I have an interest in understanding two major signalling networks that are implicated in tumourigensis and diabetes in humans. I am a biochemist (obtained a BSc in Biochemistry 1989-1992), a Geneticits (obtained a MSc in Molecular Genetics 1992-1994) and a Cell Biologist (obtained a PhD in cell biology (1995-1998 ) all from the University of Copenhagen, Denmark. In 1998, I joined the laboratory of Professor Iain Hagan at The University of Manchester/Paterson Institute for Cancer Research as a postdoctoral Research Fellow to study the role of protein kinases in regulating cell cycle progression in fission yeast. I then worked as a Research Associate with Nobel laureate Sir Paul Nurse at the Rockefeller University in New York, USA, studying the role of protein kinases in regulating cell cycle progression in fission yeast. In 2005, I became a Lecturer within the Faculty of Life Sciences at The University of Manchester, UK. In December 2009, I was awarded a Cancer Research UK Senior Research Fellowship. My appointment to Flinders University as an Associate Professor along with a Faculty appointment at SAHMRI (South Australian Health and Medical Research Institute) as part of the Nutrition and Metabolism theme commenced 2015. At Flinders University my group is a member of the Flinders Centre for Innovation in Cancer.
1998 PhD Genetics Department, The University of Copenhagen, Denmark
1994 MSc Genetics Department, The University of Copenhagen, Denmark
1992 BSc Biochemistry, The University of Copenhagen, Denmark
2019-2021: NHMRC project Grant
2018-2020: ARC Discovery Project
2017: Cancer Council Award
2015-2019: Worldwide Cancer Research Award
2009-2015: Cancer Research UK (CRUK) Senior Fellowship.
2006: Royal Society award
2000-2001: Wellcome Trust travelling fellowship
1999-2000: Carlsberg- Wellcome Trust Stipend
1998: Short Term EMBO fellowship
Head of the Environmental Control of Cell Growth and Cell Division laboratory
Environmental control of cell growth and cell division laboratory.
Target Of Rapamycin TOR and AMPK signalling networks are the major nutrient sensing pathways in all eukaryotic cells. Our work aims to extend our understanding of these major signalling networks that are implicated in tumourigensis and diabetes in humans to adjust growth and cellular metabolism in response to changes in the nutrient environment. Our main model organisms are the fission yeast S. pombe and mammalian tissue culture models. We use fission yeast as an ideal model system in which to establish the core principles of AMPK and TOR signalling before transposing rigorously tested predictions to human cells.
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