Professor Michael Sorich
Professor in Clinical Pharmacology
College of Medicine and Public Health
I am a clinical epidemiologist, biostatistician, and pharmacist with a primary research interest in the use of biological, chemical, and clinical markers to guide decisions regarding the most appropriate use of medicines (precision medicine). My research focuses on the use of machine learning and advanced biostatistical methods to predict treatment efficacy and toxicity - particularly in the area of anti-cancer medicines. This research involves analysis of big data - in particular, pooling of data across multiple clinical trials. Additionally, I research novel biomarkers to predict drug exposure which will enable personalisation of medicine dosing.
I have deep expertise in many areas of data science, including machine learning (prediction models), survival analysis, evaluation of treatment heterogeneity, clinical trial analysis, and meta-analysis. I have a high degree of proficiency in both R and python programming languages.
- PhD
- Graduate Diploma in Medical Statistics
- Bachelor of Pharmacy Honours (1A)
- Bachelor of Pharmacy
Selected Awards
- 2019: Principal Cancer Research Fellowship, Beat Cancer Project
- 2008: South Australian Tall Poppy Award, Australian Institute of Policy and Science
- 2006: Denis Wade Johnson & Johnson New Investigator Award, Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists
- 2004: CJ Martin Postdoctoral Fellowship, National Health and Medical Research Council of Australia
- 2003: New Investigator Award, Australasian Pharmaceutical Science Association
- 2002: Scholarship, Machine Learning Summer School, Australian National University
Selected Research Grants
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ADMExosomes: A new paradigm for tracking variability in drug exposure. CIs: Rowland A, Sorich MJ, Makenzie P. NHMRC Project grant (2019-2021, ID 1128332)
Sorich MJ. From Big Data to Precision Medicine: Integrated analysis of clinical trial and electronic health record data in lung cancer. Cancer Council SA, Beat Cancer Project Grant (2019, ID 1159924).
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Improving the evaluation of new cancer therapies to expedite patient access. CIs: Karnon J, Sorich MJ, Ward R, Latimer N, Coory M. Project grant. NHMRC Project Grant (2017-2019, Grant ID 1128332)
- Dynamic Prediction of Immune Checkpoint Inhibitor Response and Toxicity. CIs Sorich MJ, Gurney H, Kichenadasse G, McKinnon RA, Wiese MD, Rowland A. Cancer Council SA, Beat Cancer Project Grant (2017, GrantID 1127220)
- Optimisation of the safety and efficacy of protein kinase inhibitors using endogenous and dietary biomarkers. CIs: Sorich MJ, Rowland A, Wiese M, Miners J, Gurney H. NHMRC Project grant. (2016-2018)
- Personalised medicine markers of anti-EGFR antibody therapy in metastatic colorectal cancer: accelerating clinical translation with collaborative meta-analyses based on individual-participant data. Karapetis, C, Sorich MJ, McKinnon RA, Buyse M. Project grant. NHMRC (2015-2018)
- Flinders Centre for Gastrointestinal Cancer Prevention. CIs: Watson D, Karapetis C, Young G, Wilson C, Fraser R, Reed R, Sorich M, Ratcliffe J, Woodman R, McKinnon R. Beat Cancer Hospital Research Package. (2014-2018).
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Member, International Scientific Programming Committee (ISPC) for the 7th Pharmaceutical Sciences World Congress (PSWC), Montreal (Canada) 2020
- Member, Editorial Board of Translational Lung Cancer Research
- Member, Editorial Board of Therapeutic Advances in Drug Safety
- Member, Editorial Board of Translational Cancer Research
- Member, Editorial Board of Clinical Pharmacology & Translational Medicine
- Member, Executive Committee, FHMRI Cancer
- Topic Coordinator, Principles of Pharmacology and Therapeutics (MMED9110), Flinders University
- Topic Coordinator, Pharmacology for Advanced Professional Practice (MMED9111), Flinders University
- Member, Master of Nursing (Nurse Practitioner) Course Committee, Flinders University
Chair, Special Interest Group on Translational Research & Precision Medicine, International Pharmaceutical Federation (FIP)
Member, Board of Pharmaceutical Sciences, International Pharmaceutical Federation (FIP)
Member, International Scientific Programming Committee (ISPC) for the 7th Pharmaceutical Sciences World Congress (PSWC), Montreal (Canada) 2020
Member, Editorial Board, Therapeutic Advances in Drug Safety
Member, Editorial Board, Translational Cancer Research
Member, Editorial Board, Clinical Pharmacology & Translational Medicine
- Precision medicine
- Predication modelling in cancer
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