Dr Jianling Xie

From the beginning of my PhD, my research interests have been focused on delineating the cellular signalling pathways that regulate protein synthesis, in particular mTOR (mechanistic target of rapamycin), a master protein that controls cell growth, which is of key importance in human diseases such as cancer. My very recent discovery concerns the oversupply of nutrients, in particular amino acids, results in the build-up of faulty proteins within cells and shortens lifespan. This study highlights the detrimental effects of over-nutrition and the importance of a healthier, low-protein diet, and has attracted attention from several media outlets in both Australia and in Brazil, where part of the study was undertaken.

I have so far authored 53 peer-reviewed publications, including 24 first/last author papers in top-ranking journals such as Nature Cell Biology, PNAS, Current Biology, Diabetologia, Oncogene, Cellular & Molecular Life Sciences, among others. My articles have thus far been cited more than 3100 times (24/03/2026, Google Scholar, h-index: 32). I hold four patents, authored four book chapters and have given eight presentations at international conferences.

Stemming from those studies, my recent research interests have evolved towards studying the role of protein synthesis, transcription and epigenomics in prostate cancer progression. My research have attracted funding by NHMRC, SAHMRI and the Hospital Research Foundation (THRF).