Prof Simon Brookes

Simon at his dissecting microscope

Position/s:	Professor, Head of Discipline Human Physiology
Phone:	work+61 8 82044201
Email:	simon.brookes@flinders.edu.au
Location:	School of Medicine (6E:128)
Postal address:	GPO Box 2100, Adelaide 5001, South Australia

Biography

Simon Brookes was awarded his PhD in 1984 for studies on the nervous system of insects. From this he developed a continuing fascination with simple neural circuits. He did post-doctoral research in the Royal London Hospital, then moved to Flinders University in 1988. He has been funded by senior research fellowships from the Gastroenterological Society and NHMRC of Australia. In 2005, he was appointed Professor and Head of Human Physiology at Flinders University. Simon's research focusses on how nerve cells work together to give coordinated control of the organs of the body and how they go wrong in disease. His interests range from the molecular level through to the whole organism. He has worked extensively on 'simple' autonomic and sensory pathways to the gut and has published over 110 papers, chapters and reviews. He is convenor of the Centre for Neuroscience

Qualifications

BSc (Hons, 1st Class in Psychology and Zoology) University of Bristol (1977-1980)
PhD University of Bristol, (1980-1984)

Honours, awards and grants

1980    Bachelor of Science, Joint Honours in psychology and zoology (first class), awarded by the University of Bristol.
1980   Science Research Council postgraduate scholarship, Dept of Zoology, University of Bristol, UK
1984    PhD, University of Bristol "Studies of two unpaired median neurones in the abdominal ganglia of silkmoth caterpillars"
1986    Wellcome travel award to USA
1992    First Senior Research Fellowship in Digestive Sciences, Gastroenterological Society of Australia 1992-1997.
1995   Sandoz "Neurogastroenterology Award" for best presentation at meeting at Little Brain-Big Brain meeting, Munich
2001   Janssen Award in Basic or Clinical Research in Digestive Sciences, awarded at Digestive Disease Week, Atlanta, GA
2001   Senior Research Fellowship of the National Health and Medical Research Council of Australia
2002   Promotion to Associate Professor (Flinders University, academic status)
2005    Appointed as Professor and Head of Dept of Human Physiology, Flinders University

Key responsibilities

Head of Department
Convenor of the Centre for Neuroscience/
Deputy Head of Flinders Medical Science and Technology Cluster
Member of Faculty Research Committee
Member of the SOM Honours Committee
Member of the Level D Promotions Committee
Member of BMedSc Executive Committee
Member BMedSc Exam Board
Member BMedSc/BBiotech Joint Program Committee
Flinders University NHMRC Equipment Grant Selection Committee
Editorial boards: Neurogastroenterology and motility, American Journal of Physiology (GI & Liver), Frontiers in Autonomic Neuroscience
Grant Referee; NH&MRC, ARC, FMC Foundation and Faculty Grants Committee
Chair NHMRC Grant REview Panel (2009)
Member NHMRC Grant Review Panel (2001, 2002, 2003, 2008, 2009)
Referee for Scientific Journals (last 3 years): Journal of Physiology, Gut,

Teaching

Teaching interests

Physiology,
body systems,
visceral organs,
neuroscience,
sensory physiology,
autonomic nervous system,
gastrointestinal physiology

Topic Coordinator:

MMED2929 Neural Circuits
MMED8203 Gastrointestinal Block of Graduate Entry Medical Program (co-coordinator)

Topic Lecturer:

MMED1005 How your body works
MMED2927 Human Physiology 2A
MMED2928 Human Physiology 2B
MMED2929 Neural Circuits
MMED3924 Integrative and Higher Brain Function
MMED8203 Gastrointestinal Block of Graduate Entry Medical Program

Research and consultancy

Research interests

Simon's current research interests focus on how nerve cells give rise to sensation and how they control the organs of the body, especially the gastrointestinal tract, ranging from the molecular level through to the behaviour of the whole organism. He has worked extensively on autonomic control of the gut, especially the enteric nervous system and the extrinsic sensory innervation of the bowel. Since his PhD studies, his interests have focussed on "simple" parts of the nervous system where it is possible to understand at the cellular level, how nerve cells work within circuits to give rise to coordinated behaviour. His group has recently identified the endings of a major class of neurons that mediate pain from the bowel and is attempting to characterise systematically the types of sensory neurons that mediate sensation from the gastrointestinal tract. Simon has a growing interest in how diseases of the Central Nervous System, such as Parkinson's Disease, affect the simpler, more accessible nerves in the periphery.

