Professor John Miners

Professor - Matthew Flinders Distinguished Professor

College of Medicine and Public Health

place Flinders Medical Centre (6D:311)
GPO Box 2100, Adelaide 5001, South Australia

Professor Miners was a Postdoctoral Research Scientist at Oxford University before taking up a position as Toxicologist in the Department of Biochemistry and Chemical Pathology of Flinders Medical Centre in 1977. He subsequently joined the Department of Clinical Pharmacology in 1978. Until 2002 Professor Miners held the positions of Chief Pharmacologist (Flinders Medical Centre) and Professor in Clinical Pharmacology (Flinders University). From 2003 to 2013, he was Professor and Head of the Department of Clinical Pharmacology. He currently holds a part-time research only position as a Matthew Flinders Distiguished Professor in the Department of Clincal Pharmacology.

Qualifications
  • 1969, BSc, Victoria University of Wellington (VUW)
  • 1971, MSc (1st class honours), (VUW)
  • 1974, PhD (VUW)
  • 1997, DSc, Flinders University
Honours, awards and grants
  • Elected to Fellowship of the Australian Academy of Health and Medical Sciences (FAHMS), 2018
  • Elected to Fellowship of the Australian Academy of Science (FAA), 2013
  • Scientific Achievement Award, International Society for the Study of Xenobiotics (ISSX), 2011
  • Distiguished Achievement Award of ASCEPT, 2009
  • Elected to Honorary Fellowship of the Royal Society of New Zealand¬†(HonFRSNZ), 2008
  • Flinders University 40th Anniversay Distinguished Alumni Award, 2006
  • ASCEPT Visiting Lecturer to the British Pharmacological Society, 2005
  • ISI Highly Cited Author in the discipline of Pharmacology, 2001
  • ISI Citation Laureate, 2001 (ranked in the top 30 Australasian scientists based on the number of highly cited papers between 1982-1999)
  • Michael Rand Medallist for research excellence,¬†Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists (ASCEPT), 2001
  • DSc, Flinders University, 1997
Key responsibilities
Research leadership in pharmacology and therapeutics.
Research expertise
Pharmacology and pharmaceutical sciences
Research interests

Drug and chemical metabolism in humans, particularly sources of variability in drug elimination and its pharmacokinetic and therapeutic consequences. Current interests include:

  • Structure-function relationships and genetic polymorphisms of human UDP-glucuronosyltransferases and cytochromes P450, the two most important drug metabolising enzymes in humans
  • In vitro models for the prediction of drug and chemical metabolism parameters in vivo (in vitro - in vivo extrapolation), with applications to the preclinical development of newly discovered drugs
  • Drug-drug interactions
  • Characterisation of the plasticity of drug metabolising enzymes using advanced computational techniques
  • Metabolomics (including biomarkers of drug response)
  • The influence of chronic kidney disease on hepatic drug metabolic clearance

Citation from the Australian Academy of Sciences:

Professor Miners has made seminal contributions to the characterisation of the enzymatic basis of drug metabolism, which unlies the individualisation of drug therapy in humans. His research has interwoven molecular, biochemical and clinical approaches to identify sources of variability in drug metabolism, characterise the substrate and inhibitor selectivities and structure-function relationships of the key drug metabolisng enzymes cytochrome P450 and UDP-glucuronosyltransferase, and develop in vitro experimental paradigms that predict drug metabolism parameters in humans. The research has played a pivotal role in establishing drug metabolism as a predictive science that underpins both preclinical drug development and the clinical use of drugs.

Higher degree by research supervision
Completion
Principal supervisor: Pharmacology and Therapeutics (20)
Publications

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