MMED3933 Biochemistry of Human Disease

This topic will build on the foundations of metabolic biochemistry and molecular and cellular biology. The topic takes a disease-orientated approach, emphasising the application of biochemical and molecular biological knowledge to diseases. Students will gain an in-depth understanding of the biochemical and molecular basis of diseases arising from altered metabolism including diabetes and cardiovascular disease, the signalling pathways and genetic basis of cancer, as well as an understanding of the molecular basis of protein misfolding diseases. Students will apply their knowledge by working in small groups to explore how biochemical principles can be used to understand disease symptoms and progression and how they might be treated or avoided with medicines, diet and lifestyle. This topic will be suitable for students wishing to pursue careers in Medicine, Dietetics and Nutrition, or Biomedical Research.

This topic aims to develop students' knowledge of human metabolic biochemistry and how cell functions are regulated. This will form the basis to understand the biochemistry of prevalent diseases of metabolism, aberrant cell growth/survival and of protein malfunction or misfolding.

1. Demonstrate advanced understanding of key aspects of biochemistry and molecular biology at the individual organ and system level and the integration between body systems
2. Demonstrate understanding of how alterations to normal body biochemistry can contribute to disease
3. Demonstrate understanding of key biochemical, molecular biology, genetic and analytical techniques, including state of the art technologies used in understanding the biochemistry of human disease
4. Demonstrate skills in oral and written communication and team work