Postgraduate research supervision

Co-supervisor of Zanmin Song, who completed his PhD successfully in 1994
Co supervisor of Lilian Kow, who completed her PhD 1997
Co-supervisor of Grant Hennig who completed his PhD in 1999
Supervisor of Adrian Meedeniya who completed his PhD in 2000
Advisor to Rebecca Anderson who completed a PhD in 2001
Advisor to Anthony Porter who completed a PhD in 1999
Supervisor of Kate Brody, Honours degree student 2003
Co-supervisor of Elisabeth Murphy who completed her PhD in 2009
Co-supervisor of Dayan DeFontgallandin who completed his PhD in 2009
Supervisor of Sara Jean Sum, Honours degree student 2006
Co-supervisor of Elisabeth Murphy who completed her PhD in 2009
Co-supervisor of Dayan DeFontgallandin who completed his PhD in 2009
Supervisor of Simona Carbone, Honours degree student 2008, PhD student 2009-
Supervisor of Tim Hibberd, Honours degree student 2008, PhD student 2010-

Publications

Book chapters

Brookes, S.J. & Costa, M., 2006. Functional histoanatomy of the enteric nervous system. In Physiology of the Gastrointestinal Tract, Volume 1. Burlington, USA: Elsevier, pp. 577-602.

Brookes, S.J., Zagorodnyuk, V.P., & Costa, M., 2005. Mechanotransduction by vagal tension receptors in the upper gut. In Advances in Vagal Afferent Neurobiology. Boca Raton, Florida, USA: CRC Press / Taylor and Francis Group, pp. 147-166.

Refereed journal articles

Lynn, P.A., Chen, B.N., Zagorodnyuk, V.P., Costa, M., & Brookes, S.J., 2008. TNBS-induced inflammation modulates the function of one class of low-threshold rectal mechanoreceptors in the guinea pig. American Journal of Physiology-Gastrointestinal and Liver Physiology, 295(4), G862-G871.

Brunsden, A.M., Brookes, S.J., Bardhan, K.D., & Grundy, D., 2007. Mechanisms underlying mechanosensitivity of mesenteric afferent fibers to vascular flow. American Journal of Physiology-Gastrointestinal and Liver Physiology, 293(2), G422-G428.

Zagorodnyuk, V.P., Gibbins, I.L., Costa, M., Brookes, S.J., & Gregory, S.J., 2007. Properties of the major classes of mechanoreceptors in the guinea pig bladder. Journal of Physiology-London, 585(1), 147-163.

Olsson, C.A., Chen, B.N., Jones, S., Chataway, T.K., Costa, M., & Brookes, S.J., 2006. Comparison of extrinsic efferent innervation of guinea pig distal colon and rectum. Journal of Comparative Neurology, 496(6), 787-801.

Zagorodnyuk, V.P., Lynn, P.A., Costa, M., & Brookes, S.J., 2005. Mechanisms of mechanotransduction by specialised low-threshold mechanoreceptors in the guinea pig rectum. American Journal of Physiology-Gastrointestinal and Liver Physiology, 289(3), G397-G406.

Olsson, C.A., Costa, M., & Brookes, S.J., 2004. Neurochemical characterization of extrinsic innervation of the guinea pig rectum. Journal of Comparative Neurology, 470(4), 357-371.

Zagorodnyuk, V.P., Chen, B.N., Costa, M., & Brookes, S.J., 2003. Mechanotransduction by intraganglionic laminar endings of vagal tension receptors in the guinea-pig oesophagus. Journal of Physiology-London, 553(2), 575-587.

Lynn, P.A., Olsson, C.A., Zagorodnyuk, V.P., Costa, M., & Brookes, S.J., 2003. Rectal intraganglionic laminar endings are transduction sites of extrinsic mechanoreceptors in the guinea pig rectum. Gastroenterology, 125(3), 786-794.

