Brookes, S.J. and Spencer, N.J. (2010). Structure-function relationship of sensory endings in the gut and bladder. Autonomic Neuroscience-Basic and Clinical, 153(1) pp. 3-11.
    [10.1016/j.autneu.2009.07.018] [10.1016/j.autneu.2009.07.018] [Scopus]
  • Brookes, S.J., Dinning, P.G. and Gladman, M.A. (2009). Neuroanatomy and physiology of colorectal function and defaecation: from basic science to human clinical studies. Neurogastroenterology and Motility, 21(Suppl 2) pp. 9-19.
    [10.1111/j.1365-2982.2009.01400.x] [10.1111/j.1365-2982.2009.01400.x] [Scopus]
  • Hughes, P.A., Brierley, S.M., Martin, C.M., Brookes, S.J., Linden, D.R. and Blackshaw, L.A. (2009). Post-inflammatory colonic afferent sensitization: different subtypes, different pathways, and different time-courses. Gut, 58(10) pp. 1333-1341.
    [10.1136/gut.2008.170811] [10.1136/gut.2008.170811] [10.1136/gut.2008.170811] [Scopus]
  • Zagorodnyuk, V.P., Gregory, S.J., Costa, M., Brookes, S.J., Tramontana, M., Giuliani, S., et al. (2009). Spontaneous release of acetylcholine from autonomic nerves in the bladder. British Journal of Pharmacology, 157(4) pp. 607-619.
    [10.1111/j.1476-5381.2009.00166.x] [10.1111/j.1476-5381.2009.00166.x] [Scopus]
  • Zagorodnyuk, V.P., Brookes, S.J., Spencer, N.J. and Gregory, S.J. (2009). Mechanotransduction and chemosensitivity of two major classes of bladder afferents with endings in the vicinity to the urothelium. Journal of Physiology-London, 587(14) pp. 3523-3538.
    [10.1113/jphysiol.2009.172577] [10.1113/jphysiol.2009.172577] [Scopus]
  • Song, X., Chen, B.N., Zagorodnyuk, V.P., Lynn, P.A., Blackshaw, A., Grundy, D., et al. (2009). Identification of medium/high threshold extrinsic mechanosensitive afferent nerves to the gastrointestinal tract. Gastroenterology, 137(1) pp. 274-284.
    [10.1053/j.gastro.2009.02.061] [10.1053/j.gastro.2009.02.061] [Scopus]
  • Brookes, S.J., Zagorodnyuk, V.P., Lynn, P.A., Song, X., Chen, B.N., Olsson, C.A., et al. (2008). Structural basis of sensory nerve pathways from the gut. European Review for Medical & Pharmacological Sciences, 12(Suppl1) pp. 132-133.
    [Scopus]
  • Costa, M. and Brookes, S.J. (2008). Architecture of enteric neural circuits involved in intestinal motility. European Review for Medical & Pharmacological Sciences, 12(1(Suppl)) pp. 3-19.
    [Scopus]
  • DeFontgalland, D., Wattchow, D.A., Costa, M. and Brookes, S.J. (2008). Immunohistochemical characterization of the innervation of human colonic mesenteric and submucosal blood vessels. Neurogastroenterology and Motility, 20(11) pp. 1212-1226.
    [10.1111/j.1365-2982.2008.01150.x] [10.1111/j.1365-2982.2008.01150.x] [Scopus]
  • Lynn, P.A., Chen, B.N., Zagorodnyuk, V.P., Costa, M. and Brookes, S.J. (2008). TNBS-induced inflammation modulates the function of one class of low-threshold rectal mechanoreceptors in the guinea pig. American Journal of Physiology-Gastrointestinal and Liver Physiology, 295(4) pp. G862-G871.
    [10.1152/ajpgi.00585.2007] [10.1152/ajpgi.00585.2007] [Scopus]
  • Spencer, N.J., Kerrin, A., Zagorodnyuk, V.P., Hennig, G., Muto, M., Brookes, S.J., et al. (2008). Identification of functional intramuscular rectal mechanoreceptors in aganglionic rectal smooth muscle from piebald lethal mice. American Journal of Physiology-Gastrointestinal and Liver Physiology, 294(4) pp. G855-G867.
    [10.1152/ajpgi.00502.2007] [10.1152/ajpgi.00502.2007] [Scopus]
  • Wattchow, D.A., Brookes, S.J., Murphy, E., Carbone, S., DeFontgalland, D. and Costa, M. (2008). Regional variation in the neurochemical coding of the myenteric plexus of the human colon and changes in patients with slow transit constipation. Neurogastroenterology and Motility, 20(12) pp. 1298-1305.
