Professor Miners was a Postdoctoral Research Scientist at Oxford University before taking up a position as Toxicologist in the Department of Biochemistry and Chemical Pathology of Flinders Medical Centre in 1977. He subsequently joined the Department of Clinical Pharmacology in 1978. Until 2002 Professor Miners held the positions of Chief Pharmacologist (Flinders Medical Centre) and Professor in Clinical Pharmacology (Flinders University). From 2003 to 2013, he was Professor and Head of the Department of Clinical Pharmacology. He currently holds a part-time research only position as a Matthew Flinders Distiguished Professor in the Department of Clincal Pharmacology.
Drug and chemical metabolism in humans, particularly sources of variability in drug elimination and its pharmacokinetic and therapeutic consequences. Current interests include:
Citation from the Australian Academy of Sciences:
Professor Miners has made seminal contributions to the characterisation of the enzymatic basis of drug metabolism, which unlies the individualisation of drug therapy in humans. His research has interwoven molecular, biochemical and clinical approaches to identify sources of variability in drug metabolism, characterise the substrate and inhibitor selectivities and structure-function relationships of the key drug metabolisng enzymes cytochrome P450 and UDP-glucuronosyltransferase, and develop in vitro experimental paradigms that predict drug metabolism parameters in humans. The research has played a pivotal role in establishing drug metabolism as a predictive science that underpins both preclinical drug development and the clinical use of drugs.
Office bearer for National and International Societies:
Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists (ASCEPT)
International Society for the Study of Xenobiotics (ISSX)
International Union of of Basic and Clinical Pharmacology (IUPHAR)
Asia - Pacific Federation of Pharmacologists (previously the Southeast Asian Western Pacific Regional Federation of Pharmacologists),
International Association for Therapeutic Drug Monitoring and Clinical Toxicology
9th International Congress of Toxicology, Brisbane, 2001, Secretary, Organising Committee
8th World Congress of Clinical Pharmacology and Therapeutics, Brisbane, 2004, Executive Committee Member
Journal Editorial Boards
British Journal of Clinical Pharmacology (1996-2016; Executive Editor, 1998-2007); Current Pharmacogenomics and Personalized Mediciine (2007-2013); Drug Metabolism and Disposition (Associate Editor, 2008-2012); Drug Metabolism Reviews (2003-present); European Journal of Clinical Pharmacology (2007-present); Future Medicinal Chemistry (2008-2011); Pharmacogenetics and Genomics (2001-present); Drug Metabolism and Pharmacokinetics (Associate Editor, 2015-present); Xenobiotica (1997-2017).
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