Dr Jianling Xie

Research Fellow

College of Medicine and Public Health

place Flinders Medical Centre
GPO Box 2100, Adelaide 5001, South Australia

From the beginning of my PhD, my research interests have been focused on delineating the cellular signalling pathways that regulate protein synthesis, in particular mTOR (mechanistic target of rapamycin), a master protein that controls cell growth, which is of key importance in human diseases such as cancer. My very recent discovery concerns the oversupply of nutrients, in particular amino acids, results in the build-up of faulty proteins within cells and shortens lifespan. This study highlights the detrimental effects of over-nutrition and the importance of a healthier, low-protein diet, and has attracted attention from several media outlets in both Australia and in Brazil, where part of the study was undertaken.

I have so far authored 51 peer-reviewed publications, including 23 first/last author papers in top-ranking journals such as Nature Cell Biology, Current Biology, Cellular & Molecular Life Sciences, Diabetologia, International Journal of Cancer, among others. My articles have thus far been cited 1669 times (07/Jul/2021, Google Scholar, h-index: 22). I hold four patents, authored four book chapters and have given eight presentations at international conferences.

Stemming from those studies, my recent research interests have evolved towards studying the role of protein synthesis, transcription and epigenomics in prostate cancer progression. I have recently been awarded a seed funding by the SA state’s prestigious South Australian Health and Medical Research Institute (SAHMRI) and the Hospital Research Foundation (THRF) to advance the research in this topic.

Qualifications
  •      Research Fellow in Cancer Research, Flinders University, Adelaide, Australia (since 2020)
  •      Research Fellow in Lifelong Health, SAHRMI, Adelaide, Australia (2014-2020)
  •      Postdoctoral Research Fellow in Biological Sciences, University of Southampton, Southampton, UK (2012-2014)
  •      PhD in Cell Physiology & Pharmacology, University of Leicester, Leicester, UK
  •      MRes in Cell Physiology & Pharmacology, University of Leicester, Leicester, UK
  •      BPharm, Universidad La Salle, Mexico City, Mexico
Honours, awards and grants
  • The Hospital Research Foundation 2020 Prostate Cancer grant
  • High impact publication, SAHMRI awards night 2019
  • SAHMRI early/mid-career research seed funding 2019
  • SAHMRI Faculty member (2017 – 2020)
  • F1000 Associated member (since 2015)
  • National Investigator level I, CONACYT, Mexico (since 2014)
Expert for media contact
Biochemistry
Cancer
Nutrition and Metabolism
Prostate cancer
Available for contact via
Or contact the media team
+61 8 82012092
0427 398 713
Media expertise
  • Biochemistry
  • Cancer
Interests
  • Nutrition and Metabolism
  • Prostate cancer
Further information

My research has routinely been disseminated to other researchers and to the wider general public through local media. I also occasionally write articles about hot scientific topics that attracts attention of the general public. Below are some examples of media highlights:

  1. The Lead: http://theleadsouthaustralia.com.au/industries/health-and-medical/piercing-the-shield-to-attack-prostate-cancer/
  2. The Advertiser: https://www.adelaidenow.com.au/news/south-australia/sahmri-research-reveals-why-highprotein-diets-are-bad-for-you/news- story/9277b39a4ad84b5f1ce38b6ddfaf001f
  3. The conversation: https://theconversation.com/revealed-the-protein-spike-that-lets-the-2019-ncov-coronavirus-pierce-and-invade-human-cells-132183

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