Show all publications

Book chapters

Cook, I.J., Brookes, S.J., & Dinning, P.G., 2010. Sensory and Motor Function of the Colon. In Sleisenger and Fordtran's: Gastrointestinal and Liver Disease. Philadelphia: Saunders, pp. 1659-1674.

Costa, M. & Brookes, S.J., 2009. Neuropeptides: enteric nervous system. In Encyclopedia of Neuroscience. Oxford, UK: Academic Press, pp. 899-906.

Brookes, S.J. & Costa, M., 2006. Functional histoanatomy of the enteric nervous system. In Physiology of the Gastrointestinal Tract, Volume 1. Burlington, USA: Elsevier, pp. 577-602.

Brookes, S.J. & Costa, M., 2004. Functional neuroanatomy. In PATHOPHYSIOLOGY OF THE ENTERIC NERVOUS SYSTEM. Malden, Mass.: Blackwell Publishing, pp. 3-12.

Brookes, S.J. & Costa, M., 2002. Cellular organisation of the mammalian enteric nervous system. In Innervation of the gastrointestinal tract. London, UK: Taylor and Francis, pp. 393-467.

Cook, I.J. & Brookes, S.J., 2002. Motility of the large intestine. In Sleisenger and Fordtran's gastrointestinal and liver disease: pathophysiology, diagnosis, management. Philadelphia, USA: Saunders Elsevier, pp. 1679-1691.

Refereed journal articles

Arkwright, J., Blenman, N.G., Underhill, I.D., Maunder, S.A., Spencer, N.J., Costa, M., Brookes, S.J., Szczesniak, M.M., & Dinning, P.G., 2011. A fibre optic catheter for simultaneous measurement of longitudinal and circumferential muscular activity in the gastrointestinal tract. Journal of Biophotonics, 4(4), 244-251.

Arkwright, J., Blenman, N.G., Underhill, I.D., Maunder, S.A., Spencer, N.J., Costa, M., Brookes, S.J., Szczesniak, M.M., & Dinning, P.G., 2011. Measurement of muscular activity associated with peristalsis in the human gut using fibre Bragg grating arrays. IEEE Sensors Journal, PP(99).

Dinning, P.G., Arkwright, J., Costa, M., Wiklendt, L., Hennig, G., Brookes, S.J., & Spencer, N.J., 2011. Temporal relationships between wall motion, intraluminal pressure, and flow in the isolated rabbit small intestine. American Journal of Physiology-Gastrointestinal and Liver Physiology, 300, G577-G585.

Kyloh, M.A., Nicholas, S.J., Zagorodnyuk, V.P., Brookes, S.J., & Spencer, N.J., 2011. Identification of the visceral pain pathway activated by noxious colorectal distension in mice. Frontiers in Neuroscience, 5(16), 1-7.

Lynn, P.A. & Brookes, S.J., 2011. Function and morphology correlates of rectal nerve mechanoreceptors innervating the guinea pig internal anal sphincter. Neurogastroenterology and Motility, 23(1), 241-250.

Spencer, N.J., Nicholas, S.J., Robinson, L.V., Kyloh, M.A., Flack, N.C., Brookes, S.J., Zagorodnyuk, V.P., & Keating, D.J., 2011. Mechanisms underlying distension-evoked peristalsis in guinea pig distal colon: is there a role for enterochromaffin cells?. American Journal of Physiology-Gastrointestinal and Liver Physiology, 301(3), G519-G527.

Zagorodnyuk, V.P., Kyloh, M.A., Nicholas, S.J., Peiris, G.H., Brookes, S.J., Chen, B.N., & Spencer, N.J., 2011. Loss of visceral pain following colorectal distension in an endothelin-3 deficient mouse model of Hirschsprungâ€™s disease. Journal of Physiology-London, 589(7), 1691-1706.

Hennig, G., Gregory, S.J., Brookes, S.J., & Costa, M., 2010. Non-peristaltic patterns of motor activity in the guinea-pig proximal colon. Neurogastroenterology and Motility, 22(6), e207-e217.

O'Dea, C.J., Brookes, S.J., & Wattchow, D.A., 2010. The efficacy of treatment of patients with severe constipation or recurrent pseudo-obstruction with pyridostigmine. Colorectal Disease, 12(6), 540-548.