    [10.1111/j.1365-2982.2008.01165.x] [10.1111/j.1365-2982.2008.01165.x] [Scopus]
  • Brunsden, A.M., Brookes, S.J., Bardhan, K.D. and Grundy, D. (2007). Mechanisms underlying mechanosensitivity of mesenteric afferent fibers to vascular flow. American Journal of Physiology-Gastrointestinal and Liver Physiology, 293(2) pp. G422-G428.
    [10.1152/ajpgi.00083.2007] [10.1152/ajpgi.00083.2007] [Scopus]
  • Zagorodnyuk, V.P., Gibbins, I.L., Costa, M., Brookes, S.J. and Gregory, S.J. (2007). Properties of the major classes of mechanoreceptors in the guinea pig bladder. Journal of Physiology-London, 585(1) pp. 147-163.
    [10.1113/jphysiol.2007.140244] [10.1113/jphysiol.2007.140244] [Scopus]
  • Murphy, E., DeFontgalland, D., Costa, M., Brookes, S.J. and Wattchow, D.A. (2007). Quantification of subclasses of human colonic myenteric neurons by immunoreactivity to Hu, choline acetyltransferase and nitric oxide synthase. Neurogastroenterology and Motility, 19(2) pp. 126-134.
    [10.1111/j.1365-2982.2006.00843.x] [10.1111/j.1365-2982.2006.00843.x] [Scopus]
  • Olsson, C.A., Chen, B.N., Jones, S., Chataway, T.K., Costa, M. and Brookes, S.J. (2006). Comparison of extrinsic efferent innervation of guinea pig distal colon and rectum. Journal of Comparative Neurology, 496(6) pp. 787-801.
    [10.1002/cne.20965] [10.1002/cne.20965] [Scopus]
  • Zagorodnyuk, V.P., Costa, M. and Brookes, S.J. (2006). Major classes of sensory neurons to the urinary bladder. Autonomic Neuroscience-Basic and Clinical, 126-127 pp. 390-397.
    [10.1016/j.autneu.2006.02.007] [10.1016/j.autneu.2006.02.007] [Scopus]
  • Lynn, P.A., Zagorodnyuk, V.P., Hennig, G., Costa, M. and Brookes, S.J. (2005). Mechanical activation of rectal intraganglionic laminar endings in the guinea pig distal gut. Journal of Physiology-London, 564(2) pp. 589-601.
    [10.1113/jphysiol.2004.080879] [10.1113/jphysiol.2004.080879] [Scopus]
  • Zagorodnyuk, V.P., Lynn, P.A., Costa, M. and Brookes, S.J. (2005). Mechanisms of mechanotransduction by specialised low-threshold mechanoreceptors in the guinea pig rectum. American Journal of Physiology-Gastrointestinal and Liver Physiology, 289(3) pp. G397-G406.
    [10.1152/ajpgi.00557.2004] [10.1152/ajpgi.00557.2004] [Scopus]
  • Costa, M., Brookes, S.J. and Zagorodnyuk, V.P. (2004). How many kinds of visceral afferants? Gut, 52(suppl2) pp. ii1-ii4.
    [Scopus]
  • Olsson, C.A., Costa, M. and Brookes, S.J. (2004). Neurochemical characterization of extrinsic innervation of the guinea pig rectum. Journal of Comparative Neurology, 470(4) pp. 357-371.
    [10.1002/cne.20000] [10.1002/cne.20000] [Scopus]
  • Zagorodnyuk, V.P., Chen, B.N., Costa, M. and Brookes, S.J. (2003). Mechanotransduction by intraganglionic laminar endings of vagal tension receptors in the guinea-pig oesophagus. Journal of Physiology-London, 553(2) pp. 575-587.
    [10.1113/jphysiol.2003.051862] [10.1113/jphysiol.2003.051862] [Scopus]
  • Sander, G.R., Brookes, S.J. and Powell, B.C. (2003). Expression of Notch1 and Jagged2 in the enteric nervous system. Journal of Histochemistry and Cytochemistry, 51(7) pp. 969-972.
    [Scopus]
  • Lynn, P.A., Olsson, C.A., Zagorodnyuk, V.P., Costa, M. and Brookes, S.J. (2003). Rectal intraganglionic laminar endings are transduction sites of extrinsic mechanoreceptors in the guinea pig rectum. Gastroenterology, 125(3) pp. 786-794.
    [10.1016/S0016-5085(03)01050-3] [10.1016/S0016-5085(03)01050-3] [Scopus]
