Tissue Monitoring

Biomedical Research Support

Tissue Monitoring Accessories

FBE, Flinders Biomedical Engineering, have developed devices for the Flinders University School of Medicine to enable research of tissues and their neural pathways. 

Devices developed by Biomedical Engineering

Gut strain gauge assembly

Dual strain gauges (Kyowa 5mm, 120 ohm) are assembled for measuring gut strain. They are connected back-to-back in the "half bridge" configuration and are sealed and protected by a conformal silicon envelope. [BME1432]

Heat Ramp and Pressure Probe

Comprising Heat Ramp BME 1490 and Pressure Probe BME1491, designed to thermally and mechanically stimulate sensory nerves present in viable skin samples to 50°C and 300mN. The sensor outputs are logged on a Maclab system.

Feather stroker

This stoker function generator was created from a galvanometer and relay lifting mechanism that holds a cut duck feather. This simulates stroking a section of gut with a feather. It is for research into the electrophysiology of intestinal gut and peristalsis.

 

Gut strain gauge  ruler

Gut strain gauge assembly

Heat probe for  tissue

Feather stroker

 

Publications using BME developed devices

Strain gauges, Duodenal


Takahata S, Konomi H, Schloithe AC, Toouli J, Saccone GT. Second-generation recombinant hemoglobin molecules do not stimulate sphincter of Oddi, gallbladder or duodenal motility in the Australian brush-tailed possum. Can J Gastroenterol. 2004 Jul;18(7):441-8. (Abstract on PubMed) 

Feather stroker


Smith TK, Bornstein JC, Furness JB. Convergence of reflex pathways excited by distension and mechanical stimulation of the mucosa onto the same myenteric neurons of the guinea pig small intestine. J Neurosci. 1992 Apr;12(4):1502-10.

Bornstein JC, Furness JB, Smith TK, Trussell DC. Synaptic responses evoked by mechanical stimulation of the mucosa in morphologically characterized myenteric neurons of the guinea-pig ileum. J Neurosci. 1991 Feb;11(2):505-18.

Smith TK, Fumess JB.  Reflex changes in circular muscle activity elicited by stroking the mucosa: an electrophysiological analysis in the isolated guinea-pig. J Auton Nerv Syst 1988 25:205-2 18.

Instruments

Keast JR, Furness JB and Costa M. Different substance P receptors are found on mucosal epithelial cells and submucous neurons of the guinea-pig small intestine. Naunyn-Schmiedeberg's Archives of Pharmacology. 1985;329(4):382-387.