Zagorodnyuk, V.P., Brookes, S.J., & Spencer, N.J., 2010. Structure-function relationship of sensory endings in the gut and bladder. Autonomic Neuroscience-Basic and Clinical, 153(1), 3-11.

Brookes, S.J., Dinning, P.G., & Gladman, M.A., 2009. Neuroanatomy and physiology of colorectal function and defaecation: from basic science to human clinical studies. Neurogastroenterology and Motility, 21(Suppl 2), 9-19.

Hughes, P.A., Brierley, S.M., Martin, C.M., Brookes, S.J., Linden, D.R., & Blackshaw, L.A., 2009. Post-inflammatory colonic afferent sensitization: different subtypes, different pathways, and different time-courses. Gut, 58(10), 1333-1341.

Song, X., Chen, B.N., Zagorodnyuk, V.P., Lynn, P.A., Blackshaw, A., Grundy, D., Brunsden, A., Costa, M., & Brookes, S.J., 2009. Identification of medium/high threshold extrinsic mechanosensitive afferent nerves to the gastrointestinal tract. Gastroenterology, 137(1), 274-284.

Zagorodnyuk, V.P., Brookes, S.J., Spencer, N.J., & Gregory, S.J., 2009. Mechanotransduction and chemosensitivity of two major classes of bladder afferents with endings in the vicinity to the urothelium. Journal of Physiology-London, 587(14), 3523-3538.

Zagorodnyuk, V.P., Gregory, S.J., Costa, M., Brookes, S.J., Tramontana, M., Giuliani, S., & Maggi, C.A., 2009. Spontaneous release of acetylcholine from autonomic nerves in the bladder. British Journal of Pharmacology, 157(4), 607-619.

Brookes, S.J., Zagorodnyuk, V.P., Lynn, P.A., Song, X., Chen, B.N., Olsson, C.A., & Costa, M., 2008. Structural basis of sensory nerve pathways from the gut. European Review for Medical & Pharmacological Sciences, 12(Suppl1), 132-133.

Wattchow, D.A., Brookes, S.J., Murphy, E., Carbone, S., DeFontgalland, D., & Costa, M., 2008. Regional variation in the neurochemical coding of the myenteric plexus of the human colon and changes in patients with slow transit constipation. Neurogastroenterology and Motility, 20(12), 1298-1305.

Spencer, N.J., Kerrin, A., Zagorodnyuk, V.P., Hennig, G., Muto, M., Brookes, S.J., & McDonnell, O., 2008. Identification of functional intramuscular rectal mechanoreceptors in aganglionic rectal smooth muscle from piebald lethal mice. American Journal of Physiology-Gastrointestinal and Liver Physiology, 294(4), G855-G867.

Costa, M. & Brookes, S.J., 2008. Architecture of enteric neural circuits involved in intestinal motility. European Review for Medical & Pharmacological Sciences, 12(1(Suppl)), 3-19.

DeFontgalland, D., Wattchow, D.A., Costa, M., & Brookes, S.J., 2008. Immunohistochemical characterization of the innervation of human colonic mesenteric and submucosal blood vessels. Neurogastroenterology and Motility, 20(11), 1212-1226.

Blackshaw, L.A., Brookes, S.J., Grundy, D., & Schemann, M., 2007. Sensory transmission in the gastrointestinal tract. Neurogastroenterology and Motility, 19(Supp 1), 1-19.

Murphy, E., DeFontgalland, D., Costa, M., Brookes, S.J., & Wattchow, D.A., 2007. Quantification of subclasses of human colonic myenteric neurons by immunoreactivity to Hu, choline acetyltransferase and nitric oxide synthase. Neurogastroenterology and Motility, 19(2), 126-134.

Zagorodnyuk, V.P., Costa, M., & Brookes, S.J., 2006. Major classes of sensory neurons to the urinary bladder. Autonomic Neuroscience-Basic and Clinical, 126-127, 390-397.

Lynn, P.A., Zagorodnyuk, V.P., Hennig, G., Costa, M., & Brookes, S.J., 2005. Mechanical activation of rectal intraganglionic laminar endings in the guinea pig distal gut. Journal of Physiology-London, 564(2), 589-601.

