Emeritus Professor Peter Mackenzie

Academic Status

College of Medicine and Public Health

place Flinders Medical Centre (6D:310.1)
GPO Box 2100, Adelaide 5001, South Australia

Professor Mackenzie was awarded a PhD from the University of Sydney (Biochemistry Department, 1976). He held post doctoral positions at the University of Kuopio, Finland (Physiology Department, 1976-1980), National Institutes of Health, Maryland, USA (NICHD, 1980-1987) before returning to Flinders University (Clinical Pharmacology) in 1987 as a NHMRC Research Fellow. He is currently Emeritus Professor in the Department.

Qualifications
B.SC (hons 1)
PhD
Honours, awards and grants
  • Awarded Fogarty International Fellowship for postdoctoral studies at the National Institutes of Health USA (1980-1983) appointed visiting associate in 1983 and visiting scientist in 1986.
  • Awarded NHMRC Fellowship (1987), SRF (1991), PRF (1994), SPRF (2000).
  • Awarded UICC International Cancer Research Fellowship (1993).
  • Elected ASCEPT visitor to the British Toxicological Society, 2000.
  • Honoured as the 11th Dr Chiravat Sodavongvivad Memorial Lecturer to the Thai Pharmacological Society, Chiangmai, Thailand in 2004.
  • Awarded the Asia/Pacific Scientific Achievement Award for 2006 from the International Society for the Study of Xenobiotics, 2006.
  • Awarded the MICHAEL RAND MEDAL for 2009 by ASCEPT.
Key responsibilities
  • Research only
  • Honours and Postgraduate research supervision
Research expertise
Biochemistry and cell biology
Pharmacology and pharmaceutical sciences
Research interests
Our defense against the toxic effects of small organic molecules is mediated by families of enzymes found in the internal membranes of cells. Many small organic molecules, such as environmental pollutants, carcinogens and therapeutic drugs, are fat-soluble and will accumulate in the body to toxic levels unless they are modified, usually by the addition of sugar groups. The modified chemical, in the majority of cases, is less toxic and readily removed from the body. We have identified and characterized many of the sugar-transferring enzymes involved in this detoxification process. We are investigating how these enzymes are controlled in the cell and whether there are genetic differences in control processes that may impact on our ability to detoxify drugs and chemicals. This research may provide strategies to help reduce the risk of chemical-induced carcinogenesis and hormone-dependent cancers, such as those of the prostate and breast.
Supervisory interests
Drug metabolising enzymes, cytochrome P450 and UDP-glucuronosyltransferase
Gene expression
MicroRNA-regulated gene expression
Higher degree by research supervision
Current
Principal supervisor: Molecular Pharmacology (3)
Associate supervisor: Molecular Pharmacology (2)
Completion
Principal supervisor: Molecular Pharmacology (6)
Associate supervisor: Molecular Pharmacology (10)
Publications

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