Tissue Stretcher

Biomedical Research Support

Tissue Stretching Devices

FBE, Flinders Biomedical Engineering, have developed devices for the Flinders University School of Medicine to enable controlled stretching of tissues. Tissue stretchers are used to measure gut motility.

Devices developed by Biomedical Engineering

Tissue stretcher with DC motor

Produces an analog output of distance and strain that piece of tissue experiences during a predefined pattern of tissue stretching and relaxation. It complements BME 1357 with a DC motor replacing the stepper motor used and with a revised electronic system design. This has to be used in some situations where electrical interference from stepper motor controllers is a problem. [BME1445 ] 

8-channel tissue stretcher

A segment of small intestine, 7-10cm long, is cut into a flat sheet and pinned along one edge. The other edge is connected using a number of hooks attached to force transducers to the linear actuators. The eight channel unit consists of a maximum of eight identical modules mounted in a KM6-II universal 19” subrack. Similarly, the three channel unit consists of a maximum of three identical rack mounted modules. Each module consists of a MC68HC711E9 processor which is programmed with code written using Hi-Tech C Cross Compiler. The processor controls all facets of the tissue stretching for that particular module and allows interconnection between modules. Each module is connected to and controls a bipolar linear actuator and a force transducer (strain gauge). [BME1357]

  DC Tissue stretcher box

DC tissue stretcher

Tissue stretcher box

Tissue stretcher open

Publications using BME developed devices

Lynn PA, Chen BN, Zagorodnyuk VP, Costa M, Brookes SJ. TNBS-induced inflammation modulates the function of one class of low-threshold rectal mechanoreceptors in the guinea pig. Am J Physiol Gastrointest Liver Physiol. 2008 Oct;295(4):G862-71. 

Zagorodnyuk VP, Gibbins IL, Costa M, Brookes SJ, Gregory SJ. Properties of the major classes of mechanoreceptors in the guinea pig bladder. J Physiol. 2007 Nov 15;585(Pt 1):147-63.

Lynn PA, Olsson C, Zagorodnyuk V, Costa M, Brookes SJ. Rectal intraganglionic laminar endings are transduction sites of extrinsic mechanoreceptors in the guinea pig rectum. Gastroenterology. 2003 Sep;125(3):786-94.

Brookes SJ, D'Antona G, Zagorodnyuk VP, Humphreys CM, Costa M. Propagating contractions of the circular muscle evoked by slow stretch in flat sheets of guinea-pig ileum. Neurogastroenterol Motil. 2001 Dec;13(6):519-31.

Zagorodnyuk VP, Brookes SJ. Transduction sites of vagal mechanoreceptors in the guinea pig esophagus. J Neurosci. 2000 Aug 15;20(16):6249-55.

Brookes SJ, Chen BN, Costa M, Humphreys CM. Initiation of peristalsis by circumferential stretch of flat sheets of guinea-pig ileum. J Physiol. 1999 April 15; 516(Pt 2): 525–538. (Abstract at PubMed)