Costa, M., Brookes, S.J., & Zagorodnyuk, V.P., 2004. How many kinds of visceral afferants?. Gut, 52(suppl2), ii1-ii4.

Olsson, C.A., Costa, M., & Brookes, S.J., 2004. Neurochemical characterization of extrinsic innervation of the guinea pig rectum. Journal of Comparative Neurology, 470(4), 357-371.

Sander, G.R., Brookes, S.J., & Powell, B.C., 2003. Expression of Notch1 and Jagged2 in the enteric nervous system. Journal of Histochemistry and Cytochemistry, 51(7), 969-972.

Porter, A.J., Wattchow, D.A., Brookes, S.J., & Costa, M., 2002. Cholinergic and nitrergic interneurones in the myenteric plexus of the human colon. Gut, 51(1), 70-75.

Zagorodnyuk, V.P., Chen, B., Costa, M., & Brookes, S.J., 2002. 4-aminopyridine- and dendrotoxin-sensitive potassium channels influence excitability of vagal mechano-sensitive endings in guinea-pig oesophagus. British Journal of Pharmacology, 137(8), 1195-1206.

Zagorodnyuk, V.P., D'Antona, G., Brookes, S.J., & Costa, M., 2002. Functional GABA(B) receptors are present in guinea pig nodose ganglion cell bodies but not in peripheral mechanosensitive endings. Autonomic Neuroscience-Basic and Clinical, 102(1-2), 20-29.

Brookes, S.J., 2001. Classes of enteric nerve cells in the guinea-pig small intestine. Anatomical Record, 262(1), 58-70.

Brookes, S.J., 2001. Retrograde tracing of enteric neuronal pathways. Neurogastroenterology and Motility, 13(1), 1-18.

Brookes, S.J., D'Antona, G., Zagorodnyuk, V.P., Humphreys, C.M., & Costa, M., 2001. Propagating contractions of the circular muscle evoked by slow stretch in flat sheets of guinea-pig ileum. Neurogastroenterology and Motility, 13(6), 519-531.

D'Antona, G., Hennig, G., Costa, M., Humphreys, C.M., & Brookes, S.J., 2001. Analysis of motor patterns in the isolated guinea-pig large intestine by spatio-temporal maps. Neurogastroenterology and Motility, 13(5), 483-492.

Simula, M.E., Brookes, S.J., Meedeniya, A.C., Toouli, J., & Saccone, G.T., 2001. Distribution of nitric oxide synthase and vasoactive intestinal polypeptide immunoreactivity in the sphincter of oddi and duodenum of the possum. Cell and Tissue Research, 304(1), 31-41.

Yuan, S., Costa, M., & Brookes, S.J., 2001. Neuronal control of the pyloric sphincter of the guinea-pig. Neurogastroenterology and Motility, 13(3), 187-198.

Zagorodnyuk, V.P., Chen, B.N., & Brookes, S.J., 2001. Intraganglionic laminar endings are mechano-transduction sites of vagal tension receptors in the guinea-pig stomach. Journal of Physiology-London, 534(1), 255-268.

Refereed conference papers

Berthoud, H.R., Blackshaw, L.A., Brookes, S.J., & Grundy, D., 2004. Neuroanatomy of extrinsic afferents supplying the gastrointestinal tract. Neurogastroenterology and Motility, 16(suppl1), 28-33.

Yuan, S., Gregory, S.J., Brookes, S.J., & Costa, M., 2004. Enteric neuronal pathways across the gastro-duodenal junction in the guinea-pig. Proc. Aust. Neurosci. Soc., 15.

Yuan, S., Gregory, S.J., Brookes, S.J., & Costa, M., 2003. Transition pattern of pacemaker activity in the guinea pig gastro-duodenal junction. Neurogastroenterology & Motility, 15(5), 40-41.

Yuan, S., Brookes, S.J., & Costa, M., 2002. Pattern of pacemaker activity in the circular and longitudinal muscle layers of the guinea pig gastro-duodenal junction. Proceedings of the Australian Heath & Medical Research Congress, 1125-1125.