  • Zagorodnyuk, V.P., D'Antona, G., Brookes, S.J. and Costa, M. (2002). Functional GABA(B) receptors are present in guinea pig nodose ganglion cell bodies but not in peripheral mechanosensitive endings. Autonomic Neuroscience-Basic and Clinical, 102(1-2) pp. 20-29.
    [10.1016/S1566-0702(02)00183-2] [10.1016/S1566-0702(02)00183-2] [Scopus]
  • Zagorodnyuk, V.P., Chen, B.N., Costa, M. and Brookes, S.J. (2002). 4-aminopyridine- and dendrotoxin-sensitive potassium channels influence excitability of vagal mechano-sensitive endings in guinea-pig oesophagus. British Journal of Pharmacology, 137(8) pp. 1195-1206.
    [10.1038/sj.bjp.0704964] [10.1038/sj.bjp.0704964] [Scopus]
  • Porter, A.J., Wattchow, D.A., Brookes, S.J. and Costa, M. (2002). Cholinergic and nitrergic interneurones in the myenteric plexus of the human colon. Gut, 51(1) pp. 70-75.
    [10.1136/gut.51.1.70] [10.1136/gut.51.1.70] [Scopus]
  • D'Antona, G., Hennig, G., Costa, M., Humphreys, C.M. and Brookes, S.J. (2001). Analysis of motor patterns in the isolated guinea-pig large intestine by spatio-temporal maps. Neurogastroenterology and Motility, 13(5) pp. 483-492.
  • Simula, M.E., Brookes, S.J., Meedeniya, A.C.B., Toouli, J. and Saccone, G.T. (2001). Distribution of nitric oxide synthase and vasoactive intestinal polypeptide immunoreactivity in the sphincter of oddi and duodenum of the possum. Cell and Tissue Research, 304(1) pp. 31-41.
  • Yuan, S., Costa, M. and Brookes, S.J. (2001). Neuronal control of the pyloric sphincter of the guinea-pig. Neurogastroenterology and Motility, 13(3) pp. 187-198.
  • Brookes, S.J., D'Antona, G., Zagorodnyuk, V.P., Humphreys, C.M. and Costa, M. (2001). Propagating contractions of the circular muscle evoked by slow stretch in flat sheets of guinea-pig ileum. Neurogastroenterology and Motility, 13(6) pp. 519-531.
  • Brookes, S.J. (2001). Retrograde tracing of enteric neuronal pathways. Neurogastroenterology and Motility, 13(1) pp. 1-18.
  • Zagorodnyuk, V.P., Chen, B.N. and Brookes, S.J. (2001). Intraganglionic laminar endings are mechano-transduction sites of vagal tension receptors in the guinea-pig stomach. Journal of Physiology-London, 534(1) pp. 255-268.
  • Brookes, S.J. (2001). Classes of enteric nerve cells in the guinea-pig small intestine. Anatomical Record, 262(1) pp. 58-70.
  • Yuan, S.Y. and Brookes, S. (1999). Neuronal control of the gastric sling muscle of the guinea pig. Journal of Comparative Neurology, 412(4) pp. 669-680.
  • Yuan, S.Y., Costa, M. and Brookes, S. (1998). Neuronal pathways and transmission to the lower esophageal sphincter of the guinea pig. Gastroenterology, 115(3) pp. 661-671.
  • Yuan, S.Y., Brookes, S. and Costa, M. (1997). Distension-evoked ascending and descending reflexes in the isolated guinea-pig stomach. Journal of the Autonomic Nervous System, 62(1-2) pp. 94-102.
  • Lynn, P.A. and Brookes, S.J. (2011). Function and morphology correlates of rectal nerve mechanoreceptors innervating the guinea pig internal anal sphincter. Neurogastroenterology and Motility, 23(1) pp. 241-250.
    [10.1111/j.1365-2982.2010.01593.x] [Scopus]
  • Spencer, N., Nicholas, S., Robinson, L.V., Kyloh, M., Flack, N., Brookes, S., et al. (2011). Mechanisms underlying distension-evoked peristalsis in guinea pig distal colon: is there a role for enterochromaffin cells? American Journal of Physiology-Gastrointestinal and Liver Physiology, 301(3) pp. G519-G527.
    [10.1152/ajpgi.00101.2011] [Scopus]
