Dr Pramod Nair

Research Fellow in Computational and Molecular Pharmacology

College of Medicine and Public Health

place Flinders Medical Centre (6D334)
GPO Box 2100, Adelaide 5001, South Australia

Dr Nair obtained a Bachelor of Pharmaceutical Sciences with Distinction at the University of Mumbai (Bombay College of Pharmacy) India, in 2005. He completed his Masters of Science (Pharm.) at National Institute of Pharmaceutical Education and Research (NIPER) India, where he also worked as a Junior Research Fellow. He received the Australian government funded Endeavour IPRS fellowship in 2009 and undertook Phd studies with Professor Alan Mark at the School of Chemistry & Molecular Biosciences, The University of Queensland. In 2013 he joined the Department of Clinical Pharmacology as a Postdoctoral researcher in the laboratory of Professor John Miners and Professor Ross McKinnon.

Qualifications

PhD (Med. Chem.) The University of Queensland, Australia 2009-2013.
M.S. (Pharm.) National Institute of Pharmaceutical Education and Research (NIPER), India 2005-2007.
B. Pharm.(Distinction) Bombay College of Pharmacy, University of Mumbai, India 2001-2005.

Honours, awards and grants

2018 CERTARA New Investigator Award (ASCEPT)

2017 Flinders University Vice-Chancellor's Award for Early Career Researchers

2017 Protein Kinase inhibitors: Towards prediction of toxicity and drug-drug interaction potential, Flinders Centre for Innovation in Cancer, Flinders Medical Centre (FMC) Foundation, Early Career Research Grant $16,500, CIA.

2017 Identification of the substrate and inhibitor binding sites of UDPglucuronosyltransferase 2B7 (UGT2B7): Towards prediction of substrate selectivity and drug-drug interaction potential, FMNHS (Flinders University), Early Career Research Grant $15,000, CIA.

2016 Application of physiological based pharmacokinetic modelling to facilitate optimised small molecule kinase inhibitor dosing, Flinders Medical Centre (FMC) Foundation $18,000, CIE.

2013 Travel Grant from Adelaide Pharmacology Group (APG) for ASCEPT, Annual General Meeting.

2012-2016 Postdoctoral Research Fellowship, Flinders University (Australia).

2010 Visiting Scientist at the Swiss Federal Institute of Technology, ETH Zurich (Switzerland).

2010 Course Grant for the 8th Swiss National Center of Competence in Research (NCCR) Structural Biology Course (Switzerland).

2009-2012 Australian Government funded Endeavour International Postgraduate Research Scholarship (IPRS) (Australia).

2009-2012 University of Queensland Research Scholarship (UQRS) (Australia).

2009 Top up Scholarship, The University of Queensland (Australia).

2009 Establishment Grant, The University of Queensland (Australia).

2007-2009 Junior Research Fellowship, NIPER (India).

2004 Sir Ratan TATA merit scholarship for academic excellence (India).

Research expertise
Medicinal and biomolecular chemistry
Pharmacology and pharmaceutical sciences
Research interests

Pramod's research focuses on combining diverse computational and experimental approaches for understanding the mechanisms of ligand recognition by P450's and UGT proteins. The main aim of his research is to support the rational design of drugs, particularly, in relation to drug lead optimization, drug metabolism, and drug-drug interaction potential.

Supervisory interests
Binding free energy calculations
Computer aided drug design
Drug design
Drug discovery
Drug metabolising enzymes, cytochrome P450 and UDP-glucuronosyltransferase
Drug metabolism
Molecular dynamics simulations
Molecular modelling
Protein structure function
Structure function of drug metabolising enzymes
Publications

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