Journal articles

Shea-Donohue, T., Cook, I.J., De Giorgio, R., Tonini, M., Dent, J., Costa, M., Grundy, D., Sanders, K.M., Smith, T.K., Schemann, M., et al., 2005. A teaching module on irritable bowel syndrome. Neurogastroenterology and Motility, 17(suppl3), 20-40.

Brookes, S.J., Cook, I.J., Costa, M., De Giorgio, R., Dent, J., Grundy, D., Sanders, K.M., Schemann, M., Shea-Donohue, T., Smith, T.K., et al., 2005. Education project for pathophysiology of gastrointestinal motility. Neurogastroenterology and Motility, 17(s3), 2-3.

Conference publications

DeFontgalland, D., Wattchow, D.A., Costa, M., & Brookes, S.J., 2006. Neurochemical characterisation of the innervation of human colonic mesenteric blood vessels. Proceedings of the Australian Neuroscience Society, 17, 96-96.

Chen, B.N., Song, X., Costa, M., & Brookes, S.J., 2006. Sensory innervation of intestinal blood vessels. Program of the Annual Meeting of the Gastroenterological Association Institute and Digestive Disease Week.

Zagorodnyuk, V.P., Gregory, S.J., Costa, M., & Brookes, S.J., 2006. Different types of mechanoreceptors in the bladder. Neuroulogy and Urodynamics, 25(6), 560-561.

Lynn, P.A., Costa, M., & Brookes, S.J., 2006. Responses to Mechanical Stimuli in Low-Threshold Slowly-Adapting Rectal Mechanoreceptors after TNBS-Induced Inflammation in the Guinea Pig. Program of the Annual Meeting of the Gastroenterological Association Institute and Digestive Disease Week.

Lynn, P.A., Costa, M., & Brookes, S.J., 2006. Afferent innervation of the internal and external anal sphincter of the guinea pig. Journal of Gastroenterology and Hepatology, 21(S4), A335-A335.

Zagorodnyuk, V.P., Costa, M., & Brookes, S.J., 2006. Two classes of stretch-sensitive pelvic mechanoreceptors in the bladder. Proceedings of the Australian Neuroscience Society, 17, 33-33.

Song, X., Chen, B.N., Costa, M., & Brookes, S.J., 2006. Identification of Mechanically-Activated Pain Pathways from the Gut Wall. Program of the Annual Meeting of the Gastroenterological Association Institute and Digestive Disease Week.

Song, X., Chen, B.N., Costa, M., & Brookes, S.J., 2006. Afferent nerve innervation in the submucosa of guinea pig ileum. Proceedings of the Australian Neuroscience Society, 17, 84-84.

Yuan, S., Brookes, S.J., & Costa, M., 2003. Communication between pacemaker and smooth muscle cells in the guinea-pig stomach. (Abstract).

Zhang, L., Brody, K.M., Costa, M., & Brookes, S.J., 2003. Temperature-sensitive ion channels in nodose ganglia and gut detected with RT-PCR. (Abstract).

Murphy, E., Wattchow, D.A., Costa, M., & Brookes, S.J., 2002. Calcium binding proteins in human enteric neurons ANS Sydney. ANS, 13.

Olsson, C.A., Costa, M., & Brookes, S.J., 2002. Characterisation of extrinsic innervation of the guinea pig rectum. Journal of Gastroenterology and Hepatology, 17(suppl5), a168-a168.

Murphy, E., Wattchow, D.A., Brookes, S.J., Costa, M., & Tottrup, A., 2002. Neurochemical coding of extrinsic mesenteric nerves in human colon and guinea-pig small intestine. Royal Australasian College of Surgeons Annual Scientific Congress,.

Lynn, P.A., Costa, M., & Brookes, S.J., 2002. Comparison of pelvic and colonic mechanoreceptors in the rectum and distal colon of the guinea pig. Journal of Gastroenterology and Hepatology, 17(suppl5), a167-a167.

Costa, M., Davies, P.G., Brody, K.M., Brookes, S.J., & Bornstein, J., 2002. Identification of enteric primary afferent neurons in the guinea-pig small intestine. Gastroenterology, 122(4 suppl), A91-A92.

Costa, M., Davies, P.G., Brody, K.M., Brookes, S.J., & Bornstein, J., 2002. Histochemical identification of enteric primary afferent neurons. ANS, 13.