  • Hughes, P.A., Brierley, S.M., Martin, C.M., Brookes, S.J., Linden, D.R. and Blackshaw, L.A. (2009). Post-inflammatory colonic afferent sensitization: different subtypes, different pathways, and different time-courses. Gut, 58(10) pp. 1333-1341.
    [10.1136/gut.2008.170811] [10.1136/gut.2008.170811] [10.1136/gut.2008.170811] [Scopus]
  • Song, X., Chen, B.N., Zagorodnyuk, V.P., Lynn, P.A., Blackshaw, A., Grundy, D., et al. (2009). Identification of medium/high threshold extrinsic mechanosensitive afferent nerves to the gastrointestinal tract. Gastroenterology, 137(1) pp. 274-284.
    [10.1053/j.gastro.2009.02.061] [10.1053/j.gastro.2009.02.061] [Scopus]
  • Lynn, P.A., Chen, B.N., Zagorodnyuk, V.P., Costa, M. and Brookes, S.J. (2008). TNBS-induced inflammation modulates the function of one class of low-threshold rectal mechanoreceptors in the guinea pig. American Journal of Physiology-Gastrointestinal and Liver Physiology, 295(4) pp. G862-G871.
    [10.1152/ajpgi.00585.2007] [10.1152/ajpgi.00585.2007] [Scopus]
  • Brunsden, A.M., Brookes, S.J., Bardhan, K.D. and Grundy, D. (2007). Mechanisms underlying mechanosensitivity of mesenteric afferent fibers to vascular flow. American Journal of Physiology-Gastrointestinal and Liver Physiology, 293(2) pp. G422-G428.
    [10.1152/ajpgi.00083.2007] [10.1152/ajpgi.00083.2007] [Scopus]
  • Zagorodnyuk, V.P., Gibbins, I.L., Costa, M., Brookes, S.J. and Gregory, S.J. (2007). Properties of the major classes of mechanoreceptors in the guinea pig bladder. Journal of Physiology-London, 585(1) pp. 147-163.
    [10.1113/jphysiol.2007.140244] [10.1113/jphysiol.2007.140244] [Scopus]
  • Cook, I., Brookes, S. and Dinning, P. (2010). Colonic Motor and Sensory Function and Dysfunction. In Feldman M, Friedman LS, and Brandt LJ, ed. Sleisenger and Fordtran's Gastrointestinal and Liver Disease. 9th ed. Philadelphia: Saunders, pp. 1659-1674.
  • Brookes, S.J., Zagorodnyuk, V.P. and Costa, M. (2005). Mechanotransduction by vagal tension receptors in the upper gut. In Bradley J. Undem and Daniel Weinreich, ed. Advances in Vagal Afferent Neurobiology. Boca Raton, Florida, USA: CRC Press, pp. 147-166.
  • Brookes, S.J. and Costa, M. (2002). Cellular organisation of the mammalian enteric nervous system. In Simon Brookes and Marcello Costa, ed. Innervation of the gastrointestinal tract. London, UK: Taylor and Francis, pp. 393-467.

Professional and community engagement

Editorial boards:    Autonomic Neuroscience, Basic and Clinical (-2008) Neurogastroenterology and motility    
        American Journal of Physiology (GI & Liver) (-2009), Frontiers in Autonomic Neuroscience (2009-)
Secretary of South Australian Neuroscience Institute (SANI)
Member/Chairman of International Steering Committee, Emerging Leaders Program, Gothenburg Sweden 2005-2009
Grant Referee: NH&MRC, ARC, FMC Foundation, Faculty of Health Sciences Grant Ctee,
Member Grant Review Panel NHMRC: 2001-3, 2008-9; NHMRC Senior Fellowships Panel 2011,2012
Referee for Scientific Journals: Journal of Physiology, Gut, Gastroenterology etc

Expertise for media contact

Subject Titles

  • Gastrointestinal Physiology
  • Neuroscience

Interests

  • Gastrointestinal Motility and Pain
  • Sensory Neurobiology of The Gastrointestinal Tract
  • Molecular, Cellular and Organ Physiology of The Gut
  • Neuroanatomy of The Autonomic Nervous System

Contact

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Phone: +61 8 82044201
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Location: Flinders Medical Centre (6E:128)
Postal address: GPO Box 2100, Adelaide 5001, South Australia
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