Associate Professor Jill Carr

Associate Professor

College of Medicine and Public Health

+61 8 82046658
place Flinders Medical Centre (5D:316)
GPO Box 2100, Adelaide 5001, South Australia

I completed my undergraduate degree then worked in Plant Virology with the late Prof Bob Symons before completing my PhD with Prof John Wallace, University of Adelaide. I then worked as a post-doc with Professor Chris Burrell and Dr Peng Li at the IMVS/SA Pathology from 1996-2008, part-time from 1998-2011 due to family commitments, studying the basic mechanisms of replication of HIV and virus-host interactions. From 2008-2011 I was also involved in the diagnostic management of clinical HIV drug resistance. At the same time I developed my own research interests in dengue virus stemming from an initial collaboration with A/Professor Peter Wright (Monash University). In March 2011 I re-located to my current full-time position at Flinders University. My current research interests continue in Medical Virology, in particular dengue virus and the interaction with the host cell that is associated with pathogenesis.

Qualifications
  • BSc, University of Adelaide, 1990
  • BSc, First Class Hons, University of Adelaide, Department of Biochemistry, 1991
  • PhD, Department of Biochemistry, University of Adelaide, 1995
Honours, awards and grants

For a full publication list go to Google Scholar https://scholar.google.com.au/citations?user=HdsCukAAAAAJ&hl=en

Key responsibilities
Research Activities: Laboratory head
Teaching: Microbiology and Infectious Diseases in first year graduate entry Medicine, second and third year Bachelor of Medical Science
Research expertise
Medical microbiology
Research interests

Overall theme of host responses to viral infections and determinants of pathogenesis. For more information about the lab, go to Virology Research.

  1. DENV interaction with the sphingosine kinase (SK)/sphingosine 1-phosophate (S1P) axis. In collaboration with Prof Stuart Pitson, Centre for Cancer Biology, SA Pathology.
  2. DENV effects on the endothelium. In collaboration with Dr Claudine Bonder, Centre for Cancer Biology, SA Pathology. An important cell target for the pathogeneic effects of DENV is the endothelium. We will investigate parameters effecting DENV infection of the endothelium, the cellular response to infection and the effect of this on endothelial function.
  3. The innate immune response and DENV. In collaboration with A/Prof Michael Beard, School of Molecular and Biomedical Science, University of Adelaide to investigate the action of the anti-viral factor, viperin. Addtionally, we are studying the interatction between DENV and factor H, a negative regulator of the alternative complement pathway in collaboration with Professor Dave Gordon, Head of MID at Flinders University.
  4. Viral inflammatory eye disease. In collaboration with Professor Justine Smith, Eye and Vision Health, Flinders University. Studies include investigation of the replication of viruses such as DENV and zika virus in different cells of the eye and the effect on occular, in particular retinal inflammatory responses.
Teaching interests

Medical microbiology and virology, in particular Dengue virus.

For more information: studying virology at Flinders University.

BMedSci year 2 course co-ordinator

Topic coordinator
MMED2935 Human Immunology and Infectious Diseases
MMED3939 Virology, Immunology and Immunopathogenesis
Topic lecturer
MMED8120A Knowledge of Health and Illness 1A - IMD
Supervisory interests
Dengue virus
Virus, virology
Higher degree by research supervision
Current
Principal supervisor: Microbiology and infectious diseases (1), Role of sphinhisane kinase and endotherlial cells in dengue virus pathogenesis. (1), Analysis of the role of sphingosine kinase in dengue virus replication and pathogenesis (1)
Completion
Principal supervisor: Altered responses of dengue virus infected cells to TNF-a (Univ of Adelaide) (1)
Publications