Costa, M., Campbell, M.J., Yuan, S., Humphreys, C.M., & Brookes, S.J., 2002. Propagation of myogenic activity in the guinea-pig proximal colon. Gastroenterology, 122(4 Suppl), A408-A409.

Chen, B.N., Brookes, S.J., Zagorodnyuk, V.P., & Costa, M., 2002. Morphological characterisation of extrinsic innervation of the guinea-pig distal colon. ANS, 13.

Campbell, M.J., Costa, M., Yuan, S., & Brookes, S.J., 2002. Slow propagation of myogenic activity in guinea-pig proximal colon. ANS, 13.

Brookes, S.J., Chen, B.N., Zagorodnyuk, V.P., & Costa, M., 2002. Chemical coding of extrinsic innnervation of the guinea pig colon. Gastroenterology, 122(4 suppl), A160-A160.

Brody, K.M., Costa, M., & Brookes, S.J., 2002. Neu-N immunoreactivity marks primary afferent neurons in the guinea-pig submucous plexus. ANS, 13.

Brody, K.M., Costa, M., & Brookes, S.J., 2002. Chemical coding of putative enteric primary afferent neurons in the mouse myenteric plexus. Gastroenterology, 122(4 suppl), A92-A92.

Yuan, S., Brookes, S.J., & Costa, M., 2002. Functional identification of the pyloric sphincter in the guinea pig by localisation of the myogenic pacemaker transition zone. Journal of Gastroenterology and Hepatology, 17(suppl5), a169-a169.

Zagorodnyuk, V.P., Chen, B.N., Costa, M., & Brookes, S.J., 2002. Potassium channels influence excitability of vagal mechanosensitive endings in guinea-pig oesophagus. Neurogastroenterology and Motility, 14.

Zagorodnyuk, V.P., Chen, B.N., Costa, M., & Brookes, S.J., 2002. Glutamate is not involved in mechanotransduction of vagal tension receptors in guinea-pig oesophagus. Journal of Gastroenterology and Hepatology, 17(suppl5), a164-a164.

Zagorodnyuk, V.P., Chen, B.N., Costa, M., & Brookes, S.J., 2002. Calcium- and voltage-dependent potassium channels control excitability of vagal mechanoreceptors in guinea-pig oesophagus. ANS, 13.

Yuan, S., Costa, M., & Brookes, S.J., 2002. Effect of exogenous prostaglandin on in situ pacemaker cells in isolated guinea-pig gastric antrum. ANS, 13.

Brody, K.M., Costa, M., & Brookes, S.J., 2001. Chemical coding of myenteric neurons in the ferret small intestine. Proceedings of the Australian Neuroscience Society, 12, 120-120.

Zagorodnyuk, V.P., Chen, B.N., Costa, M., & Brookes, S.J., 2001. Transduction of mechanical stimuli by intraganglionic laminar endings of vagal mechanoreceptors in the guinea-pig stomach and oesophagus. Neurogastroenterology and Motility, 13, 446-446.

Campbell, M.J., Hennig, G., Costa, M., & Brookes, S.J., 2001. Analysis of motor activity of isolated rat small intestine using spatio-temporal maps. Proceedings of the Australian Neuroscience Society, 12, 120-120.

Chen, B.N., Brookes, S.J., Costa, M., & Zagorodnyuk, V.P., 2001. Morphological characterisation of vagal innervation of the guinea-pig upper stomach. Proceedings of the Australian Neuroscience Society, 12, 118-118.

Costa, M., Brody, K.M., & Brookes, S.J., 2001. A new marker for enteric primary afferent neurons. Neurogastroenterology and Motility, 13, 383-383.

Costa, M., Currow, D.C., Humphreys, C.M., & Brookes, S.J., 2001. Neural and myogenic polarity in the movements of the guinea-pig small intestine. Proceedings of the Australian Neuroscience Society, 12, 118-118.

Costa, M., Rainsford, T.J., Currow, D.C., Humphreys, C.M., Hennig, G., & Brookes, S.J., 2001. Effect of removal of endogenous inhibition on motor activity of the isolated guinea-pig small intestine. Neurogastroenterology and Motility, 13, 384-384.

