Diabetic retinopathy is an ocular complication of diabetes and is the leading cause of blindness in working age adults worldwide. Further understanding of the genomic and social determinants of disease progression will assist in reducing the associated disease burden in the future.
Our department has identified associations between several genes and higher rates of diabetic retinopathy.
Although not typically associated, both inflammation and abnormal blood vessel development are characteristics of diabetic retinopathy. Research within the department is also exploring the intersection between these two components, with a specific focus on the evaluation of inflammatory molecules and their novel role in abnormal retinal blood vessel development.
Funding provided through the National Health and Medical Research Council:
Funding provided through the Australia Research Council Future Fellowships
Kaidonis G, Gillies MC, Abhary S, et al. A single-nucleotide polymorphism in the MicroRNA-146a gene is associated with diabetic nephropathy and sight-threatening diabetic retinopathy in Caucasian patients . Acta Diabetol. 2016 Aug;53(4):643-50. Epub 2016 Mar 21.
Burdon KP, Fogarty RD, Shen W, et al. Genome-wide association study for sight-threatening diabetic retinopathy reveals association with genetic variation near the GRB2 gene . Diabetologia. 2015 Oct;58(10):2288-97. Epub 2015 Jul 19.
Kaidonis G, Burdon KP, Gillies MC, et al. Common Sequence Variation in the VEGFC Gene Is Associated with Diabetic Retinopathy and Diabetic Macular Edema . Ophthalmology. 2015 Sep;122(9):1828-36. Epub 2015 Jun 11.
A lack of specialist services within rural and remote parts of Australia, where higher populations of Aboriginal and Torres Strait Islander peoples reside, have been associated with higher rates of blindness from diabetic retinopathy.
A health search filter relating to diabetic retinopathy and Aboriginal and Torres Strait Islander peoples was developed in conjunction with the Lowitja Institute.
The following search combines a validated search filter for Aboriginal and Torres Strait Islander health with a topic search for diabetic retinopathy.
This topic search provides quick access to the literature about diabetic retinopathy in Aboriginal and Torres Strait Islander peoples. It ensures trustworthy reliable results and saves the user time.
Two search options are offered:
|Diabetic Retinopathy and Aboriginal and Torres Strait Islander peoples||All citations
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