Dr Shiwani Sharma's research in Ophthalmology focuses on deciphering the molecular and cellular processes underlying eye diseases, with the objective of developing diagnostic, preventative and/or treatment strategies. She is particularly interested in genetically predisposed eye diseases such as cataract, glaucoma and corneal dystrophies with both early and late onset forms. Her research has defined the molecular mechanism of inherited congenital cataract in affected families. In NH&MRC funded research she is investigating the interaction of environmental and genetic factors and its contribution to aging related cataract, the leading cause of blindness worldwide. She is also investigating the mechanisms underlying genetic susceptibility factors in glaucoma, the major cause of irreversible blindness worldwide. In addition, she is investigating the pathophysiology of Fuchs' corneal endothelial dystrophy, one of the major indications for corneal grafting in developed countries, and keratoconus. She employes molecular and cellular biology techniques, and uses pathological specimens and cell-based and animal models for her research. She guides a team of research students and staff pursuing this research.