Costa, M., Yuan, S., Rainsford, T.J., Brookes, S.J., & Hennig, G., 2001. Correlation between electrical activity of smooth muscle and spatio-temporal motor events in the guinea-pig small intestine. Gastroenterology, 120, 225-225.

Costa, M., Yuan, S., Zhong, J., Brody, K.M., Brookes, S.J., & Zhou, X., 2001. The Vanilloid-like receptor VRL-1 in the rat and guinea-pig enteric nervous system. Gastroenterology, 120, 197-197.

Murphy, E., Wattchow, D.A., Costa, M., & Brookes, S.J., 2001. Immunohistochemistry of extrinsic nerve fibres in human colon and guinea pig small intestine. Proceedings of the Australian Neuroscience Society, 12, 121-121.

Murphy, E., Wattchow, D.A., Tottrup, A., Brookes, S.J., & Costa, M., 2001. Immunohistochemistry of the extrinsic nerve fibres in human colon and guinea-pig small intestine. Proceedings of the Australian Neuroscience Society, 12, 121-121.

Rainsford, T.J., Costa, M., Hennig, G., Yuan, S., & Brookes, S.J., 2001. Electrical and mechanical activity in longitudinal and circular muscle in the isolated guinea-pig small intestine. Neurogastroenterology and Motility, 13, 423-423.

Yuan, S., Brookes, S.J., & Costa, M., 2001. Investigation of living pacemaker cells in isolated guinea-pig stomach and small intestine. Neurogastroenterology and Motility, 13, 445-446.

Yuan, S., Costa, M., & Brookes, S.J., 2001. Disinhibition of circular muscle slow waves by piroxicam in isolated guinea-pig gastric antrum and duodenum. Gastroenterology, 120, 534-534.

Zagorodnyuk, V.P., Chen, B.N., Costa, M., & Brookes, S.J., 2001. Intraganglionic laminar endings (IGLEs) are transduction sites of "in-series" vagal tension receptors in the stomach. Gastroenterology, 120, 84-84.

Zagorodnyuk, V.P., Chen, B.N., & Brookes, S.J., 2001. Mechanotransduction sites of vagal tension receptors inguinea-pig stomach. Proceedings of the Australian Neuroscience Society, 12, 117-117.

Zagorodnyuk, V.P., Brookes, S.J., D'Antona, G., & Costa, M., 2001. Effects of GABA and Baclofen on guinea-pig vagal afferent neurones. Proceedings of the Australian Neuroscience Society, 12, 119-119.

Yuan, S., Costa, M., & Brookes, S.J., 2001. Study of living pacemaker cells in isolated guinea-pig gut. Proceedings of the Australian Neuroscience Society, 12, 117-117.

Brookes, S.J., 2001. Mechanotransduction by vagal afferent nerve endings in the guinea pig oesophagus and stomach. IUPS (internet).

Other public research outputs

Zhang, L., Brody, K.M., Costa, M., & Brookes, S.J., 2003. Expression of temperature-sensitive ion channels in nodose ganglia and gut tissue, detected by RT-PCR and immunohistochemistry. Gastroenterology, 124(supple1), a39-a39.

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Professional and community engagement

Editorial boards: Autonomic Neuroscience, Basic and Clinical (-2008) Neurogastroenterology and motility
American Journal of Physiology (GI & Liver), Frontiers in Autonomic Neuroscience
Secretary of South Australian Neuroscience Institute (SANI)
Secretary of "Varenna Group" - project to develop teaching materials for Neurogastroenterology
Member/Chairman of International Steering Committee, Emerging Leaders Program, Gothenburg Sweden 2005-2009
Grant Referee: NH&MRC, ARC, FMC Foundation, Faculty of Health Sciences Grant Ctee,
Member Grant Review Panel NHMRC: 2001-3, 2008-9
Referee for Scientific Journals: Journal of Physiology, Gut, Gastroenterology

Expertise for media contact

Gastrointestinal Motility and Pain
Sensory Neurobiology of The Gastrointestinal Tract
Molecular, Cellular and Organ Physiology of The Gut
Neuroanatomy of The Autonomic Nervous System

Subject/s

Gastrointestinal Physiology
Neuroscience

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